MX365329B - Método para reticular ácido hialurónico; método para preparar un hidrogel inyectable; el hidrogel obtenido; el uso del hidrogel obtenido. - Google Patents
Método para reticular ácido hialurónico; método para preparar un hidrogel inyectable; el hidrogel obtenido; el uso del hidrogel obtenido.Info
- Publication number
- MX365329B MX365329B MX2015016835A MX2015016835A MX365329B MX 365329 B MX365329 B MX 365329B MX 2015016835 A MX2015016835 A MX 2015016835A MX 2015016835 A MX2015016835 A MX 2015016835A MX 365329 B MX365329 B MX 365329B
- Authority
- MX
- Mexico
- Prior art keywords
- hydrogel
- preparing
- hyaluronic acid
- injectable
- crosslinking hyaluronic
- Prior art date
Links
- 239000000017 hydrogel Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 238000004132 cross linking Methods 0.000 title abstract 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 1
- 229920002674 hyaluronan Polymers 0.000 title 1
- 229960003160 hyaluronic acid Drugs 0.000 title 1
Classifications
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Abstract
La presente invención se relaciona con un método para reticular ácido hialurónico, un método para preparar un hidrogel inyectable, el hidrogel obtenido de esta forma y su uso.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1301332A FR3006689A1 (fr) | 2013-06-11 | 2013-06-11 | Procede de reticulation de l'acide hyaluronique; procede de preparation d'un hydrogel injectable; hydrogel obtenu; utilisation de l'hydroget obtenu |
PCT/FR2013/000328 WO2014199022A1 (fr) | 2013-06-11 | 2013-12-10 | Procede de reticulation de l'acide hyaluronique; procede de preparation d'un hydrogel injectable; hydrogel obtenu; utilisation de l'hydrogel obtenu |
PCT/EP2014/001573 WO2014198406A1 (en) | 2013-06-11 | 2014-06-10 | Method for crosslinking hyaluronic acid; method for preparing an injectable hydrogel; hydrogel obtained; use of the obtained hydrogel |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015016835A MX2015016835A (es) | 2016-04-11 |
MX365329B true MX365329B (es) | 2019-05-30 |
Family
ID=48979826
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015016835A MX365329B (es) | 2013-06-11 | 2014-06-10 | Método para reticular ácido hialurónico; método para preparar un hidrogel inyectable; el hidrogel obtenido; el uso del hidrogel obtenido. |
Country Status (20)
Country | Link |
---|---|
US (1) | US9782490B2 (es) |
EP (1) | EP3007737B1 (es) |
JP (1) | JP6491199B2 (es) |
KR (1) | KR102256061B1 (es) |
CN (1) | CN105358186B (es) |
AU (1) | AU2014280544B2 (es) |
BR (1) | BR112015031026B1 (es) |
CA (1) | CA2914417C (es) |
DK (1) | DK3007737T3 (es) |
ES (1) | ES2647227T3 (es) |
FR (1) | FR3006689A1 (es) |
HK (1) | HK1221669A1 (es) |
IL (1) | IL242657B (es) |
LT (1) | LT3007737T (es) |
MX (1) | MX365329B (es) |
PL (1) | PL3007737T3 (es) |
RU (1) | RU2683286C2 (es) |
SG (1) | SG11201510103YA (es) |
WO (1) | WO2014199022A1 (es) |
ZA (1) | ZA201508544B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI727014B (zh) * | 2016-03-24 | 2021-05-11 | 德商梅茲製藥有限兩合公司 | 修飾透明質酸與其製造方法及其用途 |
