JP4776631B2 - ピロリジン化合物 - Google Patents

ピロリジン化合物 Download PDF

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Publication number
JP4776631B2
JP4776631B2 JP2007552427A JP2007552427A JP4776631B2 JP 4776631 B2 JP4776631 B2 JP 4776631B2 JP 2007552427 A JP2007552427 A JP 2007552427A JP 2007552427 A JP2007552427 A JP 2007552427A JP 4776631 B2 JP4776631 B2 JP 4776631B2
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JP
Japan
Prior art keywords
group
alkyl group
substituted
pyrrolidin
phenyl
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Expired - Fee Related
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JP2007552427A
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English (en)
Japanese (ja)
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JP2008540329A (ja
Inventor
宗明 栗村
伸一 平良
崇浩 友安
展明 伊藤
国憲 田井
憲昭 武村
敬之 松▲崎▼
康宏 校條
伸 宮村
庸二 櫻井
昭仁 渡部
靖代 坂田
琢巳 桝本
康平 赤澤
春日子 杉野
直樹 天田
聡 大橋
友一 篠原
博文 佐々木
知佐子 森田
純子 山下
聡子 中島
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Otsuka Pharmaceutical Co Ltd
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Otsuka Pharmaceutical Co Ltd
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Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP2007552427A priority Critical patent/JP4776631B2/ja
Publication of JP2008540329A publication Critical patent/JP2008540329A/ja
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Diabetes (AREA)
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  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Emergency Medicine (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2007552427A 2005-05-13 2006-05-12 ピロリジン化合物 Expired - Fee Related JP4776631B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2007552427A JP4776631B2 (ja) 2005-05-13 2006-05-12 ピロリジン化合物

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2005141230 2005-05-13
JP2005141230 2005-05-13
PCT/JP2006/309988 WO2006121218A1 (en) 2005-05-13 2006-05-12 N,n-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors
JP2007552427A JP4776631B2 (ja) 2005-05-13 2006-05-12 ピロリジン化合物

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JP2008540329A JP2008540329A (ja) 2008-11-20
JP4776631B2 true JP4776631B2 (ja) 2011-09-21

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JP2007552427A Expired - Fee Related JP4776631B2 (ja) 2005-05-13 2006-05-12 ピロリジン化合物

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US (6) US8084442B2 (OSRAM)
EP (2) EP1881975B8 (OSRAM)
JP (1) JP4776631B2 (OSRAM)
KR (2) KR100971850B1 (OSRAM)
CN (3) CN103613587A (OSRAM)
AR (1) AR054191A1 (OSRAM)
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BR (1) BRPI0610279A2 (OSRAM)
CA (1) CA2608184C (OSRAM)
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Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003293129B2 (en) 2002-11-27 2009-03-12 Incyte Holdings Corporation 3-aminopyrrolidine derivatives as modulators of chemokine receptors
TWI449692B (zh) * 2005-05-13 2014-08-21 Otsuka Pharma Co Ltd 吡咯烷化合物（三）
CN101316818B (zh) * 2005-11-30 2011-08-31 弗·哈夫曼-拉罗切有限公司 3-氨基-1-芳基丙基吲哚类和氮杂取代的吲哚类
JP2009518313A (ja) * 2005-11-30 2009-05-07 スミスクライン・ビーチャム・コーポレイション ピロリジンアニリン
JP5219465B2 (ja) * 2006-11-10 2013-06-26 大塚製薬株式会社 医薬
JP2011515355A (ja) * 2008-03-20 2011-05-19 エフ．ホフマン−ラ ロシュ アーゲー ピロリジニル誘導体およびその使用
EP2496234A1 (en) 2009-11-07 2012-09-12 Merck Patent GmbH Heteroarylaminoquinolines as tgf-beta receptor kinase inhibitors
JP5945532B2 (ja) * 2010-04-21 2016-07-05 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
CN102766079B (zh) * 2011-05-06 2015-04-08 上海医药工业研究院 一类吡咯烷衍生物、其制备方法及应用
EP3052190A4 (en) 2013-10-01 2017-07-19 New York University Amino, amido, and heterocyclic compounds as modulators of rage activity and uses thereof
KR20160148871A (ko) 2015-06-17 2016-12-27 양순구 일방향 클러치 제동장치
WO2017070796A1 (en) * 2015-10-30 2017-05-04 Trillium Therapeutics Inc. Heterocycle derivatives and their use for the treatment of cns disorders
EP3846793B1 (en) 2018-09-07 2024-01-24 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
RU2698400C1 (ru) * 2018-12-17 2019-08-26 Георгий Сергеевич Немов Способ лечения депрессии у собак и кошек
CN113024518A (zh) * 2019-12-09 2021-06-25 武汉九州钰民医药科技有限公司 一种厄达替尼的制备方法
CN113024517A (zh) * 2019-12-09 2021-06-25 武汉九州钰民医药科技有限公司 一种制备厄达替尼的方法
WO2021178488A1 (en) 2020-03-03 2021-09-10 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
CN118103368A (zh) 2021-08-25 2024-05-28 皮克医疗公司 Eif4e抑制剂及其用途
US12157732B2 (en) 2021-08-25 2024-12-03 PIC Therapeutics, Inc. eIF4E inhibitors and uses thereof
WO2024168426A1 (en) * 2023-02-13 2024-08-22 Apogee Pharmaceuticals, Inc. Small molecules as monoacylglycerol lipase (magl) inhibitors, compositions and use thereof
WO2025030117A1 (en) * 2023-08-02 2025-02-06 Arpeggio Biosciences, Inc. Ferroptosis inducers

