DE602004018163D1 - Hydrogel-porenbildner zur herstellung von biologisch abbaubaren gerüsten - Google Patents
Hydrogel-porenbildner zur herstellung von biologisch abbaubaren gerüstenInfo
- Publication number
- DE602004018163D1 DE602004018163D1 DE602004018163T DE602004018163T DE602004018163D1 DE 602004018163 D1 DE602004018163 D1 DE 602004018163D1 DE 602004018163 T DE602004018163 T DE 602004018163T DE 602004018163 T DE602004018163 T DE 602004018163T DE 602004018163 D1 DE602004018163 D1 DE 602004018163D1
- Authority
- DE
- Germany
- Prior art keywords
- biodegradable
- uncrosslinked
- poly
- fumarate
- hydrogel microparticles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 poly(propylene fumarate) Polymers 0.000 abstract 4
- 239000000017 hydrogel Substances 0.000 abstract 3
- 239000011859 microparticle Substances 0.000 abstract 3
- 102000008186 Collagen Human genes 0.000 abstract 2
- 108010035532 Collagen Proteins 0.000 abstract 2
- 229920001436 collagen Polymers 0.000 abstract 2
- 239000003999 initiator Substances 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 239000003361 porogen Substances 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 1
- 229920001963 Synthetic biodegradable polymer Polymers 0.000 abstract 1
- 238000012644 addition polymerization Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003431 cross linking reagent Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229920001299 polypropylene fumarate Polymers 0.000 abstract 1
- 239000011148 porous material Substances 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Composite Materials (AREA)
- Dispersion Chemistry (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
- Biological Depolymerization Polymers (AREA)
- Polymerisation Methods In General (AREA)
- Polyesters Or Polycarbonates (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49883203P | 2003-08-29 | 2003-08-29 | |
PCT/US2004/027926 WO2005020849A2 (en) | 2003-08-29 | 2004-08-27 | Hydrogel porogens for fabricating biodegradable scaffolds |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004018163D1 true DE602004018163D1 (de) | 2009-01-15 |
Family
ID=34272737
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004018163T Expired - Lifetime DE602004018163D1 (de) | 2003-08-29 | 2004-08-27 | Hydrogel-porenbildner zur herstellung von biologisch abbaubaren gerüsten |
Country Status (9)
Country | Link |
---|---|
US (1) | US20080206308A1 (de) |
EP (1) | EP1664168B1 (de) |
JP (1) | JP5059406B2 (de) |
AT (1) | ATE416223T1 (de) |
AU (1) | AU2004268013B2 (de) |
CA (1) | CA2535857A1 (de) |
DE (1) | DE602004018163D1 (de) |
ES (1) | ES2318339T3 (de) |
WO (1) | WO2005020849A2 (de) |
Families Citing this family (84)
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AU2005304567B2 (en) | 2004-11-12 | 2011-10-27 | Mayo Foundation For Medical Education And Research | Photocrosslinkable poly(caprolactone fumarate) |
US20060204539A1 (en) | 2005-03-11 | 2006-09-14 | Anthony Atala | Electrospun cell matrices |
US7531503B2 (en) | 2005-03-11 | 2009-05-12 | Wake Forest University Health Sciences | Cell scaffold matrices with incorporated therapeutic agents |
AU2006223063B2 (en) | 2005-03-11 | 2011-11-17 | Wake Forest University Health Sciences | Tissue engineered blood vessels |
US9248015B2 (en) | 2005-03-11 | 2016-02-02 | Wake Forest University Health Services | Production of tissue engineered heart valves |
WO2006099332A2 (en) | 2005-03-11 | 2006-09-21 | Wake Forest University Health Sciences | Production of tissue engineered digits and limbs |
AU2006226923B2 (en) * | 2005-03-23 | 2011-10-13 | Mayo Foundation For Medical Education And Research | Photocrosslinkable oligo(poly (ethylene glycol) fumarate) hydrogels for cell and drug delivery |
EP1874525B1 (de) | 2005-04-29 | 2011-06-01 | Mayo Foundation for Medical Education and Research | Hydrophile/hydrophobe polymernetze auf der basis von poly(caprolactonfumarat), poly(ethylenglycolfumarat) und copolymere davon |