RU2019101419A (ru) * | 2016-07-27 | 2020-07-20 | Марбелле Треадс Лтд. | Нити поперечно сшитой гиалуроновой кислоты и гидроксиапатита |
KR101866678B1 (ko) * | 2017-01-11 | 2018-06-12 | 서울대학교산학협력단 | 저온 가교 공정을 통한 점탄성과 체내지속성이 증진된 하이드로젤의 제조방법 |
EP3354258A1 (en) * | 2017-01-31 | 2018-08-01 | Teoxane SA | Use of a cohesive gel as a matrix material in a periodontal pocket |
AU2018228299B2 (en) * | 2017-02-28 | 2020-05-07 | Cg Bio Co., Ltd. | Composition For Dermal Injection |
KR102107699B1 (ko) * | 2017-02-28 | 2020-05-14 | (주)시지바이오 | 피부 주입용 조성물 |
AU2018228301B2 (en) * | 2017-02-28 | 2020-12-17 | Cg Bio Co., Ltd. | Composition For Dermal Injection |
KR102067187B1 (ko) * | 2017-08-30 | 2020-01-16 | (주)웰빙해피팜 | 이중 가교를 이용한 조직수복용 생체조성물의 제조방법 및 그로부터 제조된 생체조성물 |
CA3075099A1 (en) * | 2017-10-18 | 2019-04-25 | Lifecell Corporation | Adipose tissue products and methods of production |
EP3697462B1 (en) | 2017-10-19 | 2023-07-12 | LifeCell Corporation | Flowable acellular tissue matrix products and methods of production |
KR102320153B1 (ko) * | 2017-11-23 | 2021-11-02 | 주식회사 파마리서치 | 이중 가교를 통한 히알루론산 겔 및 이의 제조방법 |
CN107955194A (zh) * | 2017-11-29 | 2018-04-24 | 桂林华诺威生物科技有限公司 | 高质量交联透明质酸钠凝胶的制备方法 |
CN108392729A (zh) * | 2018-04-20 | 2018-08-14 | 威海迈尼生物科技有限公司 | 一种接枝药物的交联透明质酸微针 |
GB201901671D0 (en) * | 2019-02-06 | 2019-03-27 | Regen Lab Sa | Cross-linked hya;uronic acids and combinations with PRP/BMC |
KR20220046542A (ko) * | 2019-06-04 | 2022-04-14 | 아쿠아빗 파마슈티컬즈, 아이엔씨. | 마이크로채널 기술을 사용하여 히알루론산으로 피부를 마이크로 충전하기 위한 방법 및 조성물 |
KR102176486B1 (ko) * | 2019-06-14 | 2020-11-10 | 동국대학교 산학협력단 | 히알루론산 기반의 안과용 약물전달체의 제조방법 |
KR102201482B1 (ko) * | 2019-07-29 | 2021-01-13 | 주식회사 피움바이오 | 주입력이 우수한 가교된 히알루론산 기반 기능성 생체 적합성 고분자 복합체의 제조 방법 |
US11795320B2 (en) * | 2019-09-20 | 2023-10-24 | Bausch + Lomb Ireland Limited | Grafted polymer and use thereof |
IT201900017387A1 (it) * | 2019-09-27 | 2021-03-27 | Bmg Pharma S P A | Idrogelo a base di zinco gluconato ed esteri dell’acido ialuronico |
US11202753B1 (en) | 2020-03-06 | 2021-12-21 | Aquavit Pharmaceuticals, Inc. | Systems and methods for generating immune responses in subjects using microchannel delivery devices |
KR102395184B1 (ko) * | 2020-03-10 | 2022-05-10 | (주)메디톡스 | 단일상도 아니고 이성상도 아닌 히알루론산 가교체, 및 이의 용도 |
EP4135772A4 (en) * | 2020-04-17 | 2024-04-24 | Brendan Patrick Purcell | CONTROLLED RELEASE HYALURONIC ACID COMPOSITIONS |
WO2022225476A1 (en) * | 2021-04-20 | 2022-10-27 | Vsy Biyoteknoloji Ve Ilac Sanayi Anonim Sirketi | Injectable hyaluronic acid formulations for use in intraarticular, intradermal and ophthalmic applications |
CN113521388A (zh) * | 2021-07-30 | 2021-10-22 | 张广利 | 一种注射型美容整形用面部填充剂组合物及其制备方法 |
KR102652905B1 (ko) * | 2021-08-09 | 2024-04-01 | 주식회사 메디폴리머 | 주사용 사전-제형 및 이를 이용한 도네페질 초기방출 억제형 키트 |
CN114177352B (zh) * | 2021-12-22 | 2023-01-10 | 西安德诺海思医疗科技有限公司 | 一种梯度降解皮肤填充剂及其制备方法 |
WO2024172910A1 (en) * | 2023-02-15 | 2024-08-22 | Lifesprout, Inc. | Modified crosslinked polymers |
