EA200500244A1 - Тетрапропиламмония тетратиомолибдат и родственные соединения для антиангиогенной терапии - Google Patents
Тетрапропиламмония тетратиомолибдат и родственные соединения для антиангиогенной терапииInfo
- Publication number
- EA200500244A1 EA200500244A1 EA200500244A EA200500244A EA200500244A1 EA 200500244 A1 EA200500244 A1 EA 200500244A1 EA 200500244 A EA200500244 A EA 200500244A EA 200500244 A EA200500244 A EA 200500244A EA 200500244 A1 EA200500244 A1 EA 200500244A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- tetratiomolybdat
- tetrapropilammonia
- compounds
- related compounds
- antiangiogenic therapy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Раскрыты соединения, связывающие медь, с усовершенствованными свойствами и способы применения таких соединений для предупреждения и лечения ангиогенных заболеваний, как, например, рака. Преимущества изобретения включают повышенную стабильность соединений, которая достигается без снижения эффективности. Также предложены фармацевтические композиции, терапевтические наборы, способы комбинированного лечения и применение.Отчет о международном поиске был опубликован 2004.04.08.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39780402P | 2002-07-23 | 2002-07-23 | |
PCT/US2003/022914 WO2004009072A2 (en) | 2002-07-23 | 2003-07-23 | Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200500244A1 true EA200500244A1 (ru) | 2005-12-29 |
EA008683B1 EA008683B1 (ru) | 2007-06-29 |
Family
ID=30771119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200500244A EA008683B1 (ru) | 2002-07-23 | 2003-07-23 | Тетрапропиламмония тетратиомолибдат и родственные соединения для антиангиогенной терапии |
Country Status (16)
Country | Link |
---|---|
US (1) | US7888389B2 (ru) |
EP (1) | EP1539131A4 (ru) |
JP (1) | JP2005538093A (ru) |
KR (1) | KR20050025976A (ru) |
CN (1) | CN1688303A (ru) |
AU (1) | AU2003261222B2 (ru) |
BR (1) | BR0312845A (ru) |
CA (1) | CA2493341A1 (ru) |
EA (1) | EA008683B1 (ru) |
GE (1) | GEP20074270B (ru) |
IL (1) | IL166385A0 (ru) |
MX (1) | MXPA05000875A (ru) |
NO (1) | NO20050902L (ru) |
NZ (1) | NZ537896A (ru) |
WO (1) | WO2004009072A2 (ru) |
ZA (1) | ZA200501162B (ru) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6703050B1 (en) | 1998-09-04 | 2004-03-09 | The Regents Of The University Of Michigan | Methods and compositions for the prevention or treatment of cancer |
EP1115389B1 (en) * | 1998-09-25 | 2014-03-12 | PhilERA New Zealand Limited | Fructosamine oxidase: antagonists and inhibitors |
WO2003077901A1 (en) * | 2002-03-08 | 2003-09-25 | Protemix Corporation Limited | Preventing and/or treating cardiovascular disease and/or associated heart failure |
US20070292533A1 (en) * | 2002-05-24 | 2007-12-20 | Regents Of The University Of Michigan | Copper lowering treatment of autoimmune diseases |
US20070248689A1 (en) * | 2002-05-24 | 2007-10-25 | Regents Of The University Of Michigan | Copper lowering treatment of inflammatory and fibrotic diseases |
JP2005538093A (ja) | 2002-07-23 | 2005-12-15 | ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン | 抗血管形成療法のための、テトラポリアンモニウムテトラチオモリブデートおよび関連化合物 |
US7189865B2 (en) * | 2002-07-23 | 2007-03-13 | Attenuon, Llc | Thiomolybdate analogues and uses thereof |
WO2004017956A1 (en) * | 2002-08-20 | 2004-03-04 | Protemix Corporation Limited | Dosage forms and related therapies |
RU2002128364A (ru) * | 2002-10-23 | 2004-04-27 | Институт нефтехимического синтеза РАН им. А.В. Топчиева | Способ получения присадки к смазочным материалам (варианты) |
BRPI0410651A (pt) * | 2003-05-27 | 2006-07-04 | Attenuon Llc | composto, composição farmacêutica, e, métodos para tratar ou prevenir cáncer, degeneração macular do tipo úmida ou artrite reumatóide, vascularização aberrante, nìveis de cobre em excesso, obesidade e doença neurodegenerativa em um paciente |
EP1729784A1 (en) * | 2004-02-23 | 2006-12-13 | Attenuon, LLC | Formulations of thiomolybdate or thiotungstate compounds and uses thereof |
EP1721010A2 (en) * | 2004-02-24 | 2006-11-15 | Attenuon, LLC | Inhibition of superoxide dismutase by tetrathiomolybdate: identification of new anti-angiogenic and antitumor agents |
DK1778618T3 (da) | 2004-07-19 | 2014-03-10 | Philera New Zealand Ltd | Syntese af triethylentetraminer |