CA2612195A1 (en) * | 2005-07-01 | 2007-01-11 | Cinvention Ag | Medical devices comprising a reticulated composite material |
AU2006326405B2 (en) | 2005-12-13 | 2013-10-31 | President And Fellows Of Harvard College | Scaffolds for cell transplantation |
US8235939B2 (en) | 2006-02-06 | 2012-08-07 | Kci Licensing, Inc. | System and method for purging a reduced pressure apparatus during the administration of reduced pressure treatment |
US9456860B2 (en) | 2006-03-14 | 2016-10-04 | Kci Licensing, Inc. | Bioresorbable foaming tissue dressing |
US8267918B2 (en) | 2006-03-14 | 2012-09-18 | Kci Licensing, Inc. | System and method for percutaneously administering reduced pressure treatment using a flowable manifold |
DE102006033168A1 (de) | 2006-07-10 | 2008-01-17 | Gelita Ag | Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung einer vernetzenden therapeutischen Zusammensetzung |
DE102006033167A1 (de) | 2006-07-10 | 2008-01-24 | Gelita Ag | Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung eines vernetzenden medizinischen Klebers |
WO2008112826A1 (en) | 2007-03-12 | 2008-09-18 | Board Of Regents, The University Of Texas System | Method and process for the production of multi-coated recognitive and releasing systems |
US8821899B2 (en) | 2007-03-12 | 2014-09-02 | Board Of Regents, The University Of Texas System | Method and process for the production of multi-coated recognitive and releasing systems |
US8741316B2 (en) | 2007-03-12 | 2014-06-03 | Board Of Regents, The University Of Texas System | Highly porous, recognitive polymer systems |
US8771713B2 (en) | 2007-03-12 | 2014-07-08 | Board Of Regents, The University Of Texas System | Method and process for the production of multi-coated recognitive and releasing systems |
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CA2715460C (en) | 2008-02-13 | 2020-02-18 | President And Fellows Of Harvard College | Continuous cell programming devices |
US9370558B2 (en) | 2008-02-13 | 2016-06-21 | President And Fellows Of Harvard College | Controlled delivery of TLR agonists in structural polymeric devices |
US8668863B2 (en) | 2008-02-26 | 2014-03-11 | Board Of Regents, The University Of Texas System | Dendritic macroporous hydrogels prepared by crystal templating |
WO2009146456A1 (en) * | 2008-05-30 | 2009-12-03 | President And Fellows Of Harvard College | Controlled release of growth factors and signaling molecules for promoting angiogenesis |
US8574629B2 (en) * | 2008-08-01 | 2013-11-05 | Anteis S.A. | Injectable hydrogel with an enhanced remanence and with an enhanced ability to create volume |
US9050184B2 (en) | 2008-08-13 | 2015-06-09 | Allergan, Inc. | Dual plane breast implant |
KR20110102931A (ko) | 2008-12-31 | 2011-09-19 | 케이씨아이 라이센싱 인코포레이티드 | 피하 조직 부위에 감압을 시행하는 매니폴드, 시스템 및 방법 |
US9297005B2 (en) | 2009-04-13 | 2016-03-29 | President And Fellows Of Harvard College | Harnessing cell dynamics to engineer materials |
WO2010123938A2 (en) * | 2009-04-20 | 2010-10-28 | Oregon Health & Science University | Bioresponsive hydrogel |
WO2010132028A1 (en) * | 2009-05-15 | 2010-11-18 | Nanyang Technological University | Composition for manufacturing a scaffold for tissue engineering, and a method of making it |
CA2768552A1 (en) | 2009-07-31 | 2011-02-03 | President And Fellows Of Harvard College | Programming of cells for tolerogenic therapies |
WO2011088296A1 (en) * | 2010-01-15 | 2011-07-21 | William Marsh Rice University | Combined space maintenance and bone regeneration system for the reconstruction of large osseous defects |
US8877822B2 (en) | 2010-09-28 | 2014-11-04 | Allergan, Inc. | Porogen compositions, methods of making and uses |
US9205577B2 (en) | 2010-02-05 | 2015-12-08 | Allergan, Inc. | Porogen compositions, methods of making and uses |
US9138309B2 (en) | 2010-02-05 | 2015-09-22 | Allergan, Inc. | Porous materials, methods of making and uses |
WO2011109834A2 (en) | 2010-03-05 | 2011-09-09 | President And Fellows Of Harvard College | Enhancement of skeletal muscle stem cell engrafment by dual delivery of vegf and igf-1 |
