UA6043A1 - Method for producing chloroambucyl derivatives (variants) - Google Patents
Method for producing chloroambucyl derivatives (variants)Info
- Publication number
- UA6043A1 UA6043A1 UA2804752A UA2804752A UA6043A1 UA 6043 A1 UA6043 A1 UA 6043A1 UA 2804752 A UA2804752 A UA 2804752A UA 2804752 A UA2804752 A UA 2804752A UA 6043 A1 UA6043 A1 UA 6043A1
- Authority
- UA
- Ukraine
- Prior art keywords
- chloroambucyl
- derivatives
- producing
- variants
- reacted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to the method for producing chloroambucyl derivatives. Estradiol or its acylated derivative is reacted with monobromacetic acid or monobromacetylbromide in the presence of the organic solvent. The modified estradiol or its acylated derivative is reacted with the carboxylic group of chloroambucyl in the organic solvent followed by the isolation of the end-product.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53098795A JPS5810393B2 (en) | 1978-08-14 | 1978-08-14 | Novel estradiol conjugate, its production method and antitumor agent |
Publications (1)
Publication Number | Publication Date |
---|---|
UA6043A1 true UA6043A1 (en) | 1994-12-29 |
Family
ID=14229286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA2804752A UA6043A1 (en) | 1978-08-14 | 1979-08-13 | Method for producing chloroambucyl derivatives (variants) |
Country Status (8)
Country | Link |
---|---|
JP (1) | JPS5810393B2 (en) |
BE (1) | BE878186A (en) |
CS (1) | CS242856B2 (en) |
GE (1) | GEP19960478B (en) |
HU (1) | HU180002B (en) |
SU (1) | SU1001860A3 (en) |
UA (1) | UA6043A1 (en) |
YU (1) | YU41345B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2169900B (en) * | 1984-06-27 | 1988-02-17 | Onkologi N Ct Ak Med V | Derivatives of steroids of androstane series |
-
1978
- 1978-08-14 JP JP53098795A patent/JPS5810393B2/en not_active Expired
-
1979
- 1979-07-19 HU HU79KU545A patent/HU180002B/en not_active IP Right Cessation
- 1979-08-10 BE BE0/196683A patent/BE878186A/en not_active IP Right Cessation
- 1979-08-13 UA UA2804752A patent/UA6043A1/en unknown
- 1979-08-13 SU SU792804752A patent/SU1001860A3/en active
- 1979-08-14 CS CS795566A patent/CS242856B2/en unknown
- 1979-08-14 YU YU1981/79A patent/YU41345B/en unknown
-
1994
- 1994-09-07 GE GEAP19942153A patent/GEP19960478B/en unknown
Also Published As
Publication number | Publication date |
---|---|
SU1001860A3 (en) | 1983-02-28 |
CS556679A2 (en) | 1985-08-15 |
HU180002B (en) | 1983-01-28 |
JPS5527121A (en) | 1980-02-27 |
YU41345B (en) | 1987-02-28 |
YU198179A (en) | 1983-01-21 |
JPS5810393B2 (en) | 1983-02-25 |
GEP19960478B (en) | 1996-08-29 |
BE878186A (en) | 1980-02-11 |
CS242856B2 (en) | 1986-05-15 |
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