FI94413B - Förfarande för framställning av terapeutiskt aktiva 2-(1-piperazinyl)-4-fenylcykloalkanopyridinderivat - Google Patents
Förfarande för framställning av terapeutiskt aktiva 2-(1-piperazinyl)-4-fenylcykloalkanopyridinderivat Download PDFInfo
- Publication number
- FI94413B FI94413B FI901030A FI901030A FI94413B FI 94413 B FI94413 B FI 94413B FI 901030 A FI901030 A FI 901030A FI 901030 A FI901030 A FI 901030A FI 94413 B FI94413 B FI 94413B
- Authority
- FI
- Finland
- Prior art keywords
- alkyl
- piperazinyl
- formula
- compound
- hydrogen atom
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (10)
1. Förfarande för framställning av terapeutiskt aktiva 2-(1-piperazinyl)-4-fenylcykloalkanopyridinderivat med formeln 5 (I) R2 R3
10 R< v ς -7 d) R -Γ- Il I (CHo) R' ««2)n Li,/ \ <>-R R6 ' ^\R8 15 där n är 3, 4, 5, 6 eller 7, R1 är en väteatom, C1-C10 alkyl, C2-Cg alkenyl, C2-Cg alkynyl,
20 C3-C8 cykloalkyl, C3-Cg cykloalkyl-(1~C4)alkyl, hydroxi-C2-Cg alkyl, C^-C-j alkoxi-C2-Cg alkyl, osubstituerad eller monohalo-gensubstituerad bensoyl-C1-Cg alkyl, osubstituerad eller raono-halogensubstituerad fenyl, pyridyl, pyrimidyl, C2-C4 alkänoyl, bensoyl eller furoyl,
25 R2 och R3, som är lika eller olika, är var och en en väteatom, : halogenatom, C^-Cg alkyl, C1-Cg alkoxi eller trifluormetyl, R4, R5 och R6, som kan vara lika eller olika, är var och en en väteatom, C^-Cg alkyl eller fenyl, eller tvä av grupperna R4, R5 och R6 bildar tillsammans en enkel bindning eller C-^-C^ 30 alkylen, R7 och R8, som kan vara lika eller olika, är var och en en väteatom, alkyl, m är 2 eller 3, förutsatt, att dä R1 är pyridyl eller pyrimidyl, sä är m 2 eller dess syraadditionssalt, k ä n n e -35 tecknat därav, att l! 57 94413 (a) en förening med formeln (II): R2 R3 R di) R5 -/— Y| <c«2>n L A 10 \ZA N x R6^ där X är en avgäende atom eller grupp och R2, R3, R4, R5, R6 och n 15 avser det samma som ovan, omsätts med en forening med formeln (III) : ,(CH2U/R7
20 HN ^N-R1 (III) där R1, R7, R8 och m avser det samma som ovan 25 :·' (b) i fall, att R1 är en väteatom Λ c·. -, ' νιη* omsatts en forening med formeln (1-5) : R2 R3 30 ' R4 7^\X R5 -/— HI ACH2) 1 (I"5) <CH2)n I Λ/ A—R7 35 ^ ΝχΟ>Α*15 R6 \ \8 där 58 94413 R15 är metyl eller osubstituerad eller substituerad bensyl (substituenten i bensylens fenylring är vald bland lägre alkyl, lägre alkoxi eller en halogenatom), och R2, R3, R4, R5,
5 R6, R7, R8, m och n avser det samma som ovan, omsätts med etylklorkarbonat eller 1-kloretylkarbonat sä, att en förening med formeln (1-6) erhälls: R2 R3 r5 -(CH2U/r7 ,= “y- KM Hli. R6 där R16 är etoxikarbonyl eller 1-kloretoxikarbonyl och R2, R3, R4,
20 R5, R6, R7, R8, m och n avser det samma som ovan, varefter en förening med formeln (1-6) hydrolyseras, eller (c) i fall, att R1 är nägot annat än en väteatom, osubstituerad eller monohalogensubstituerad fenyl, pyridyl, pyrimidyl,
25 C2-C4-alkanoyl, bensoyl eller furoyl, omsätts en förening med : formeln (1-8) R2 R3 > 5 R A,H^ ciy N \ v.N-H
35 R6 ' ^^R8 59 94413 där R2, R3, R4, R5, R6, R7, R8, m och n avser det samma som ovan, med med en förening med forraeln (IV):
