DE3021792A1 - Neue 4-aroylimidazol-2-one - Google Patents

Neue 4-aroylimidazol-2-one

Info

Publication number
DE3021792A1
DE3021792A1 DE19803021792 DE3021792A DE3021792A1 DE 3021792 A1 DE3021792 A1 DE 3021792A1 DE 19803021792 DE19803021792 DE 19803021792 DE 3021792 A DE3021792 A DE 3021792A DE 3021792 A1 DE3021792 A1 DE 3021792A1
Authority
DE
Germany
Prior art keywords
radical
straight
chain
carbon atoms
branched lower
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19803021792
Other languages
German (de)
English (en)
Other versions
DE3021792C2 (xx
Inventor
Richard C Dage
J Martin Grisar
Richard A Schnettler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Vicks Inc
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26727558&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3021792(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of DE3021792A1 publication Critical patent/DE3021792A1/de
Application granted granted Critical
Publication of DE3021792C2 publication Critical patent/DE3021792C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19803021792 1979-06-18 1980-06-11 Neue 4-aroylimidazol-2-one Granted DE3021792A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4980879A 1979-06-18 1979-06-18
US11920780A 1980-02-07 1980-02-07

Publications (2)

Publication Number Publication Date
DE3021792A1 true DE3021792A1 (de) 1981-01-22
DE3021792C2 DE3021792C2 (xx) 1989-08-10

Family

ID=26727558

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19803021792 Granted DE3021792A1 (de) 1979-06-18 1980-06-11 Neue 4-aroylimidazol-2-one

Country Status (20)

Country Link
AT (1) AT375349B (xx)
AU (1) AU532783B2 (xx)
CA (1) CA1132554A (xx)
CH (1) CH646155A5 (xx)
DE (1) DE3021792A1 (xx)
DK (1) DK160269C (xx)
ES (1) ES8105299A1 (xx)
FR (1) FR2459233A1 (xx)
GB (1) GB2055364B (xx)
HK (1) HK61486A (xx)
HU (1) HU186736B (xx)
IE (1) IE50646B1 (xx)
IL (1) IL60243A (xx)
IT (1) IT1143922B (xx)
MY (1) MY8600709A (xx)
NL (2) NL193752C (xx)
NO (1) NO152841C (xx)
NZ (1) NZ193935A (xx)
PH (1) PH18683A (xx)
SE (2) SE447107B (xx)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4329471A (en) * 1981-05-04 1982-05-11 Merrell Dow Pharmaceuticals Inc. 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
US4329470A (en) 1981-05-04 1982-05-11 Merrell Dow Pharmaceuticals Inc. 5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
US4367236A (en) 1981-11-04 1983-01-04 Merrell Dow Pharmaceuticals Inc. Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
US4371737A (en) * 1981-05-04 1983-02-01 Merrell Dow Pharmaceuticals Inc. 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
US4381393A (en) * 1981-05-04 1983-04-26 Merrell Dow Pharmaceuticals Inc. 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
US4526981A (en) * 1981-05-04 1985-07-02 Merrell Dow Pharmaceuticals Inc. [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates
EP2088154A1 (en) 2004-03-09 2009-08-12 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP2218442A1 (en) 2005-11-09 2010-08-18 CombinatoRx, Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
WO2011069038A2 (en) 2009-12-03 2011-06-09 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2012118972A2 (en) 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2013138352A1 (en) 2012-03-15 2013-09-19 Synergy Pharmaceuticals Inc. Formulations of guanylate cyclase c agonists and methods of use
WO2014131024A2 (en) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP2810951A2 (en) 2008-06-04 2014-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2014197720A2 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
WO2015021358A2 (en) 2013-08-09 2015-02-12 Dominique Charmot Compounds and methods for inhibiting phosphate transport
EP2998314A1 (en) 2007-06-04 2016-03-23 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839A1 (en) 2008-07-16 2017-11-08 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH18106A (en) * 1981-02-18 1985-03-21 Merrell Dow Pharma Novel-4-aroylimidazol-2-ones
US4405628A (en) * 1981-03-05 1983-09-20 Merrell Dow Pharmaceuticals Inc. 4-Pyridylimidazolones and method of use
ZA822990B (en) * 1981-05-04 1983-03-30 Merrell Dow Pharma 4-oxymethyl-5-acyl-1,3-dihydro-2h-imidazol-2-ones
US4410540A (en) * 1981-11-04 1983-10-18 Merrell Dow Pharmaceuticals Inc. Cardiotonic 4-aroylimidazolidin-2-ones
WO2005092333A1 (en) * 2004-03-22 2005-10-06 Myogen, Inc. (r)-enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases
US20060025463A1 (en) * 2004-03-22 2006-02-02 Michael Bristow Enoximone sulfoxide enantiomers and their use in the treatment of PDE-III mediated diseases
CN114539157B (zh) * 2022-03-03 2023-12-22 曲靖师范学院 一种碘促进氧化法制备4-碘代n-芳基吡唑类化合物的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441933A (en) * 1945-07-30 1948-05-18 Hoffmann La Roche Substituted imidazolones and process of making them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441933A (en) * 1945-07-30 1948-05-18 Hoffmann La Roche Substituted imidazolones and process of making them

