ES8105299A1 - Procedimiento para preparar aroilimidazol-2-onas - Google Patents

Procedimiento para preparar aroilimidazol-2-onas

Info

Publication number
ES8105299A1
ES8105299A1 ES492255A ES492255A ES8105299A1 ES 8105299 A1 ES8105299 A1 ES 8105299A1 ES 492255 A ES492255 A ES 492255A ES 492255 A ES492255 A ES 492255A ES 8105299 A1 ES8105299 A1 ES 8105299A1
Authority
ES
Spain
Prior art keywords
alkyl
phenyl
hydrogen
alkoxy
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES492255A
Other languages
English (en)
Other versions
ES492255A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Vicks Inc
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26727558&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8105299(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of ES8105299A1 publication Critical patent/ES8105299A1/es
Publication of ES492255A0 publication Critical patent/ES492255A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom

Abstract

PROCEDIMIENTO DE OBTENCION DE ARCILIMIDAZOL-2-ONAS. CONSISTE EN SOMETER A ACILACION DE FRIEDEL-CRAFTS UN COMPUESTO (I) CON UN 2-FUROIL-HALURO, 2-TIENOIL HALURO O UN BENZOIL HALURO MONOSUSTITUIDO EN PRESENCIA DE 1 A 10 EQUIVALENTES SOLARES DE UN CATALIZADOR ACIDO DE LEWIS, EN UN DISOLVENTE Y A UNA TEMPERATURA DE 0 A 100GC DURANTE UN TIEMPO DE 1 A 10 HORAS. SE OBTIENE EL COMPUESTO II Y CUANDO SE DESEE SE ACILA O ALQUILIZA LA AROILIMIDAZOL-2-ONAS RESULTANTE CON UN ACILHALURO O AGENTE ALQUILIZANTE. *FORMULA* ANTIHIPERTENSIVOS, CARDIOLOGICOS Y ANTITROMBOTICOS.
ES492255A 1979-06-18 1980-06-09 Procedimiento para preparar aroilimidazol-2-onas Granted ES492255A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4980879A 1979-06-18 1979-06-18
US11920780A 1980-02-07 1980-02-07

Publications (2)

Publication Number Publication Date
ES8105299A1 true ES8105299A1 (es) 1981-06-01
ES492255A0 ES492255A0 (es) 1981-06-01

Family

ID=26727558

Family Applications (1)

Application Number Title Priority Date Filing Date
ES492255A Granted ES492255A0 (es) 1979-06-18 1980-06-09 Procedimiento para preparar aroilimidazol-2-onas

Country Status (20)

Country Link
AT (1) AT375349B (es)
AU (1) AU532783B2 (es)
CA (1) CA1132554A (es)
CH (1) CH646155A5 (es)
DE (1) DE3021792A1 (es)
DK (1) DK160269C (es)
ES (1) ES492255A0 (es)
FR (1) FR2459233A1 (es)
GB (1) GB2055364B (es)
HK (1) HK61486A (es)
HU (1) HU186736B (es)
IE (1) IE50646B1 (es)
IL (1) IL60243A (es)
IT (1) IT1143922B (es)
MY (1) MY8600709A (es)
NL (2) NL193752C (es)
NO (1) NO152841C (es)
NZ (1) NZ193935A (es)
PH (1) PH18683A (es)
SE (2) SE447107B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH18106A (en) * 1981-02-18 1985-03-21 Merrell Dow Pharma Novel-4-aroylimidazol-2-ones
US4405628A (en) * 1981-03-05 1983-09-20 Merrell Dow Pharmaceuticals Inc. 4-Pyridylimidazolones and method of use
US4526981A (en) * 1981-05-04 1985-07-02 Merrell Dow Pharmaceuticals Inc. [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates
US4371737A (en) * 1981-05-04 1983-02-01 Merrell Dow Pharmaceuticals Inc. 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
GB2097792B (en) * 1981-05-04 1985-01-03 Merrell Dow Pharma 1,3-dihydro-2h-imidazol-2-ones
US4329470A (en) 1981-05-04 1982-05-11 Merrell Dow Pharmaceuticals Inc. 5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
US4329471A (en) * 1981-05-04 1982-05-11 Merrell Dow Pharmaceuticals Inc. 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
US4381393A (en) * 1981-05-04 1983-04-26 Merrell Dow Pharmaceuticals Inc. 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
US4367236A (en) 1981-11-04 1983-01-04 Merrell Dow Pharmaceuticals Inc. Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
US4410540A (en) * 1981-11-04 1983-10-18 Merrell Dow Pharmaceuticals Inc. Cardiotonic 4-aroylimidazolidin-2-ones
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
JP2007530563A (ja) * 2004-03-22 2007-11-01 ミオゲン インコーポレイティッド （ｓ）−エノキシモンスルホキシドおよびｐｄｅ−ｉｉｉ媒介疾患の治療におけるその使用
US20060030611A1 (en) * 2004-03-22 2006-02-09 Myogen, Inc. Enoximone sulfoxide enantiomers and their use in the treatment of PDE-III mediated diseases
US8067433B2 (en) 2005-11-09 2011-11-29 Zalicus Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA3089569C (en) 2007-06-04 2023-12-05 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2828346C (en) 2011-03-01 2021-01-26 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
KR20160042039A (ko) 2013-08-09 2016-04-18 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
EP3972599A1 (en) 2019-05-21 2022-03-30 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
CN114539157B (zh) * 2022-03-03 2023-12-22 曲靖师范学院 一种碘促进氧化法制备4-碘代n-芳基吡唑类化合物的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441933A (en) * 1945-07-30 1948-05-18 Hoffmann La Roche Substituted imidazolones and process of making them

Also Published As

Publication number Publication date
DE3021792A1 (de) 1981-01-22
FR2459233A1 (fr) 1981-01-09
AT375349B (de) 1984-07-25
DK160269C (da) 1991-07-22
DK259080A (da) 1980-12-19
NL300015I1 (nl) 2000-11-01
GB2055364A (en) 1981-03-04
CA1132554A (en) 1982-09-28
NL193752C (nl) 2000-09-04
IE801162L (en) 1980-12-18
CH646155A5 (de) 1984-11-15
IE50646B1 (en) 1986-06-11
FR2459233B1 (es) 1983-09-23
NL8003498A (nl) 1980-12-22
IL60243A (en) 1987-01-30
NL300015I2 (nl) 2000-10-02
SE8501452L (sv) 1985-03-25
IT1143922B (it) 1986-10-29
NO152841C (no) 1985-11-27
NL193752B (nl) 2000-05-01
SE464559B (sv) 1991-05-13
PH18683A (en) 1985-08-29
NZ193935A (en) 1985-05-31
IL60243A0 (en) 1980-09-16
DE3021792C2 (es) 1989-08-10
DK160269B (da) 1991-02-18
HU186736B (en) 1985-09-30
MY8600709A (en) 1986-12-31
ATA314280A (de) 1983-12-15
AU532783B2 (en) 1983-10-13
NO801796L (no) 1980-12-19
ES492255A0 (es) 1981-06-01
NO152841B (no) 1985-08-19
SE8501452D0 (sv) 1985-03-25
GB2055364B (en) 1983-06-08
AU5911880A (en) 1981-01-08
IT8048997A0 (it) 1980-06-17
SE447107B (sv) 1986-10-27
SE8004253L (sv) 1980-12-19
HK61486A (en) 1986-08-29

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