WO2006044779A1 (en) * | 2004-10-14 | 2006-04-27 | Northwestern University | Detection and treatment of renal cancer |
US7893289B2 (en) * | 2007-02-21 | 2011-02-22 | Ssv Therapeutics, Inc. | Adamantanamines and neramexane salts of thiomolybdic and thiotungstic acids |
WO2009009622A2 (en) * | 2007-07-09 | 2009-01-15 | Pipex Pharmaceuticals, Inc. | Pharmaceutical compositions, including attm, and methods to achieve and maintain a targeted and stable copper status and prevent and treat copper-related central nervous system diseases |
US20100312139A1 (en) * | 2009-06-04 | 2010-12-09 | Board Of Regents Of The University Of Texas System | Method for Identifying Mammals at Risk for Elevated intracranial Pressure |
ES2758554T3 (es) | 2009-12-08 | 2020-05-05 | Univ Case Western Reserve | Aminoácidos gama para tratamiento de trastornos oculares |
US20160220500A1 (en) * | 2014-11-14 | 2016-08-04 | Kent State University | Targeting Intracellular Copper Ions for Inhibiting Angiogenesis Using Nanoparticles of Ternary Inorganic Metal Sulfide M1M2S4 (M1, independently, is Mg, Ca, Mn, Fe, or Zn; M2 = Mo or W) Compounds to Treat Metastatic Cancer |
CN107530311A (zh) | 2015-02-03 | 2018-01-02 | 卡德门制药有限公司 | 稳定的曲恩汀制剂 |
US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
JP2023549037A (ja) | 2020-10-07 | 2023-11-22 | シーティーアイ バスキュラー アーゲー | 生物活性型に変換可能なデバイスおよび関連する方法 |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2909541A (en) | 1955-01-07 | 1959-10-20 | Inst Francais Du Petrole | Nitrogenous thiomolybdates |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US4343746A (en) | 1980-12-10 | 1982-08-10 | Gulf Research & Development Company | Quaternary ammonium thiomolybdates |
US4762705A (en) | 1981-11-10 | 1988-08-09 | Adolf W. Schwimmer | Cancer therapy with interferon |
US4952607A (en) | 1982-05-27 | 1990-08-28 | International Copper Research Association, Inc. | Copper complex for treating cancer |
US4430443A (en) | 1982-07-20 | 1984-02-07 | Exxon Research And Engineering Co. | Supported carbon-containing molybdenum and tungsten sulfide catalysts, their preparation and use |
US4766226A (en) | 1984-02-01 | 1988-08-23 | Smithkline Beckman Corporation | Antitumor pharmaceutical compositions and methods for treating tumors employing α,ω-bis(disubstitutedphosphino)hydrocarbon derivatives or [α, ω-bis(disubstitutedphosphino)hydrocarbon] di |
DE3586683T2 (de) | 1984-12-18 | 1993-04-08 | Clark Pharma Dev | Antitumorzusammensetzungen enthaltend ein reaktionsprodukt zwischen einem cytotoxischen aldehyd und penicillamin und deren verwendung zur herstellung von arzneimitteln. |
GB8504253D0 (en) | 1985-02-19 | 1985-03-20 | Ici Plc | Electrostatic spraying apparatus |
US4604278A (en) * | 1985-05-17 | 1986-08-05 | Gte Products Corporation | Production of ammonium tetrathiomolybdate |
US4678667A (en) | 1985-07-02 | 1987-07-07 | 501 Regents of the University of California | Macrocyclic bifunctional chelating agents |
US5776093A (en) | 1985-07-05 | 1998-07-07 | Immunomedics, Inc. | Method for imaging and treating organs and tissues |
US5162231A (en) | 1989-10-25 | 1992-11-10 | Cole Dean A | Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung |
US5057302A (en) | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
US5385933A (en) | 1989-02-27 | 1995-01-31 | The United States Of America As Represented By The Department Of Health And Human Services | Method for the treatment of cancer by use of the copper complex of S-(methylthio)-DL-homocysteine or the L-enantiomorph thereof |
US5100885A (en) | 1989-08-01 | 1992-03-31 | Johnson Matthey, Inc. | Copper radiosensitizers |
US5443816A (en) | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
MX172248B (es) | 1989-12-20 | 1993-12-09 | Univ Mexico | Procedimiento para la obtencion de nuevos complejos aminoacidatos de cobre mixtos a base de fenantrolinas feniladas como agentes anticancerigenos |
US5972922A (en) | 1990-06-11 | 1999-10-26 | Alcon Laboratories, Inc. | Steroids which inhibit angiogenesis |
US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
AU682149B2 (en) | 1992-06-19 | 1997-09-25 | Medical College Of Ohio, The | Production and use of imines of porphyrins |
US5629327A (en) | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
US5565491A (en) | 1994-01-31 | 1996-10-15 | Bristol-Myers Squibb Company | Use of phosphotyrosine phospatase inhibitors for controlling cellular proliferation |
US5753230A (en) | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
US5639725A (en) | 1994-04-26 | 1997-06-17 | Children's Hospital Medical Center Corp. | Angiostatin protein |
US5563132A (en) | 1994-06-21 | 1996-10-08 | Bodaness; Richard S. | Two-step cancer treatment method |
US5583153A (en) | 1994-10-06 | 1996-12-10 | Regents Of The University Of California | Use of taxol in the treatment of rheumatoid arthritis |
US5527533A (en) | 1994-10-27 | 1996-06-18 | Board Of Trustees Of The University Of Illinois | Method of retarding and ameliorating central nervous system and eye damage |
DK0814861T3 (da) | 1995-03-14 | 2002-10-07 | Siemens Ag | Udskiftelig præcisionsdoseringsenhed til ultralydforstøveranordning |
DK0814860T3 (da) | 1995-03-14 | 2000-05-08 | Siemens Ag | Ultrasonisk forstøveranordning med aftagelig præcisionsdoseringsendhed |
US5639757A (en) | 1995-05-23 | 1997-06-17 | Pfizer Inc. | 4-aminopyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors |
NZ504021A (en) | 1997-10-17 | 2003-04-29 | Systemic Pulmonary Delivery Lt | Method and apparatus for delivering aerosolized medication having air discharged through air tube directly into plume of aerosolized medication |
EP1234585A3 (en) | 1998-09-04 | 2004-01-21 | The Regents Of The University Of Michigan | Methods and compositions for the prevention or treatment of cancer |
US6703050B1 (en) | 1998-09-04 | 2004-03-09 | The Regents Of The University Of Michigan | Methods and compositions for the prevention or treatment of cancer |
WO2000013712A2 (en) | 1998-09-04 | 2000-03-16 | The Regents Of The University Of Michigan | Methods and compositions for the prevention or treatment of cancer |
CA2458622A1 (en) * | 2001-08-24 | 2003-03-06 | Maine Medical Center Research Institute | Copper-dependent non-traditional pro-inflammatory cytokine export and methods, compositions and kits relating thereto |
EP1531827A4 (en) * | 2002-05-24 | 2009-07-08 | Univ Michigan | COPPER-REDUCING TREATMENT FOR INFLAMMATORY AND FIBROTIC DISEASES |
US7189865B2 (en) | 2002-07-23 | 2007-03-13 | Attenuon, Llc | Thiomolybdate analogues and uses thereof |
JP2005538093A (ja) | 2002-07-23 | 2005-12-15 | ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン | 抗血管形成療法のための、テトラポリアンモニウムテトラチオモリブデートおよび関連化合物 |
-
2003
- 2003-07-23 JP JP2004523295A patent/JP2005538093A/ja active Pending
- 2003-07-23 CN CNA03820746XA patent/CN1688303A/zh active Pending
- 2003-07-23 AU AU2003261222A patent/AU2003261222B2/en not_active Expired - Fee Related
- 2003-07-23 GE GEAP20038654A patent/GEP20074270B/en unknown
- 2003-07-23 US US10/625,839 patent/US7888389B2/en active Active
- 2003-07-23 NZ NZ537896A patent/NZ537896A/en unknown
- 2003-07-23 MX MXPA05000875A patent/MXPA05000875A/es unknown
- 2003-07-23 BR BR0312845-8A patent/BR0312845A/pt not_active Application Discontinuation
- 2003-07-23 EA EA200500244A patent/EA008683B1/ru not_active IP Right Cessation
- 2003-07-23 EP EP03765921A patent/EP1539131A4/en not_active Withdrawn
- 2003-07-23 KR KR1020057001226A patent/KR20050025976A/ko not_active Application Discontinuation
- 2003-07-23 CA CA002493341A patent/CA2493341A1/en not_active Abandoned
- 2003-07-23 WO PCT/US2003/022914 patent/WO2004009072A2/en active Application Filing
-
2005
- 2005-01-20 IL IL16638505A patent/IL166385A0/xx unknown
- 2005-02-09 ZA ZA200501162A patent/ZA200501162B/xx unknown
- 2005-02-18 NO NO20050902A patent/NO20050902L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20050902L (no) | 2005-04-19 |
ZA200501162B (en) | 2005-09-05 |
CN1688303A (zh) | 2005-10-26 |
US7888389B2 (en) | 2011-02-15 |
NZ537896A (en) | 2007-12-21 |
WO2004009072B1 (en) | 2004-07-08 |
GEP20074270B (en) | 2007-12-25 |
AU2003261222A1 (en) | 2004-02-09 |
EP1539131A4 (en) | 2009-07-08 |
MXPA05000875A (es) | 2005-09-30 |
WO2004009072A3 (en) | 2004-04-08 |
US20040259945A1 (en) | 2004-12-23 |
WO2004009072A2 (en) | 2004-01-29 |
EA008683B1 (ru) | 2007-06-29 |
AU2003261222B2 (en) | 2009-07-09 |
EP1539131A2 (en) | 2005-06-15 |
CA2493341A1 (en) | 2004-01-29 |
IL166385A0 (en) | 2006-01-16 |
BR0312845A (pt) | 2005-06-07 |
JP2005538093A (ja) | 2005-12-15 |
KR20050025976A (ko) | 2005-03-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |