DD292909A5 - Verfahren zur herstellung neuer 2-(1-piperazinyl)-4-phenylcycloalkanopyridinderivate - Google Patents
Verfahren zur herstellung neuer 2-(1-piperazinyl)-4-phenylcycloalkanopyridinderivate Download PDFInfo
- Publication number
- DD292909A5 DD292909A5 DD90338287A DD33828790A DD292909A5 DD 292909 A5 DD292909 A5 DD 292909A5 DD 90338287 A DD90338287 A DD 90338287A DD 33828790 A DD33828790 A DD 33828790A DD 292909 A5 DD292909 A5 DD 292909A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- compound
- formula
- alkyl
- piperazinyl
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5254489 | 1989-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD292909A5 true DD292909A5 (de) | 1991-08-14 |
Family
ID=12917732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD90338287A DD292909A5 (de) | 1989-03-03 | 1990-03-01 | Verfahren zur herstellung neuer 2-(1-piperazinyl)-4-phenylcycloalkanopyridinderivate |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5021421A (sv) |
| EP (1) | EP0385237B1 (sv) |
| KR (1) | KR0149649B1 (sv) |
| AT (1) | ATE107922T1 (sv) |
| AU (1) | AU623981B2 (sv) |
| CA (1) | CA2011346C (sv) |
| DD (1) | DD292909A5 (sv) |
| DE (1) | DE69010232T2 (sv) |
| DK (1) | DK0385237T3 (sv) |
| ES (1) | ES2058630T3 (sv) |
| FI (1) | FI94413C (sv) |
| HK (1) | HK1005872A1 (sv) |
| HU (1) | HU204810B (sv) |
| NO (1) | NO177095C (sv) |
| RU (1) | RU2075478C1 (sv) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5041443A (en) * | 1989-02-21 | 1991-08-20 | Dainippon Pharmaceutical Co., Ltd. | Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof |
| ATE199318T1 (de) * | 1993-06-25 | 2001-03-15 | Pola Chem Ind Inc | Dopaminreinkorporationshemmer zur behandlung des parkinsonschen syndroms |
| CA2144669A1 (en) * | 1994-03-29 | 1995-09-30 | Kozo Akasaka | Biphenyl derivatives |
| US6458789B1 (en) | 1999-09-29 | 2002-10-01 | Lion Bioscience Ag | 2-aminopyridine derivatives and combinatorial libraries thereof |
| AU2003203148A1 (en) * | 2002-02-05 | 2003-09-02 | High Point Pharmaceuticals, Llc | Novel aryl- and heteroarylpiperazines |
| AU2006228378A1 (en) | 2005-03-31 | 2006-10-05 | Pfizer Products Inc. | Cyclopentapyridine and tetrahydroquinoline derivatives |
| MX2007015675A (es) | 2005-07-04 | 2008-02-20 | Novo Nordisk As | Antagonistas del receptor de histamina h3. |
| EP2038256A1 (en) | 2006-05-23 | 2009-03-25 | TransTech Pharma, Inc | 6- (4-cyclopropylpiperazin-1-yl) -2 ' -methyl- [3, 4 ']-bipyridine and its use as a medicament |
| CN101460487A (zh) | 2006-05-29 | 2009-06-17 | 高点制药有限责任公司 | 3-(1，3-苯并间二氧杂环戊烯- 5-基)-6-(4-环丙基哌嗪-1-基)-哒嗪、其盐和溶剂合物及其作为组胺h3受体拮抗剂的用途 |
| JP5001271B2 (ja) * | 2006-06-09 | 2012-08-15 | 大日本住友製薬株式会社 | 新規テープ製剤 |
| CA2657552A1 (en) * | 2006-07-14 | 2008-01-17 | Merck & Co., Inc. | Substituted diazepan orexin receptor antagonists |
| WO2008066750A1 (en) | 2006-11-22 | 2008-06-05 | Seaside Therapeutics, Llc | Methods of treating mental retardation, down's syndrome, fragile x syndrome and autism |