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Chem. Abstr. 70, 37720f, 1969, (2) *

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4329470A (en) 1981-05-04 1982-05-11 Merrell Dow Pharmaceuticals Inc. 5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
US4371737A (en) * 1981-05-04 1983-02-01 Merrell Dow Pharmaceuticals Inc. 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
US4381393A (en) * 1981-05-04 1983-04-26 Merrell Dow Pharmaceuticals Inc. 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
US4526981A (en) * 1981-05-04 1985-07-02 Merrell Dow Pharmaceuticals Inc. [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates
US4329471A (en) * 1981-05-04 1982-05-11 Merrell Dow Pharmaceuticals Inc. 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
US4367236A (en) 1981-11-04 1983-01-04 Merrell Dow Pharmaceuticals Inc. Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
EP2088154A1 (en) 2004-03-09 2009-08-12 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP2218442A1 (en) 2005-11-09 2010-08-18 CombinatoRx, Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
EP2998314A1 (en) 2007-06-04 2016-03-23 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2810951A2 (en) 2008-06-04 2014-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839A1 (en) 2008-07-16 2017-11-08 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
EP2923706A1 (en) 2009-12-03 2015-09-30 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia
WO2011069038A2 (en) 2009-12-03 2011-06-09 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2012118972A2 (en) 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2013138352A1 (en) 2012-03-15 2013-09-19 Synergy Pharmaceuticals Inc. Formulations of guanylate cyclase c agonists and methods of use
EP3708179A1 (en) 2012-03-15 2020-09-16 Bausch Health Ireland Limited Formulations of guanylate cyclase c agonists and methods of use
EP4309673A2 (en) 2012-03-15 2024-01-24 Bausch Health Ireland Limited Formulations of guanylate cyclase c agonists and methods of use
WO2014131024A2 (en) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP3718557A2 (en) 2013-02-25 2020-10-07 Bausch Health Ireland Limited Guanylate cyclase receptor agonist sp-333 for use in colonic cleansing
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014197720A2 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
WO2015021358A2 (en) 2013-08-09 2015-02-12 Dominique Charmot Compounds and methods for inhibiting phosphate transport
EP3492106A1 (en) 2013-08-09 2019-06-05 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
EP3884935A1 (en) 2013-08-09 2021-09-29 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Also Published As

