DD212897A5 - Verfahren zur herstellung einer topisch applizierbaren pharmazeutischen zusammensetzung - Google Patents
Verfahren zur herstellung einer topisch applizierbaren pharmazeutischen zusammensetzung Download PDFInfo
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- DD212897A5 DD212897A5 DD83255436A DD25543683A DD212897A5 DD 212897 A5 DD212897 A5 DD 212897A5 DD 83255436 A DD83255436 A DD 83255436A DD 25543683 A DD25543683 A DD 25543683A DD 212897 A5 DD212897 A5 DD 212897A5
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- German Democratic Republic
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- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
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- 229910052700 potassium Inorganic materials 0.000 description 1
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- DJEHXEMURTVAOE-UHFFFAOYSA-M potassium bisulfite Chemical compound [K+].OS([O-])=O DJEHXEMURTVAOE-UHFFFAOYSA-M 0.000 description 1
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- ZPWFUIUNWDIYCJ-UHFFFAOYSA-N propan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C ZPWFUIUNWDIYCJ-UHFFFAOYSA-N 0.000 description 1
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- 235000010413 sodium alginate Nutrition 0.000 description 1
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- GGXKEBACDBNFAF-UHFFFAOYSA-M sodium;hexadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCC([O-])=O GGXKEBACDBNFAF-UHFFFAOYSA-M 0.000 description 1
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- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- GKBHKNPLNHLYHT-LWQAOISPSA-N stigmastane Chemical compound C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 GKBHKNPLNHLYHT-LWQAOISPSA-N 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000000498 stratum granulosum Anatomy 0.000 description 1
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- 235000011044 succinic acid Nutrition 0.000 description 1
- 150000003444 succinic acids Chemical class 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
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- 229960000894 sulindac Drugs 0.000 description 1
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
- 229960004492 suprofen Drugs 0.000 description 1
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- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
- VSLOIHHRIJJNOM-YSMBQZINSA-N tetradec-9-enoic acid;(z)-tetradec-9-enoic acid Chemical compound CCCCC=CCCCCCCCC(O)=O.CCCC\C=C/CCCCCCCC(O)=O VSLOIHHRIJJNOM-YSMBQZINSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
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- 125000002640 tocopherol group Chemical class 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 229960002905 tolfenamic acid Drugs 0.000 description 1
- YEZNLOUZAIOMLT-UHFFFAOYSA-N tolfenamic acid Chemical compound CC1=C(Cl)C=CC=C1NC1=CC=CC=C1C(O)=O YEZNLOUZAIOMLT-UHFFFAOYSA-N 0.000 description 1
- 229960001017 tolmetin Drugs 0.000 description 1
- UPSPUYADGBWSHF-UHFFFAOYSA-N tolmetin Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=C(CC(O)=O)N1C UPSPUYADGBWSHF-UHFFFAOYSA-N 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
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- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- FKLSONDBCYHMOQ-ONEGZZNKSA-N trans-dodec-9-enoic acid Chemical compound CC\C=C\CCCCCCCC(O)=O FKLSONDBCYHMOQ-ONEGZZNKSA-N 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229960003414 zomepirac Drugs 0.000 description 1