| EP2014656A3 (en) | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | New heteocyclic h3 antagonists |
| CN101531634B (zh) * | 2008-03-10 | 2013-09-18 | 北京德众万全医药科技有限公司 | 一种高纯度的布南色林及其制备方法 |
| CN101530412A (zh) * | 2008-03-10 | 2009-09-16 | 北京德众万全医药科技有限公司 | 一种布南色林的药物组合物及其制备方法 |
| CN101747272B (zh) * | 2008-12-02 | 2012-11-28 | 浙江华海药业股份有限公司 | 布南色林晶型b及其制备方法 |
| CN101747273B (zh) * | 2008-12-02 | 2012-03-07 | 浙江华海药业股份有限公司 | 布南色林中间体的制备方法 |
| CN101766626B (zh) * | 2008-12-30 | 2012-03-07 | 丽珠医药集团股份有限公司 | 一种治疗精神分裂症的含布南色林的口服制剂 |
| CN108524505A (zh) | 2009-03-13 | 2018-09-14 | 安吉奥斯医药品有限公司 | 用于细胞增殖相关病症的方法和组合物 |
| CN102481300B (zh) | 2009-06-29 | 2015-04-15 | 安吉奥斯医药品有限公司 | 治疗性化合物和组合物 |
| CN101619039B (zh) * | 2009-06-30 | 2011-04-13 | 严洁 | 2-(4-乙基-1-哌嗪基)-4-(4-氟苯基)-5,6,7,8,9,10-六氢芳辛并[b]吡啶及其组合物 |
| ES2812537T3 (es) | 2009-10-21 | 2021-03-17 | Agios Pharmaceuticals Inc | Métodos y composiciones para trastornos relacionados con la proliferación celular |
| ES2594402T3 (es) | 2009-10-21 | 2016-12-20 | Agios Pharmaceuticals, Inc. | Métodos y composiciones para trastornos relacionados con la proliferación celular |
| US20130143897A1 (en) | 2010-08-10 | 2013-06-06 | Lupin Limited | Oral controlled release pharmaceutical compositions of blonanserin |
| CN102372673B (zh) * | 2010-08-27 | 2014-04-09 | 天津市医药集团技术发展有限公司 | 布南色林结晶及其制备方法 |
| CN102093289B (zh) * | 2010-10-29 | 2012-12-19 | 常州华生制药有限公司 | 布南色林中间体的制备方法 |
| CN102030707A (zh) * | 2010-11-12 | 2011-04-27 | 深圳万和制药有限公司 | 布南色林中间体的制备方法 |
| PL3406251T3 (pl) | 2011-05-03 | 2024-04-29 | Agios Pharmaceuticals, Inc. | Aktywatory kinazy pirogronianowej do stosowania w terapii |
| CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| CN102827170A (zh) * | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| EP2800743B1 (en) | 2012-01-06 | 2018-04-04 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
| NZ706999A (en) | 2012-10-15 | 2018-12-21 | Agios Pharmaceuticals Inc | Inhibitors of mutant isocitrate dehydrogenase and therapeutical uses thereof |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| CA2917671A1 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | 2,4-or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer |
| WO2015003355A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| KR20240010105A (ko) | 2014-03-14 | 2024-01-23 | 아지오스 파마슈티컬스 아이엔씨. | 치료적으로 활성인 화합물의 약제학적 조성물 |
| CN104311487B (zh) * | 2014-09-22 | 2016-08-24 | 江苏正大丰海制药有限公司 | 一种布南色林晶型及其制备方法 |
| PT3307271T (pt) | 2015-06-11 | 2023-10-10 | Agios Pharmaceuticals Inc | Métodos de utilização de ativadores da piruvato-cinase |
| MX2018004586A (es) | 2015-10-15 | 2018-08-16 | Agios Pharmaceuticals Inc | Terapia de combinacion para tratar tumores malignos. |
| LT3362065T (lt) | 2015-10-15 | 2024-07-25 | Les Laboratoires Servier | Kompleksinė terapija, apimanti ivosidenibą, citarabiną ir daunorubiciną arba idarubiciną, skirta ūminės mielogeninės leukemijos gydymui |
| KR20190028109A (ko) | 2017-09-08 | 2019-03-18 | 연성정밀화학(주) | 블로난세린 함유 서방성 제제 |
| CN110575438A (zh) * | 2018-06-07 | 2019-12-17 | 湖南省湘中制药有限公司 | 一种布南色林固体分散体的制备及其应用 |
