DK1934345T3 - Modifikationer af rna, der fører til en forøget transkriptstabilitet og translationseffektivitet - Google Patents

Modifikationer af rna, der fører til en forøget transkriptstabilitet og translationseffektivitet

Info

Publication number
DK1934345T3
DK1934345T3 DK06805937.7T DK06805937T DK1934345T3 DK 1934345 T3 DK1934345 T3 DK 1934345T3 DK 06805937 T DK06805937 T DK 06805937T DK 1934345 T3 DK1934345 T3 DK 1934345T3
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DK
Denmark
Prior art keywords
nucleic acid
acid sequence
transcription
molecule
transcriptable
Prior art date
Application number
DK06805937.7T
Other languages
English (en)
Inventor
Ugur Sahin
Oezlem Tuereci
Sebastian Kreiter
Silke Holtkamp
Original Assignee
Biontech Ag
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Publication date
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Application granted granted Critical
Publication of DK1934345T3 publication Critical patent/DK1934345T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/68—Stabilisation of the vector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK06805937.7T 2005-09-28 2006-09-28 Modifikationer af rna, der fører til en forøget transkriptstabilitet og translationseffektivitet DK1934345T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005046490A DE102005046490A1 (de) 2005-09-28 2005-09-28 Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
PCT/EP2006/009448 WO2007036366A2 (de) 2005-09-28 2006-09-28 Modifikationen von rna, die zu einer erhöhten transkriptstabilität und translationseffizienz führen

Publications (1)

Publication Number Publication Date
DK1934345T3 true DK1934345T3 (da) 2012-07-23

Family

ID=37685276

Family Applications (2)

Application Number Title Priority Date Filing Date
DK10014763.6T DK2357230T3 (da) 2005-09-28 2006-09-28 Modifikationer af rna, der fører til en forøget transkriptstabilitet og translationseffektivitet
DK06805937.7T DK1934345T3 (da) 2005-09-28 2006-09-28 Modifikationer af rna, der fører til en forøget transkriptstabilitet og translationseffektivitet

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK10014763.6T DK2357230T3 (da) 2005-09-28 2006-09-28 Modifikationer af rna, der fører til en forøget transkriptstabilitet og translationseffektivitet

Country Status (18)

Country Link
US (4) US9476055B2 (da)
EP (2) EP2357230B1 (da)
JP (3) JP5435949B2 (da)
AT (1) ATE550427T1 (da)
AU (1) AU2006296702B2 (da)
CA (2) CA2621444C (da)
CY (2) CY1113526T1 (da)
DE (1) DE102005046490A1 (da)
DK (2) DK2357230T3 (da)
ES (2) ES2384113T3 (da)
HK (1) HK1155477A1 (da)
HR (2) HRP20120480T1 (da)
IN (1) IN2014CN02116A (da)
PL (2) PL2357230T3 (da)
PT (2) PT2357230E (da)
RS (2) RS53351B (da)
SI (2) SI2357230T1 (da)
WO (1) WO2007036366A2 (da)

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US20190062762A1 (en) 2019-02-28
US20230193296A1 (en) 2023-06-22
ES2467678T3 (es) 2014-06-12
EP1934345A2 (de) 2008-06-25
SI1934345T1 (sl) 2012-07-31
ATE550427T1 (de) 2012-04-15
WO2007036366A8 (de) 2012-05-31
CA3023101C (en) 2022-09-06
DK2357230T3 (da) 2014-06-02
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