IT1270846B - Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica. - Google Patents

Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica.

Info

Publication number
IT1270846B
IT1270846B ITBO930205A ITBO930205A IT1270846B IT 1270846 B IT1270846 B IT 1270846B IT BO930205 A ITBO930205 A IT BO930205A IT BO930205 A ITBO930205 A IT BO930205A IT 1270846 B IT1270846 B IT 1270846B
Authority
IT
Italy
Prior art keywords
sulodexide
contain
treatment
diabetic nephropathy
specialties
Prior art date
Application number
ITBO930205A
Other languages
English (en)
Inventor
Egidio Marchi
Gianfranco Tamagnone
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of ITBO930205A0 publication Critical patent/ITBO930205A0/it
Priority to ITBO930205A priority Critical patent/IT1270846B/it
Priority to CA002120062A priority patent/CA2120062C/en
Priority to US08/227,502 priority patent/US5496807A/en
Priority to JP6091713A priority patent/JP2702400B2/ja
Priority to KR1019940009102A priority patent/KR0165567B1/ko
Priority to AT94107051T priority patent/ATE198278T1/de
Priority to EP94107051A priority patent/EP0624374B1/en
Priority to ES94107051T priority patent/ES2152272T3/es
Priority to DK94107051T priority patent/DK0624374T3/da
Priority to PT94107051T priority patent/PT624374E/pt
Priority to DE69426471T priority patent/DE69426471T2/de
Publication of ITBO930205A1 publication Critical patent/ITBO930205A1/it
Application granted granted Critical
Publication of IT1270846B publication Critical patent/IT1270846B/it
Priority to GR20010400047T priority patent/GR3035231T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

L'oggetto della presente invenzione è costituito dall'uso di sulodexide, glicosaminoglicano di origine naturale estratto da mucosa intestinale di mammifero, e di specialità medicinali che lo contengono nel trattamento di pazienti affetti da nefropatia di origine diabetica.L'efficacia del sulodexide è stata dimostrata dalla significativa diminuzione dell'albumina in pazienti diabetici microalbuminurici trattati con composizioni farmaceutiche somministrate per via orale contenenti quantità terapeuticamente efficaci di farmaco;/
ITBO930205A 1993-05-10 1993-05-10 Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica. IT1270846B (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
ITBO930205A IT1270846B (it) 1993-05-10 1993-05-10 Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica.
CA002120062A CA2120062C (en) 1993-05-10 1994-03-28 Use of sulodexide and of medicines containing it in the treatment of diabetic nephropathy
US08/227,502 US5496807A (en) 1993-05-10 1994-04-14 Method of treatment of diabetic nephropathy by means of sulodexide of medicines containing it
JP6091713A JP2702400B2 (ja) 1993-05-10 1994-04-28 糖尿病性腎症治療用スロデキサイド含有医薬
KR1019940009102A KR0165567B1 (ko) 1993-05-10 1994-04-28 술로덱사이드를 함유하는 당뇨성 신장병증 치료약
EP94107051A EP0624374B1 (en) 1993-05-10 1994-05-05 Use of sulodexide and of medicines containing it for the treatment of diabetic nephropathy
AT94107051T ATE198278T1 (de) 1993-05-10 1994-05-05 Verwendung von sulodexid und von arzneimitteln, die dieses enthalten, zur behandlung der diabetischen nephropathie
ES94107051T ES2152272T3 (es) 1993-05-10 1994-05-05 Uso de sulodexide y de medicamentos que lo contienen para el tratamiento de la nefropatia diabetica.
DK94107051T DK0624374T3 (da) 1993-05-10 1994-05-05 Anvendelse af sulodexid og medicin, som indeholder dette, til behandlingen af diabetisk nephropati
PT94107051T PT624374E (pt) 1993-05-10 1994-05-05 Utilizacao de sulodexida e de medicamentos que contem tal composto para o tratamento de nefropatia diabetica
DE69426471T DE69426471T2 (de) 1993-05-10 1994-05-05 Verwendung von Sulodexid und von Arzneimitteln, die dieses enthalten, zur Behandlung der diabetischen Nephropathie
GR20010400047T GR3035231T3 (en) 1993-05-10 2001-01-11 Use of sulodexide and of medicines containing it for the treatment of diabetic nephropathy.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITBO930205A IT1270846B (it) 1993-05-10 1993-05-10 Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica.

Publications (3)

Publication Number Publication Date
ITBO930205A0 ITBO930205A0 (it) 1993-05-10
ITBO930205A1 ITBO930205A1 (it) 1994-11-10
IT1270846B true IT1270846B (it) 1997-05-13

Family

ID=11339016

Family Applications (1)

Application Number Title Priority Date Filing Date
ITBO930205A IT1270846B (it) 1993-05-10 1993-05-10 Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica.

Country Status (12)

Country Link
US (1) US5496807A (it)
EP (1) EP0624374B1 (it)
JP (1) JP2702400B2 (it)
KR (1) KR0165567B1 (it)
AT (1) ATE198278T1 (it)
CA (1) CA2120062C (it)
DE (1) DE69426471T2 (it)
DK (1) DK0624374T3 (it)
ES (1) ES2152272T3 (it)
GR (1) GR3035231T3 (it)
IT (1) IT1270846B (it)
PT (1) PT624374E (it)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1274351B (it) * 1994-10-06 1997-07-17 Alfa Wassermann Spa Uso di alcuni glicosaminoglicani nella dialisi peritoneale.
IT1299969B1 (it) * 1998-04-15 2000-04-04 Alfa Wassermann Spa Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della retinopatia diabetica.
IL127896A0 (en) * 1998-12-31 1999-10-28 Gail Laster A novel treatment for preeclampsia and related diseases
US7259152B2 (en) * 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
NZ530037A (en) * 2001-06-12 2006-03-31 Keryx Biopharmaceuticals Inc Use of glycosaminoglycans for the treatment of HIV-associated nephropathy
WO2006039709A1 (en) * 2004-10-01 2006-04-13 Keryx Biopharmaceuticals, Inc. Methods using glycosaminoglycans for the treatment of kidney disease
JP4705628B2 (ja) 2005-02-03 2011-06-22 太陽化学株式会社 糖尿病および／または糖尿病性腎症の予防、改善、または治療用組成物
JP2008540448A (ja) * 2005-05-05 2008-11-20 ケリク ビオファルマセウチカルス インコーポレーテッド 糖尿病性腎症の治療において、スロデキシド及び血圧低下薬を用いた併用療法
EP1968561B8 (en) * 2005-12-22 2010-10-20 Kiacta Sàrl Treatment of diabetic nephropathy
KR20090035581A (ko) * 2006-08-04 2009-04-09 아지노모토 가부시키가이샤 신장 기능 장해 예방ㆍ치료제
WO2008070778A2 (en) * 2006-12-06 2008-06-12 Nephrogenex Inc. Pyridoxamine and low molecular weight heparinoids for diabetic kidney disease
AU2007337806A1 (en) * 2006-12-22 2008-07-03 Bellus Health (International) Limited Methods, compounds, and compositions for treating metabolic disorders and diabetes
CN101632686A (zh) * 2008-04-04 2010-01-27 马斯特里赫特大学 糖胺聚糖用于修复糖萼的用途
DK2427416T3 (en) 2009-05-04 2016-06-13 Prometic Pharma Smt Ltd Substituted aromatic compounds, and pharmaceutical uses thereof
EP2632885B1 (en) 2010-10-27 2018-01-03 Prometic Pharma Smt Limited Phenylketone carboxylate compounds and pharmaceutical uses thereof
JP7357948B2 (ja) 2018-07-13 2023-10-10 ユニヴァーシティー オブ マイアミ 腎臓障害を治療するための方法
US20200085810A1 (en) 2018-07-26 2020-03-19 Hoffmann-La Roche Inc. Compounds for use in treating kidney disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1245761B (it) * 1991-01-30 1994-10-14 Alfa Wassermann Spa Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale.
IT1245907B (it) * 1991-05-17 1994-10-25 Alfa Wassermann Spa Uso dei glicosaminoglicani nel trattamento della nefropatia diabetica e della neuropatia diabetica.