- ZXVNMYWKKDOREA-UHFFFAOYSA-N zomepirac Chemical compound C1=C(CC(O)=O)N(C)C(C(=O)C=2C=CC(Cl)=CC=2)=C1C ZXVNMYWKKDOREA-UHFFFAOYSA-N 0.000 description 1
- DTOSIQBPPRVQHS-UHFFFAOYSA-N α-Linolenic acid Chemical compound CCC=CCC=CCC=CCCCCCCCC(O)=O DTOSIQBPPRVQHS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH589882A CH655656B (pt) | 1982-10-07 | 1982-10-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD212897A5 true DD212897A5 (de) | 1984-08-29 |
Family
ID=4301192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD83255436A DD212897A5 (de) | 1982-10-07 | 1983-10-05 | Verfahren zur herstellung einer topisch applizierbaren pharmazeutischen zusammensetzung |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US4917886A (pt) |
| JP (1) | JPS5989621A (pt) |
| KR (1) | KR890000493B1 (pt) |
| AT (1) | AT381638B (pt) |
| AU (1) | AU567890B2 (pt) |
| BE (1) | BE897934A (pt) |
| CA (1) | CA1228812A (pt) |
| CH (1) | CH655656B (pt) |
| DD (1) | DD212897A5 (pt) |
| DE (1) | DE3336047C2 (pt) |
| DK (1) | DK160913C (pt) |
| DO (1) | DOP1990004770A (pt) |
| ES (1) | ES8503944A1 (pt) |
| FI (1) | FI82185C (pt) |
| FR (1) | FR2540726B1 (pt) |
| GB (1) | GB2128087B (pt) |
| GR (1) | GR79660B (pt) |
| HK (1) | HK88590A (pt) |
| HU (1) | HU190168B (pt) |
| IE (1) | IE56023B1 (pt) |
| IL (1) | IL69925A (pt) |
| IT (1) | IT1174791B (pt) |
| LU (1) | LU85030A1 (pt) |
| NL (1) | NL193419C (pt) |
| NO (1) | NO833645L (pt) |
| NZ (1) | NZ205882A (pt) |
| PH (1) | PH18646A (pt) |
| PT (1) | PT77459B (pt) |
| SE (1) | SE455835B (pt) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3620674A1 (de) * | 1986-06-20 | 1987-12-23 | Nattermann A & Cie | Salbe zur behandlung von hauterkrankungen |
| CH666621A5 (de) * | 1986-06-27 | 1988-08-15 | Ciba Geigy Ag | Topisch applizierbare pharmazeutische zusammensetzungen mit systemischer wirkung. |
| JP2557657B2 (ja) * | 1987-08-28 | 1996-11-27 | エスエス製薬株式会社 | 経皮吸収促進基剤組成物 |
| NZ228431A (en) * | 1988-03-21 | 1991-08-27 | Daratech Pty Ltd | Teat dip composition comprising a c16 to c20 fatty acid and a surfactant |
| US5438076A (en) * | 1988-05-03 | 1995-08-01 | Perio Products, Ltd. | Liquid polymer composition, and method of use |
| US5160737A (en) * | 1988-05-03 | 1992-11-03 | Perio Products Ltd. | Liquid polymer composition, and method of use |
| US5271945A (en) * | 1988-07-05 | 1993-12-21 | Takeda Chemical Industries, Ltd. | Sustained release microcapsule for water soluble drug |
| US5126141A (en) * | 1988-11-16 | 1992-06-30 | Mediventures Incorporated | Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides |
| US6436425B1 (en) | 1988-11-16 | 2002-08-20 | Mdv Technologies, Inc. | Method and non-gelling composition for inhibiting post-surgical adhesions |
| US5032384A (en) * | 1989-01-27 | 1991-07-16 | Block Drug Company, Inc. | Compositions and method for the treatment of disease |
| AU642899B2 (en) * | 1989-08-18 | 1993-11-04 | Hisamitsu Pharmaceutical Co., Inc. | Ketotifen preparation for external use |
| JP3273430B2 (ja) * | 1989-12-28 | 2002-04-08 | 日東電工株式会社 | エストロゲン含有ゲル製剤 |
| US5149719A (en) * | 1990-04-27 | 1992-09-22 | Minnesota Mining And Manufacturing Company | Composition for transdermal penetration of medicaments |
| US5124151A (en) * | 1990-08-07 | 1992-06-23 | Mediventures Inc. | Drug delivery by injection with thermo-irreversible gels |
| US5143731A (en) * | 1990-08-07 | 1992-09-01 | Mediventures Incorporated | Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels |
| US5071644A (en) * | 1990-08-07 | 1991-12-10 | Mediventures, Inc. | Topical drug delivery with thermo-irreversible gels |
| US5077033A (en) * | 1990-08-07 | 1991-12-31 | Mediventures Inc. | Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide |
| US5346703A (en) | 1990-08-07 | 1994-09-13 | Mediventures, Inc. | Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels |
| ATE121724T1 (de) * | 1991-02-07 | 1995-05-15 | Heumann Pharma Gmbh & Co | Neue salze der 2-(2,6-dichloranilino)- phenylessigsäure, verfahren zu ihrer herstellung und ihre verwendung für topisch anwendbare pharmazeutische zubereitungen. |
| EP0592569A1 (en) * | 1991-07-03 | 1994-04-20 | Sano Corporation | Composition and method for transdermal delivery of diclofenac |
| US5474985A (en) * | 1993-12-22 | 1995-12-12 | The Regents Of The University Of California | Preventing and treating elevated intraocular pressure associated with administered or endogenous steroids using non-steroidal cyclooxygenase inhibitors |
| AT408067B (de) * | 1995-03-17 | 2001-08-27 | Gebro Pharma Gmbh | Pharmazeutische zusammensetzung zur topischen applizierung und verfahren zu ihrer herstellung |
| US5599535A (en) * | 1995-06-07 | 1997-02-04 | Regents Of The University Of California | Methods for the cyto-protection of the trabecular meshwork |
| US5674888A (en) * | 1995-06-07 | 1997-10-07 | University Of California | Method for the treatment of a trabecular meshwork whose cells are subject to inhibition of cell division |
| DE19641259A1 (de) * | 1996-10-07 | 1998-04-16 | Kade Pharma Fab Gmbh | Arzneimittel auf Basis von Diclofenac |
| WO2001006993A1 (fr) * | 1999-07-27 | 2001-02-01 | Shiseido Company, Ltd. | Composition d'emulsion huile dans l'eau |
| IL137559A (en) * | 2000-07-27 | 2006-12-31 | Amnon Sintov | A system for administering drugs through the skin |
| TWI290464B (en) * | 2000-09-01 | 2007-12-01 | Novartis Consumer Health Sa | Treatment of burns |
| EP1328278A4 (en) | 2000-09-26 | 2004-06-16 | Univ Temple | ANALGETIC AND GLUCOSAMINE COMPOSITIONS |
| GB0108082D0 (en) * | 2001-03-30 | 2001-05-23 | Novartis Consumer Health Sa | Topical composition |
| US20030017133A1 (en) * | 2001-06-15 | 2003-01-23 | Wyeth (Formerly American Home Products Corporation) | Mucoadhesive composition |
| US20040028744A1 (en) * | 2002-06-17 | 2004-02-12 | Sauwaluxana Tongaree | Mucoadhesive composition |
| AR041021A1 (es) | 2002-08-22 | 2005-04-27 | Novartis Consumer Health Sa | Composicion topica |
| EP1588697A1 (en) * | 2004-04-16 | 2005-10-26 | Kurt H. Prof. Dr. Bauer | Emulsion gel for topical application of pharmaceuticals |
| EP1863858A1 (de) * | 2005-03-18 | 2007-12-12 | Basf Aktiengesellschaft | Kationische polymere als verdicker für wässrige und alkoholische zusammensetzungen |
| ATE429255T1 (de) | 2005-03-24 | 2009-05-15 | Nolabs Ab | Kosmetische behandlung mit stickoxid, vorrichtung zur durchführung dieser behandlung und herstellungsverfahren dafür |
| US8673960B2 (en) * | 2005-10-17 | 2014-03-18 | Kowa Co., Ltd. | External liquid preparation containing indomethacin |
| ATE510861T1 (de) | 2006-09-21 | 2011-06-15 | Basf Se | Kationische polymere als verdicker für wässrige und alkoholische zusammensetzungen |
| EP2055298A1 (en) * | 2007-10-30 | 2009-05-06 | Novartis AG | Topical composition |
| US7943668B2 (en) * | 2008-03-03 | 2011-05-17 | Altergon S.A. | Process for preparing a pharmaceutical composition with anti-inflammatory and analgesic activity for administration via a patch for external use, and composition thus obtained |
