CY1108051T1 - Συνθεση με βαση παραγωγα υποκατεστημενης 1,3-διφαινυλπροπ-2-εν-1-ονης - Google Patents
Συνθεση με βαση παραγωγα υποκατεστημενης 1,3-διφαινυλπροπ-2-εν-1-ονηςInfo
- Publication number
- CY1108051T1 CY1108051T1 CY20071100879T CY071100879T CY1108051T1 CY 1108051 T1 CY1108051 T1 CY 1108051T1 CY 20071100879 T CY20071100879 T CY 20071100879T CY 071100879 T CY071100879 T CY 071100879T CY 1108051 T1 CY1108051 T1 CY 1108051T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compositions
- diffinylpro
- producers
- composition
- prevent
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000013200 Stress disease Diseases 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000036542 oxidative stress Effects 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 230000009759 skin aging Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical class C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 abstract 1
- 230000037303 wrinkles Effects 0.000 abstract 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/055—Phenols the aromatic ring being substituted by halogen
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
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- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Η παρούσα εφεύρεση αφορά συνθέσεις που περιλαμβάνουν τα παράγωγα υποκατεστημένης 1,3-διφαινυλπροπ-2-εν-1-όνης προορισμένα για θεραπευτική χρήση. Οι συνθέσεις της ο εφεύρεσης είναι χρησιμοποιήσιμες κυρίως για να αποτρέπονται ή να θεραπεύονται οι καρδιαγγειακές ασθένειες, το σύνδρομο Χ, η επαναστένωση, ο διαβήτης, η παχυσαρκία, η υπέρταση, οι φλεγμονώδεις ασθένειες, οι καρκίνοι ή νεοπλάσματα (καλοήθεις ή κακοήθεις όγκοι), οι νευροεκφυλιστικές ασθένειες, δερματολογικές και οι διαταραχές που σχετίζονται με το οξειδωτικό στρες, για να αποτρέπονται ή να θεραπεύονται τα αποτελέσματα γήρανσης γενικά και για παράδειγμα η γήρανση του δέρματος, κυρίως στο καλλυντικό πεδίο (η εμφάνιση ρυτίδων, κλπ.).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0208570A FR2841784B1 (fr) | 2002-07-08 | 2002-07-08 | Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations |
EP03762750A EP1519908B1 (fr) | 2002-07-08 | 2003-07-08 | Composition a base de derives de 1,3-diphenylprop-2-en-1-one substitues, preparations et utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108051T1 true CY1108051T1 (el) | 2013-09-04 |
Family
ID=29725282
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100879T CY1108051T1 (el) | 2002-07-08 | 2007-07-03 | Συνθεση με βαση παραγωγα υποκατεστημενης 1,3-διφαινυλπροπ-2-εν-1-ονης |
Country Status (24)
Country | Link |
---|---|
US (3) | US7632870B2 (el) |
EP (1) | EP1519908B1 (el) |
JP (1) | JP4907083B2 (el) |
KR (1) | KR100947907B1 (el) |
CN (1) | CN1688532B (el) |
AT (1) | ATE364588T1 (el) |
AU (1) | AU2003264699B2 (el) |
BR (1) | BRPI0312399B8 (el) |
CA (1) | CA2490993C (el) |
CY (1) | CY1108051T1 (el) |
DE (1) | DE60314420T2 (el) |
DK (1) | DK1519908T3 (el) |
EA (1) | EA012699B1 (el) |
ES (1) | ES2287529T3 (el) |
FR (1) | FR2841784B1 (el) |
IL (1) | IL165454A (el) |
MX (1) | MXPA05000425A (el) |
NO (1) | NO334650B1 (el) |
NZ (1) | NZ538052A (el) |
PL (1) | PL207707B1 (el) |
PT (1) | PT1519908E (el) |
SI (1) | SI1519908T1 (el) |
WO (1) | WO2004005243A2 (el) |
ZA (1) | ZA200501081B (el) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2841784B1 (fr) | 2002-07-08 | 2007-03-02 | Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations | |
FR2841900B1 (fr) * | 2002-07-08 | 2007-03-02 | Genfit S A | Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations |
BRPI0506718A (pt) * | 2004-01-08 | 2007-05-02 | Genfit | compostos, processo de preparação dos mesmos, e, composição farmacêutica ou cosmética |
RU2431634C2 (ru) | 2005-03-11 | 2011-10-20 | Говард Флори Инститьют Оф Експериментл Физиолоджи Энд Медсин | Соединения флавоноидов и их применение |