Also Published As

Publication number Publication date
PT624374E (pt) 2001-04-30
ITBO930205A0 (it) 1993-05-10
DE69426471D1 (de) 2001-02-01
EP0624374B1 (en) 2000-12-27
JPH06329541A (ja) 1994-11-29
ITBO930205A1 (it) 1994-11-10
CA2120062A1 (en) 1994-11-11
DK0624374T3 (da) 2001-01-29
CA2120062C (en) 1999-05-25
JP2702400B2 (ja) 1998-01-21
DE69426471T2 (de) 2001-05-03
EP0624374A1 (en) 1994-11-17
US5496807A (en) 1996-03-05
ES2152272T3 (es) 2001-02-01
ATE198278T1 (de) 2001-01-15
GR3035231T3 (en) 2001-04-30
KR0165567B1 (ko) 1999-01-15

Similar Documents

Publication Publication Date Title
IT1270846B (it) Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica.
BR9909672A (pt) uso de um composto medicinal ativo no preparo de um medicamento para o tratamento de hipertensão
BR0009016A (pt) Composição de apomorfina e sildenafil
HUT60630A (en) Process or producing peroral pharmaceutical compositions suitable for treating internal diseases of inflammatory nature
ATE282418T1 (de) Orale verabreichung wirksamer mengen von hyaluronsäure
FI940787A0 (fi) Annostusmuoto lääkkeen annostelemiseksi lyhyessä ajanjaksossa
ES2109899T1 (es) Metodo, composiciones y kits para aumentar la biodisponibilidad oral de agentes farmaceuticos.
BR9709838A (pt) Regime de administração que fornece um perfil de plasma no sangue de um inibidor de h+,k+-atpase composição farmacêutica oral uso da mesma e de inibidor h+,k+-atpase e processos para melhorar a inibição de secreção de ácido gástrico e o efeito terapêutico no tratamento de perturbações gastrintestinais e para receber um perfil estendido de plasma de um inibidor de h+,k+-atpase
BR9814378A (pt) Forma de dosagem de liberação prolongada farmacêutica revestida entérica de um inibidor de h+, k+-atpase, processos para a manufatura da mesma, para melhorar a inibição de secreção de ácido gástrico, para melhorar o efeito terapêutico no tratamento de distúrbios gastrointentinais, para receber um perfil de plasma prolongado de um inibidor da h+, k+-atpase, e, usos de uma composição farmacêutica e de inibidor da h+, k+-atpase
BR9608435A (pt) Metodo para medicação do sistema de controle inflatório e de reações inflamatórias adversas e para produção de composto para o tratamento da patologia de reações inflamatórias adversas.
BR0116862A (pt) Medicamento, métodos para tratar um paciente com osteonecrose e/ou osteocondrite dissecans, para prevenir a osteonecrose e/ou osteocondrite dissecans em um paciente em risco de cada uma das ditas doenças, uso de um medicamento, e, método para prevenir a destruição da cartilagem ou condrólise associadas com osteonecrose e/ou osteocondrite dissecans
KR970061244A (ko) 치매 치료용 약학 조성물
BR0214075A (pt) Dosagem unitária que compreende um análogo de prostaglandina para tratar constipação
ES2139842T3 (es) Uso de la melatonina para tratar a pacientes que sufren drogodependencia.
BR0009380A (pt) Tratamento de câncer melhorado comtemozolomida
JP2000512270A (ja) 単純ヘルペスの処置のための組成物および方法
BR9908716A (pt) Tratamento de disfunção sexual em certos grupos de pacientes
EA200200801A1 (ru) Применение фолликулостимулирующего гормона (fsh) для лечения бесплодия
BR9907234A (pt) Polìmeros ligantes de gordura
HUP0301831A2 (hu) Gepiron bioaktív metabolitjainak alkalmazása pszichológiai rendellenességek kezelésére
BE1002256A3 (fr) Medicaments.
HUP9901935A2 (hu) Gyógyszerek és terápiás szerek és más glikozaminoglikánok (GAG) dózisainak célbajuttatására alkalmas dóziskészlet
DE3688787D1 (de) Herstellung eines arzneimittels gegen arthritis und rheumatismus.
EE9900346A (et) Viljatusevastane ja viljastumisvõimet tõstev ravim
MX9303985A (es) Nucleosidos terapeuticos.

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970423