MX2016006990A - Peptidos autoensamblables, peptidomimeticos y conjugados peptidicos como bloques de construccion para la biofabricacion e impresion. - Google Patents

Peptidos autoensamblables, peptidomimeticos y conjugados peptidicos como bloques de construccion para la biofabricacion e impresion.

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Publication number
MX2016006990A
MX2016006990A MX2016006990A MX2016006990A MX2016006990A MX 2016006990 A MX2016006990 A MX 2016006990A MX 2016006990 A MX2016006990 A MX 2016006990A MX 2016006990 A MX2016006990 A MX 2016006990A MX 2016006990 A MX2016006990 A MX 2016006990A
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MX
Mexico
Prior art keywords
biofabrication
self
peptidomimetics
printing
building blocks
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MX2016006990A
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English (en)
Inventor
LOO Yihua
Hauser Charlotte
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Agency Science Tech & Res
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Publication of MX2016006990A publication Critical patent/MX2016006990A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Surgery (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se relaciona con el uso de péptidos, peptoides y/o peptidomiméticos capaces de autoensamblarse y formar un hidrogel (nanofibroso) en la biofabricación. La presente invención se relaciona además, con métodos para preparar hidrogeles y con métodos para preparar fibras continuas y con métodos para obtener constructos con múltiples células con geometrías definidas, precisas. La presente invención se relaciona además, con varios usos de tales hidrogeles para obtener miniarreglos de hidrogel y estructuras organoides en 3D o constructos biológicos macromoleculares en 3D.
MX2016006990A 2013-11-30 2014-12-01 Peptidos autoensamblables, peptidomimeticos y conjugados peptidicos como bloques de construccion para la biofabricacion e impresion. MX2016006990A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG2013088919 2013-11-30
PCT/SG2014/000569 WO2015080671A1 (en) 2013-11-30 2014-12-01 Self-assembling peptides, peptidomimetics and peptidic conjugates as building blocks for biofabrication and printing

Publications (1)

Publication Number Publication Date
MX2016006990A true MX2016006990A (es) 2017-05-04

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MX2016006990A MX2016006990A (es) 2013-11-30 2014-12-01 Peptidos autoensamblables, peptidomimeticos y conjugados peptidicos como bloques de construccion para la biofabricacion e impresion.

Country Status (11)