US11202853B2 (en) | 2010-05-11 | 2021-12-21 | Allergan, Inc. | Porogen compositions, methods of making and uses |
US20110282464A1 (en) * | 2010-05-12 | 2011-11-17 | Timothy Sargeant | Reactive Surgical Implants |
WO2011163669A2 (en) | 2010-06-25 | 2011-12-29 | President And Fellows Of Harvard College | Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones |
WO2012005783A1 (en) | 2010-07-09 | 2012-01-12 | Board Of Regents Of The University Of Texas System | Biodegradable scaffolds |
IT1406053B1 (it) | 2010-08-17 | 2014-02-06 | Fond T Campanella C O E | Scaffold tridimensionale polimerico di policaprolattone |
PT2624873T (pt) | 2010-10-06 | 2020-03-04 | Harvard College | Hidrogéis injectáveis formadores de poros para terapias celulares à base de materiais |
US9095558B2 (en) | 2010-10-08 | 2015-08-04 | Board Of Regents, The University Of Texas System | Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications |
WO2012048283A1 (en) * | 2010-10-08 | 2012-04-12 | Board Of Regents, The University Of Texas System | One-step processing of hydrogels for mechanically robust and chemically desired features |
US9603894B2 (en) | 2010-11-08 | 2017-03-28 | President And Fellows Of Harvard College | Materials presenting notch signaling molecules to control cell behavior |
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US8679279B2 (en) | 2010-11-16 | 2014-03-25 | Allergan, Inc. | Methods for creating foam-like texture |
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US9458357B2 (en) | 2011-03-02 | 2016-10-04 | Massachusetts Institute Of Technology | ph-sensitive sacrificial materials for the microfabrication of structures |
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EP2714073B1 (de) | 2011-06-03 | 2021-03-10 | President and Fellows of Harvard College | Krebsimpfstoff zur in-situ-antigen-erzeugung |
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DK2830595T3 (da) | 2012-03-29 | 2019-12-02 | Translate Bio Inc | Ioniserbare kationiske lipider |
HUE047973T2 (hu) | 2012-04-16 | 2020-05-28 | Harvard College | Mezoporózus szilíciumdioxid készítmények immunválaszok modulálására |
EP2900289A1 (de) * | 2012-09-28 | 2015-08-05 | Allergan, Inc. | Porogenzusammensetzungen, verfahren zur herstellung und verwendungen |
US11565027B2 (en) | 2012-12-11 | 2023-01-31 | Board Of Regents, The University Of Texas System | Hydrogel membrane for adhesion prevention |
CA2895083A1 (en) | 2012-12-13 | 2014-06-19 | Allergan, Inc. | Device and method for making a variable surface breast implant |
ITTO20121159A1 (it) * | 2012-12-28 | 2014-06-29 | Fond Istituto Italiano Di Tecnologia | Procedimento per la produzione di spugne polimeriche |
CN104436298B (zh) * | 2013-09-17 | 2016-04-06 | 中国人民解放军第二军医大学 | 一种可注射的镶嵌含bmp-2微粒的plga多孔复合微球制剂及其制备方法与应用 |
CN103495205B (zh) * | 2013-09-17 | 2015-04-01 | 中国人民解放军第二军医大学 | 一种可注射的镶嵌含药微粒的多孔复合微球制剂及其制备方法 |
US10092679B2 (en) | 2013-10-18 | 2018-10-09 | Wake Forest University Health Sciences | Laminous vascular constructs combining cell sheet engineering and electrospinning technologies |
JP6120392B2 (ja) * | 2013-11-22 | 2017-04-26 | 国立研究開発法人物質・材料研究機構 | 組織接着性多孔質膜、その製造方法及び組織接着性多孔質膜テープ |
CN107073090A (zh) | 2014-04-30 | 2017-08-18 | 哈佛学院董事会 | 结合的疫苗装置和杀死癌细胞的方法 |
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EP3240563B1 (de) | 2014-12-29 | 2020-12-09 | Bioventus LLC | Systeme und verfahren zur verbesserten freisetzung von osteoinduktiven moleküle zur knochenreparatur |
EP3250250A4 (de) | 2015-01-30 | 2019-05-22 | President and Fellows of Harvard College | Peritumorale und intratumorale materialien zur krebstherapie |
CN107708756A (zh) | 2015-04-10 | 2018-02-16 | 哈佛学院院长等 | 免疫细胞捕获装置及其制备和使用方法 |
EP3153187B1 (de) * | 2015-10-09 | 2018-02-14 | Yeditepe Universitesi | Gewebegerüstherstellungsverfahren |
JP7138864B2 (ja) | 2016-02-06 | 2022-09-20 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 免疫を再構成するための造血ニッチの再現 |
CN115404196A (zh) | 2016-07-13 | 2022-11-29 | 哈佛学院院长等 | 抗原呈递细胞模拟支架及其制备和使用方法 |
