IN2014CN02116A - - Google Patents

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Publication number
IN2014CN02116A
IN2014CN02116A IN2116CHN2014A IN2014CN02116A IN 2014CN02116 A IN2014CN02116 A IN 2014CN02116A IN 2116CHN2014 A IN2116CHN2014 A IN 2116CHN2014A IN 2014CN02116 A IN2014CN02116 A IN 2014CN02116A
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IN
India
Prior art keywords
rna
mrna
increased
translation
relates
Prior art date
Application number
Inventor
Ugur Sahin
Silke Holtkamp
Özlem Türeci
Sebastian Kreiter
Original Assignee
Johannes Gutenberg Universität Mainz Vertreten Durch Den Präsidenten
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Application filed by Johannes Gutenberg Universität Mainz Vertreten Durch Den Präsidenten filed Critical Johannes Gutenberg Universität Mainz Vertreten Durch Den Präsidenten
Publication of IN2014CN02116A publication Critical patent/IN2014CN02116A/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/68—Stabilisation of the vector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to the stabilisation of RNA in particular mRNA and to the increased translation of mRNA. The invention specifically relates to three modifications of RNA in particular in vitro transcribed RNA which produce an increased transcript stability and translation efficiency.
IN2116CHN2014 2005-09-28 2006-09-28 IN2014CN02116A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005046490A DE102005046490A1 (en) 2005-09-28 2005-09-28 New nucleic acid molecule comprising promoter, a transcriptable nucleic acid sequence, a first and second nucleic acid sequence for producing modified RNA with transcriptional stability and translational efficiency
PCT/EP2006/009448 WO2007036366A2 (en) 2005-09-28 2006-09-28 Modification of rna, producing an increased transcript stability and translation efficiency

Publications (1)

Publication Number Publication Date
IN2014CN02116A true IN2014CN02116A (en) 2015-05-29

Family

ID=37685276

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2116CHN2014 IN2014CN02116A (en) 2005-09-28 2006-09-28

Country Status (18)

Country Link
US (4) US9476055B2 (en)
EP (2) EP2357230B1 (en)
JP (3) JP5435949B2 (en)
AT (1) ATE550427T1 (en)
AU (1) AU2006296702B2 (en)
CA (2) CA3023101C (en)
CY (2) CY1113526T1 (en)
DE (1) DE102005046490A1 (en)
DK (2) DK2357230T3 (en)
ES (2) ES2384113T3 (en)
HK (1) HK1155477A1 (en)
HR (2) HRP20120480T1 (en)
IN (1) IN2014CN02116A (en)
PL (2) PL2357230T3 (en)
PT (2) PT1934345E (en)
RS (2) RS52353B (en)
SI (2) SI1934345T1 (en)
WO (1) WO2007036366A2 (en)

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US20230193296A1 (en) 2023-06-22
DE102005046490A1 (en) 2007-03-29
SI1934345T1 (en) 2012-07-31
PL2357230T3 (en) 2014-08-29
WO2007036366A2 (en) 2007-04-05
JP2012235786A (en) 2012-12-06
EP1934345B9 (en) 2012-07-18
ATE550427T1 (en) 2012-04-15
AU2006296702B2 (en) 2011-12-08
SI2357230T1 (en) 2014-07-31
WO2007036366A8 (en) 2012-05-31
CA3023101A1 (en) 2007-04-05
US20100129877A1 (en) 2010-05-27
AU2006296702A1 (en) 2007-04-05
US10106800B2 (en) 2018-10-23
US9476055B2 (en) 2016-10-25
HK1155477A1 (en) 2012-05-18
HRP20120480T1 (en) 2012-07-31
ES2384113T9 (en) 2012-10-16
EP1934345B1 (en) 2012-03-21
RS53351B (en) 2014-10-31
PT1934345E (en) 2012-06-21
CY1115246T1 (en) 2017-01-04
EP2357230B1 (en) 2014-05-07
CY1113526T1 (en) 2016-06-22
WO2007036366A3 (en) 2007-06-21
PL1934345T3 (en) 2012-09-28
ES2467678T3 (en) 2014-06-12
CA2621444C (en) 2019-11-12
CA3023101C (en) 2022-09-06
EP1934345A2 (en) 2008-06-25
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JP2016027811A (en) 2016-02-25

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