Country Link
US (1) US10179194B2 (es)
EP (1) EP3074416A4 (es)
JP (1) JP2017501136A (es)
KR (1) KR20160091993A (es)
CN (1) CN105960411A (es)
AU (1) AU2014355214A1 (es)
BR (1) BR112016012128A2 (es)
CA (1) CA2932021A1 (es)
HK (1) HK1225745A1 (es)
MX (1) MX2016006990A (es)
WO (1) WO2015080671A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6618892B2 (ja) 2013-04-23 2019-12-11 プレジデント アンド フェローズ オブ ハーバード カレッジ 細菌バイオフィルムの遺伝的リプログラミング
BR112016012230A2 (pt) * 2013-11-30 2017-08-08 Agency Science Tech & Res Peptídeo hidrofóbico e/ou peptídeo-mimético, capaz de formar um hidrogel; composição ou mistura; hidrogel; uso do hidrogel; método para preparar um hidrogel; curativo de ferida ou agente cicatrizante de ferida; implante cirúrgico; composição cosmética e/ou farmacêutica e/ou um dispositivo biomédico e/ou dispositivo eletrônico; kit de peças; método in vitro ou in vivo de regeneração de tecido; método de tratamento de uma ferida e para cicatrização de ferida; dispositivo de bioimagem; e; substrato de cultura da célula 2d ou 3d
MX2016006990A (es) 2013-11-30 2017-05-04 Agency Science Tech & Res Peptidos autoensamblables, peptidomimeticos y conjugados peptidicos como bloques de construccion para la biofabricacion e impresion.
CN107406486A (zh) * 2015-03-31 2017-11-28 新加坡科技研究局 用于生物医学应用的自组装超短脂族环肽
EP3280397A4 (en) 2015-04-06 2018-08-22 President and Fellows of Harvard College Biosynthetic amyloid-based materials displaying functional protein sequences
US10058502B2 (en) 2015-12-31 2018-08-28 L'oreal Nail polish compositions
US11098133B2 (en) * 2016-05-19 2021-08-24 President And Fellows Of Harvard College Methods of making gels and films using curli nanofibers
CN107915848A (zh) * 2016-10-11 2018-04-17 中国海洋大学 一种甲壳素晶须/羟丁基壳聚糖温敏水凝胶的制备方法
CN110072565A (zh) * 2016-12-09 2019-07-30 比奥格莱克斯有限公司 改进的3d打印和药物递送
CN106699841B (zh) * 2017-01-05 2020-07-24 北京大学深圳研究生院 一种自组装的多肽纳米棒及其制备方法
CN106946982B (zh) * 2017-03-29 2020-08-28 中国石油大学(华东) 一种具有抗肿瘤功能的多肽
US11702623B2 (en) 2017-05-11 2023-07-18 King Abdullah University Of Science And Technology Device and method for microfluidics-based 3D bioprinting
WO2018207036A1 (en) * 2017-05-11 2018-11-15 King Abdullah University Of Science And Technology A peptide capable of forming a gel for use in tissue engineering and bioprinting
WO2019092049A1 (en) * 2017-11-07 2019-05-16 Royal College Of Surgeons In Ireland A thermo-responsive hydrogel for intratumoral administration as a treatment in solid tumor cancers
KR102219828B1 (ko) * 2018-04-11 2021-02-24 연세대학교 산학협력단 pH 감응성 펩타이드 구조체, 및 이의 용도
CN112752788A (zh) * 2018-07-24 2021-05-04 新南创新私人有限公司 3d打印用生物墨水
CN109276755B (zh) * 2018-10-11 2021-04-20 山东大学齐鲁医院(青岛) 基于自组装纳米多肽和干细胞的3d打印组织工程血管及其制备方法
ES2754824A1 (es) * 2018-10-17 2020-04-20 Univ Valladolid Composicion a base de biopolimeros recombinantes y usos de la misma como biotinta
CN109730976B (zh) * 2018-12-24 2020-06-09 华中科技大学 一种基于自由基氧化制备白蛋白纳米粒的方法
CN110394985B (zh) * 2019-06-21 2021-08-20 南京大学 一种利用Taylor喷射效应构造双层液锥进行三维连续分子自组装的装置及其方法
KR102228400B1 (ko) * 2019-09-24 2021-03-16 고려대학교 산학협력단 뇌 오가노이드 제조 방법
US11559389B2 (en) * 2020-05-05 2023-01-24 International Business Machines Corporation Bioprinted living tissue with therapy capability
CN111840636B (zh) * 2020-07-30 2022-01-18 齐鲁工业大学 伯氨基暴露量为5％的多肽单层膜及其制备方法与应用
WO2022035778A1 (en) * 2020-08-10 2022-02-17 Gel4Med, Inc. Delivery of cells and tissues with self-assembling peptide hydrogel materials
US11673324B2 (en) 2020-08-20 2023-06-13 King Abdullah University Of Science And Technology Nozzle for 3D bioprinting
US20220056074A1 (en) * 2020-08-20 2022-02-24 King Abdullah University Of Science And Technology Peptide compound with repetitive sequences
WO2022049494A1 (en) * 2020-09-02 2022-03-10 King Adbullah University Of Science And Technology Air-loaded gas vesicle nanoparticles for promoting cell growth in 3d bioprinted tissue constructs