| US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
| JP7455810B2 (ja) | 2019-03-13 | 2024-03-26 | 大塚製薬株式会社 | 二級アミンを含有する化合物のアミン部分に重水素低級アルキルを導入する方法 |
| CN113698346A (zh) * | 2020-05-22 | 2021-11-26 | 湖南省湘中制药有限公司 | 一种布南色林工艺杂质b的制备方法 |
| CN113698347A (zh) * | 2020-05-22 | 2021-11-26 | 湖南省湘中制药有限公司 | 一种布南色林工艺杂质f的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54128588A (en) * | 1978-03-29 | 1979-10-05 | Dainippon Pharmaceut Co Ltd | Antidepressive drugs consisting mainly of 2-(1-piperazinyl)- 4-phenylquinoline |
| DE3124673A1 (de) * | 1981-06-24 | 1983-01-13 | Bayer Ag, 5090 Leverkusen | Subsituierte 2-amino-pyridinderivate, verfahren zu ihrer herstellung, ihre verwendung in arzneimitteln, sowie deren herstellung |
| FR2602771B1 (fr) * | 1986-08-12 | 1988-11-04 | Rhone Poulenc Sante | Nouveaux derives de la benzyl-4 piperazine, leur preparation et les compositions pharmaceutiques qui les contiennent |
-
1990
- 1990-02-20 US US07/481,183 patent/US5021421A/en not_active Expired - Lifetime
- 1990-02-20 AT AT90103244T patent/ATE107922T1/de not_active IP Right Cessation
- 1990-02-20 DE DE69010232T patent/DE69010232T2/de not_active Expired - Lifetime
- 1990-02-20 EP EP90103244A patent/EP0385237B1/en not_active Expired - Lifetime
- 1990-02-20 ES ES90103244T patent/ES2058630T3/es not_active Expired - Lifetime
- 1990-02-20 DK DK90103244.1T patent/DK0385237T3/da active
- 1990-03-01 NO NO900991A patent/NO177095C/no not_active IP Right Cessation
- 1990-03-01 AU AU50604/90A patent/AU623981B2/en not_active Expired
- 1990-03-01 FI FI901030A patent/FI94413C/sv active IP Right Grant
- 1990-03-01 DD DD90338287A patent/DD292909A5/de unknown
- 1990-03-02 CA CA002011346A patent/CA2011346C/en not_active Expired - Lifetime
- 1990-03-02 HU HU901275A patent/HU204810B/hu unknown
- 1990-03-03 KR KR1019900002874A patent/KR0149649B1/ko not_active IP Right Cessation
-
1992
- 1992-11-12 RU RU92004429/04A patent/RU2075478C1/ru active
-
1998
- 1998-06-05 HK HK98105004A patent/HK1005872A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU623981B2 (en) | 1992-05-28 |
| KR900014358A (ko) | 1990-10-23 |
| ATE107922T1 (de) | 1994-07-15 |
| NO900991L (no) | 1990-09-04 |
| NO900991D0 (no) | 1990-03-01 |
| DE69010232D1 (de) | 1994-08-04 |
| CA2011346A1 (en) | 1990-09-03 |
| HUT53361A (en) | 1990-10-28 |
| EP0385237A3 (en) | 1991-03-20 |
| DK0385237T3 (da) | 1994-07-25 |
| CA2011346C (en) | 1999-08-03 |
| FI901030A0 (sv) | 1990-03-01 |
| NO177095C (no) | 1995-07-19 |
| ES2058630T3 (es) | 1994-11-01 |
| US5021421A (en) | 1991-06-04 |
| RU2075478C1 (ru) | 1997-03-20 |
| AU5060490A (en) | 1990-09-06 |
| HU204810B (en) | 1992-02-28 |
| NO177095B (no) | 1995-04-10 |
| DE69010232T2 (de) | 1994-12-01 |
| KR0149649B1 (ko) | 1998-10-15 |
| EP0385237B1 (en) | 1994-06-29 |
| HU901275D0 (en) | 1990-05-28 |
| HK1005872A1 (en) | 1999-01-29 |
| FI94413B (sv) | 1995-05-31 |
| EP0385237A2 (en) | 1990-09-05 |
| FI94413C (sv) | 1995-09-11 |
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