DE2840142A1 - Die mit cyclodextrin gebildeten einschlusskomplexe des prostacyclins und seiner derivate sowie verfahren zur herstellung dieser komplexe - Google Patents

Die mit cyclodextrin gebildeten einschlusskomplexe des prostacyclins und seiner derivate sowie verfahren zur herstellung dieser komplexe

Info

Publication number
DE2840142A1
DE2840142A1 DE19782840142 DE2840142A DE2840142A1 DE 2840142 A1 DE2840142 A1 DE 2840142A1 DE 19782840142 DE19782840142 DE 19782840142 DE 2840142 A DE2840142 A DE 2840142A DE 2840142 A1 DE2840142 A1 DE 2840142A1
Authority
DE
Germany
Prior art keywords
cyclodextrin
derivatives
solution
organic
complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19782840142
Other languages
German (de)
English (en)
Inventor
Gyoergy Dr Cseh
Istvan Dr Stadler
Geb Rengei Magdolna Dr Szejtli
Jozsef Dipl Ing Chem D Szejtli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of DE2840142A1 publication Critical patent/DE2840142A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE19782840142 1977-09-23 1978-09-15 Die mit cyclodextrin gebildeten einschlusskomplexe des prostacyclins und seiner derivate sowie verfahren zur herstellung dieser komplexe Ceased DE2840142A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU77CI1770A HU179141B (enExample) 1977-09-23 1977-09-23

Publications (1)

Publication Number Publication Date
DE2840142A1 true DE2840142A1 (de) 1979-04-05

Family

ID=10994670

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782840142 Ceased DE2840142A1 (de) 1977-09-23 1978-09-15 Die mit cyclodextrin gebildeten einschlusskomplexe des prostacyclins und seiner derivate sowie verfahren zur herstellung dieser komplexe

Country Status (20)

Country Link
JP (1) JPS5456685A (enExample)
AT (1) AT369362B (enExample)
BE (1) BE870646A (enExample)
CH (1) CH637388A5 (enExample)
CS (1) CS200242B2 (enExample)
DD (1) DD138600A5 (enExample)
DE (1) DE2840142A1 (enExample)
DK (1) DK420778A (enExample)
FI (1) FI65912C (enExample)
FR (1) FR2404006A1 (enExample)
GB (1) GB2006193B (enExample)
GR (1) GR65001B (enExample)
HU (1) HU179141B (enExample)
IL (1) IL55569A (enExample)
IT (1) IT1160661B (enExample)
NL (1) NL7809643A (enExample)
PL (1) PL121664B1 (enExample)
SE (1) SE447574B (enExample)
SU (1) SU847914A3 (enExample)
YU (1) YU220678A (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989004828A1 (fr) * 1987-11-27 1989-06-01 Schering Aktiengesellschaft Clathrates de cyclodextrine de derives de 5-cyano-prostacycline et leur emploi comme medicaments
US4886788A (en) * 1986-03-07 1989-12-12 Schering Aktiengesellschaft Cyclodextrin clathrates of carbacyclin derivatives and their use as medicinal agents

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53136513A (en) * 1977-05-06 1978-11-29 Ono Pharmaceut Co Ltd Stabilization of prostaglandin-x-related compounds
US4352793A (en) * 1979-04-26 1982-10-05 Sumitomo Chemical Company, Limited Pharmaceutical composition comprising bencyclane fumarate and cyclodextrin
JPS5920230A (ja) * 1982-07-19 1984-02-01 チバ−ガイギ−・アクチエンゲゼルシヤフト ピルプロフエン含有薬剤
JPS61289034A (ja) * 1985-06-17 1986-12-19 Teijin Ltd イソカルバサイクリン類脂肪乳剤
US7655442B2 (en) 2004-01-29 2010-02-02 Eisai R&D Management Co., Ltd. Method for stabilizing macrolide compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2500451A1 (de) * 1974-01-10 1975-07-17 Ono Pharmaceutical Co Prostaglandinanaloge, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE2819447A1 (de) * 1977-05-06 1978-11-09 Ono Pharmaceutical Co Prostaglandin-analoge enthaltende praeparate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS503362B1 (enExample) * 1970-06-10 1975-02-04
JPS5395958A (en) * 1977-01-31 1978-08-22 Ono Pharmaceut Co Ltd Prostaglandin analogues and process for their preparation
US4178367A (en) * 1977-02-21 1979-12-11 Ono Pharmaceutical Co. Ltd. Prostaglandin I2 analogues

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2500451A1 (de) * 1974-01-10 1975-07-17 Ono Pharmaceutical Co Prostaglandinanaloge, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE2819447A1 (de) * 1977-05-06 1978-11-09 Ono Pharmaceutical Co Prostaglandin-analoge enthaltende praeparate

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886788A (en) * 1986-03-07 1989-12-12 Schering Aktiengesellschaft Cyclodextrin clathrates of carbacyclin derivatives and their use as medicinal agents
WO1989004828A1 (fr) * 1987-11-27 1989-06-01 Schering Aktiengesellschaft Clathrates de cyclodextrine de derives de 5-cyano-prostacycline et leur emploi comme medicaments
DE3740838A1 (de) * 1987-11-27 1989-06-08 Schering Ag Cyclodextrinclathrate von 5-cyano-prostacyclinderivaten und ihre verwendung als arzneimittel
US5010065A (en) * 1987-11-27 1991-04-23 Schering Aktiengesellschaft Cyclodextrin clathrates of 5-cyanoprostacyclin derivatives and their use as pharmaceutical agents
AT396687B (de) * 1987-11-27 1993-11-25 Schering Ag Cyclodextrinclathrate von 5-cyanoprostacyclinderivaten und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
FI65912C (fi) 1984-08-10
SE7809946L (sv) 1979-03-24
DK420778A (da) 1979-03-24
SU847914A3 (ru) 1981-07-15
IT7869160A0 (it) 1978-09-19
HU179141B (enExample) 1982-08-28
FI65912B (fi) 1984-04-30
CH637388A5 (de) 1983-07-29
YU220678A (en) 1983-10-31
CS200242B2 (en) 1980-08-29
ATA677478A (de) 1982-05-15
FR2404006A1 (fr) 1979-04-20
GR65001B (en) 1980-06-12
FR2404006B1 (enExample) 1981-07-31
GB2006193A (en) 1979-05-02
DD138600A5 (de) 1979-11-14
IT1160661B (it) 1987-03-11
IL55569A (en) 1981-12-31
NL7809643A (nl) 1979-03-27
PL121664B1 (en) 1982-05-31
PL209773A1 (pl) 1979-06-04
BE870646A (fr) 1979-01-15
JPS5456685A (en) 1979-05-07
SE447574B (sv) 1986-11-24
IL55569A0 (en) 1978-12-17
AT369362B (de) 1982-12-27
GB2006193B (en) 1982-05-26
FI782878A7 (fi) 1979-03-24

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8125 Change of the main classification

Ipc: C07D307/935

8131 Rejection