DD261156A5 - Verfahren zur herstellung von tertiaeren hydroxyalkylxanthinen - Google Patents
Verfahren zur herstellung von tertiaeren hydroxyalkylxanthinen Download PDFInfo
- Publication number
- DD261156A5 DD261156A5 DD86292595A DD29259586A DD261156A5 DD 261156 A5 DD261156 A5 DD 261156A5 DD 86292595 A DD86292595 A DD 86292595A DD 29259586 A DD29259586 A DD 29259586A DD 261156 A5 DD261156 A5 DD 261156A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- formula
- compounds
- methyl
- radical
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19853525801 DE3525801A1 (de) | 1985-07-19 | 1985-07-19 | Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
DD261156A5 true DD261156A5 (de) | 1988-10-19 |
Family
ID=6276182
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DD86292595A DD261156A5 (de) | 1985-07-19 | 1986-07-17 | Verfahren zur herstellung von tertiaeren hydroxyalkylxanthinen |
Country Status (33)
Country | Link |
---|---|
US (1) | US4833146A (da) |
EP (1) | EP0268585B1 (da) |
JP (1) | JPH0788382B2 (da) |
KR (1) | KR950001019B1 (da) |
CN (1) | CN1026112C (da) |
AR (1) | AR244689A1 (da) |
AT (1) | ATE53211T1 (da) |
AU (1) | AU588350B2 (da) |
BG (1) | BG60767B2 (da) |
CA (1) | CA1262248A (da) |
CS (1) | CS272766B2 (da) |
DD (1) | DD261156A5 (da) |
DE (2) | DE3525801A1 (da) |
DK (1) | DK157867C (da) |
ES (1) | ES2001019A6 (da) |
FI (1) | FI89921C (da) |
GR (1) | GR861866B (da) |
HU (1) | HU198486B (da) |
IE (1) | IE59025B1 (da) |
IL (1) | IL79457A0 (da) |
LT (1) | LT3869B (da) |
LV (1) | LV5703A3 (da) |
MA (1) | MA20739A1 (da) |
MX (1) | MX9254A (da) |
NO (1) | NO165803C (da) |
NZ (1) | NZ216888A (da) |
OA (1) | OA08707A (da) |
PH (1) | PH26262A (da) |
PT (1) | PT83013B (da) |
RU (1) | RU2051918C1 (da) |
TN (1) | TNSN86111A1 (da) |
WO (1) | WO1987000523A2 (da) |
ZA (1) | ZA865374B (da) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8621870D0 (en) * | 1986-09-11 | 1986-10-15 | Beecham Group Plc | Active compounds |
US5338741A (en) * | 1986-10-27 | 1994-08-16 | Nestec S.A. | 1-hydroxyalkylxanthines and medicaments containing them |
JP2661666B2 (ja) * | 1988-02-19 | 1997-10-08 | ヘキスト薬品工業株式会社 | 抗消化性潰瘍剤 |
GB8826595D0 (en) * | 1988-11-14 | 1988-12-21 | Beecham Wuelfing Gmbh & Co Kg | Active compounds |
DD298051A5 (de) * | 1989-08-16 | 1992-02-06 | ��@���������@�������k�� | Verfahren zur herstellung eines therapeutischen agens zur behandlung von verdauungskrankheiten |
GB8924392D0 (en) * | 1989-10-30 | 1989-12-20 | Bayer Ag | Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides |
EP0430300A3 (en) * | 1989-12-01 | 1992-03-25 | Takeda Chemical Industries, Ltd. | Xanthine derivatives, their production and use |
DE3942872A1 (de) * | 1989-12-23 | 1991-06-27 | Hoechst Ag | Verfahren zur enantioselektiven darstellung von ((omega)-1)-hydroxyalkylxanthinen |
IT1240843B (it) * | 1990-05-24 | 1993-12-17 | Malesci Istituto Farmacobiologico | Derivati xantinici 1-7 sostituiti ad attivita' antiasmatica, loro sali fisiologicamente accettabili, loro composizioni farmaceutiche e procedimento per la loro preparazione. |
DE4019892A1 (de) * | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | Neue xanthinderivate |
US5039666A (en) * | 1990-10-30 | 1991-08-13 | Hoechst-Roussel Pharmaceuticals Inc. | Aminoglycoside composition having substantially reduced nephrotoxicity induced by the aminoglycoside |
DE69119700T2 (de) * | 1990-11-07 | 1996-11-07 | Hoechst Roussel Pharma | Verwendung von Xanthinen zur Herstellung von Arzneimitteln zur Hemmung der Vermehrung menschlicher Retroviren |