| AU2009319167A1 (en) * | 2008-11-28 | 2010-06-03 | Lectio Pharmaentwicklungs-Und Verwertungs Gmbh | Pharmaceutical formulation comprising diclofenac and a hydroxy fatty acid polyoxyalkylene ester |
| SI2405892T1 (sl) * | 2009-03-12 | 2013-06-28 | Lectio Pharmaentwicklungs- Und Verwertungs Gmbh | Farmacevtska formulacija, ki obsega ketoprofen in polioksialkilenski ester hidroksimaščobne kisline |
| GB0921686D0 (en) * | 2009-12-11 | 2010-01-27 | Reckitt Benckiser Healthcare I | Topical formulation |
| WO2011076401A1 (de) * | 2009-12-23 | 2011-06-30 | Holger Schankin | Acetylsalicylsäure-haltige, im wesentlichen wasserfreie pharmazeutische zusammensetzungen |
| WO2013006608A1 (en) | 2011-07-05 | 2013-01-10 | Novan, Inc. | Topical compositions |
| ES2402289B1 (es) * | 2011-10-04 | 2014-03-04 | Eduardo COS ALFONSO | Composición farmacéutica para el tratamiento de la tendinitis y/o bursitis calcificada. |
| PT2735309T (pt) | 2012-11-27 | 2016-09-26 | Cos Alfonso Eduardo | Composição farmacêutica para o tratamento da tendinite calcificada e/ou da bursite calcificada |
| US9855211B2 (en) | 2013-02-28 | 2018-01-02 | Novan, Inc. | Topical compositions and methods of using the same |
| JP6513667B2 (ja) | 2013-08-08 | 2019-05-15 | ノヴァン，インコーポレイテッド | 局所用組成物およびそれを使用する方法 |
| CN105813617B (zh) * | 2014-08-08 | 2021-05-28 | 诺万公司 | 局部用组合物和使用所述组合物的方法 |
| RU2702898C2 (ru) * | 2014-09-10 | 2019-10-14 | Гск Консьюмер Хелткер С.А. | Композиции диклофенака натрия для местного применения |
| JP6921493B2 (ja) * | 2015-10-30 | 2021-08-18 | 小林製薬株式会社 | 水中油型乳化組成物 |
| JP7090549B2 (ja) | 2016-03-02 | 2022-06-24 | ノヴァン，インコーポレイテッド | 炎症のための治療用組成物およびその治療方法 |
| US11166980B2 (en) | 2016-04-13 | 2021-11-09 | Novan, Inc. | Compositions, systems, kits, and methods for treating an infection |
| EP4223280A1 (en) | 2022-02-02 | 2023-08-09 | GSK Consumer Healthcare SARL | Diclofenac formulations |
| EP4342450A1 (en) | 2022-09-21 | 2024-03-27 | Haleon CH SARL | Hydroalcoholic topical diclofenac formulations |
| EP4342449A1 (en) | 2022-09-21 | 2024-03-27 | Haleon CH SARL | Hydroalcoholic single phase gel compositions for topical delivery of diclofenac |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE626627A (pt) * | 1962-04-26 | |||
| GB1261881A (en) * | 1967-12-04 | 1972-01-26 | Ethichem Ltd | Improvements in or relating to pharmaceutical compositions comprising witch hazel |
| US3629412A (en) * | 1969-09-19 | 1971-12-21 | Merck & Co Inc | Topical anti-inflammatory agent |
| DK135267A (pt) * | 1971-02-25 | |||
| CA938555A (en) * | 1971-02-26 | 1973-12-18 | W. Hughes Donald | Veterinary ointment composition |
| JPS475827A (pt) * | 1971-08-27 | 1972-03-29 | ||
| DE2350315C2 (de) * | 1973-10-06 | 1984-01-12 | Johnson & Johnson GmbH, 4000 Düsseldorf | Pharmazeutische und kosmetische Präparate zur äußerlichen Anwendung |
| AU513753B2 (en) * | 1974-07-08 | 1980-12-18 | Johnson & Johnson | Antimicrobial composition |
| IN142640B (pt) * | 1975-01-17 | 1977-08-06 | Johnson & Johnson | |
| US4185100A (en) * | 1976-05-13 | 1980-01-22 | Johnson & Johnson | Topical anti-inflammatory drug therapy |
| DE2755224A1 (de) * | 1976-12-15 | 1978-07-13 | Procter & Gamble | Schmerzen und entzuendungen linderndes mittel zur oertlichen anwendung |
| US4120166A (en) * | 1977-03-25 | 1978-10-17 | Exxon Production Research Company | Cement monitoring method |
| SE418686B (sv) * | 1978-03-31 | 1981-06-22 | Landstingens Inkopscentral | Vattenbaserad salva for huddesinfektion innehallande alkohol som desinfektionsmedel |
