IT1245761B - Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale. - Google Patents

Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale.

Info

Publication number
IT1245761B
IT1245761B ITBO910024A ITBO910024A IT1245761B IT 1245761 B IT1245761 B IT 1245761B IT BO910024 A ITBO910024 A IT BO910024A IT BO910024 A ITBO910024 A IT BO910024A IT 1245761 B IT1245761 B IT 1245761B
Authority
IT
Italy
Prior art keywords
pharmaceutical formulations
glycosaminoglicans
formulations containing
orally
absorbable
Prior art date
Application number
ITBO910024A
Other languages
English (en)
Inventor
Manlio Cristofori
Egidio Marchi
Leone Gabriele Rotini
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of ITBO910024A0 publication Critical patent/ITBO910024A0/it
Priority to ITBO910024A priority Critical patent/IT1245761B/it
Priority to US07/821,455 priority patent/US5252339A/en
Priority to EP92100732A priority patent/EP0497162B1/en
Priority to DE69212608T priority patent/DE69212608T2/de
Priority to ES92100732T priority patent/ES2090368T3/es
Priority to CA002059865A priority patent/CA2059865C/en
Priority to JP4013943A priority patent/JPH0755907B2/ja
Priority to KR1019920001330A priority patent/KR100210359B1/ko
Publication of ITBO910024A1 publication Critical patent/ITBO910024A1/it
Application granted granted Critical
Publication of IT1245761B publication Critical patent/IT1245761B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Abstract

Formulazioni farmaceutiche per uso orale, preferibilmente scelte fra capsule, compresse o confetti, ricoperte da una pellicola gastroresistente enterosolubile, contenenti un liofilizzato costituito da quantità terapeuticamente efficaci di un glicosaminoglicano, da una sostanza addensante e da sostanze tensioattive e processo per ottenerle.Dette formulazioni permettono l'assorbimento nel duodeno e nell'intestino dei glicosaminoglicani somministrati per via orale e la conseguente esplicazione delle loro proprietà anticoagulanti, fibrinolitiche, antitrombotiche, antiaterosclerotiche e antiipoproteinemiche.
ITBO910024A 1991-01-30 1991-01-30 Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale. IT1245761B (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ITBO910024A IT1245761B (it) 1991-01-30 1991-01-30 Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale.
US07/821,455 US5252339A (en) 1991-01-30 1992-01-15 Pharmaceutical compositions containing orally absorbable glycosamimoglycans
ES92100732T ES2090368T3 (es) 1991-01-30 1992-01-17 Composiciones farmaceuticas que contienen glucosaminoglicanos absorbibles por via oral.
DE69212608T DE69212608T2 (de) 1991-01-30 1992-01-17 Arzneimittel enthaltend oral absorbierbare Glycosaminoglycane
EP92100732A EP0497162B1 (en) 1991-01-30 1992-01-17 Pharmaceutical compositions containing orally absorbable glycosaminoglycans
CA002059865A CA2059865C (en) 1991-01-30 1992-01-22 Pharmaceutical compositions containing orally absorbable glycosaminoglycans
JP4013943A JPH0755907B2 (ja) 1991-01-30 1992-01-29 経口吸収可能なグリコサミノグリカンを含有する製剤
KR1019920001330A KR100210359B1 (ko) 1991-01-30 1992-01-30 경구용 글리코스아미노글리칸을 함유하는 의약 조성물

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITBO910024A IT1245761B (it) 1991-01-30 1991-01-30 Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale.

Publications (3)

Publication Number Publication Date
ITBO910024A0 ITBO910024A0 (it) 1991-01-30
ITBO910024A1 ITBO910024A1 (it) 1992-07-30
IT1245761B true IT1245761B (it) 1994-10-14

Family

ID=11337212

Family Applications (1)

Application Number Title Priority Date Filing Date
ITBO910024A IT1245761B (it) 1991-01-30 1991-01-30 Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale.

Country Status (8)

Country Link
US (1) US5252339A (it)
EP (1) EP0497162B1 (it)
JP (1) JPH0755907B2 (it)
KR (1) KR100210359B1 (it)
CA (1) CA2059865C (it)
DE (1) DE69212608T2 (it)
ES (1) ES2090368T3 (it)
IT (1) IT1245761B (it)

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Also Published As

Publication number Publication date
JPH0543471A (ja) 1993-02-23
ES2090368T3 (es) 1996-10-16
DE69212608D1 (de) 1996-09-12
JPH0755907B2 (ja) 1995-06-14
US5252339A (en) 1993-10-12
EP0497162A1 (en) 1992-08-05
ITBO910024A1 (it) 1992-07-30
ITBO910024A0 (it) 1991-01-30
CA2059865A1 (en) 1992-07-31
KR920014467A (ko) 1992-08-25
DE69212608T2 (de) 1996-11-28
CA2059865C (en) 1999-01-26
EP0497162B1 (en) 1996-08-07
KR100210359B1 (ko) 1999-07-15

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