SI2641596T1 (sl) | 2009-11-26 | 2018-09-28 | Genfit | Uporaba 1,3-difenilprop-2-en-1-on derivatov za zdravljenje motenj jeter |
WO2011080276A1 (en) | 2009-12-29 | 2011-07-07 | Genfit | Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative |
AR082138A1 (es) * | 2010-07-12 | 2012-11-14 | Hoffmann La Roche | 1-hidroxiimino-3-fenil-propanos |
WO2013012760A1 (en) | 2011-07-15 | 2013-01-24 | Numeta Sciences, Inc. | Compositions and methods for modulating metabolic pathways |
CA2851062A1 (en) * | 2011-10-26 | 2013-05-02 | F. Hoffmann-La Roche Ag | 1-cycloalkyl- or 1-heterocyclyl-hydroxyimino-3-phenyl-propanes |
US9198454B2 (en) | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
CN108452311A (zh) | 2012-11-13 | 2018-08-28 | 纽斯尔特科学公司 | 用于增强能量代谢的组合物和方法 |
EA031718B1 (ru) * | 2013-01-18 | 2019-02-28 | Женфит | Лечение фиброза и рака, связанных с тирозинкиназой |
SG11201507046UA (en) | 2013-03-15 | 2015-10-29 | Nusirt Sciences Inc | Leucine and nicotinic acid reduces lipid levels |
MX2016011063A (es) | 2014-02-27 | 2016-11-30 | Nusirt Sciences Inc | Composiciones y metodos para la reduccion o prevencion de esteatosis hepatica. |
US10442761B2 (en) | 2016-02-16 | 2019-10-15 | Concert Pharmaceuticals, Inc. | Deuterated GFT-505 |
EA201892201A1 (ru) * | 2016-03-30 | 2019-03-29 | Женфит | Неинвазивная диагностика неалкогольного стеатогепатита |
KR20230156167A (ko) * | 2016-04-16 | 2023-11-13 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 바큘로바이러스 시스템-생산된 재조합 아데노-연관 바이러스의 생물학적 효력을 증진시키는 방법 |
CN109316601B (zh) * | 2017-07-31 | 2021-11-09 | 武汉朗来科技发展有限公司 | 药物组合物及其用途 |
CN108658908B (zh) * | 2017-07-31 | 2019-05-10 | 广州必贝特医药技术有限公司 | 1,3-二取代烯酮类化合物及其应用 |
EP3719010B1 (en) | 2017-11-30 | 2023-07-26 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Aromatic compound, pharmaceutical composition thereof and use thereof |
TW202019870A (zh) | 2018-08-03 | 2020-06-01 | 法商Genfit公司 | 艾拉菲諾鹽 |
US11634387B2 (en) | 2019-09-26 | 2023-04-25 | Abionyx Pharma Sa | Compounds useful for treating liver diseases |
BR112022015807A2 (pt) | 2020-02-10 | 2023-03-14 | Genfit | Polimorfos de elafibranor |
WO2024029639A1 (ko) * | 2022-08-02 | 2024-02-08 | 제이투에이치바이오텍 주식회사 | 3성분 프로드럭, 이의 약학적 조성물 및 의약 용도 |
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-
2002
- 2002-07-08 FR FR0208570A patent/FR2841784B1/fr not_active Expired - Fee Related
-
2003
- 2003-07-08 PL PL373465A patent/PL207707B1/pl unknown
- 2003-07-08 CA CA2490993A patent/CA2490993C/fr not_active Expired - Fee Related
- 2003-07-08 EP EP03762750A patent/EP1519908B1/fr not_active Expired - Lifetime
- 2003-07-08 PT PT03762750T patent/PT1519908E/pt unknown
- 2003-07-08 MX MXPA05000425A patent/MXPA05000425A/es active IP Right Grant
- 2003-07-08 AU AU2003264699A patent/AU2003264699B2/en not_active Ceased
- 2003-07-08 JP JP2004518891A patent/JP4907083B2/ja not_active Expired - Lifetime
- 2003-07-08 NZ NZ538052A patent/NZ538052A/en not_active IP Right Cessation
- 2003-07-08 BR BRPI0312399A patent/BRPI0312399B8/pt not_active IP Right Cessation
- 2003-07-08 WO PCT/FR2003/002128 patent/WO2004005243A2/fr active IP Right Grant
- 2003-07-08 SI SI200330841T patent/SI1519908T1/sl unknown
- 2003-07-08 DK DK03762750T patent/DK1519908T3/da active
- 2003-07-08 US US10/520,078 patent/US7632870B2/en active Active
- 2003-07-08 DE DE60314420T patent/DE60314420T2/de not_active Expired - Lifetime
- 2003-07-08 KR KR1020047021625A patent/KR100947907B1/ko active IP Right Grant
- 2003-07-08 ES ES03762750T patent/ES2287529T3/es not_active Expired - Lifetime
- 2003-07-08 AT AT03762750T patent/ATE364588T1/de active
- 2003-07-08 EA EA200500170A patent/EA012699B1/ru not_active IP Right Cessation
- 2003-07-08 CN CN038163519A patent/CN1688532B/zh not_active Expired - Lifetime
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