ITBO910024A1 - Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale. - Google Patents

Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale.

Info

Publication number
ITBO910024A1
ITBO910024A1 IT000024A ITBO910024A ITBO910024A1 IT BO910024 A1 ITBO910024 A1 IT BO910024A1 IT 000024 A IT000024 A IT 000024A IT BO910024 A ITBO910024 A IT BO910024A IT BO910024 A1 ITBO910024 A1 IT BO910024A1
Authority
IT
Italy
Prior art keywords
glycosaminoglicans
pharmaceutical formulations
formulations containing
absorbable
orally
Prior art date
Application number
IT000024A
Other languages
English (en)
Inventor
Manlio Cristofori
Egidio Marchi
Leone Gabriele Rotini
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of ITBO910024A0 publication Critical patent/ITBO910024A0/it
Priority to ITBO910024A priority Critical patent/IT1245761B/it
Priority to US07/821,455 priority patent/US5252339A/en
Priority to ES92100732T priority patent/ES2090368T3/es
Priority to DE69212608T priority patent/DE69212608T2/de
Priority to EP92100732A priority patent/EP0497162B1/en
Priority to CA002059865A priority patent/CA2059865C/en
Priority to JP4013943A priority patent/JPH0755907B2/ja
Priority to KR1019920001330A priority patent/KR100210359B1/ko
Publication of ITBO910024A1 publication Critical patent/ITBO910024A1/it
Application granted granted Critical
Publication of IT1245761B publication Critical patent/IT1245761B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
ITBO910024A 1991-01-30 1991-01-30 Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale. IT1245761B (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ITBO910024A IT1245761B (it) 1991-01-30 1991-01-30 Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale.
US07/821,455 US5252339A (en) 1991-01-30 1992-01-15 Pharmaceutical compositions containing orally absorbable glycosamimoglycans
EP92100732A EP0497162B1 (en) 1991-01-30 1992-01-17 Pharmaceutical compositions containing orally absorbable glycosaminoglycans
DE69212608T DE69212608T2 (de) 1991-01-30 1992-01-17 Arzneimittel enthaltend oral absorbierbare Glycosaminoglycane
ES92100732T ES2090368T3 (es) 1991-01-30 1992-01-17 Composiciones farmaceuticas que contienen glucosaminoglicanos absorbibles por via oral.
CA002059865A CA2059865C (en) 1991-01-30 1992-01-22 Pharmaceutical compositions containing orally absorbable glycosaminoglycans
JP4013943A JPH0755907B2 (ja) 1991-01-30 1992-01-29 経口吸収可能なグリコサミノグリカンを含有する製剤
KR1019920001330A KR100210359B1 (ko) 1991-01-30 1992-01-30 경구용 글리코스아미노글리칸을 함유하는 의약 조성물

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITBO910024A IT1245761B (it) 1991-01-30 1991-01-30 Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale.

Publications (3)

Publication Number Publication Date
ITBO910024A0 ITBO910024A0 (it) 1991-01-30
ITBO910024A1 true ITBO910024A1 (it) 1992-07-30
IT1245761B IT1245761B (it) 1994-10-14

Family

ID=11337212

Family Applications (1)

Application Number Title Priority Date Filing Date
ITBO910024A IT1245761B (it) 1991-01-30 1991-01-30 Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale.

Country Status (8)

Country Link
US (1) US5252339A (it)
EP (1) EP0497162B1 (it)
JP (1) JPH0755907B2 (it)
KR (1) KR100210359B1 (it)
CA (1) CA2059865C (it)
DE (1) DE69212608T2 (it)
ES (1) ES2090368T3 (it)
IT (1) IT1245761B (it)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1256236B (it) * 1992-12-23 1995-11-29 Mediolanum Farmaceutici Srl Oligosaccaridi aventi attivita' biologica e procedimento per la loro preparazione di glicosaminoglicani
IT1270846B (it) * 1993-05-10 1997-05-13 Alfa Wassermann Spa Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica.
US5801162A (en) * 1993-09-30 1998-09-01 Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) Dermatan sulfate compositions and antithrombotic compositions containing same
US5888984A (en) * 1994-05-12 1999-03-30 Dermal Research Laboratories, Inc. Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
DE19501266A1 (de) * 1995-01-18 1996-07-25 Madaus Ag Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln
US6262255B1 (en) 1995-04-05 2001-07-17 Biomm, Inc. Non-immunogenic, biocompatible macromolecular membrane compositions, and methods for making them
GB2305604B (en) * 1995-09-29 1999-06-23 Quest Vitamins Ltd Carrier base material
US6217863B1 (en) 1995-10-30 2001-04-17 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase I
IT1285546B1 (it) * 1996-01-16 1998-06-18 Alfa Wassermann Spa Uso del dermatano solfato a basso peso molecolare e delle specialita' medicinali che lo contengono nella terapia e nella prevenzione della
US6607751B1 (en) * 1997-10-10 2003-08-19 Intellipharamaceutics Corp. Controlled release delivery device for pharmaceutical agents incorporating microbial polysaccharide gum
US6476005B1 (en) 1998-03-24 2002-11-05 George D. Petito Oral and injectable nutritional composition
US7691829B2 (en) * 1998-03-24 2010-04-06 Petito George D Composition and method for healing tissues
US20050208114A1 (en) * 1998-03-24 2005-09-22 Petito George D Composition and method for healing tissues
US6645948B2 (en) 1998-03-24 2003-11-11 George D. Petito Nutritional composition for the treatment of connective tissue
WO2000012726A2 (en) * 1998-08-27 2000-03-09 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase i and ii
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
IL127826A0 (en) * 1998-12-29 1999-10-28 Laster Gail Restenosis drug therapy
IL127896A0 (en) * 1998-12-31 1999-10-28 Gail Laster A novel treatment for preeclampsia and related diseases
WO2000044367A2 (en) 1999-02-01 2000-08-03 Dermal Research Laboratories, Inc. A pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
US8119159B2 (en) 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
ES2301477T3 (es) * 1999-02-22 2008-07-01 Merrion Research I Limited Forma de dosificacion oral solida que contiene un potenciador.
US7412332B1 (en) * 1999-04-23 2008-08-12 Massachusetts Institute Of Technology Method for analyzing polysaccharides
WO2001002443A1 (en) * 1999-06-30 2001-01-11 Hamilton Civic Hospitals Research Development, Inc Heparin compositions that inhibit clot associated coagulation factors
US6458383B2 (en) * 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
AU2001243512C1 (en) * 2000-03-08 2008-04-17 Massachusetts Institute Of Technology Heparinase III and uses thereof
US7259152B2 (en) * 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
US7879824B2 (en) 2001-07-31 2011-02-01 Dermal Research Laboratories, Inc. Methods of preventing or treating diseases and conditions using complex carbohydrates
IL154771A0 (en) * 2000-09-08 2003-10-31 Hamilton Civic Hospitals Res Antithrombotic compositions
AU2001292618A1 (en) 2000-09-12 2002-03-26 Massachusetts Institute Of Technology Methods and products related to low molecular weight heparin
WO2002032406A2 (en) 2000-10-18 2002-04-25 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
JP2004525110A (ja) * 2001-02-16 2004-08-19 清水製薬株式会社 ムコ多糖類製剤およびその製造法
DE60211494T2 (de) * 2001-03-26 2006-10-12 Novartis Ag Pharmazeutische zusammensetzung enthaltend ein schlecht wasserlösliches staurosporin, eine oberflächenaktive substanz und ein wasserlösliches polymer
BRPI0101486B1 (pt) * 2001-04-17 2017-09-19 Cristália Produtos Químicos Farmacêuticos Ltda. Pharmaceutical composition for topic use containing heparin for the treatment of skin or mucosal injuries caused by burns
EP1385530A4 (en) * 2001-05-09 2005-11-09 Mediplex Corp FORMULATION OF AMPHIPHILENE HEPARIN DERIVATIVES FOR IMPROVING SLIME SKIN ABSORPTION
US7820722B2 (en) 2001-05-11 2010-10-26 Merrion Research Iii Limited Permeation enhancers
US20030070584A1 (en) 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
US20030013680A1 (en) * 2001-06-12 2003-01-16 Keryx Methods using glycosaminoglycans for the treatment of nephropathy
US20030228368A1 (en) * 2001-09-28 2003-12-11 David Wynn Edible solid composition and dosage form
US8309118B2 (en) 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
US7429619B2 (en) 2002-08-02 2008-09-30 Mcneil Consumer Healthcare Polyacrylic film forming compositions
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
WO2004112756A1 (en) 2003-06-26 2004-12-29 Isa Odidi Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
US20060004098A1 (en) * 2003-07-28 2006-01-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compounds useful for treating neurological disorders
US20050181047A1 (en) * 2004-02-18 2005-08-18 Jaime Romero Compositions and methods for timed release of water-soluble nutritional supplements
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
WO2006015171A2 (en) * 2004-07-28 2006-02-09 The Texas A & M University System Use of glycosoaminoglycans for the prevention and treatment of sepsis
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
JP2006298791A (ja) * 2005-04-18 2006-11-02 Kotobuki Seiyaku Kk グリコサミノグリカン又はその塩を含む経口投与用医薬品、健康食品又は栄養薬品組成物。
US8298602B2 (en) * 2005-10-11 2012-10-30 Purecircle Sdn Bhd Process for manufacturing a sweetener and use thereof
CA2896083A1 (en) 2005-12-08 2007-06-14 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
US9561188B2 (en) 2006-04-03 2017-02-07 Intellipharmaceutics Corporation Controlled release delivery device comprising an organosol coat
JP5600432B2 (ja) * 2006-04-06 2014-10-01 インスメッド， インコーポレイテッド コアセルベート化誘導リポソーム被包法及びその調合物
MX2008012678A (es) 2006-04-07 2008-12-17 Merrion Res Iii Ltd Forma de dosis oral solida que contiene un mejorador.
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
WO2008137717A1 (en) 2007-05-04 2008-11-13 Transave, Inc. Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
WO2009137080A1 (en) 2008-05-07 2009-11-12 Merrion Research Iii Limited Compositions of gnrh related compounds and processes of preparation
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
EP2525783A1 (en) * 2010-01-18 2012-11-28 Cephalon France Improved oral lysophilisates containing pvp/va
WO2011120033A1 (en) 2010-03-26 2011-09-29 Merrion Research Iii Limited Pharmaceutical compositions of selective factor xa inhibitors for oral administration
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
EP2661273A4 (en) 2011-01-07 2014-06-04 Merrion Res Iii Ltd IRON PHARMACEUTICAL COMPOSITIONS FOR ORAL ADMINISTRATION
US9357765B2 (en) 2012-04-03 2016-06-07 Smiths Medical Asd, Inc. Heparain-bulking agent compositions and methods thereof
JP6402097B2 (ja) 2012-05-21 2018-10-10 インスメッド インコーポレイテッド 肺感染症を処置するためのシステム
RU2018135921A (ru) 2012-11-29 2019-02-05 Инсмед Инкорпорейтед Стабилизированные составы ванкомицина
BR112016026699B1 (pt) 2014-05-15 2022-09-13 Insmed Incorporated Uso de uma composição farmaceutica de amicacina ou de um sal farmaceuticamente aceitável desta
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
EP3250191B1 (en) 2015-01-29 2024-01-17 Novo Nordisk A/S Tablets comprising glp-1 agonist and enteric coating
JP2020503269A (ja) 2016-11-28 2020-01-30 リポカイン インコーポレーテッド 経口ウンデカン酸テストステロン療法
JP7460534B2 (ja) 2018-03-30 2024-04-02 インスメッド インコーポレイテッド リポソーム医薬品の連続製造方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3548052A (en) * 1964-10-27 1970-12-15 Canada Packers Ltd Heparin compositions and methods of using same
US3482014A (en) * 1966-06-29 1969-12-02 Canada Packers Ltd Orally active heparin and method for making and using same
US3506642A (en) * 1967-07-03 1970-04-14 Canada Packers Ltd Stable orally active heparinoid complexes
US3574832A (en) * 1968-05-29 1971-04-13 American Cyanamid Co Therapeutic heparin-surfactant compositions
US3577534A (en) * 1968-06-20 1971-05-04 Canada Packers Ltd Stable orally active heparinoid complexes
IT1062779B (it) * 1974-04-04 1985-01-14 Crinos Industria Farmaco Composizione farmaceutica contenente un fattore eparinoidico
IT1069492B (it) * 1976-10-13 1985-03-25 Alfa Farmaceutici Spa Composizione farmaceutica sommini stratrice per via orale contenente un fattore eparinoide sospeso in un veicolo oleoso costituito da triace tato di glicerina
GB1591306A (en) * 1976-10-23 1981-06-17 Choay Sa Liposomes containing heparin and a process for obtaining them
FR2492259A1 (fr) * 1980-10-21 1982-04-23 Idinvex Sa Formulation d'heparine
US4654327A (en) * 1982-04-21 1987-03-31 Research Corp. Quaternary ammonium complexes of heparin
US4510135A (en) * 1982-04-21 1985-04-09 Research Corporation Orally administered heparin
US4604376A (en) * 1982-04-21 1986-08-05 Research Corporation Enteric compounds and complexes
CH656533A5 (de) * 1982-12-10 1986-07-15 Sandoz Ag Therapeutisches praeparat enthaltend hydrierte ergotalkaloide und niedermolekulares heparin.
DE3331009A1 (de) * 1983-08-27 1985-03-14 Basf Ag, 6700 Ludwigshafen Verfahren zur erhoehung der enteralen resorbierbarkeit von heparin bzw. heparinoiden sowie das so erhaeltliche heparin- bzw. heparinoidpraeparat
JPS6054313A (ja) * 1983-09-01 1985-03-28 Terumo Corp 腸管吸収性ヘパリン組成物
EP0189427B1 (en) * 1984-05-21 1989-02-08 BODOR, Nicholas S. Orally active heparin multiplets
US5102788A (en) * 1988-11-21 1992-04-07 Hygeia Sciences, Inc. Immunoassay including lyophilized reactant mixture
US5032405A (en) * 1989-09-27 1991-07-16 Warner-Lambert Company Oral pharmaceutical composition for acid sensitive proteinaceous agents

