NL193752B - 1,3-Dihydro-4-(aroyl)-2H-imidazool-2-onen en anti-hypertensief, cardiotoon en anti-trombotisch werkzaam farmaceutisch preparaat. - Google Patents

1,3-Dihydro-4-(aroyl)-2H-imidazool-2-onen en anti-hypertensief, cardiotoon en anti-trombotisch werkzaam farmaceutisch preparaat.

Info

Publication number
NL193752B
NL193752B NL8003498A NL8003498A NL193752B NL 193752 B NL193752 B NL 193752B NL 8003498 A NL8003498 A NL 8003498A NL 8003498 A NL8003498 A NL 8003498A NL 193752 B NL193752 B NL 193752B
Authority
NL
Netherlands
Prior art keywords
cardiotonic
aroyl
hypertensive
dihydro
imidazole
Prior art date
Application number
NL8003498A
Other languages
English (en)
Other versions
NL8003498A (nl
NL193752C (nl
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26727558&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL193752(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of NL8003498A publication Critical patent/NL8003498A/nl
Publication of NL193752B publication Critical patent/NL193752B/nl
Application granted granted Critical
Publication of NL193752C publication Critical patent/NL193752C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NL8003498A 1979-06-18 1980-06-17 1,3-Dihydro-4-(aroyl)-2H-imidazool-2-onen en anti-hypertensief, cardiotoon en anti-trombotisch werkzaam farmaceutisch preparaat. NL193752C (nl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4980879A 1979-06-18 1979-06-18
US4980879 1979-06-18
US11920780A 1980-02-07 1980-02-07
US11920780 1980-02-07

Publications (3)

Publication Number Publication Date
NL8003498A NL8003498A (nl) 1980-12-22
NL193752B true NL193752B (nl) 2000-05-01
NL193752C NL193752C (nl) 2000-09-04

Family

ID=26727558

Family Applications (2)

Application Number Title Priority Date Filing Date
NL8003498A NL193752C (nl) 1979-06-18 1980-06-17 1,3-Dihydro-4-(aroyl)-2H-imidazool-2-onen en anti-hypertensief, cardiotoon en anti-trombotisch werkzaam farmaceutisch preparaat.
NL300015C NL300015I1 (nl) 1979-06-18 2000-09-04 1,3-Dihydro-4-(aroyl)-2H-imidazool-2-onen en anti-hypertensief, cardiotoon en anti-trombotisch werkzaam farmaceutisch preparaat.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NL300015C NL300015I1 (nl) 1979-06-18 2000-09-04 1,3-Dihydro-4-(aroyl)-2H-imidazool-2-onen en anti-hypertensief, cardiotoon en anti-trombotisch werkzaam farmaceutisch preparaat.

Country Status (20)

Country Link
AT (1) AT375349B (nl)
AU (1) AU532783B2 (nl)
CA (1) CA1132554A (nl)
CH (1) CH646155A5 (nl)
DE (1) DE3021792A1 (nl)
DK (1) DK160269C (nl)
ES (1) ES492255A0 (nl)
FR (1) FR2459233A1 (nl)
GB (1) GB2055364B (nl)
HK (1) HK61486A (nl)
HU (1) HU186736B (nl)
IE (1) IE50646B1 (nl)
IL (1) IL60243A (nl)
IT (1) IT1143922B (nl)
MY (1) MY8600709A (nl)
NL (2) NL193752C (nl)
NO (1) NO152841C (nl)
NZ (1) NZ193935A (nl)
PH (1) PH18683A (nl)
SE (2) SE447107B (nl)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH18106A (en) * 1981-02-18 1985-03-21 Merrell Dow Pharma Novel-4-aroylimidazol-2-ones
US4405628A (en) * 1981-03-05 1983-09-20 Merrell Dow Pharmaceuticals Inc. 4-Pyridylimidazolones and method of use
US4371737A (en) * 1981-05-04 1983-02-01 Merrell Dow Pharmaceuticals Inc. 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
US4329470A (en) 1981-05-04 1982-05-11 Merrell Dow Pharmaceuticals Inc. 5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
US4526981A (en) * 1981-05-04 1985-07-02 Merrell Dow Pharmaceuticals Inc. [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates
AU549872B2 (en) * 1981-05-04 1986-02-20 Merrell Dow Pharmaceuticals Inc. 4-oxymethyl-5-acyl-1,3-dihydro-2h-imidazol-2-ones
US4381393A (en) * 1981-05-04 1983-04-26 Merrell Dow Pharmaceuticals Inc. 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
US4329471A (en) * 1981-05-04 1982-05-11 Merrell Dow Pharmaceuticals Inc. 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
US4367236A (en) * 1981-11-04 1983-01-04 Merrell Dow Pharmaceuticals Inc. Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
US4410540A (en) * 1981-11-04 1983-10-18 Merrell Dow Pharmaceuticals Inc. Cardiotonic 4-aroylimidazolidin-2-ones
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP1737448A1 (en) * 2004-03-22 2007-01-03 Myogen, Inc. (s) - enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases
JP2007530566A (ja) * 2004-03-22 2007-11-01 ミオゲン インコーポレイティッド （ｒ）−エノキシモンスルホキシドおよびｐｄｅ−ｉｉｉ媒介疾患の治療におけるその使用
EP1956906A4 (en) 2005-11-09 2009-12-30 Combinatorx Inc METHODS, COMPOSITIONS AND KITS FOR THE TREATMENT OF PATHOLOGIES
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
CA3089569C (en) 2007-06-04 2023-12-05 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (zh) 2011-03-01 2018-10-19 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
JP6499591B2 (ja) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
RS65632B1 (sr) 2013-06-05 2024-07-31 Bausch Health Ireland Ltd Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe
WO2015021358A2 (en) 2013-08-09 2015-02-12 Dominique Charmot Compounds and methods for inhibiting phosphate transport
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ
CN114539157B (zh) * 2022-03-03 2023-12-22 曲靖师范学院 一种碘促进氧化法制备4-碘代n-芳基吡唑类化合物的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441933A (en) * 1945-07-30 1948-05-18 Hoffmann La Roche Substituted imidazolones and process of making them

Also Published As

Publication number Publication date
HK61486A (en) 1986-08-29
NO152841B (no) 1985-08-19
IE50646B1 (en) 1986-06-11
DK160269C (da) 1991-07-22
IE801162L (en) 1980-12-18
NZ193935A (en) 1985-05-31
IT8048997A0 (it) 1980-06-17
SE447107B (sv) 1986-10-27
DK160269B (da) 1991-02-18
FR2459233B1 (nl) 1983-09-23
MY8600709A (en) 1986-12-31
NL8003498A (nl) 1980-12-22
SE8501452D0 (sv) 1985-03-25
NO152841C (no) 1985-11-27
AT375349B (de) 1984-07-25
AU532783B2 (en) 1983-10-13
CH646155A5 (de) 1984-11-15
IT1143922B (it) 1986-10-29
HU186736B (en) 1985-09-30
GB2055364B (en) 1983-06-08
NL193752C (nl) 2000-09-04
NL300015I2 (nl) 2000-10-02
DE3021792C2 (nl) 1989-08-10
DK259080A (da) 1980-12-19
AU5911880A (en) 1981-01-08
SE8501452L (sv) 1985-03-25
NL300015I1 (nl) 2000-11-01
NO801796L (no) 1980-12-19
FR2459233A1 (fr) 1981-01-09
ES8105299A1 (es) 1981-06-01
DE3021792A1 (de) 1981-01-22
ES492255A0 (es) 1981-06-01
GB2055364A (en) 1981-03-04
SE8004253L (sv) 1980-12-19
CA1132554A (en) 1982-09-28
IL60243A (en) 1987-01-30
IL60243A0 (en) 1980-09-16
PH18683A (en) 1985-08-29
ATA314280A (de) 1983-12-15
SE464559B (sv) 1991-05-13

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Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
CNR Transfer of rights (patent application after its laying open for public inspection)

Free format text: MERREL DOW PHARMACEUTICALS INC.

DNT Communications of changes of names of applicants whose applications have been laid open to public inspection

Free format text: MERRELL PHARMACEUTICALS INC.

AC1 Application for a supplementary protection certificate

Free format text: 300015, 20000904

KC1 Grant of a supplementary protection certificate

Free format text: 300015, 20000617, EXPIRES: 20021026

V4 Discontinued because of reaching the maximum lifetime of a patent

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