US6420374B1 (en) | 1990-11-30 | 2002-07-16 | Fred Hutchinson Cancer Research Center | Use of xanthines as immunosuppressants and to inhibit allograft reactions |
MX9203323A (es) * | 1991-07-11 | 1994-07-29 | Hoechst Ag | El empleo de derivados de xantina para el tratamiento de lesiones secundarias de las celulas nerviosas y trastornos funcionales despues de traumas craneo-cerebrales. |
TW209834B (da) * | 1991-12-11 | 1993-07-21 | Hoechst Ag | |
EP0557876B1 (de) * | 1992-02-22 | 1996-12-11 | Hoechst Aktiengesellschaft | Verwendung von Xanthinderivaten zur Behandlung von Muskelschädigungen nach vollständiger Unterbrechung der Blutzirkulation |
WO1993017684A2 (en) * | 1992-03-04 | 1993-09-16 | Cell Therapeutics, Inc. | Enantiomeric hydroxylated xanthine compounds |
EP0570831A2 (de) * | 1992-05-20 | 1993-11-24 | Hoechst Aktiengesellschaft | Verwendung von Xanthinderivaten zur Behandlung von Nervenschädigungen nach Unterbrechung der Blutzirkulation |
US5288721A (en) * | 1992-09-22 | 1994-02-22 | Cell Therapeutics, Inc. | Substituted epoxyalkyl xanthines |
US5817662A (en) * | 1992-11-09 | 1998-10-06 | Cell Therapeutics, Inc. | Substituted amino alkyl compounds |
US5804584A (en) * | 1992-11-16 | 1998-09-08 | Cell Therapeutics, Inc. | Therapeutic compounds containing a monocyclic five- to six- membered ring structure having one to two nitrogen atoms |
US6693105B1 (en) | 1992-11-16 | 2004-02-17 | Cell Therapeutics, Inc. | Hydroxyl-containing compounds |
US5473070A (en) * | 1992-11-16 | 1995-12-05 | Cell Therapeutics, Inc. | Substituted long chain alcohol xanthine compounds |
US5866576A (en) * | 1992-12-16 | 1999-02-02 | Cell Therapeutics, Inc. | Epoxide-containing compounds |
AU6087894A (en) * | 1993-01-14 | 1994-08-15 | Cell Therapeutics, Inc. | Acetal or ketal substituted therapeutic compounds |
AU6092794A (en) * | 1993-01-19 | 1994-08-15 | Cell Therapeutics, Inc. | Oxime-substituted therapeutic compounds |
US5837703A (en) * | 1993-03-31 | 1998-11-17 | Cell Therapeutics, Inc. | Amino-alcohol substituted cyclic compounds |
US5641783A (en) * | 1993-11-12 | 1997-06-24 | Cell Therapeutics, Inc. | Substituted amino alcohol compounds |
US6020337A (en) * | 1993-04-05 | 2000-02-01 | Cell Therapeutics, Inc. | Electronegative-substituted long chain xanthine compounds |
WO1995019171A1 (en) * | 1994-01-14 | 1995-07-20 | Cell Therapeutics, Inc. | Method for treating diseases mediated by cellular proliferation in response to pdgf, egf, fgf and vegf |
US6103730A (en) * | 1994-03-24 | 2000-08-15 | Cell Therapeutics, Inc. | Amine substituted compounds |
CA2183562A1 (en) * | 1994-02-18 | 1995-08-24 | J. Peter Klein | Intracellular signalling mediators |
US5807861A (en) * | 1994-03-24 | 1998-09-15 | Cell Therapeutics, Inc. | Amine substituted xanthinyl compounds |
US5801182A (en) * | 1994-03-24 | 1998-09-01 | Cell Therapeutics, Inc. | Amine substituted compounds |
DE19540798A1 (de) * | 1995-11-02 | 1997-05-07 | Hoechst Ag | Alkylxanthinphosphonate und Alkylxanthinphosphinoxide und deren Verwendung als Arzneimittel |
US5965555A (en) * | 1996-06-07 | 1999-10-12 | Hoechst Aktiengesellschaft | Xanthine compounds having terminally animated alkynol side chains |
US5856330A (en) * | 1996-07-31 | 1999-01-05 | Hoechst Aktiengesellschaft | Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin |
US5981536A (en) * | 1996-07-31 | 1999-11-09 | Hoechst Aktiengesellschaft | Use of xanthine derivatives for the modulation of apoptosis |
