CY1115246T1 - Τροποποιησεις toy rna, οι οποιες οδηγουν σε αυξημενη σταθεροτητα μεταγραφηματων και αποτελεσματικοτητα μεταφρασης - Google Patents

Τροποποιησεις toy rna, οι οποιες οδηγουν σε αυξημενη σταθεροτητα μεταγραφηματων και αποτελεσματικοτητα μεταφρασης

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Publication number
CY1115246T1
CY1115246T1 CY20141100498T CY141100498T CY1115246T1 CY 1115246 T1 CY1115246 T1 CY 1115246T1 CY 20141100498 T CY20141100498 T CY 20141100498T CY 141100498 T CY141100498 T CY 141100498T CY 1115246 T1 CY1115246 T1 CY 1115246T1
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Cyprus
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transfer
toy
lead
stability
increased
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CY20141100498T
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English (en)
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Ugur Sahin
Silke Holtkamp
Özlem Türeci
Sebastian Kreiter
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Biontech Ag
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Publication of CY1115246T1 publication Critical patent/CY1115246T1/el

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/68—Stabilisation of the vector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Η παρούσα εφεύρεση αφορά τη σταθεροποίηση του RNA, ιδιαιτέρως του mRNA, και την αύξηση της μετάφρασης του mRNA. Η παρούσα εφεύρεση αφορά ιδιαιτέρως τρεις τροποποιήσεις του RNA, ιδιαιτέρως in vitro μεταγραμμένου RNA, οι οποίες οδηγούν σε αυξημένη σταθερότητα μεταγραφημάτων και αποτελεσματικότητα μετάφρασης.
CY20141100498T 2005-09-28 2014-07-02 Τροποποιησεις toy rna, οι οποιες οδηγουν σε αυξημενη σταθεροτητα μεταγραφηματων και αποτελεσματικοτητα μεταφρασης CY1115246T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005046490A DE102005046490A1 (de) 2005-09-28 2005-09-28 Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
EP10014763.6A EP2357230B1 (de) 2005-09-28 2006-09-28 Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen

Publications (1)

Publication Number Publication Date
CY1115246T1 true CY1115246T1 (el) 2017-01-04

Family

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CY20121100514T CY1113526T1 (el) 2005-09-28 2012-06-06 Τροποποιησεις του rνα, οι οποιες οδηγουν σε αυξημενη σταθεροτητα μεταγραφηματων και αποτελεσματικοτητα mεταφρασης
CY20141100498T CY1115246T1 (el) 2005-09-28 2014-07-02 Τροποποιησεις toy rna, οι οποιες οδηγουν σε αυξημενη σταθεροτητα μεταγραφηματων και αποτελεσματικοτητα μεταφρασης

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CY20121100514T CY1113526T1 (el) 2005-09-28 2012-06-06 Τροποποιησεις του rνα, οι οποιες οδηγουν σε αυξημενη σταθεροτητα μεταγραφηματων και αποτελεσματικοτητα mεταφρασης

Country Status (18)

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US (4) US9476055B2 (el)
EP (2) EP1934345B9 (el)
JP (3) JP5435949B2 (el)
AT (1) ATE550427T1 (el)
AU (1) AU2006296702B2 (el)
CA (2) CA2621444C (el)
CY (2) CY1113526T1 (el)
DE (1) DE102005046490A1 (el)
DK (2) DK2357230T3 (el)
ES (2) ES2467678T3 (el)
HK (1) HK1155477A1 (el)
HR (2) HRP20120480T1 (el)
IN (1) IN2014CN02116A (el)
PL (2) PL1934345T3 (el)
PT (2) PT1934345E (el)
RS (2) RS53351B (el)
SI (2) SI1934345T1 (el)
WO (1) WO2007036366A2 (el)

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