US20230374069A1 (en) * 2020-09-02 2023-11-23 King Abdullah University Of Science And Technology Peptide-based dopa containing adhesive gels
EP4232558A1 (en) * 2020-10-21 2023-08-30 King Abdullah University Of Science And Technology Delivery of endothelial cell-laden microgel elicits angiogenesis in self-assembling ultrashort peptide hydrogels
CN112263547B (zh) * 2020-11-26 2022-12-20 深圳大学 一种多功能纳米药物载体及其制备方法与载药组合物
CN113321706B (zh) * 2021-07-15 2022-01-07 南开大学 一种自组装多肽衍生物及其制备的水凝胶
CN115583990B (zh) * 2022-11-22 2023-04-21 潍坊医学院 一种响应性小分子肽、纳米载药载体及应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003224710A1 (en) 2002-03-18 2003-10-08 Carnegie Mellon University Method and apparatus for preparing biomimetic scaffold
US20090117087A1 (en) 2007-04-13 2009-05-07 Wake Forest University Methods and compositions for printing biologically compatible nanotube composites of autologous tissue
US8999916B2 (en) * 2010-03-31 2015-04-07 Agency For Science, Technology And Research Crosslinked peptide hydrogels
WO2011123061A1 (en) * 2010-03-31 2011-10-06 Agency For Science, Technology And Research Amphiphilic linear peptide/peptoid and hydrogel comprising the same
SG187271A1 (en) * 2011-07-07 2013-02-28 Agency Science Tech & Res Anti-amyloidogenic, alpha-helix breaking ultra-small peptide therapeutic
CA3157246A1 (en) * 2011-09-12 2013-03-21 Organovo, Inc. Engineered tissues for in vitro research uses, arrays thereof, and methods of making the same
WO2013066274A1 (en) * 2011-11-04 2013-05-10 Agency For Science, Technology And Research Self-assembled composite ultrasmall peptide-polymer hydrogels
GB201203085D0 (en) 2012-02-22 2012-04-04 Univ Manchester Hydrogels
SG193042A1 (en) 2012-02-22 2013-09-30 Agency Science Tech & Res Organogels from ultrasmall peptides that can be used for biological and non-biological applications
US9120841B2 (en) * 2012-09-28 2015-09-01 Agency For Science, Technology And Research Amphiphilic linear peptidepeptoid and hydrogel comprising the same
WO2014104974A2 (en) * 2012-12-24 2014-07-03 Agency For Science, Technology And Research Self-assembling ultrashort peptides modified with bioactive agents by click chemistry
SG2012096699A (en) 2012-12-31 2014-07-30 Agency Science Tech & Res Amphiphilic linear peptide/peptoid and hydrogel comprising the same
WO2014116187A1 (en) * 2013-01-28 2014-07-31 Agency For Science, Technology And Research Crosslinked peptide hydrogels
CN105828838B (zh) * 2013-10-18 2020-03-10 新加坡科技研究局 含有纳米粒子的水凝胶
MX2016006990A (es) 2013-11-30 2017-05-04 Agency Science Tech & Res Peptidos autoensamblables, peptidomimeticos y conjugados peptidicos como bloques de construccion para la biofabricacion e impresion.
BR112016012230A2 (pt) 2013-11-30 2017-08-08 Agency Science Tech & Res Peptídeo hidrofóbico e/ou peptídeo-mimético, capaz de formar um hidrogel; composição ou mistura; hidrogel; uso do hidrogel; método para preparar um hidrogel; curativo de ferida ou agente cicatrizante de ferida; implante cirúrgico; composição cosmética e/ou farmacêutica e/ou um dispositivo biomédico e/ou dispositivo eletrônico; kit de peças; método in vitro ou in vivo de regeneração de tecido; método de tratamento de uma ferida e para cicatrização de ferida; dispositivo de bioimagem; e; substrato de cultura da célula 2d ou 3d

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US20160375177A1 (en) 2016-12-29
KR20160091993A (ko) 2016-08-03
JP2017501136A (ja) 2017-01-12
HK1225745A1 (zh) 2017-09-15
CN105960411A (zh) 2016-09-21
WO2015080671A1 (en) 2015-06-04
AU2014355214A1 (en) 2016-07-07
EP3074416A1 (en) 2016-10-05
BR112016012128A2 (pt) 2017-08-08
CA2932021A1 (en) 2015-06-04

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