5 R18 - Z (IV) där Z är en reaktiv rest av en alkohol, och R18 avser det samma som R1 med undantag för en väteatom, osubstituerad eller 10 monohalogensubstituerad fenyl, pyridyl, pyrimidyl, C2-C4-alkanoyl, bensoyl eller furoyl, ja eventuell omvandlas en förening med formeln (I) tili sitt syraadditionssalt. 15 2. Förfarande enligt patentkravet 1, kännetecknat därav, att 2-(4-etyl-l-piperazinyl)-4-(4-fluorfenyl)-5,6,7,8,- 9.10- hexahydrocyklo-okta[b]pyridin eller dess syraadditionssalt framställs. 20 3. Förfarande enligt patentkravet 1, kännetecknat därav, att 2-(4-etyl-l-piperazinyl)-4-(2,4-difluorfenyl)-5,6,- 7.8.9.10- hexahydrocyklo-okta[b]pyridin eller dess syraadditionssalt framställs. 25 4. Förfarande enligt patentkravet 1, kännetecknat »" därav, att 2-(4-n-propyl-l-piperazinyl)-4-(4-fluorfenyl)-5,6,- 7.8.9.10- hexahydrocyklo-okta[b]pyridin eller dess syraadditionssalt framställs. »
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5254489 | 1989-03-03 | ||
JP5254489 | 1989-03-03 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI901030A0 FI901030A0 (sv) | 1990-03-01 |
FI94413B true FI94413B (sv) | 1995-05-31 |
FI94413C FI94413C (sv) | 1995-09-11 |
Family
ID=12917732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI901030A FI94413C (sv) | 1989-03-03 | 1990-03-01 | Förfarande för framställning av terapeutiskt aktiva 2-(1-piperazinyl)-4-fenylcykloalkanopyridinderivat |
Country Status (15)
Country | Link |
---|---|
US (1) | US5021421A (sv) |
EP (1) | EP0385237B1 (sv) |
KR (1) | KR0149649B1 (sv) |
AT (1) | ATE107922T1 (sv) |
AU (1) | AU623981B2 (sv) |
CA (1) | CA2011346C (sv) |
DD (1) | DD292909A5 (sv) |
DE (1) | DE69010232T2 (sv) |
DK (1) | DK0385237T3 (sv) |
ES (1) | ES2058630T3 (sv) |
FI (1) | FI94413C (sv) |
HK (1) | HK1005872A1 (sv) |
HU (1) | HU204810B (sv) |
NO (1) | NO177095C (sv) |
RU (1) | RU2075478C1 (sv) |
Families Citing this family (49)
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US5041443A (en) * | 1989-02-21 | 1991-08-20 | Dainippon Pharmaceutical Co., Ltd. | Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof |
WO1995000149A1 (fr) * | 1993-06-25 | 1995-01-05 | Pola Chemical Industries, Inc. | Inhibiteur de reincorporation de dopamine |
CA2144669A1 (en) * | 1994-03-29 | 1995-09-30 | Kozo Akasaka | Biphenyl derivatives |
US6458789B1 (en) | 1999-09-29 | 2002-10-01 | Lion Bioscience Ag | 2-aminopyridine derivatives and combinatorial libraries thereof |
MXPA04007612A (es) * | 2002-02-05 | 2004-11-10 | Novo Nordisk As | Aril- y heteroarilpiperazinas novedosas. |
WO2006103511A1 (en) | 2005-03-31 | 2006-10-05 | Pfizer Products Inc. | Cyclopentapyridine and tetrahydroquinoline derivatives |
US8501739B2 (en) | 2005-07-04 | 2013-08-06 | High Point Pharmaceuticals, Llc | Medicaments |
JP2009537596A (ja) | 2006-05-23 | 2009-10-29 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 6−(4−シクロプロピルピペリジン−1−イル)−2’−メチル−[3,4’]−ビピリジン及びその医薬としての使用 |
KR20090040259A (ko) | 2006-05-29 | 2009-04-23 | 하이 포인트 파마슈티칼스, 엘엘씨 | 3-(1,3-벤조디옥솔-5-일)-6-(4-시클로프로필피페라진-1-일)-피리다진, 그것의 염과 용매화합물 및 그것의 히스타민 h3 수용체 안타고니스트로서의 용도 |
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US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
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WO2016201227A1 (en) | 2015-06-11 | 2016-12-15 | Agios Pharmaceuticals, Inc. | Methods of using pyruvate kinase activators |