| US4525347A (en) * | 1978-06-17 | 1985-06-25 | Kowa Company Limited | Antiinflammatory analgesic gelled ointment |
| GB2023000B (en) * | 1978-06-17 | 1982-10-13 | Kowa Co | Antinflammatory analgesic gelled ointments |
| DE2843901A1 (de) * | 1978-10-07 | 1980-04-24 | Basf Ag | Mittel, enthaltend all-e- oder 13-z-7, 8-dehydro-retinsaeure |
| JPS5927478B2 (ja) * | 1979-07-06 | 1984-07-05 | 富士空調工業株式会社 | エルボの製造方法 |
| JPS5651410A (en) * | 1979-10-01 | 1981-05-09 | Sumitomo Chem Co Ltd | Ointment |
| GB2075837B (en) * | 1980-05-14 | 1984-03-14 | Hisamitsu Pharmaceutical Co | Topical pharmaceutical gel containing anti-inflammatory analgesic agents |
| CA1165240A (en) * | 1980-07-09 | 1984-04-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions |
| DE3045913A1 (de) * | 1980-12-05 | 1982-07-08 | Bayer Ag, 5090 Leverkusen | Antimykotische mittel mit hoher wirkstoff-freisetzung |
| JPS57126414A (en) * | 1981-01-28 | 1982-08-06 | Sumitomo Chem Co Ltd | Ointment |
| AT370721B (de) * | 1981-02-24 | 1983-04-25 | Ciba Geigy Ag | Verfahren zur herstellung von neuen salzen der 2- (2,6-dichloranilino)-phenylessigsaeure, der |
| FR2502951B1 (fr) * | 1981-04-06 | 1985-12-06 | Sandoz Sa | Compositions pharmaceutiques topiques sous forme d'une micro-emulsion |
| JPS5948413A (ja) * | 1982-09-14 | 1984-03-19 | Grelan Pharmaceut Co Ltd | クリダナクを含有する消炎鎮痛外用剤 |
| US4807824A (en) * | 1988-06-27 | 1989-02-28 | James River Ii, Inc. | Paper roll towel dispenser |
-
1982
- 1982-10-07 CH CH589882A patent/CH655656B/de unknown
-
1983
- 1983-09-29 SE SE8305316A patent/SE455835B/sv not_active IP Right Cessation
- 1983-10-03 FI FI833568A patent/FI82185C/fi not_active IP Right Cessation
- 1983-10-04 GB GB08326565A patent/GB2128087B/en not_active Expired
- 1983-10-04 DE DE3336047A patent/DE3336047C2/de not_active Expired - Lifetime
- 1983-10-04 IL IL69925A patent/IL69925A/xx not_active IP Right Cessation
- 1983-10-05 CA CA000438372A patent/CA1228812A/en not_active Expired
- 1983-10-05 GR GR72628A patent/GR79660B/el unknown
- 1983-10-05 LU LU85030A patent/LU85030A1/de unknown
- 1983-10-05 FR FR8315858A patent/FR2540726B1/fr not_active Expired
- 1983-10-05 NL NL8303412A patent/NL193419C/nl not_active IP Right Cessation
- 1983-10-05 IT IT49109/83A patent/IT1174791B/it active
- 1983-10-05 DD DD83255436A patent/DD212897A5/de not_active IP Right Cessation
- 1983-10-06 DK DK460283A patent/DK160913C/da not_active IP Right Cessation
- 1983-10-06 IE IE2356/83A patent/IE56023B1/en not_active IP Right Cessation
- 1983-10-06 ES ES526290A patent/ES8503944A1/es not_active Expired
- 1983-10-06 PH PH29667A patent/PH18646A/en unknown
- 1983-10-06 BE BE0/211657A patent/BE897934A/fr not_active IP Right Cessation
- 1983-10-06 NZ NZ205882A patent/NZ205882A/xx unknown
- 1983-10-06 AU AU19947/83A patent/AU567890B2/en not_active Expired
- 1983-10-06 AT AT0354683A patent/AT381638B/de not_active IP Right Cessation
- 1983-10-06 PT PT77459A patent/PT77459B/pt unknown
- 1983-10-06 HU HU833462A patent/HU190168B/hu unknown
- 1983-10-06 NO NO833645A patent/NO833645L/no unknown
- 1983-10-06 KR KR1019830004739A patent/KR890000493B1/ko not_active IP Right Cessation
- 1983-10-07 JP JP58187160A patent/JPS5989621A/ja active Granted
-
1989
- 1989-08-21 US US07/396,781 patent/US4917886A/en not_active Expired - Lifetime
-
1990
- 1990-10-25 HK HK885/90A patent/HK88590A/xx not_active IP Right Cessation
- 1990-11-15 DO DO1990004770A patent/DOP1990004770A/es unknown
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