CY1115879T1 - ΤΑΥΤΟΠΟΙΗΣΗ ΚΑΙ ΚΑΤΑΣΚΕΥΗ ΑΝΤΙΣΩΜΑΤΩΝ ΜΕ ΠΑΡΑΛΛΑΓΜΕΝΑ ΤΜΗΜΑΤΑ Fc ΚΑΙ ΜΕΘΟΔΟΥΣ ΧΡΗΣΗΣ ΤΟΥΣ - Google Patents

ΤΑΥΤΟΠΟΙΗΣΗ ΚΑΙ ΚΑΤΑΣΚΕΥΗ ΑΝΤΙΣΩΜΑΤΩΝ ΜΕ ΠΑΡΑΛΛΑΓΜΕΝΑ ΤΜΗΜΑΤΑ Fc ΚΑΙ ΜΕΘΟΔΟΥΣ ΧΡΗΣΗΣ ΤΟΥΣ

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Publication number
CY1115879T1
CY1115879T1 CY20141101083T CY141101083T CY1115879T1 CY 1115879 T1 CY1115879 T1 CY 1115879T1 CY 20141101083 T CY20141101083 T CY 20141101083T CY 141101083 T CY141101083 T CY 141101083T CY 1115879 T1 CY1115879 T1 CY 1115879T1
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CY
Cyprus
Prior art keywords
fragment
variant
antibodies
molecules
disease
Prior art date
Application number
CY20141101083T
Other languages
English (en)
Inventor
Jeffery Stavenhagen
Sergey Gorlatov
Christopher Rankin
Nadine Tuaillon
Original Assignee
Macrogenics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrogenics, Inc. filed Critical Macrogenics, Inc.
Publication of CY1115879T1 publication Critical patent/CY1115879T1/el

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με μόρια, ιδιαίτερα πολυπεπτίδια, πιο συγκεκριμένα ανοσοσφαιρίνες (π.χ. αντισώματα) με παραλλαγή τμήματος Fc όπου αυτή η παραλλαγή του τμήματος Fc περιέχει τουλάχιστον μία παραλλαγή αμινοξέος σε σχέση με τμήμα Fc άγριου τύπου, η οποία παραλλαγή τμήματος Fc δεσμεύει FcγRΙIΙΑ και/ή FcγRΙΙΙΑ με μεγαλύτερη συγγένεια σε σχέση με συγκρίσιμο μόριο που αποτελείται από τμήμα άγριου τύπου. Τα μόρια της εφεύρεσης είναι ιδιαίτερα χρήσιμα για την πρόληψη, την αντιμετώπιση ή τη βελτίωση ενός ή περισσοτέρων συμπτωμάτων που σχετίζονται με νόσο, διαταραχή ή λοίμωξη. Τα μόρια της εφεύρεσης είναι ιδιαίτερα χρήσιμα για την αντιμετώπιση ή πρόληψη νόσου ή διαταραχής όπου είναι επιθυμητή η βελτιωμένη απόδοση της λειτουργίας δραστικών κυττάρων (π.χ. ADCC) με μεσολάβηση FcγR, π.χ. καρκίνος, λοιμώδης νόσος και βελτίωση της θεραπευτικής αποτελεσματικότητας θεραπευτικών αντισωμάτων το αποτέλεσμα των οποίων διαμεσολαβείται με ADCC.
CY20141101083T 2005-08-10 2014-12-23 ΤΑΥΤΟΠΟΙΗΣΗ ΚΑΙ ΚΑΤΑΣΚΕΥΗ ΑΝΤΙΣΩΜΑΤΩΝ ΜΕ ΠΑΡΑΛΛΑΓΜΕΝΑ ΤΜΗΜΑΤΑ Fc ΚΑΙ ΜΕΘΟΔΟΥΣ ΧΡΗΣΗΣ ΤΟΥΣ CY1115879T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70741905P 2005-08-10 2005-08-10
PCT/US2006/031201 WO2007021841A2 (en) 2005-08-10 2006-08-10 Identification and engineering of antibodies with variant fc regions and methods of using same

Publications (1)

Publication Number Publication Date
CY1115879T1 true CY1115879T1 (el) 2019-07-10

Family

ID=37758158

Family Applications (2)

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CY20141101083T CY1115879T1 (el) 2005-08-10 2014-12-23 ΤΑΥΤΟΠΟΙΗΣΗ ΚΑΙ ΚΑΤΑΣΚΕΥΗ ΑΝΤΙΣΩΜΑΤΩΝ ΜΕ ΠΑΡΑΛΛΑΓΜΕΝΑ ΤΜΗΜΑΤΑ Fc ΚΑΙ ΜΕΘΟΔΟΥΣ ΧΡΗΣΗΣ ΤΟΥΣ
CY20161100588T CY1117754T1 (el) 2005-08-10 2016-06-29 ΤΑΥΤΟΠΟΙΗΣΗ ΚΑΙ ΓΕΝΕΤΙΚΗ ΜΗΧΑΝΙΚΗ ΑΝΤΙΣΩΜΑΤΩΝ ΜΕ ΠΕΡΙΟΧΕΣ Fc ΠΑΡΑΛΛΑΓΜΑΤΩΝ ΚΑΙ ΜΕΘΟΔΟΙ ΧΡΗΣΗΣ ΤΩΝ ΙΔΙΩΝ

Family Applications After (1)

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CY20161100588T CY1117754T1 (el) 2005-08-10 2016-06-29 ΤΑΥΤΟΠΟΙΗΣΗ ΚΑΙ ΓΕΝΕΤΙΚΗ ΜΗΧΑΝΙΚΗ ΑΝΤΙΣΩΜΑΤΩΝ ΜΕ ΠΕΡΙΟΧΕΣ Fc ΠΑΡΑΛΛΑΓΜΑΤΩΝ ΚΑΙ ΜΕΘΟΔΟΙ ΧΡΗΣΗΣ ΤΩΝ ΙΔΙΩΝ

Country Status (15)

Country Link
US (2) US8217147B2 (el)
EP (2) EP2573114B1 (el)
JP (1) JP5105485B2 (el)
AU (1) AU2006279945B2 (el)
CA (1) CA2618681C (el)
CY (2) CY1115879T1 (el)
DK (2) DK2573114T3 (el)
ES (2) ES2526811T3 (el)
HU (1) HUE029465T2 (el)
IL (1) IL189263B (el)
LT (1) LT2573114T (el)
PL (2) PL1919503T3 (el)
PT (2) PT2573114T (el)
SI (2) SI1919503T1 (el)
WO (1) WO2007021841A2 (el)

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