DE19707655A1 (de) * | 1997-02-26 | 1998-08-27 | Hoechst Ag | Kombinationspräparat zur Anwendung bei Demenz |
US5985592A (en) * | 1997-06-05 | 1999-11-16 | Dalhousie University | Uses for pentoxifylline or functional derivatives/metabolites thereof |
US6294350B1 (en) | 1997-06-05 | 2001-09-25 | Dalhousie University | Methods for treating fibroproliferative diseases |
US6075029A (en) * | 1998-01-02 | 2000-06-13 | Cell Therapeutics, Inc. | Xanthine modulators of metabolism of cellular P-450 |
US20030207901A1 (en) * | 1999-07-27 | 2003-11-06 | Cell Therapeutics, Inc. | Hydroxyl-containing compounds |
DE10042152A1 (de) * | 2000-08-26 | 2002-03-28 | Basf Coatings Ag | Mit aktinischer Strahlung aktivierbares Thixotropierungsmittel, Verfahren zu seiner Herstellung und seine Verwendung |
DE10122390A1 (de) * | 2001-05-09 | 2002-11-28 | Basf Coatings Ag | Carbamat-und/oder Allophanatgruppen enthaltende, thermisch härtbare, thixotrope Gemische |
DE10139262C1 (de) * | 2001-08-09 | 2003-01-02 | Basf Coatings Ag | Rheologiehilfsmittel, Verfahren zu seiner Herstellung und seine Verwendung |
AU2002304685A1 (en) * | 2002-04-24 | 2003-11-10 | Basf Coatings Ag | Thermally curable, thixotropic mixtures containing carbamate and/or allophanate groups |
KR100872788B1 (ko) * | 2002-05-28 | 2008-12-09 | 엘지전자 주식회사 | 드럼세탁기 |
US8686090B2 (en) * | 2003-12-10 | 2014-04-01 | Basf Coatings Gmbh | Use of urea crystals for non-polymeric coatings |
US20080081816A1 (en) * | 2006-10-03 | 2008-04-03 | Kaohsiung Medical University | Anti-inflammation activity of newly synthesized xanthine derivatives kmup-1 and kmup-3 |
EP2265334A2 (en) * | 2008-02-29 | 2010-12-29 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
EP2262813A4 (en) * | 2008-03-31 | 2011-10-12 | Sun Pharmaceutical Ind Ltd | IMPROVED PROCESS FOR THE PREPARATION OF MORPHINANE ANALOGS |
US8952016B2 (en) | 2009-02-27 | 2015-02-10 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
US8263601B2 (en) | 2009-02-27 | 2012-09-11 | Concert Pharmaceuticals, Inc. | Deuterium substituted xanthine derivatives |
WO2011028820A1 (en) | 2009-09-02 | 2011-03-10 | Concert Pharmaceuticals, Inc. | Substituted derivatives of bicyclic [4.3.0] heteroaryl compounds |
WO2012031072A1 (en) | 2010-09-01 | 2012-03-08 | Concert Pharmaceuticals, Inc. | Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation |
US9074233B2 (en) | 2010-09-01 | 2015-07-07 | Concert Pharmaceuticals, Inc. | Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation |
IN2014DN08443A (da) | 2012-04-13 | 2015-05-08 | Concert Pharmaceuticals Inc |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1245969B (de) * | 1967-08-03 | VEB Arzneimittelwerk Dresden, Radebeul | Verfahren zur Herstellung von Xanthinderivaten | |
US2517410A (en) * | 1947-08-15 | 1950-08-01 | Searle & Co | Hydroxy alkyl xanthines and the production thereof |
FR1211333A (fr) * | 1955-10-19 | 1960-03-15 | Boehringer Sohn Ingelheim | Perfectionnements apportés aux procédés pour fabriquer des oxyalcoylxanthines |
DE2335170C2 (de) * | 1973-07-11 | 1989-07-20 | Hoechst Ag, 6230 Frankfurt | 1,3-Dialkyl-7-(hydroxyalkyl)-xanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
US4576947A (en) * | 1967-12-16 | 1986-03-18 | Hoechst Aktiengesellschaft | Pharmaceutical compositions |
BE795345A (fr) * | 1972-02-19 | 1973-08-13 | Albert Ag Chem Werke | MEDICAMENT UTILE NOTAMMENT POUR L'IRRIGATION CEREBRALE, PROCEDE DE PREPARATION DE SES MATIERES ACTIVES ET CES MATIERES ElLES-MEMES |
