DE3120460A1 - Pyridoimidazolorifamycinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel - Google Patents

Pyridoimidazolorifamycinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Info

Publication number
DE3120460A1
DE3120460A1 DE19813120460 DE3120460A DE3120460A1 DE 3120460 A1 DE3120460 A1 DE 3120460A1 DE 19813120460 DE19813120460 DE 19813120460 DE 3120460 A DE3120460 A DE 3120460A DE 3120460 A1 DE3120460 A1 DE 3120460A1
Authority
DE
Germany
Prior art keywords
general formula
pyridoimidazolorifamycin
derivatives
radicals
meaning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19813120460
Other languages
German (de)
English (en)
Other versions
DE3120460C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Egidio Marchi
Lauretta 40033 Casalecchio di Reno Bologna Montecchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Farmaceutici SpA
Original Assignee
Alfa Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Farmaceutici SpA filed Critical Alfa Farmaceutici SpA
Publication of DE3120460A1 publication Critical patent/DE3120460A1/de
Application granted granted Critical
Publication of DE3120460C2 publication Critical patent/DE3120460C2/de
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE19813120460 1980-05-22 1981-05-22 Pyridoimidazolorifamycinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel Granted DE3120460A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03429/80A IT1154655B (it) 1980-05-22 1980-05-22 Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica

Publications (2)

Publication Number Publication Date
DE3120460A1 true DE3120460A1 (de) 1982-03-11
DE3120460C2 DE3120460C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-12-13

Family

ID=11107198

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19813120460 Granted DE3120460A1 (de) 1980-05-22 1981-05-22 Pyridoimidazolorifamycinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Country Status (25)

