CY1114767T1 - Ν,ν-υποκατεστημενες ενωσεις 3-αμινοπυρρολιδινης χρησιμες ως αναστολεις επαναπροσληψης μονοαμινων - Google Patents

Ν,ν-υποκατεστημενες ενωσεις 3-αμινοπυρρολιδινης χρησιμες ως αναστολεις επαναπροσληψης μονοαμινων

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Publication number
CY1114767T1
CY1114767T1 CY20141100049T CY141100049T CY1114767T1 CY 1114767 T1 CY1114767 T1 CY 1114767T1 CY 20141100049 T CY20141100049 T CY 20141100049T CY 141100049 T CY141100049 T CY 141100049T CY 1114767 T1 CY1114767 T1 CY 1114767T1
Authority
CY
Cyprus
Prior art keywords
monoamines
substituted
compounds useful
salt
halogen atoms
Prior art date
Application number
CY20141100049T
Other languages
Greek (el)
English (en)
Inventor
Muneaki Kurimura
Shinichi Taira
Takahiro Tomoyasu
Nobuaki Ito
Kuninori Tai
Noriaki Takemura
Takayuki Matsuzaki
Yasuhiro Menjo
Shin Miyamura
Yohji Sakurai
Akihito Watanabe
Yasuyo Sakata
Takumi Masumoto
Kohei Akazawa
Haruhiko Sugino
Naoki Amada
Satoshi Ohashi
Tomoichi Shinohara
Hirofumi Sasaki
Chisako Morita
Junko Yamashita
Satoko Nakajima
Original Assignee
Otsuka Pharmaceutical Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36693623&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1114767(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharmaceutical Co., Ltd filed Critical Otsuka Pharmaceutical Co., Ltd
Publication of CY1114767T1 publication Critical patent/CY1114767T1/el

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CY20141100049T 2005-05-13 2014-01-20 Ν,ν-υποκατεστημενες ενωσεις 3-αμινοπυρρολιδινης χρησιμες ως αναστολεις επαναπροσληψης μονοαμινων CY1114767T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005141230 2005-05-13
EP11185205.9A EP2407451B1 (en) 2005-05-13 2006-05-12 N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors

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Publication Number Publication Date
CY1114767T1 true CY1114767T1 (el) 2016-12-14

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US (6) US8084442B2 (OSRAM)
EP (2) EP1881975B8 (OSRAM)
JP (1) JP4776631B2 (OSRAM)
KR (2) KR100971850B1 (OSRAM)
CN (3) CN103613587A (OSRAM)
AR (1) AR054191A1 (OSRAM)
AU (2) AU2006244851B2 (OSRAM)
BR (1) BRPI0610279A2 (OSRAM)
CA (1) CA2608184C (OSRAM)
CY (1) CY1114767T1 (OSRAM)
DK (1) DK2407451T3 (OSRAM)
ES (2) ES2446375T3 (OSRAM)
IL (1) IL187311A (OSRAM)
IN (1) IN2012DN00758A (OSRAM)
MX (1) MX2007014252A (OSRAM)
MY (1) MY148653A (OSRAM)
PL (1) PL2407451T3 (OSRAM)
PT (1) PT2407451E (OSRAM)
RU (1) RU2414454C2 (OSRAM)
SG (1) SG162722A1 (OSRAM)
SI (1) SI2407451T1 (OSRAM)
TW (3) TWI449692B (OSRAM)
WO (1) WO2006121218A1 (OSRAM)
ZA (1) ZA200709691B (OSRAM)

Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
AU2003293129B2 (en) 2002-11-27 2009-03-12 Incyte Holdings Corporation 3-aminopyrrolidine derivatives as modulators of chemokine receptors
TWI449692B (zh) * 2005-05-13 2014-08-21 Otsuka Pharma Co Ltd 吡咯烷化合物(三)
CN101316818B (zh) * 2005-11-30 2011-08-31 弗·哈夫曼-拉罗切有限公司 3-氨基-1-芳基丙基吲哚类和氮杂取代的吲哚类
JP2009518313A (ja) * 2005-11-30 2009-05-07 スミスクライン・ビーチャム・コーポレイション ピロリジンアニリン
JP5219465B2 (ja) * 2006-11-10 2013-06-26 大塚製薬株式会社 医薬
JP2011515355A (ja) * 2008-03-20 2011-05-19 エフ.ホフマン−ラ ロシュ アーゲー ピロリジニル誘導体およびその使用
EP2496234A1 (en) 2009-11-07 2012-09-12 Merck Patent GmbH Heteroarylaminoquinolines as tgf-beta receptor kinase inhibitors
JP5945532B2 (ja) * 2010-04-21 2016-07-05 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
CN102766079B (zh) * 2011-05-06 2015-04-08 上海医药工业研究院 一类吡咯烷衍生物、其制备方法及应用
EP3052190A4 (en) 2013-10-01 2017-07-19 New York University Amino, amido, and heterocyclic compounds as modulators of rage activity and uses thereof
KR20160148871A (ko) 2015-06-17 2016-12-27 양순구 일방향 클러치 제동장치
WO2017070796A1 (en) * 2015-10-30 2017-05-04 Trillium Therapeutics Inc. Heterocycle derivatives and their use for the treatment of cns disorders
EP3846793B1 (en) 2018-09-07 2024-01-24 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
RU2698400C1 (ru) * 2018-12-17 2019-08-26 Георгий Сергеевич Немов Способ лечения депрессии у собак и кошек
CN113024518A (zh) * 2019-12-09 2021-06-25 武汉九州钰民医药科技有限公司 一种厄达替尼的制备方法
CN113024517A (zh) * 2019-12-09 2021-06-25 武汉九州钰民医药科技有限公司 一种制备厄达替尼的方法
WO2021178488A1 (en) 2020-03-03 2021-09-10 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
CN118103368A (zh) 2021-08-25 2024-05-28 皮克医疗公司 Eif4e抑制剂及其用途
US12157732B2 (en) 2021-08-25 2024-12-03 PIC Therapeutics, Inc. eIF4E inhibitors and uses thereof
WO2024168426A1 (en) * 2023-02-13 2024-08-22 Apogee Pharmaceuticals, Inc. Small molecules as monoacylglycerol lipase (magl) inhibitors, compositions and use thereof
WO2025030117A1 (en) * 2023-08-02 2025-02-06 Arpeggio Biosciences, Inc. Ferroptosis inducers

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1164828A (en) 1965-10-23 1969-09-24 Robins Co Inc A H 3-(2-Substituted Ethyl)Indoles and their Manufacture and Use
GB1173373A (en) 1966-03-22 1969-12-10 Robins Co Inc A H Substituted 3-Aminopyrrolidines
US3509171A (en) 1967-09-14 1970-04-28 Robins Co Inc A H 3-amino-1-carbamyl and thiocarbamyl pyrrolidines
US3433802A (en) 1968-06-25 1969-03-18 Robins Co Inc A H 3-(n-lower-alkylanilino)pyrrolidines
US3577440A (en) 1968-12-23 1971-05-04 Robins Co Inc A H 1-substituted-3-amido-pyrrolidines
GB1523631A (en) 1975-07-08 1978-09-06 Leo Pharm Prod Ltd Sulphonamide derivatives
US4254135A (en) 1979-10-16 1981-03-03 A. H. Robins Company, Inc. 3-Amino-4-hydroxypyrrolidines
GB2295387A (en) 1994-11-23 1996-05-29 Glaxo Inc Quinazoline antagonists of alpha 1c adrenergic receptors
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
EP1138672A1 (en) 1998-01-12 2001-10-04 Basilea Pharmaceutica AG Process for the preparation of 3-amino-pyrrolidine derivatives
JP4422331B2 (ja) * 1998-02-26 2010-02-24 ナームローゼ・フエンノートチヤツプ・オルガノン アゼチジン誘導体およびピロリジン誘導体
US7271176B2 (en) * 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
CN100374416C (zh) * 2000-04-28 2008-03-12 霍夫曼-拉罗奇有限公司 对(磺酰基)芳基和杂芳基类化合物
EP1395567B1 (en) 2001-05-18 2009-01-14 AstraZeneca AB 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders
EP1638934B1 (en) * 2003-06-11 2008-01-09 Eli Lilly And Company 3-aminopyrrolidines as inhibitors of monoamine uptake
GB0314054D0 (en) 2003-06-17 2003-07-23 Pfizer Ltd Amide derivatives as selective serotonin re-uptake inhibitors
PL1638933T3 (pl) * 2003-06-17 2008-10-31 Pfizer Pochodne n-pirolidyn-3-yloamidu jako inhibitory wychwytu zwrotnego serotoniny i noradrenaliny
US7432280B2 (en) 2003-06-20 2008-10-07 Eli Lilly And Company 3-aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake
CA2545644C (en) 2003-11-12 2011-11-01 Lg Life Sciences Ltd. Melanocortin receptor agonists
KR20060121178A (ko) * 2003-12-12 2006-11-28 일라이 릴리 앤드 캄파니 일과성 전신 열감, 충동 조절 장애 및 일반적인 의학상태로 인한 인격 변화 치료용 선택적 노르에피네프린재흡수 억제제
US20070078135A1 (en) 2005-04-18 2007-04-05 Neurogen Corporation Substituted heteroaryl CB1 antagonists
TWI449692B (zh) * 2005-05-13 2014-08-21 Otsuka Pharma Co Ltd 吡咯烷化合物(三)
WO2008000811A1 (en) * 2006-06-30 2008-01-03 Arcelik Anonim Sirketi A cooling device

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