DD211114A5 - Verfahren zur herstellung von n-alkyl-norscopinen - Google Patents

Verfahren zur herstellung von n-alkyl-norscopinen Download PDF

Info

Publication number
DD211114A5
DD211114A5 DD83250031A DD25003183A DD211114A5 DD 211114 A5 DD211114 A5 DD 211114A5 DD 83250031 A DD83250031 A DD 83250031A DD 25003183 A DD25003183 A DD 25003183A DD 211114 A5 DD211114 A5 DD 211114A5
Authority
DD
German Democratic Republic
Prior art keywords
alkyl
preparation
general formula
ethanol
norscopines
Prior art date
Application number
DD83250031A
Other languages
German (de)
English (en)
Inventor
Rolf Banholzer
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of DD211114A5 publication Critical patent/DD211114A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Mushroom Cultivation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Preparation Of Fruits And Vegetables (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
DD83250031A 1982-04-26 1983-04-20 Verfahren zur herstellung von n-alkyl-norscopinen DD211114A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823215493 DE3215493A1 (de) 1982-04-26 1982-04-26 Neue zwischenprodukte, verfahren zu ihrer herstellung und ihre verwendung

Publications (1)

Publication Number Publication Date
DD211114A5 true DD211114A5 (de) 1984-07-04

Family

ID=6161961

Family Applications (1)

Application Number Title Priority Date Filing Date
DD83250031A DD211114A5 (de) 1982-04-26 1983-04-20 Verfahren zur herstellung von n-alkyl-norscopinen

Country Status (24)

Country Link
US (1) US4783534A (fr)
EP (1) EP0092814B1 (fr)
JP (1) JPS58201779A (fr)
KR (1) KR900004127B1 (fr)
AT (1) ATE16185T1 (fr)
AU (1) AU557680B2 (fr)
CA (1) CA1254566A (fr)
CS (1) CS236873B2 (fr)
DD (1) DD211114A5 (fr)
DE (2) DE3215493A1 (fr)
DK (1) DK159777C (fr)
ES (1) ES521809A0 (fr)
FI (1) FI831234L (fr)
GR (1) GR78837B (fr)
HU (1) HU193161B (fr)
IE (1) IE55308B1 (fr)
IL (1) IL68479A0 (fr)
NO (1) NO159172C (fr)
NZ (1) NZ203980A (fr)
PH (1) PH23301A (fr)
PL (1) PL138718B1 (fr)
PT (1) PT76584B (fr)
YU (1) YU43731B (fr)
ZA (1) ZA832883B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4021847C2 (de) * 1990-07-09 1994-09-08 Stockhausen Chem Fab Gmbh Verfahren zur Herstellung wasserquellbarer Produkte unter Verwendung von Feinstanteilen wasserquellbarer Polymerer
HUP0300832A2 (hu) * 2000-04-27 2003-08-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Új, lassú hatású bétamimetikumok, eljárás előállításukra és alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
US6908928B2 (en) 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
KR100488644B1 (ko) * 2000-10-12 2005-05-11 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 티오트로퓸을 함유하는 신규 흡입용 산제
US6852728B2 (en) * 2000-10-14 2005-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them
US6706726B2 (en) 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
US7776315B2 (en) * 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020151541A1 (en) * 2000-10-31 2002-10-17 Michel Pairet Pharmaceutical compositions containing tiotropium salts and antihistamines and their use
US20020137764A1 (en) * 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
DE10062712A1 (de) * 2000-12-15 2002-06-20 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Corticosteroiden
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
US20100310477A1 (en) * 2000-11-28 2010-12-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg. Pharmaceutical compositions based on anticholingerics and additional active ingredients
US20030013675A1 (en) * 2001-05-25 2003-01-16 Boehringer Ingelheim Pharma Kg Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
US20030018019A1 (en) * 2001-06-23 2003-01-23 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
DE10141377A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6919325B2 (en) * 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
US7405224B2 (en) * 2002-01-31 2008-07-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
US6790856B2 (en) * 2002-01-31 2004-09-14 Boehringer Ingelheim Pharma Kg Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments
US7309707B2 (en) * 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
US7311894B2 (en) * 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
US7244415B2 (en) * 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
ATE339951T1 (de) * 2002-04-04 2006-10-15 Boehringer Ingelheim Pharma Pulverzubereitungen zur inhalation
US20030235538A1 (en) 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
US7084153B2 (en) * 2002-04-12 2006-08-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising steroids and a novel anticholinergic
US7417051B2 (en) * 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
DE10345065A1 (de) * 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
TWI274641B (en) * 2005-08-30 2007-03-01 Rexon Ind Corp Ltd Cutting machine
CN115572291A (zh) * 2022-09-28 2023-01-06 成都第一制药有限公司 一种氢溴酸山莨菪碱及其制备方法和质量控制方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3211185A1 (de) * 1982-03-26 1983-09-29 Boehringer Ingelheim KG, 6507 Ingelheim Neue quartaere 6,11-dihydro-dibenzo-(b,e)-thiepin-11-n-alkyl- norscopinether und verfahren zu deren herstellung

Also Published As

Publication number Publication date
DK159777B (da) 1990-12-03
KR840004425A (ko) 1984-10-15
EP0092814A1 (fr) 1983-11-02
CS236873B2 (en) 1985-05-15
PH23301A (en) 1989-06-30
NO159172B (no) 1988-08-29
JPH052678B2 (fr) 1993-01-13
FI831234L (fi) 1983-10-27
NZ203980A (en) 1986-02-21
ATE16185T1 (de) 1985-11-15
ES8402292A1 (es) 1984-01-16
FI831234A0 (fi) 1983-04-13
DK182583D0 (da) 1983-04-25
YU93983A (en) 1985-10-31
KR900004127B1 (ko) 1990-06-16
DE3361054D1 (en) 1985-11-28
DK182583A (da) 1983-10-27
ES521809A0 (es) 1984-01-16
US4783534A (en) 1988-11-08
DK159777C (da) 1991-04-22
PL241635A1 (en) 1983-11-21
AU557680B2 (en) 1987-01-08
NO831447L (no) 1983-10-27
CA1254566A (fr) 1989-05-23
PT76584A (de) 1983-05-01
HU193161B (en) 1987-08-28
IE830938L (en) 1983-10-26
IE55308B1 (en) 1990-08-01
PT76584B (de) 1986-02-27
JPS58201779A (ja) 1983-11-24
AU1394583A (en) 1983-11-03
ZA832883B (en) 1984-12-24
EP0092814B1 (fr) 1985-10-23
NO159172C (no) 1988-12-07
DE3215493A1 (de) 1983-11-03
IL68479A0 (en) 1983-07-31
GR78837B (fr) 1984-10-02
YU43731B (en) 1989-10-31
PL138718B1 (en) 1986-10-31

Similar Documents

Publication Publication Date Title
DD211114A5 (de) Verfahren zur herstellung von n-alkyl-norscopinen
DE1795841C3 (de) H2&#39;-Chlor)-benzyl-2-di-sec.-butylamino-acetyl-pyrrol, seine Salze und Verfahren zu deren Herstellung
CH623335A5 (fr)
DE2351281C3 (de) Aminophenyl-äthanolamin-Derivate, deren Herstellung und Verwendung
DE2409675C3 (de) 5-Hydroxytryptophan-Derivate und Verfahren zu ihrer Herstellung
DE60014330T2 (de) Verfahren zur herstellung von 1,4,7,10-tetraazacyclododecan
EP0117531B1 (fr) N-(trifluorométhyl-3-phényl)-N&#39;-propargyl-pipérazine, son procédé de préparation et son utilisation
DE1936452C3 (de) Verfahren zur Herstellung von 4,4-Diphenylpiperidlnen
EP0093343A1 (fr) Procédé pour la préparation de norscopine
CH396941A (de) Verfahren zur Herstellung neuer sekundärer Amine
DE1468221C (de) Verfahren zur Herstellung von Aminoalkinyldenvaten des pibenzo cycloheptens
DE1793549A1 (de) Substituierte Dibenzocycloheptene und Verfahren zu ihrer Herstellung
DE1543578C3 (de) Verfahren zur Herstellung basisch substituierter Oxime von 6,11-Dihydrodibenz- eckige Klammer auf b,e eckige Klammer zu -oxepin- bzw. -thiepin-11onen und von deren pharmakologisch verträglichen Salzen
AT338786B (de) Verfahren zur herstellung von neuen 2-(2-pyridyl)-omega-phenylalkylaminen und deren saureadditionssalzen
DE1470197C (de) alpha.alpha Diphenyl alpha eckige Klammer auf 1 methylpyrrohdyl (3) eckige Klammer zu N,N dimethylace tamid und seine pharmakologisch ge eigneten Saureanlagerungssalze sowie Verfahren zur Herstellung dieser Ver bindungen
DE2433176A1 (de) 2-halopyrimidinderivate und verfahren zu ihrer herstellung
AT344907B (de) Verfahren zur herstellung neuer 9-alkylamino-erythromycine und ihrer salze
AT214934B (de) Verfahren zur Herstellung von neuen N-Derivaten von 10,11-Dihydro-5-benzo [b,f]azepinen und 5-Dibenzo [b,f]azepinen
DE2311637C3 (de) Verfahren zur Herstellung von 2-Aminobenzylaminen
AT269148B (de) Verfahren zur Herstellung neuer basisch substituierter Oxime von 6,11-Dihydro-dibenz-[b,e]-oxepin- bzw. -thiepin-11-onen und von deren Salzen
AT238184B (de) Verfahren zur Herstellung neuer Pyrrolidinverbindungen
AT347423B (de) Verfahren zur herstellung von neuen 7- aminobenzocycloheptenen und von deren salzen
LU84202A1 (de) Neues verfahren zur herstellung von ketoaminen
DE1276046B (de) Verfahren zur Herstellung von ª‡-substituierten N-Alkoxyaethylaminen
EP0128437A2 (fr) Dérivé de nortropine, son procédé de préparation et son utilisation

Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee