IT1245907B - Uso dei glicosaminoglicani nel trattamento della nefropatia diabetica e della neuropatia diabetica. - Google Patents

Uso dei glicosaminoglicani nel trattamento della nefropatia diabetica e della neuropatia diabetica.

Info

Publication number
IT1245907B
IT1245907B ITBO910163A ITBO910163A IT1245907B IT 1245907 B IT1245907 B IT 1245907B IT BO910163 A ITBO910163 A IT BO910163A IT BO910163 A ITBO910163 A IT BO910163A IT 1245907 B IT1245907 B IT 1245907B
Authority
IT
Italy
Prior art keywords
treatment
diabetic
glycosaminoglycans
diabetic nephropathy
glycosaminoglicans
Prior art date
Application number
ITBO910163A
Other languages
English (en)
Inventor
Egidio Marchi
Gianfranco Tamagnone
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Priority to ITBO910163A priority Critical patent/IT1245907B/it
Publication of ITBO910163A0 publication Critical patent/ITBO910163A0/it
Priority to DE69212620T priority patent/DE69212620T2/de
Priority to EP92105692A priority patent/EP0513513B1/en
Priority to US07/871,048 priority patent/US5236910A/en
Priority to CA002066785A priority patent/CA2066785C/en
Priority to KR1019920008367A priority patent/KR970005181B1/ko
Publication of ITBO910163A1 publication Critical patent/ITBO910163A1/it
Application granted granted Critical
Publication of IT1245907B publication Critical patent/IT1245907B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

L'oggetto della presente invenzione è costituito dall'uso dei glicosaminoglicani nella prevenzione e nel trattamento di alcune patologie indotte dal diabete quali la nefropatia diabetica e la neuropatia diabetica.L'efficacia dei glicosaminoglicani nella prevenzione e nel trattamento di dette patologie è stata dimostrata mediante il trattamento di alcuni tipi di glicosaminoglicani di ratti albini maschi resi diabetici per trattamento con streptozotocina o con allossano e mediante la successiva determinazione di parametri morfologici e clinici quali lo spessore della membrana basale glomerulare, il numero di cariche anioniche glomerulari e l'albuminuria per quanto riguarda la nefropatia diabetica, i livelli di sostanza P e di met-Encefalina in alcuni distretti intestinali, quali duodeno e digiuno, per quanto riguarda la neuropatia diabetica.
ITBO910163A 1991-05-17 1991-05-17 Uso dei glicosaminoglicani nel trattamento della nefropatia diabetica e della neuropatia diabetica. IT1245907B (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ITBO910163A IT1245907B (it) 1991-05-17 1991-05-17 Uso dei glicosaminoglicani nel trattamento della nefropatia diabetica e della neuropatia diabetica.
DE69212620T DE69212620T2 (de) 1991-05-17 1992-04-02 Verwendung von Glycosaminoglycanen zur Behandlung von diabetischer Nephropathie und diabetischer Neuropathie
EP92105692A EP0513513B1 (en) 1991-05-17 1992-04-02 Use of glycosaminoglycans in the treatment of diabetic nephropathy and diabetic neuropathy
US07/871,048 US5236910A (en) 1991-05-17 1992-04-20 Use of glycosaminoglycans in the treatment of diabetic nephropathy and diabetic neuropathy
CA002066785A CA2066785C (en) 1991-05-17 1992-04-22 Glycosaminoglycans in the treatment of diabetic nephropathy and diabetic neuropathy
KR1019920008367A KR970005181B1 (ko) 1991-05-17 1992-05-18 글리코스아미노글리칸을 주성분으로 하는 당뇨병 치료제

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITBO910163A IT1245907B (it) 1991-05-17 1991-05-17 Uso dei glicosaminoglicani nel trattamento della nefropatia diabetica e della neuropatia diabetica.

Publications (3)

Publication Number Publication Date
ITBO910163A0 ITBO910163A0 (it) 1991-05-17
ITBO910163A1 ITBO910163A1 (it) 1992-11-17
IT1245907B true IT1245907B (it) 1994-10-25

Family

ID=11337489

Family Applications (1)

Application Number Title Priority Date Filing Date
ITBO910163A IT1245907B (it) 1991-05-17 1991-05-17 Uso dei glicosaminoglicani nel trattamento della nefropatia diabetica e della neuropatia diabetica.

