CY1114685T1 - Παρατεταμενη απελευθερωση αντιμολυσματικων αμινογλυκοζιτων - Google Patents

Παρατεταμενη απελευθερωση αντιμολυσματικων αμινογλυκοζιτων

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Publication number
CY1114685T1
CY1114685T1 CY20131101075T CY131101075T CY1114685T1 CY 1114685 T1 CY1114685 T1 CY 1114685T1 CY 20131101075 T CY20131101075 T CY 20131101075T CY 131101075 T CY131101075 T CY 131101075T CY 1114685 T1 CY1114685 T1 CY 1114685T1
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CY
Cyprus
Prior art keywords
lipid
patient
less
present
treating
Prior art date
Application number
CY20131101075T
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English (en)
Inventor
Lawrence T Boni
Brian S Miller
Vladimir Malinin
Xingong Li
Original Assignee
Insmed Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37669512&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1114685(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Insmed Incorporated filed Critical Insmed Incorporated
Publication of CY1114685T1 publication Critical patent/CY1114685T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Virology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Εδώ παρέχονται λιπιδικά αντιμολυσματικά σκευάσματα ουσιαστικά ελεύθερα από ανιοντικά λιπίδια με ένα λόγο λιπιδίου προς αντιμολυσματικό να είναι περίπου 1:1 έως περίπου 4:1, και μια μέση κατά μέσο όρο διάμετρο μικρότερη από περίπου 1 μm. Επίσης παρέχεται μια μέθοδος παρασκευής ενός λιπιδικού αντι-μολυσματικού σκευάσματος περιλαμβάνουσα μια διεργασία έγχυσης. Επίσης παρέχονται λιπιδικά αντιμολυ-σματικά σκευάσματα όπου ο λόγος λιπιδίου προς φάρμακο είναι περίπου 1:1 ή λιγότερο, περίπου 0,75:1 ή λιγότερο, ή περίπου 0,50:1 ή λιγότερο παρασκευαζόμενα με μια διεργασία σύντηξης εν σειρά. Η παρούσα εφεύρεση αναφέρεται επίσης σε μια μέθοδο θεραπείας ενός ασθενή με μια πνευμονική λοίμωξη η οποία μέθοδος περιλαμβάνει τη χορήγηση στον ασθενή μιας θεραπευτικώς αποτελεσματικής ποσότητας από ένα λιπιδικό αντιμολυσματικό σκεύασμα της παρούσας εφεύρεσης. Η παρούσα εφεύρεση αναφέρεται επίσης σε μια μέθοδο θεραπείας ενός ασθενή για κυστική ίνωση η οποία μέθοδος περιλαμβάνει τη χορήγηση στον ασθενή μιας θεραπευτικώς αποτελεσματικής ποσότητας από ένα λιπιδικό αντιμολυσματικό σκεύασμα της παρούσας εφεύρεσης.
CY20131101075T 2005-07-19 2013-11-29 Παρατεταμενη απελευθερωση αντιμολυσματικων αμινογλυκοζιτων CY1114685T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/185,448 US7718189B2 (en) 2002-10-29 2005-07-19 Sustained release of antiinfectives
EP06787716.7A EP1909759B2 (en) 2005-07-19 2006-07-19 Sustained release of antiinfective aminoglycosides

Publications (1)

Publication Number Publication Date
CY1114685T1 true CY1114685T1 (el) 2016-10-05

Family

ID=37669512

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131101075T CY1114685T1 (el) 2005-07-19 2013-11-29 Παρατεταμενη απελευθερωση αντιμολυσματικων αμινογλυκοζιτων

Country Status (26)

Country Link
US (7) US7718189B2 (el)
EP (2) EP1909759B2 (el)
JP (6) JP5415759B2 (el)
KR (2) KR101437338B1 (el)
CN (2) CN103263387B (el)
AU (1) AU2006270008B2 (el)
BR (1) BRPI0613865A2 (el)
CA (2) CA2614764C (el)
CR (1) CR9736A (el)
CY (1) CY1114685T1 (el)
DK (1) DK1909759T3 (el)
EC (1) ECSP088175A (el)
ES (1) ES2437866T5 (el)
HK (1) HK1124770A1 (el)
HN (1) HN2008000084A (el)
IL (3) IL188406A0 (el)
ME (1) ME00597B (el)
MX (1) MX2008000425A (el)
NZ (1) NZ565300A (el)
PL (1) PL1909759T3 (el)
PT (1) PT1909759E (el)
RS (1) RS20080019A (el)
RU (1) RU2438655C2 (el)
SI (1) SI1909759T1 (el)
WO (1) WO2007011940A2 (el)
ZA (1) ZA200800367B (el)

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RU2438655C2 (ru) 2012-01-10
WO2007011940A3 (en) 2007-10-25
IL246026A0 (en) 2016-07-31
CA2838108A1 (en) 2007-01-25
CN101267806A (zh) 2008-09-17
PL1909759T3 (pl) 2014-02-28
RS20080019A (en) 2009-07-15
JP2014237729A (ja) 2014-12-18
ECSP088175A (es) 2008-05-30
US9827317B2 (en) 2017-11-28
KR101437338B1 (ko) 2014-09-05
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BRPI0613865A2 (pt) 2011-02-15
CA2838108C (en) 2016-05-17
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JP5902782B2 (ja) 2016-04-13
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JP5415759B2 (ja) 2014-02-12
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JP2013256503A (ja) 2013-12-26
PT1909759E (pt) 2013-12-09
WO2007011940A2 (en) 2007-01-25
SI1909759T1 (sl) 2014-02-28
MX2008000425A (es) 2008-03-10
CN101267806B (zh) 2013-08-07
JP2019052170A (ja) 2019-04-04
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JP2009502794A (ja) 2009-01-29
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