GEP19960478B - Procprocess for preparing derivatives of chloroambucyl (modifications)ess for preparing derivatives of chloroambucyl (modifications) - Google Patents

Procprocess for preparing derivatives of chloroambucyl (modifications)ess for preparing derivatives of chloroambucyl (modifications)

Info

Publication number
GEP19960478B
GEP19960478B GEAP19942153A GEAP1994002153A GEP19960478B GE P19960478 B GEP19960478 B GE P19960478B GE AP19942153 A GEAP19942153 A GE AP19942153A GE AP1994002153 A GEAP1994002153 A GE AP1994002153A GE P19960478 B GEP19960478 B GE P19960478B
Authority
GE
Georgia
Prior art keywords
chloroambucyl
interaction
organic solvent
modifications
oestradiol
Prior art date
Application number
GEAP19942153A
Inventor
Satoru Enomoto
Kiro Asano
Khiromitsu Tanaka
Khumio Tamura
Original Assignee
Kureha Chemical Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kureha Chemical Ind Co Ltd filed Critical Kureha Chemical Ind Co Ltd
Publication of GEP19960478B publication Critical patent/GEP19960478B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention refers to a method of reception of new derivatives of chloroambucyl, which possess antineoplastic activity. Technical result is expansion of an area of the medical properties attacking an alive organism. Derivatives of chloroambucyl of the formulas where R-hydrogen or acyl group are obtained in one case of interaction of oestradiol or its acidified derivant by 17 position with binding agent-monobromoacetic acid or monobromacetilbromide in the presence of organic solvent, then the modified oestradiol or its acidified derivant are subjected to interaction with carboxylaled group of chloroambucyl in organic solvent with the subsequent isolation of the final product. In the second case chloroambucyl is subjected to interaction on carboxylaled group with the binding agent - a monobromoacetic acid or monobromacetilbromide in the presence of organic solvent, then modified chloroambucyl is subjected to interaction with a hydroxyl group in 17 position of oestradiol or its acidified derivant in organic solvent with the subsequent isolation of the final product. 2 independent claims
GEAP19942153A 1978-08-14 1994-09-07 Procprocess for preparing derivatives of chloroambucyl (modifications)ess for preparing derivatives of chloroambucyl (modifications) GEP19960478B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53098795A JPS5810393B2 (en) 1978-08-14 1978-08-14 Novel estradiol conjugate, its production method and antitumor agent

Publications (1)

Publication Number Publication Date
GEP19960478B true GEP19960478B (en) 1996-08-29

Family

ID=14229286

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP19942153A GEP19960478B (en) 1978-08-14 1994-09-07 Procprocess for preparing derivatives of chloroambucyl (modifications)ess for preparing derivatives of chloroambucyl (modifications)

Country Status (8)

Country Link
JP (1) JPS5810393B2 (en)
BE (1) BE878186A (en)
CS (1) CS242856B2 (en)
GE (1) GEP19960478B (en)
HU (1) HU180002B (en)
SU (1) SU1001860A3 (en)
UA (1) UA6043A1 (en)
YU (1) YU41345B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2169900B (en) * 1984-06-27 1988-02-17 Onkologi N Ct Ak Med V Derivatives of steroids of androstane series

Also Published As

Publication number Publication date
YU198179A (en) 1983-01-21
CS242856B2 (en) 1986-05-15
HU180002B (en) 1983-01-28
UA6043A1 (en) 1994-12-29
CS556679A2 (en) 1985-08-15
BE878186A (en) 1980-02-11
SU1001860A3 (en) 1983-02-28
JPS5810393B2 (en) 1983-02-25
YU41345B (en) 1987-02-28
JPS5527121A (en) 1980-02-27

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