Publication number Publication date
NL8003498A (nl) 1980-12-22
HK61486A (en) 1986-08-29
NO152841B (no) 1985-08-19
CA1132554A (en) 1982-09-28
MY8600709A (en) 1986-12-31
NL193752C (nl) 2000-09-04
HU186736B (en) 1985-09-30
ES492255A0 (es) 1981-06-01
IT8048997A0 (it) 1980-06-17
CH646155A5 (de) 1984-11-15
IE801162L (en) 1980-12-18
GB2055364A (en) 1981-03-04
IT1143922B (it) 1986-10-29
SE464559B (sv) 1991-05-13
DK160269B (da) 1991-02-18
NO801796L (no) 1980-12-19
SE447107B (sv) 1986-10-27
SE8004253L (sv) 1980-12-19
GB2055364B (en) 1983-06-08
IL60243A (en) 1987-01-30
AU532783B2 (en) 1983-10-13
SE8501452D0 (sv) 1985-03-25
NO152841C (no) 1985-11-27
IE50646B1 (en) 1986-06-11
AT375349B (de) 1984-07-25
ES8105299A1 (es) 1981-06-01
NL193752B (nl) 2000-05-01
AU5911880A (en) 1981-01-08
DE3021792C2 (xx) 1989-08-10
PH18683A (en) 1985-08-29
FR2459233A1 (fr) 1981-01-09
ATA314280A (de) 1983-12-15
NL300015I1 (nl) 2000-11-01
DK160269C (da) 1991-07-22
FR2459233B1 (xx) 1983-09-23
NZ193935A (en) 1985-05-31
DK259080A (da) 1980-12-19
IL60243A0 (en) 1980-09-16
NL300015I2 (nl) 2000-10-02
SE8501452L (sv) 1985-03-25

Similar Documents

Publication Publication Date Title
DE3021792A1 (de) Neue 4-aroylimidazol-2-one
EP0068261B1 (de) N-Oxacyclyl-Alkylpiperidin-Derivate, Verfahren zu ihrer Herstellung, sie enthaltende pharmazeutische Präparate und deren Verwendung
DE1907670C3 (xx)
DE60004671T2 (de) Neue piperazinylalkylthiopyrimidine derivate, diese enthaltende pharmazeutische zusammenstellungen und verfahren zu deren herstellung
DE3622036A1 (de) Benzimidazolderivate
DE69820066T2 (de) Piperazinderivate zur behandlung der niedrigen harnwege
DE2106694A1 (de) 5 Aryl 2 3 dihydro 2 2(oder 3 3)-dimethyl 5H imidazo eckige Klammer auf 2 1 a eckige Klammer zu Isomdol 5 öle und 2(4 4(oder 5 5) Dimethyl 2 lmidazolin 2 yl) benzophenonsaure additionssalze und Verfahren zu ihrer Her stellung
DE2257443A1 (de) Neue heterocyclische verbindungen und verfahren zu deren herstellung
DE1470089A1 (de) Verfahren zur Herstellung von 3-Amino-5-subst.-Pyrazinoylguanidinen
EP0058435A2 (en) Novel 4-aroylimidazol-2-ones
DE2456098C3 (de) Xanthen- und Thioxanthen-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
JPH0223548B2 (xx)
DE2131330A1 (de) Imidazo-[1,2-a]-benzimidazolderivate und Verfahren zur Herstellung derselben
DE1941534B2 (de) Hexahydroazepine und diese Verbindungen enthaltende Arzneimittel
DE2000775B2 (de) Substituierte 1,2,3,4-Tetrahydrobenzothieno [23-c] pyridin-Verbindungen, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung, die diese Verbindungen enthält
DE3124013A1 (de) 2-acylaminomethyl-1,4-benzodiazepin-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3028064A1 (de) Neue 4-(naphthalinyloxy)piperidin- derivate
DE3404193A1 (de) 5-fluor-pyrimidin-2-yl-piperazin-verbindung, verfahren zu ihrer herstellung und pharmazeutische mittel
DE3121137A1 (de) Neue pyridazino(4,5-b)indole, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen, zwischenprodukte und deren herstellung"
DE2340010A1 (de) Cyclische, n-substituierte 1,4benzoldisulfonamid-derivate
DE2340217A1 (de) 3-benzoylthiophene, ihre salze, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2360852A1 (de) Neue azabenzo-1,5-diazepine
CH337203A (de) Verfahren zur Herstellung einer neuen heterocyclischen Verbindung
DE2061994A1 (de) Substituierte Anthramlsauren
DE1545551C3 (de) 7-Brom-6-halogen-3-[3-(3.hydroxy-2-piperidyl)acetonyl]-4(3H)-chinazolinone und ein Verfahren zu ihrer Herstellung

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition