PL2357230T3 - Modyfikacje RNA skutkujące ulepszoną stabilnością transkryptu i skutecznością translacji - Google Patents

Modyfikacje RNA skutkujące ulepszoną stabilnością transkryptu i skutecznością translacji

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Publication number
PL2357230T3
PL2357230T3 PL10014763T PL10014763T PL2357230T3 PL 2357230 T3 PL2357230 T3 PL 2357230T3 PL 10014763 T PL10014763 T PL 10014763T PL 10014763 T PL10014763 T PL 10014763T PL 2357230 T3 PL2357230 T3 PL 2357230T3
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PL
Poland
Prior art keywords
nucleic acid
acid sequence
transcription
molecule
transcriptable
Prior art date
Application number
PL10014763T
Other languages
English (en)
Inventor
Ugur Sahin
Silke Holtkamp
Özlem Türeci
Sebastian Kreiter
Original Assignee
Biontech Ag
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Publication date
Application filed by Biontech Ag filed Critical Biontech Ag
Publication of PL2357230T3 publication Critical patent/PL2357230T3/pl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/68—Stabilisation of the vector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL10014763T 2005-09-28 2006-09-28 Modyfikacje RNA skutkujące ulepszoną stabilnością transkryptu i skutecznością translacji PL2357230T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005046490A DE102005046490A1 (de) 2005-09-28 2005-09-28 Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
EP10014763.6A EP2357230B1 (de) 2005-09-28 2006-09-28 Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
EP06805937A EP1934345B9 (de) 2005-09-28 2006-09-28 Modifikationen von rna, die zu einer erhöhten transkriptstabilität und translationseffizienz führen

Publications (1)

Publication Number Publication Date
PL2357230T3 true PL2357230T3 (pl) 2014-08-29

Family

ID=37685276

Family Applications (2)

Application Number Title Priority Date Filing Date
PL06805937T PL1934345T3 (pl) 2005-09-28 2006-09-28 Modyfikacje RNA prowadzące do zwiększonej stabilności transkryptu i skuteczności translacji
PL10014763T PL2357230T3 (pl) 2005-09-28 2006-09-28 Modyfikacje RNA skutkujące ulepszoną stabilnością transkryptu i skutecznością translacji

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL06805937T PL1934345T3 (pl) 2005-09-28 2006-09-28 Modyfikacje RNA prowadzące do zwiększonej stabilności transkryptu i skuteczności translacji

Country Status (17)

Country Link
US (4) US9476055B2 (pl)
EP (2) EP1934345B9 (pl)
JP (3) JP5435949B2 (pl)
AT (1) ATE550427T1 (pl)
AU (1) AU2006296702B2 (pl)
CA (2) CA3023101C (pl)
CY (2) CY1113526T1 (pl)
DE (1) DE102005046490A1 (pl)
DK (2) DK2357230T3 (pl)
ES (2) ES2467678T3 (pl)
HR (2) HRP20120480T1 (pl)
IN (1) IN2014CN02116A (pl)
PL (2) PL1934345T3 (pl)
PT (2) PT1934345E (pl)
RS (2) RS53351B (pl)
SI (2) SI1934345T1 (pl)
WO (1) WO2007036366A2 (pl)

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