Country Link
US (1) US4341785A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS5711987A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AR (1) AR226212A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) AT373599B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU537093B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE888895A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1142518A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH648037A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3120460A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK157876C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EG (1) EG14891A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES502906A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI69467C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2482967A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB2079270B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR75640B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE51204B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1154655B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU83376A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL187022C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO155622C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (2) PH17207A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT73064B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE453089B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA813430B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199374B (it) * 1984-05-15 1988-12-30 Alfa Farmaceutici Spa Processo per la preparazione di pirido-imidazo-rifamicine
IT1264494B1 (it) * 1993-03-23 1996-09-24 Alfa Wassermann Spa Uso di rifaximin e di formulazioni che la contengono nel trattamento delle dispepsie gastriche originate da helicobacter
US7048906B2 (en) * 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6861053B1 (en) 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US5981522A (en) * 1995-09-01 1999-11-09 Kaneka Corporation Treatment of disease caused by infection of Helicobacter
TW534813B (en) * 1997-02-28 2003-06-01 Kaneka Corp Treating agent for diseases due to infection with helicobacter
CA2465846A1 (en) * 2001-11-21 2003-06-05 Activbiotics, Inc. Targeted therapeutics and uses thereof
US7078399B2 (en) * 2001-12-13 2006-07-18 Activbiotics, Inc. Sulfhydryl rifamycins and uses thereof
ES2385477T3 (es) * 2002-11-05 2012-07-25 Fadim S.R.L. Liberación continua y controlada de rifaximina
US7820652B2 (en) * 2003-09-24 2010-10-26 Activbiotics Pharma, Llc Regimen for the administration of rifamycin-class antibiotics
US7923553B2 (en) * 2003-11-07 2011-04-12 Alfa Wassermann, S.P.A. Processes for the production of polymorphic forms of rifaximin
US7906542B2 (en) * 2004-11-04 2011-03-15 Alfa Wassermann, S.P.A. Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin
US7902206B2 (en) * 2003-11-07 2011-03-08 Alfa Wassermann, S.P.A. Polymorphic forms α, β and γ of rifaximin
US20080262024A1 (en) * 2003-11-07 2008-10-23 Giuseppe Claudio Viscomi Rifaximin compositions and method of use
ITMI20032144A1 (it) * 2003-11-07 2005-05-08 Alfa Wassermann Spa Forme polimorfe di rifaximina, processi per ottenerle e
US7265107B2 (en) * 2004-03-10 2007-09-04 Cumbre Pharmaceuticals Inc. Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes
US7256187B2 (en) * 2004-03-10 2007-08-14 Cumbre Pharmaceuticals Inc. Rifamycin C-11 oxime derivatives effective against drug-resistant microbes
US7202246B2 (en) * 2004-06-09 2007-04-10 Cumbre Pharmaceuticals Inc. Spiro-rifamycin derivatives targeting RNA polymerase
US20060210483A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections
US20060210492A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Use of rifaximin for treatment and prevention of periodontal conditions
US8003118B2 (en) * 2005-03-02 2011-08-23 Kodsi Robert E Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis
EP1698630B1 (en) * 2005-03-03 2014-09-03 ALFA WASSERMANN S.p.A. New polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations
ITBO20050123A1 (it) 2005-03-07 2005-06-06 Alfa Wassermann Spa Formulazioni farmaceutiche gastroresistenti contenenti rifaximina
KR101327635B1 (ko) 2005-08-11 2013-11-12 타간타 테라퓨틱스 인크. 포스폰산화 리파마이신, 및 그의 뼈 및 관절 감염의 저지및 치료 용도
CN103263668A (zh) 2006-03-09 2013-08-28 萨利克斯药品公司 利福昔明抗直肠功能障碍制剂
PT2054066E (pt) 2006-08-02 2015-07-16 Salix Pharmaceuticals Inc Métodos para tratamento de enterite por radiação
ITMI20061692A1 (it) 2006-09-05 2008-03-06 Alfa Wassermann Spa Uso di polioli per ottenere forme polimorfe stabili di rifaximina
AU2007298733B2 (en) * 2006-09-22 2012-11-08 Cipla Limited Rifaximin
US20080159987A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Restless Legs Syndrome
US20080161337A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Chronic Prostatitis
ITMI20071241A1 (it) * 2007-06-20 2008-12-21 Solmag S P A Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta
EP2011486B2 (en) 2007-07-06 2015-08-12 Lupin Ltd. Pharmaceutical compositions of rifaximin
JP5755878B2 (ja) 2007-07-06 2015-07-29 ルパン リミテッドLupin Limited リファキシミンの薬剤組成物
US7709634B2 (en) * 2007-09-20 2010-05-04 Apotex Pharmachem Inc. Amorphous form of rifaximin and processes for its preparation
US8486956B2 (en) 2008-02-25 2013-07-16 Salix Pharmaceuticals, Ltd Forms of rifaximin and uses thereof
MX2010009389A (es) 2008-02-25 2010-11-22 Salix Pharmaceuticals Ltd Formas de rifaximina y sus usos.
US11779571B2 (en) 2008-02-26 2023-10-10 Salix Pharmaceuticals, Inc. Methods for treating irritable bowel syndrome (IBS)
PT2252148T (pt) 2008-02-26 2020-01-23 Salix Pharmaceuticals Ltd Métodos de tratamento da síndrome do intestino irritável
DK2294012T3 (da) 2008-05-07 2014-10-06 Salix Pharmaceuticals Ltd Administration af et tarmrensemiddel og et antibiotika til behandlingen af tarmsygdom
WO2010019511A2 (en) 2008-08-13 2010-02-18 Targanta Therapeutics Corp. Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections
US8980872B2 (en) 2008-09-26 2015-03-17 Aska Pharmaceutical Co., Ltd. Agent for preventing and/or treating functional gastrointestinal disorder
US12285414B2 (en) 2008-10-02 2025-04-29 Salix Pharmaceuticals, Inc. Methods of treating hepatic encephalopathy
BRPI0920465A2 (pt) 2008-10-02 2018-03-20 Salix Pharmaceuticals, Inc. metodo de tratamento de encefalopatia hepática
US8916193B2 (en) 2008-12-10 2014-12-23 Cipla Limited Rifaximin complexes
IT1397617B1 (it) * 2009-04-20 2013-01-18 Alfa Wassermann Spa Nuovi derivati della rifamicina
MX2011012829A (es) 2009-06-02 2012-02-28 Salix Pharmaceuticals Ltd Metodos para tratar encefalopatia hepatica.
KR20120062897A (ko) 2009-09-13 2012-06-14 샐릭스 파마슈티컬스 리미티드 과민성 장 증후군(ibs)의 치료방법
MY177151A (en) 2009-10-27 2020-09-08 Lupin Ltd Solid dispersion of rifaximin
CA2781580A1 (en) 2009-11-23 2011-05-26 Cipla Limited Topical foam composition
EP2401282B2 (en) 2009-12-28 2017-01-04 Silvio Massimo Lavagna Method for the production of amorphous rifaximin
JP5896380B2 (ja) 2010-02-18 2016-03-30 サリックス ファーマスーティカルズ,リミテッド 感染症を治療するための方法
IT1398550B1 (it) 2010-03-05 2013-03-01 Alfa Wassermann Spa Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo
WO2011110930A2 (en) 2010-03-10 2011-09-15 Lupin Limited Rifaximin ready-to-use suspension
MX345697B (es) 2010-07-12 2017-02-13 Salix Pharmaceuticals Ltd Formulaciones de rifaximina y usos de las mismas.
WO2012035544A2 (en) 2010-09-13 2012-03-22 Sequent Scientific Ltd. A novel polymorphic form of rifaximin and process for its preparation
AU2012214239B2 (en) 2011-02-11 2016-06-30 Salix Pharmaceuticals, Ltd. Forms of Rifaximin and uses thereof
WO2012150561A1 (en) 2011-05-02 2012-11-08 Ranbaxy Laboratories Limited Rifaximin dimethylformamide solvate
ITMI20110890A1 (it) 2011-05-19 2012-11-20 A M S A Anonima Materie Sint & Affini S P A Polimorfo di rifaximina e processo per la sua preparazione
ITBO20110461A1 (it) 2011-07-29 2013-01-30 Alfa Wassermann Spa Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali.
RU2496475C2 (ru) 2011-10-26 2013-10-27 Александр Васильевич Иващенко Фармацевтическая композиция и набор для лечения бактериальных инфекций
ES2986825T3 (es) 2011-11-02 2024-11-12 Salix Pharmaceuticals Inc Rifaximina para la repetición de tratamiento del síndrome del intestino irritable con predominio de diarrea
WO2013112809A2 (en) 2012-01-25 2013-08-01 Salix Pharmaceuticals, Ltd Rifaximin derivative and uses thereof
ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
WO2014091432A1 (en) 2012-12-12 2014-06-19 Ranbaxy Laboratories Limited Pharmaceutical compositions of rifaximin
CA2897758A1 (en) 2013-03-15 2014-09-18 Alfa Wassermann S.P.A. Rifaximin for use in the treating of vaginal infections
JP2016516988A (ja) 2013-03-15 2016-06-09 アルファ ワッセルマン ソシエタ ペル アチオニAlfa Wassermann S.P.A. 膣感染症を診断するための方法
NZ713440A (en) 2013-04-12 2019-02-22 Alfasigma Spa Nsaid administration and related compositions, methods and systems.
US9018225B1 (en) 2013-07-26 2015-04-28 Novel Laboratories Rifaximin crystalline forms and methods of preparation thereof
ES2621557T3 (es) 2014-03-31 2017-07-04 Euticals S.P.A. Mezcla polimórfica de rifaximina y su uso para la preparación de formulaciones sólidas
WO2015159275A2 (en) * 2014-04-19 2015-10-22 Granules India Limited An improved process for the preparation of rifamycin derivatives
EP3140313B1 (en) 2014-05-04 2020-02-26 Salix Pharmaceuticals, Inc. Ibs microbiota and uses thereof
NZ723571A (en) 2014-05-12 2020-02-28 Alfasigma Spa New solvated crystal form of rifaximin, production, compositions and uses thereof
EP2982764A1 (en) 2014-08-05 2016-02-10 ALFA WASSERMANN S.p.A. Identification of vaginal bacteria
US9988398B2 (en) 2016-06-07 2018-06-05 Cadila Healthcare Limited Crystalline form of rifaximin and process for its preparation
CN110072525B (zh) 2016-09-30 2022-12-02 萨利克斯药品公司 利福昔明的固态分散形式
IT201700091912A1 (it) * 2017-08-08 2019-02-08 Biofer Spa Nuove pirido-imidazo rifamicine
RU2020102511A (ru) 2017-06-26 2021-07-27 Биофер С.П.А. Соединения пиридо-имидазо рифамицина в качестве антибактериального средства

