DE2739912A1 - Uracilderivate und herstellungsverfahren - Google Patents
Uracilderivate und herstellungsverfahrenInfo
- Publication number
- DE2739912A1 DE2739912A1 DE19772739912 DE2739912A DE2739912A1 DE 2739912 A1 DE2739912 A1 DE 2739912A1 DE 19772739912 DE19772739912 DE 19772739912 DE 2739912 A DE2739912 A DE 2739912A DE 2739912 A1 DE2739912 A1 DE 2739912A1
- Authority
- DE
- Germany
- Prior art keywords
- fluorouracil
- reaction
- chloromethyl
- uracil derivatives
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10571476A JPS5331676A (en) | 1976-09-06 | 1976-09-06 | Uracil derivatives and their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2739912A1 true DE2739912A1 (de) | 1978-03-09 |
Family
ID=14414993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19772739912 Ceased DE2739912A1 (de) | 1976-09-06 | 1977-09-05 | Uracilderivate und herstellungsverfahren |
Country Status (16)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54122281A (en) * | 1978-03-13 | 1979-09-21 | Mitsui Toatsu Chem Inc | 5-fluorouracil derivative and its preparation |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5379879A (en) * | 1976-12-23 | 1978-07-14 | Mitsui Toatsu Chem Inc | 1,3-substituted-5-fluorouracils and process for their preparation |
| JPS5668674A (en) * | 1979-11-08 | 1981-06-09 | Shionogi & Co Ltd | 5-fluorouracil derivative |
| JPS5724369A (en) * | 1980-07-19 | 1982-02-08 | Tokyo Kinzoku Kogyo Kk | Pyrimidine derivative and its preparation |
| JPS5738774A (en) * | 1980-08-19 | 1982-03-03 | Chugai Pharmaceut Co Ltd | Uracil derivative and its preparation |
| DE3480706D1 (de) * | 1983-10-20 | 1990-01-18 | Terumo Corp | 5-fluoruracilabkoemmlinge sowie medizinische zusammensetzungen die diese enthalten. |
| DK197486A (da) * | 1986-04-30 | 1987-10-31 | Ferring Farma Lab | 5-fluoruracilprodug |
| US6051576A (en) * | 1994-01-28 | 2000-04-18 | University Of Kentucky Research Foundation | Means to achieve sustained release of synergistic drugs by conjugation |
| SI2445502T1 (sl) | 2009-06-25 | 2017-10-30 | Alkermes Pharma Ireland Limited | Heterociklične spojine za zdravljenje neuroloških in psiholoških motenj |
| EP2445343B1 (en) | 2009-06-25 | 2021-08-04 | Alkermes Pharma Ireland Limited | Prodrugs of nh-acidic compounds |
| EP2897592B1 (en) | 2012-09-19 | 2020-02-19 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions having improved storage stability |
| RU2688233C2 (ru) | 2014-03-20 | 2019-05-21 | Алкермес Фарма Айэленд Лимитед | Препараты арипипразола, имеющие повышенные скорости впрыска |
| CN112423754A (zh) | 2018-03-05 | 2021-02-26 | 奥克梅斯制药爱尔兰有限公司 | 阿立哌唑的给药策略 |
| CN109761915B (zh) * | 2019-03-05 | 2021-12-21 | 沈阳药科大学 | 靶向mct1转运体的5-氟尿嘧啶成酯前药 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2455423A1 (de) * | 1973-11-28 | 1975-06-05 | Mitsui Pharmaceuticals | 5-fluoruracil-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS603071B2 (ja) * | 1975-02-17 | 1985-01-25 | 三井製薬工業株式会社 | １−（α−アシロキシアルキル）−５−フルオロウラシル類の製造方法 |
-
1976
- 1976-09-06 JP JP10571476A patent/JPS5331676A/ja active Granted
-
1977
- 1977-09-01 FI FI772594A patent/FI62071C/fi not_active IP Right Cessation
- 1977-09-02 HU HU77MI623A patent/HU177482B/hu unknown
- 1977-09-05 GB GB36964/77A patent/GB1543467A/en not_active Expired
- 1977-09-05 DE DE19772739912 patent/DE2739912A1/de not_active Ceased
- 1977-09-05 SE SE7709942A patent/SE438856B/xx unknown
- 1977-09-05 DK DK394477AA patent/DK142413B/da not_active IP Right Cessation
- 1977-09-06 CH CH1087377A patent/CH634567A5/de not_active IP Right Cessation
- 1977-09-06 PL PL1977200685A patent/PL108914B1/pl unknown
- 1977-09-06 FR FR7726980A patent/FR2363563A1/fr active Granted
- 1977-09-06 AU AU28571/77A patent/AU513153B2/en not_active Expired
- 1977-09-06 NL NL7709808A patent/NL7709808A/xx not_active Application Discontinuation
- 1977-09-06 PH PH20206A patent/PH14000A/en unknown
- 1977-09-06 ZA ZA00775361A patent/ZA775361B/xx unknown
- 1977-09-06 SU SU772521748A patent/SU795468A3/ru active
-
1979
- 1979-02-26 US US06/015,149 patent/US4267326A/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2455423A1 (de) * | 1973-11-28 | 1975-06-05 | Mitsui Pharmaceuticals | 5-fluoruracil-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
Non-Patent Citations (3)
| Title |
|---|
| EHRHARDT/RUSCHIG: Arzneimittel V, S.368 (1972) * |
| J.Pharm.Dyn. 3 (1982), S.208-212 * |
| JP 98280-76 = C.A. 86, 121361c * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54122281A (en) * | 1978-03-13 | 1979-09-21 | Mitsui Toatsu Chem Inc | 5-fluorouracil derivative and its preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7709808A (nl) | 1978-03-08 |
| FR2363563B1 (US20100223739A1-20100909-C00005.png) | 1980-06-20 |
| JPS5331676A (en) | 1978-03-25 |
| DK394477A (US20100223739A1-20100909-C00005.png) | 1978-03-07 |
| PL200685A1 (pl) | 1978-10-09 |
| CH634567A5 (de) | 1983-02-15 |
| ZA775361B (en) | 1978-07-26 |
| FI772594A (fi) | 1978-03-07 |
| JPS6114148B2 (US20100223739A1-20100909-C00005.png) | 1986-04-17 |
| AU2857177A (en) | 1979-03-15 |
| US4267326A (en) | 1981-05-12 |
| AU513153B2 (en) | 1980-11-20 |
| DK142413C (US20100223739A1-20100909-C00005.png) | 1981-03-23 |
| FI62071B (fi) | 1982-07-30 |
| PL108914B1 (en) | 1980-05-31 |
| FI62071C (fi) | 1982-11-10 |
| PH14000A (en) | 1980-11-28 |
| FR2363563A1 (fr) | 1978-03-31 |
| SE438856B (sv) | 1985-05-13 |
| DK142413B (da) | 1980-10-27 |
| GB1543467A (en) | 1979-04-04 |
| SE7709942L (sv) | 1978-03-07 |
| SU795468A3 (ru) | 1981-01-07 |
| HU177482B (en) | 1981-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8131 | Rejection |