CH622519A5 (en) * | 1974-07-05 | 1981-04-15 | Hoechst Ag | Process for the preparation of hydroxyalkylxanthines |
DE2432702C2 (de) * | 1974-07-08 | 1983-01-20 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Herstellung von Hydroxyalkylxanthinen |
CA1075690A (en) * | 1974-12-13 | 1980-04-15 | Hoechst Aktiengesellschaft | Xanthine derivatives |
DE3062499D1 (en) * | 1979-04-05 | 1983-05-05 | Beecham Wuelfing Gmbh & Co Kg | Dialkoxy- and dioxacycloalkyl-alkyltheobromines, pharmaceutical compositions containing them and their preparation |
JPS5838284A (ja) * | 1981-09-01 | 1983-03-05 | Teikoku Chem Ind Corp Ltd | 1−(5′−オキソヘキシル)−3,7−ジメチルキサンチンの製造方法 |
DE3138397A1 (de) * | 1981-09-26 | 1983-04-07 | Hoechst Ag, 6230 Frankfurt | "arzneimittel, darin enthaltene vicinale dihydroxyalkylxanthine und herstellungsverfahren fuer diese xanthinverbindungen" |
US4575795A (en) * | 1983-04-01 | 1986-03-11 | Honeywell Information Systems Inc. | Apparatus for detecting a predetermined character of a data string |
-
1985
- 1985-07-19 DE DE19853525801 patent/DE3525801A1/de not_active Withdrawn
-
1986
- 1986-07-08 US US07/032,729 patent/US4833146A/en not_active Expired - Lifetime
- 1986-07-08 AT AT86904158T patent/ATE53211T1/de not_active IP Right Cessation
- 1986-07-08 KR KR1019870700245A patent/KR950001019B1/ko not_active IP Right Cessation
- 1986-07-08 JP JP61504113A patent/JPH0788382B2/ja not_active Expired - Lifetime
- 1986-07-08 RU SU864355018A patent/RU2051918C1/ru active
- 1986-07-08 WO PCT/EP1986/000401 patent/WO1987000523A2/de active IP Right Grant
- 1986-07-08 AU AU61439/86A patent/AU588350B2/en not_active Ceased
- 1986-07-08 HU HU863670A patent/HU198486B/hu not_active IP Right Cessation
- 1986-07-08 EP EP86904158A patent/EP0268585B1/de not_active Expired - Lifetime
- 1986-07-08 DE DE8686904158T patent/DE3671627D1/de not_active Expired - Fee Related
- 1986-07-17 NZ NZ216888A patent/NZ216888A/xx unknown
- 1986-07-17 PH PH34027A patent/PH26262A/en unknown
- 1986-07-17 CS CS545386A patent/CS272766B2/cs unknown
- 1986-07-17 DD DD86292595A patent/DD261156A5/de not_active IP Right Cessation
- 1986-07-17 GR GR861866A patent/GR861866B/el unknown
- 1986-07-17 ES ES8600356A patent/ES2001019A6/es not_active Expired
- 1986-07-18 MX MX925486A patent/MX9254A/es unknown
- 1986-07-18 MA MA20967A patent/MA20739A1/fr unknown
- 1986-07-18 IE IE191786A patent/IE59025B1/en not_active IP Right Cessation
- 1986-07-18 CA CA000514174A patent/CA1262248A/en not_active Expired
- 1986-07-18 PT PT83013A patent/PT83013B/pt not_active IP Right Cessation
- 1986-07-18 ZA ZA865374A patent/ZA865374B/xx unknown
- 1986-07-18 IL IL79457A patent/IL79457A0/xx not_active IP Right Cessation
- 1986-07-18 AR AR86304545A patent/AR244689A1/es active
- 1986-07-18 CN CN86105835A patent/CN1026112C/zh not_active Expired - Lifetime
- 1986-07-18 TN TNTNSN86111A patent/TNSN86111A1/fr unknown
-
1987
- 1987-03-18 NO NO871111A patent/NO165803C/no not_active IP Right Cessation
- 1987-03-18 DK DK139287A patent/DK157867C/da not_active IP Right Cessation
-
1988
- 1988-01-15 FI FI880174A patent/FI89921C/fi not_active IP Right Cessation
- 1988-01-18 OA OA59264A patent/OA08707A/xx unknown
-
1993
- 1993-05-05 LV LV930291A patent/LV5703A3/xx unknown
- 1993-11-12 LT LTIP1467A patent/LT3869B/lt not_active IP Right Cessation
-
1994
- 1994-02-23 BG BG98535A patent/BG60767B2/bg unknown
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Date | Code | Title | Description |
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ENJ | Ceased due to non-payment of renewal fee |