BR112018007671B1 (pt) | 2015-10-15 | 2023-10-17 | Les Laboratoires Servier | Usos de um inibidor da idh1 e combinações |
HRP20211790T1 (hr) | 2015-10-15 | 2022-03-04 | Les Laboratoires Servier | Kombinirana terapija za liječenje maligniteta |
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CN110575438A (zh) * | 2018-06-07 | 2019-12-17 | 湖南省湘中制药有限公司 | 一种布南色林固体分散体的制备及其应用 |
US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
CA3132953A1 (en) | 2019-03-13 | 2020-09-17 | Otsuka Pharmaceutical Co., Ltd. | Method for introducing deuterated lower alkyl into amine moiety of compound containing secondary amine |
CN113698346A (zh) * | 2020-05-22 | 2021-11-26 | 湖南省湘中制药有限公司 | 一种布南色林工艺杂质b的制备方法 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54128588A (en) * | 1978-03-29 | 1979-10-05 | Dainippon Pharmaceut Co Ltd | Antidepressive drugs consisting mainly of 2-(1-piperazinyl)- 4-phenylquinoline |
DE3124673A1 (de) * | 1981-06-24 | 1983-01-13 | Bayer Ag, 5090 Leverkusen | Subsituierte 2-amino-pyridinderivate, verfahren zu ihrer herstellung, ihre verwendung in arzneimitteln, sowie deren herstellung |
FR2602771B1 (fr) * | 1986-08-12 | 1988-11-04 | Rhone Poulenc Sante | Nouveaux derives de la benzyl-4 piperazine, leur preparation et les compositions pharmaceutiques qui les contiennent |
-
1990
- 1990-02-20 DK DK90103244.1T patent/DK0385237T3/da active
- 1990-02-20 EP EP90103244A patent/EP0385237B1/en not_active Expired - Lifetime
- 1990-02-20 ES ES90103244T patent/ES2058630T3/es not_active Expired - Lifetime
- 1990-02-20 AT AT90103244T patent/ATE107922T1/de not_active IP Right Cessation
- 1990-02-20 DE DE69010232T patent/DE69010232T2/de not_active Expired - Lifetime
- 1990-02-20 US US07/481,183 patent/US5021421A/en not_active Expired - Lifetime
- 1990-03-01 AU AU50604/90A patent/AU623981B2/en not_active Expired
- 1990-03-01 FI FI901030A patent/FI94413C/sv active IP Right Grant
- 1990-03-01 NO NO900991A patent/NO177095C/no not_active IP Right Cessation
- 1990-03-01 DD DD90338287A patent/DD292909A5/de unknown
- 1990-03-02 CA CA002011346A patent/CA2011346C/en not_active Expired - Lifetime
- 1990-03-02 HU HU901275A patent/HU204810B/hu unknown
- 1990-03-03 KR KR1019900002874A patent/KR0149649B1/ko not_active IP Right Cessation
-
1992
- 1992-11-12 RU RU92004429/04A patent/RU2075478C1/ru active
-
1998
- 1998-06-05 HK HK98105004A patent/HK1005872A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0385237A3 (en) | 1991-03-20 |
NO177095C (no) | 1995-07-19 |
NO900991D0 (no) | 1990-03-01 |
DD292909A5 (de) | 1991-08-14 |
CA2011346A1 (en) | 1990-09-03 |
CA2011346C (en) | 1999-08-03 |
EP0385237A2 (en) | 1990-09-05 |
DE69010232T2 (de) | 1994-12-01 |
KR0149649B1 (ko) | 1998-10-15 |
AU623981B2 (en) | 1992-05-28 |
ATE107922T1 (de) | 1994-07-15 |
NO900991L (no) | 1990-09-04 |
HUT53361A (en) | 1990-10-28 |
US5021421A (en) | 1991-06-04 |
EP0385237B1 (en) | 1994-06-29 |
HK1005872A1 (en) | 1999-01-29 |
ES2058630T3 (es) | 1994-11-01 |
FI94413C (sv) | 1995-09-11 |
HU204810B (en) | 1992-02-28 |
RU2075478C1 (ru) | 1997-03-20 |
DK0385237T3 (da) | 1994-07-25 |
HU901275D0 (en) | 1990-05-28 |
FI901030A0 (sv) | 1990-03-01 |
DE69010232D1 (de) | 1994-08-04 |
NO177095B (no) | 1995-04-10 |
AU5060490A (en) | 1990-09-06 |
KR900014358A (ko) | 1990-10-23 |
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