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003531886A (ja) * 2000-04-28 2003-10-28 エフ．ホフマン−ラ ロシュ アーゲー ｐ−（スルホニル）アリール及びヘテロアリール
WO2005000811A1 (en) * 2003-06-11 2005-01-06 Eli Lilly And Company 3-aminopyrrolidines as inhibitors of monoamine uptake
US20050070549A1 (en) * 1998-09-04 2005-03-31 Luly Jay R. Chemokine receptor antagonists and methods of use thereof
JP2007513945A (ja) * 2003-12-12 2007-05-31 イーライ リリー アンド カンパニー 体熱感、衝動調節障害および一般的な病状による人格変化の治療

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1164828A (en) 1965-10-23 1969-09-24 Robins Co Inc A H 3-(2-Substituted Ethyl)Indoles and their Manufacture and Use
GB1173373A (en) 1966-03-22 1969-12-10 Robins Co Inc A H Substituted 3-Aminopyrrolidines
US3509171A (en) 1967-09-14 1970-04-28 Robins Co Inc A H 3-amino-1-carbamyl and thiocarbamyl pyrrolidines
US3433802A (en) 1968-06-25 1969-03-18 Robins Co Inc A H 3-(n-lower-alkylanilino)pyrrolidines
US3577440A (en) 1968-12-23 1971-05-04 Robins Co Inc A H 1-substituted-3-amido-pyrrolidines
GB1523631A (en) 1975-07-08 1978-09-06 Leo Pharm Prod Ltd Sulphonamide derivatives
US4254135A (en) 1979-10-16 1981-03-03 A. H. Robins Company, Inc. 3-Amino-4-hydroxypyrrolidines
GB2295387A (en) 1994-11-23 1996-05-29 Glaxo Inc Quinazoline antagonists of alpha 1c adrenergic receptors
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
EP1138672A1 (en) 1998-01-12 2001-10-04 Basilea Pharmaceutica AG Process for the preparation of 3-amino-pyrrolidine derivatives
JP4422331B2 (ja) * 1998-02-26 2010-02-24 ナームローゼ・フエンノートチヤツプ・オルガノン アゼチジン誘導体およびピロリジン誘導体
EP1395567B1 (en) 2001-05-18 2009-01-14 AstraZeneca AB 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders
GB0314054D0 (en) 2003-06-17 2003-07-23 Pfizer Ltd Amide derivatives as selective serotonin re-uptake inhibitors
PL1638933T3 (pl) * 2003-06-17 2008-10-31 Pfizer Pochodne n-pirolidyn-3-yloamidu jako inhibitory wychwytu zwrotnego serotoniny i noradrenaliny
US7432280B2 (en) 2003-06-20 2008-10-07 Eli Lilly And Company 3-aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake
CA2545644C (en) 2003-11-12 2011-11-01 Lg Life Sciences Ltd. Melanocortin receptor agonists
US20070078135A1 (en) 2005-04-18 2007-04-05 Neurogen Corporation Substituted heteroaryl CB1 antagonists
TWI449692B (zh) * 2005-05-13 2014-08-21 Otsuka Pharma Co Ltd 吡咯烷化合物（三）
WO2008000811A1 (en) * 2006-06-30 2008-01-03 Arcelik Anonim Sirketi A cooling device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050070549A1 (en) * 1998-09-04 2005-03-31 Luly Jay R. Chemokine receptor antagonists and methods of use thereof
JP2003531886A (ja) * 2000-04-28 2003-10-28 エフ．ホフマン−ラ ロシュ アーゲー ｐ−（スルホニル）アリール及びヘテロアリール
WO2005000811A1 (en) * 2003-06-11 2005-01-06 Eli Lilly And Company 3-aminopyrrolidines as inhibitors of monoamine uptake
JP2007513945A (ja) * 2003-12-12 2007-05-31 イーライ リリー アンド カンパニー 体熱感、衝動調節障害および一般的な病状による人格変化の治療

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