US10723774B2 (en) | 2016-11-17 | 2020-07-28 | University Of South Carolina | Keratin-based hydrogels |
US10967098B2 (en) | 2017-03-01 | 2021-04-06 | University' of South Carolina | Drug conjugated nanogels in microcapsule for delayed sustained protein delivery |
WO2018165327A1 (en) | 2017-03-08 | 2018-09-13 | Alafair Biosciences, Inc. | Hydrogel medium for the storage and preservation of tissue |
US11058797B2 (en) | 2017-03-08 | 2021-07-13 | University Of South Carolina | Compositions and layered structures formed therewith for regeneration of articular cartilage |
GB201707143D0 (en) | 2017-05-04 | 2017-06-21 | Plasticell Ltd | Method for producing cells |
US11672767B2 (en) | 2019-05-13 | 2023-06-13 | University Of South Carolina | Enzymatically cleavable self-assembled nanoparticles for morphogen delivery |
CN111978588B (zh) * | 2020-08-05 | 2022-05-03 | 广东省医疗器械研究所 | 一种大孔水凝胶及其制备方法和应用 |
US20220175534A1 (en) * | 2020-12-07 | 2022-06-09 | The Curators Of The University Of Missouri | Liquid collagen bioinks and methods to make and use collagen structures |
US20240197965A1 (en) * | 2021-04-09 | 2024-06-20 | University Of Connecticut | Foam biomaterial and systems, methods, and devices for making and using same |
CN113817214A (zh) * | 2021-08-06 | 2021-12-21 | 广东省科学院健康医学研究所 | 一种多孔水凝胶海绵及其制备方法和应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0000507B1 (de) * | 1977-07-20 | 1982-09-29 | Ciba-Geigy Ag | Verfahren zur Herstellung von Hydrogelen in Form kugelförmiger Perlen grösseren Durchmessers |
US4888413A (en) * | 1988-01-11 | 1989-12-19 | Domb Abraham J | Poly(propylene glycol fumarate) compositions for biomedical applications |
US5514378A (en) * | 1993-02-01 | 1996-05-07 | Massachusetts Institute Of Technology | Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures |
AU736102B2 (en) * | 1997-03-31 | 2001-07-26 | Regents Of The University Of Michigan, The | Open pore biodegradable matrices |
US6271278B1 (en) * | 1997-05-13 | 2001-08-07 | Purdue Research Foundation | Hydrogel composites and superporous hydrogel composites having fast swelling, high mechanical strength, and superabsorbent properties |
CA2221195A1 (en) * | 1997-11-14 | 1999-05-14 | Chantal E. Holy | Biodegradable polymer matrix |
US6395300B1 (en) * | 1999-05-27 | 2002-05-28 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
KR100355563B1 (ko) * | 2000-06-23 | 2002-10-11 | 주식회사 바이오메드랩 | 비등성 혼합물을 이용한 조직공학용 생분해성의 다공성고분자 지지체 및 그의 제조방법 |
TWI232873B (en) * | 2000-08-18 | 2005-05-21 | Ind Tech Res Inst | Process for producing porous polymer materials |
JP2003103905A (ja) * | 2001-09-27 | 2003-04-09 | Mitsubishi Paper Mills Ltd | インクジェット記録物の作成方法 |
JP4006992B2 (ja) * | 2001-12-17 | 2007-11-14 | 東洋紡績株式会社 | 記録材料の製造方法 |
US8021680B2 (en) * | 2003-05-02 | 2011-09-20 | Surmodics, Inc. | Controlled release bioactive agent delivery device |
-
2004
- 2004-08-27 ES ES04782412T patent/ES2318339T3/es not_active Expired - Lifetime
- 2004-08-27 AT AT04782412T patent/ATE416223T1/de active
- 2004-08-27 DE DE602004018163T patent/DE602004018163D1/de not_active Expired - Lifetime
- 2004-08-27 WO PCT/US2004/027926 patent/WO2005020849A2/en active Application Filing
- 2004-08-27 EP EP04782412A patent/EP1664168B1/de not_active Expired - Lifetime
- 2004-08-27 CA CA002535857A patent/CA2535857A1/en not_active Abandoned
- 2004-08-27 US US10/568,058 patent/US20080206308A1/en not_active Abandoned
- 2004-08-27 AU AU2004268013A patent/AU2004268013B2/en not_active Ceased
- 2004-08-27 JP JP2006524887A patent/JP5059406B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE416223T1 (de) | 2008-12-15 |
AU2004268013A1 (en) | 2005-03-10 |
AU2004268013B2 (en) | 2011-05-12 |
US20080206308A1 (en) | 2008-08-28 |
CA2535857A1 (en) | 2005-03-10 |
WO2005020849A3 (en) | 2005-07-14 |
JP2007503881A (ja) | 2007-03-01 |
ES2318339T3 (es) | 2009-05-01 |
JP5059406B2 (ja) | 2012-10-24 |
EP1664168B1 (de) | 2008-12-03 |
EP1664168A4 (de) | 2006-09-13 |
EP1664168A2 (de) | 2006-06-07 |
WO2005020849A2 (en) | 2005-03-10 |
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