Also Published As

Publication number Publication date
IT1245761B (it) 1994-10-14
ES2090368T3 (es) 1996-10-16
CA2059865A1 (en) 1992-07-31
ITBO910024A0 (it) 1991-01-30
DE69212608D1 (de) 1996-09-12
US5252339A (en) 1993-10-12
EP0497162A1 (en) 1992-08-05
KR920014467A (ko) 1992-08-25
DE69212608T2 (de) 1996-11-28
JPH0543471A (ja) 1993-02-23
CA2059865C (en) 1999-01-26
JPH0755907B2 (ja) 1995-06-14
EP0497162B1 (en) 1996-08-07
KR100210359B1 (ko) 1999-07-15

Similar Documents

Publication Publication Date Title
ITBO910024A1 (it) Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale.
DK0585252T3 (da) Farmaceutiske formuleringer
FI921060A0 (fi) Farmaceutiska aerosolformuleringar.
FI922958A0 (fi) Farmaceutisk sammansaettning.
FI922252A0 (fi) Farmaceutisk sammansaettning.
FI922316A0 (fi) Farmaceutisk sammansaettning.
FI923581A0 (fi) Farmaceutisk kombinationsformation.
DE69101931T2 (de) Pharmazeutische Zusammensetzung.
ITBO910113A1 (it) Formulazioni farmaceutiche per uso orale gastroresistenti contenenti acidi biliari.
DE4291156T1 (de) Verbesserte pharmazeutische Zusammensetzungen
DE69115263T2 (de) Pharmazeutische zusammensetzungen.
MX9201969A (es) Formulacion de tableta optimizada.
IT1231012B (it) Composizione farmaceutica per uso orale contenente nac.
DZ1559A1 (fr) Compositions pharmaceutiques.
FR2698268B1 (fr) Composition photoprotectrice administrée par voie orale.
MX9200146A (es) Composiciones farmaceuticas deglutibles
DE69300492D1 (de) Orale Zusammensetzung.
FI923371A0 (fi) En farmaceutisk formulation.
FI921786A0 (fi) Farmaceutisk foerening.
FI921785A0 (fi) Farmaceutisk foerening.
DE69202059D1 (de) Propensäurederivate.
FI920845A0 (fi) Farmaceutiska kompositioner innehaollande interleukin-2.
MX9206975A (es) Composicion farmaceutica.
FI916035A0 (fi) Ny farmaceutisk komposition.
IT8922215A0 (it) Formulazioni farmaceutiche.

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970115