CY1122736T1 - Ενεσιμες υδρογελες σχηματισμου πορων για βασισμενες σε υλικο κυτταρικες θεραπειες - Google Patents
Ενεσιμες υδρογελες σχηματισμου πορων για βασισμενες σε υλικο κυτταρικες θεραπειεςInfo
- Publication number
- CY1122736T1 CY1122736T1 CY20201100146T CY201100146T CY1122736T1 CY 1122736 T1 CY1122736 T1 CY 1122736T1 CY 20201100146 T CY20201100146 T CY 20201100146T CY 201100146 T CY201100146 T CY 201100146T CY 1122736 T1 CY1122736 T1 CY 1122736T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pore
- injectable
- based cell
- cell therapies
- forming hydrogels
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
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- A—HUMAN NECESSITIES
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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Abstract
Η εφεύρεση παρέχει συνθέσεις και μεθόδους για σχηματισμό πόρων in situ εντός υδρογελών μετά από ένεση υδρογέλης. Οι πόροι οι οποίοι σχηματίζονται in situ μέσω αποικοδόμησης θυσιαστικών πορογόνων εντός της περιβάλλουσας υδρογέλης διευκολύνουν την επιστράτευση ή απελευθέρωση κυττάρων. Γνωστοποιείται στο παρόν ένα υλικό το οποίο δεν είναι αρχικά πορώδες, αλλά το οποίο καθίσταται μακροπορώδες με την πάροδο του χρόνου.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39059410P | 2010-10-06 | 2010-10-06 | |
PCT/US2011/055174 WO2012048165A2 (en) | 2010-10-06 | 2011-10-06 | Injectable, pore-forming hydrogels for materials-based cell therapies |
Publications (1)
Publication Number | Publication Date |
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CY1122736T1 true CY1122736T1 (el) | 2021-03-12 |
Family
ID=45928447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CY20201100146T CY1122736T1 (el) | 2010-10-06 | 2020-02-18 | Ενεσιμες υδρογελες σχηματισμου πορων για βασισμενες σε υλικο κυτταρικες θεραπειες |
Country Status (16)
Country | Link |
---|---|
US (2) | US11202759B2 (el) |
EP (2) | EP3620185A1 (el) |
JP (3) | JP6104806B2 (el) |
KR (2) | KR102155383B1 (el) |
CN (2) | CN103237565B (el) |
AU (1) | AU2011311904B2 (el) |
CA (1) | CA2813751C (el) |
CY (1) | CY1122736T1 (el) |
DK (1) | DK2624873T3 (el) |
ES (1) | ES2773858T3 (el) |
HR (1) | HRP20200310T1 (el) |
LT (1) | LT2624873T (el) |
PL (1) | PL2624873T3 (el) |
PT (1) | PT2624873T (el) |
SI (1) | SI2624873T1 (el) |
WO (1) | WO2012048165A2 (el) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2007070660A2 (en) | 2005-12-13 | 2007-06-21 | President And Fellows Of Harvard College | Scaffolds for cell transplantation |
US9770535B2 (en) * | 2007-06-21 | 2017-09-26 | President And Fellows Of Harvard College | Scaffolds for cell collection or elimination |
CN102006891B (zh) | 2008-02-13 | 2017-04-26 | 哈佛学院董事会 | 连续的细胞程序化装置 |
US9370558B2 (en) | 2008-02-13 | 2016-06-21 | President And Fellows Of Harvard College | Controlled delivery of TLR agonists in structural polymeric devices |
US9012399B2 (en) | 2008-05-30 | 2015-04-21 | President And Fellows Of Harvard College | Controlled release of growth factors and signaling molecules for promoting angiogenesis |
WO2010120749A2 (en) | 2009-04-13 | 2010-10-21 | President And Fellow Of Harvard College | Harnessing cell dynamics to engineer materials |
JP5926180B2 (ja) | 2009-07-31 | 2016-05-25 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 寛容原性療法のための細胞のプログラミングの方法 |
EP2542230A4 (en) * | 2010-03-05 | 2013-08-28 | Harvard College | ENHANCEMENT OF SKELETAL MUSCLE STRAIN CELL GRAFT WITH DUAL DELIVERY OF VEGF AND IGF-1 |
EP2585053A4 (en) | 2010-06-25 | 2014-02-26 | Harvard College | COMMON RELEASE OF STIMULATING AND HEMMING FACTORS FOR THE PRODUCTION OF TEMPORARY STABILIZED AND SPATULARLY LIMITED ZONES |
PT2624873T (pt) | 2010-10-06 | 2020-03-04 | Harvard College | Hidrogéis injectáveis formadores de poros para terapias celulares à base de materiais |
WO2012064697A2 (en) | 2010-11-08 | 2012-05-18 | President And Fellows Of Harvard College | Materials presenting notch signaling molecules to control cell behavior |
WO2012148684A1 (en) * | 2011-04-27 | 2012-11-01 | President And Fellows Of Harvard College | Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation |
US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
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