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE273377C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) *
AT273377B (de) * 1967-03-01 1969-08-11 Lepetit Spa Verfahren zur Herstellung von neuen Rifamycinen
AT358171B (de) * 1975-06-13 1980-08-25 Archifar Lab Chim Farm Verfahren zur herstellung von neuen rifamycin- -verbindungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK345977A (da) * 1976-09-30 1978-03-31 Archifar Ind Chim Trentino G rifamycinforbindelser og fremgangsmaade til deres fremstillin
CH629212A5 (it) * 1976-10-18 1982-04-15 Erba Farmitalia Procedimento per la preparazione di composti di rifamicina.
CH633014A5 (en) * 1978-06-09 1982-11-15 Erba Farmitalia Rifamycin compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE273377C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) *
AT273377B (de) * 1967-03-01 1969-08-11 Lepetit Spa Verfahren zur Herstellung von neuen Rifamycinen
AT358171B (de) * 1975-06-13 1980-08-25 Archifar Lab Chim Farm Verfahren zur herstellung von neuen rifamycin- -verbindungen

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
FORTH, W., HENSCHLER, D., REUMMEL, W.: Pharmakologie und Toxikologie, 4. Aufl., S. 322 *
FÜLGRAFT, G., PALM, D.:Pharmacotherapie, 3. Aufl.,1979, S. 145 *
GB-Appl. 20 84 575 A *
Journal of Antibiotics, Vol. XXXVII, 1984, S. 178-181 *
Rote Liste 77/78, 59147 B *
WALTER, A.M., HEILMEYER, L.: Antibiotica- Fibel, 4. Aufl., 1975, S. 549 *

Also Published As

Publication number Publication date
GB2079270B (en) 1984-01-18
IE51204B1 (en) 1986-10-29
NO155622C (no) 1987-04-29
ATA222781A (de) 1983-06-15
ES8203388A1 (es) 1982-04-01
AR226212A1 (es) 1982-06-15
IT1154655B (it) 1987-01-21
GR75640B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-08-02
NL8102290A (nl) 1981-12-16
NO155622B (no) 1987-01-19
LU83376A1 (fr) 1981-09-11
FR2482967B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1985-03-29
IE811139L (en) 1981-11-22
PT73064B (en) 1982-07-05
SE8103216L (sv) 1981-11-23
PT73064A (en) 1981-06-01
DK157876C (da) 1990-07-30
ES502906A0 (es) 1982-04-01
FR2482967A1 (fr) 1981-11-27
ZA813430B (en) 1982-06-30
FI69467B (fi) 1985-10-31
CH648037A5 (de) 1985-02-28
DK224781A (da) 1981-11-23
JPS6123192B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1986-06-04
AU7065581A (en) 1981-11-26
NL187022C (nl) 1991-05-01
JPS5711987A (en) 1982-01-21
GB2079270A (en) 1982-01-20
NO811731L (no) 1981-11-23
SE453089B (sv) 1988-01-11
PH17207A (en) 1984-06-19
CA1142518A (en) 1983-03-08
EG14891A (en) 1985-12-31
DE3120460C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-12-13
DK157876B (da) 1990-02-26
AT373599B (de) 1984-02-10
AU537093B2 (en) 1984-06-07
BE888895A (fr) 1981-09-16
FI69467C (fi) 1986-02-10
US4341785A (en) 1982-07-27
PH18704A (en) 1985-09-05
FI811565L (fi) 1981-11-23
IT8003429A0 (it) 1980-05-22
NL187022B (nl) 1990-12-03

Similar Documents

Publication Publication Date Title
DE3120460A1 (de) Pyridoimidazolorifamycinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2804097A1 (de) 1-ethyl-6-fluor-1,4-dihydro-7-(1- piperazinyl)-4-oxochinolin-3-carbonsaeure, ihre hydrate und salze mit saeuren
DE3043502A1 (de) Analoga von lincomycin und clindamycin
DE1946315C2 (de) 4,5-Dihydro-5-oxo-s-triazolo-[1,5-a]-pyrimidin-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
DE2462691C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT391864B (de) Verfahren zur herstellung von neuen 5-pyrimidincarboxamiden und deren additionssalzen
DE2502296C2 (de) 1-N-(S)-3-Amino-2-hydroxypropionyl- und 1-N-(S)-4-Amino-2-hydroxybutyryl-substituierte 4,6-Di-(aminoglycosyl)-1,3-diaminocyclitole und deren Salze, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
DE2921660A1 (de) 5-nitroimidazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende antiprotozoen-mittel
DE2509260C3 (de) a-(23,43,6-Penta-O-acetyl-D-gluconyl-thioureido)benzylpenicillin
DE1595876A1 (de) Verfahren zur Herstellung von Aminomethylderivaten von Rifamycin SV
DE2726820A1 (de) Imidazothiazine
DE1545699A1 (de) Neue Aminopyrazole
DE2035573A1 (de) Neue Imidazolderivate, ihre Herstellung und die sie enthaltenden medizinischen Zu sammensetzungen
DE2612287A1 (de) Aminoglykosid-antibiotika, verfahren zu ihrer herstellung und sie enthaltende arzneimittelzubereitungen
DE1695375C3 (de) 25-Desacetyl-rifamycin-SV-derivate u. Verfahren zu ihrer Herstellung
DE2005959B2 (de) Nitrochinoline
DE3438244C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE3618724A1 (de) N-(3-(nitro)-chinol-4-yl)-carboxamidinamide, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3418382A1 (de) Verfahren zur herstellung von 1,8-dihydroxy-10-acyl-9-anthronen
DE1934392C3 (de) Neue 2-Pyridylthioamide und Verfahren zu ihrer Herstellung
DE2917890C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD149528A5 (de) Verfahren zur herstellung von neuen beta-lactam-verbindungen
DE1545727C (de) 1 (5 Nitro 2 furyl) 2 (beta pyridyl) athylen und dessen N Oxyd sowie Verfahren zu deren Herstellung
AT229863B (de) Verfahren zur Herstellung des neuen 2-(5-Nitro-2-furyl)-imidazo-[1,2-a]-pyridins bzw. -pyrimidins
DE2222308A1 (de) 2,5-bis-substituierte pyrimidine

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition