UA6043A1 - Method for producing chloroambucyl derivatives (variants) - Google Patents

Method for producing chloroambucyl derivatives (variants)

Info

Publication number
UA6043A1
UA6043A1 UA2804752A UA2804752A UA6043A1 UA 6043 A1 UA6043 A1 UA 6043A1 UA 2804752 A UA2804752 A UA 2804752A UA 2804752 A UA2804752 A UA 2804752A UA 6043 A1 UA6043 A1 UA 6043A1
Authority
UA
Ukraine
Prior art keywords
chloroambucyl
derivatives
producing
variants
reacted
Prior art date
Application number
UA2804752A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Асано Кіро
Тамура Хуміо
Володимир Hіканорович Молотков
Єномото Сатору
Original Assignee
Куреха Кагаку Когіо Кабусікі Кайся
Куреха Кагаку Когио Кабусики Кайся
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Куреха Кагаку Когіо Кабусікі Кайся, Куреха Кагаку Когио Кабусики Кайся filed Critical Куреха Кагаку Когіо Кабусікі Кайся
Publication of UA6043A1 publication Critical patent/UA6043A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals

Abstract

The invention relates to the method for producing chloroambucyl derivatives. Estradiol or its acylated derivative is reacted with monobromacetic acid or monobromacetylbromide in the presence of the organic solvent. The modified estradiol or its acylated derivative is reacted with the carboxylic group of chloroambucyl in the organic solvent followed by the isolation of the end-product.
UA2804752A 1978-08-14 1979-08-13 Method for producing chloroambucyl derivatives (variants) UA6043A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53098795A JPS5810393B2 (en) 1978-08-14 1978-08-14 Novel estradiol conjugate, its production method and antitumor agent

Publications (1)

Publication Number Publication Date
UA6043A1 true UA6043A1 (en) 1994-12-29

Family

ID=14229286

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2804752A UA6043A1 (en) 1978-08-14 1979-08-13 Method for producing chloroambucyl derivatives (variants)

Country Status (8)

Country Link
JP (1) JPS5810393B2 (en)
BE (1) BE878186A (en)
CS (1) CS242856B2 (en)
GE (1) GEP19960478B (en)
HU (1) HU180002B (en)
SU (1) SU1001860A3 (en)
UA (1) UA6043A1 (en)
YU (1) YU41345B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3490728T1 (en) * 1984-06-27 1986-06-05 Char'kovskij naučno-issledovatel'skij institut endokrinologii i chimii gormonov, Charkov Steroid derivatives of the androstane series

Also Published As

Publication number Publication date
BE878186A (en) 1980-02-11
SU1001860A3 (en) 1983-02-28
CS242856B2 (en) 1986-05-15
GEP19960478B (en) 1996-08-29
YU198179A (en) 1983-01-21
YU41345B (en) 1987-02-28
CS556679A2 (en) 1985-08-15
JPS5810393B2 (en) 1983-02-25
HU180002B (en) 1983-01-28
JPS5527121A (en) 1980-02-27

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