CN116444826A (zh) * | 2023-06-05 | 2023-07-18 | 天新福(北京)医疗器材股份有限公司 | 一种交联改性胶原蛋白凝胶、其制备方法和凝胶产品 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE442820B (sv) * | 1984-06-08 | 1986-02-03 | Pharmacia Ab | Gel av tverbunden hyaluronsyra for anvendning som glaskroppssubstitut |
FR2733426B1 (fr) * | 1995-04-25 | 1997-07-18 | Debacker Yves | Dispositif medical pour le comblement des deformations du volume de la peau telles que rides et cicatrices par injection de 2 formes physico-chimiques differentes d'un polymere biologique |
FR2861734B1 (fr) | 2003-04-10 | 2006-04-14 | Corneal Ind | Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus |
FR2865737B1 (fr) * | 2004-02-03 | 2006-03-31 | Anteis Sa | Gel reticule biocompatible |
WO2007026362A2 (en) * | 2005-09-02 | 2007-03-08 | Colbar Lifescience Ltd. | Cross-linked polysaccharide and protein matrices and methods for their preparation |
FR2918377B1 (fr) * | 2007-07-05 | 2010-10-08 | Estelle Piron | Gel co-reticule de polysaccharides |
FR2924615B1 (fr) * | 2007-12-07 | 2010-01-22 | Vivacy Lab | Hydrogel cohesif biodegradable. |
JP5574083B2 (ja) | 2008-08-01 | 2014-08-20 | アンタイス エス.エイ. | 高い残留性及び容量を与える高い能力を有する注入可能なヒドロゲル |
US8450475B2 (en) * | 2008-08-04 | 2013-05-28 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
FR2945293B1 (fr) * | 2009-05-11 | 2011-06-17 | Teoxane | Procede de preparation d'un gel reticule. |
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2013
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- 2013-12-10 WO PCT/FR2013/000328 patent/WO2014199022A1/fr active Application Filing
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2014
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- 2014-06-10 ES ES14729220.5T patent/ES2647227T3/es active Active
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- 2014-06-10 EP EP14729220.5A patent/EP3007737B1/en not_active Revoked
- 2014-06-10 RU RU2015154035A patent/RU2683286C2/ru active
- 2014-06-10 MX MX2015016835A patent/MX365329B/es active IP Right Grant
- 2014-06-10 KR KR1020157036950A patent/KR102256061B1/ko active IP Right Grant
- 2014-06-10 DK DK14729220.5T patent/DK3007737T3/da active
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JP2016527338A (ja) | 2016-09-08 |
CN105358186A (zh) | 2016-02-24 |
MX2015016835A (es) | 2016-04-11 |
FR3006689A1 (fr) | 2014-12-12 |
AU2014280544B2 (en) | 2017-10-26 |
AU2014280544A1 (en) | 2015-12-03 |
EP3007737B1 (en) | 2017-10-18 |
HK1221669A1 (zh) | 2017-06-09 |
ES2647227T3 (es) | 2017-12-20 |
US9782490B2 (en) | 2017-10-10 |
CN105358186B (zh) | 2017-09-08 |
PL3007737T3 (pl) | 2018-03-30 |
BR112015031026B1 (pt) | 2020-07-07 |
ZA201508544B (en) | 2016-11-30 |
US20160144043A1 (en) | 2016-05-26 |
CA2914417C (en) | 2021-03-09 |
RU2683286C2 (ru) | 2019-03-27 |
KR102256061B1 (ko) | 2021-05-25 |
RU2015154035A3 (es) | 2018-05-28 |
WO2014199022A1 (fr) | 2014-12-18 |
RU2015154035A (ru) | 2017-07-14 |
JP6491199B2 (ja) | 2019-03-27 |
DK3007737T3 (da) | 2017-11-27 |
SG11201510103YA (en) | 2016-01-28 |
LT3007737T (lt) | 2017-12-11 |
EP3007737A1 (en) | 2016-04-20 |
CA2914417A1 (en) | 2014-12-18 |
IL242657B (en) | 2020-01-30 |
KR20160031465A (ko) | 2016-03-22 |
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