Country Status (6)

Country Link
US (1) US5236910A (it)
EP (1) EP0513513B1 (it)
KR (1) KR970005181B1 (it)
CA (1) CA2066785C (it)
DE (1) DE69212620T2 (it)
IT (1) IT1245907B (it)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264530B (it) * 1992-07-31 1996-10-02 Crinos Industria Farmaco Impiego dei polisaccaridi nelle neuropatie atrofico degenerative
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
IT1270846B (it) * 1993-05-10 1997-05-13 Alfa Wassermann Spa Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica.
IT1271685B (it) * 1994-08-03 1997-06-04 Crinos Industria Farmaco Impiego dei polidesossiribonucleotidi nelle neuropati diabetiche
IT1274351B (it) * 1994-10-06 1997-07-17 Alfa Wassermann Spa Uso di alcuni glicosaminoglicani nella dialisi peritoneale.
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
DE29900874U1 (de) 1999-01-20 1999-07-22 Knoll AG, 67061 Ludwigshafen Organprotektive Lösungen
US6083933A (en) * 1999-04-19 2000-07-04 Stellar International Inc. Treatment of cystitis-like symptoms with chondroitin sulfate following administration of a challenge solution
US6562836B1 (en) * 1999-05-24 2003-05-13 Queen's University Of Kingston Methods and compounds for inhibiting amyloid deposits
EP1192187A1 (en) * 1999-06-30 2002-04-03 Hamilton Civic Hospitals Research Development, Inc. Heparin compositions that inhibit clot associated coagulation factors
CA2377382A1 (en) * 1999-07-01 2001-01-11 Scios, Inc. Prevention and treatment of amyloid-associated disorders
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
CN1473061A (zh) * 2000-09-08 2004-02-04 ���ܶ�����ҽԺ�о���չ���޹�˾ 抗血栓形成的组合物
NZ530037A (en) * 2001-06-12 2006-03-31 Keryx Biopharmaceuticals Inc Use of glycosaminoglycans for the treatment of HIV-associated nephropathy
US20040161476A1 (en) 2003-02-19 2004-08-19 Hahn Sungtack Samuel Cystitis treatment with high dose chondroitin sulfate
WO2004084932A2 (en) * 2003-03-28 2004-10-07 Applied Research Systems Ars Holding N.V. Use of clusterin for the treatment and/or prevention of peripheral neurological diseases
JP2008515807A (ja) * 2004-10-01 2008-05-15 ケリク ビオファルマセウチカルス インコーポレーテッド 腎臓疾患の治療にグリコサミノグリカンを用いる方法
ITBO20050123A1 (it) 2005-03-07 2005-06-06 Alfa Wassermann Spa Formulazioni farmaceutiche gastroresistenti contenenti rifaximina
DE102005017799A1 (de) * 2005-04-18 2006-10-19 Abbott Gmbh & Co. Kg Verwendung von Heparin und Heparinderivaten zur Modulation des Neuritenwachstum-kontrollierenden Nogo-Rezeptors
JP5622346B2 (ja) * 2006-05-19 2014-11-12 愛知県 神経細胞の細胞死抑制剤等
ITMI20061692A1 (it) 2006-09-05 2008-03-06 Alfa Wassermann Spa Uso di polioli per ottenere forme polimorfe stabili di rifaximina
GB0714500D0 (en) * 2007-07-25 2007-09-05 Hunter Fleming Ltd composition and treatment
CN101632686A (zh) * 2008-04-04 2010-01-27 马斯特里赫特大学 糖胺聚糖用于修复糖萼的用途
ES2340902B1 (es) * 2008-07-01 2011-05-03 Laboratorios Farmaceuticos Rovi, S.A. Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas.
WO2011109877A1 (en) * 2010-03-12 2011-09-15 The Australian National University Heparan sulfate replacement therapy
IT1401253B1 (it) * 2010-04-23 2013-07-18 Uni Degli Studi Carlo Bo Urbino Uso del sulodexide per la riduzione delle metalloproteinasi di matrice.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2139388A (en) * 1988-06-27 1990-01-23 Roland Reiner Glycosaminoglycane for the treatment of diabetic microangiopathy

Also Published As

Publication number Publication date
EP0513513B1 (en) 1996-08-07
DE69212620T2 (de) 1996-11-28
ITBO910163A0 (it) 1991-05-17
KR920021153A (ko) 1992-12-18
ITBO910163A1 (it) 1992-11-17
US5236910A (en) 1993-08-17
CA2066785A1 (en) 1992-11-18
DE69212620D1 (de) 1996-09-12
KR970005181B1 (ko) 1997-04-14
CA2066785C (en) 1999-01-12
EP0513513A1 (en) 1992-11-19

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970423