MX172248B - Procedimiento para la obtencion de nuevos complejos aminoacidatos de cobre mixtos a base de fenantrolinas feniladas como agentes anticancerigenos - Google Patents
Procedimiento para la obtencion de nuevos complejos aminoacidatos de cobre mixtos a base de fenantrolinas feniladas como agentes anticancerigenosInfo
- Publication number
- MX172248B MX172248B MX018802A MX1880289A MX172248B MX 172248 B MX172248 B MX 172248B MX 018802 A MX018802 A MX 018802A MX 1880289 A MX1880289 A MX 1880289A MX 172248 B MX172248 B MX 172248B
- Authority
- MX
- Mexico
- Prior art keywords
- amino acid
- solution
- copper
- acid complexes
- weight percent
- Prior art date
Links
- 239000010949 copper Substances 0.000 title abstract 6
- -1 COPPER AMINO ACID Chemical class 0.000 title abstract 4
- 229910052802 copper Inorganic materials 0.000 title abstract 4
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 239000000243 solution Substances 0.000 abstract 4
- 229910002651 NO3 Inorganic materials 0.000 abstract 3
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 229910000071 diazene Inorganic materials 0.000 abstract 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 239000005749 Copper compound Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000004699 copper complex Chemical class 0.000 abstract 1
- 150000001880 copper compounds Chemical class 0.000 abstract 1
- RAABOESOVLLHRU-UHFFFAOYSA-N diazene Chemical compound N=N RAABOESOVLLHRU-UHFFFAOYSA-N 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/005—Compounds containing elements of Groups 1 or 11 of the Periodic Table without C-Metal linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a procedimiento para la obtención de nuevos complejos aminoacidatos de cobre mixtos a base de fenantrolinas feniladas, de tipo aromático de fórmula [Cu (N-N) (N-O)] + -NO3, caracterizado porque comprende los pasos de preparar una solución acuosa a base de un compuesto de cobre, preferentemente Cu (NO3)2.5H2O en una relación de 30 - 35 por ciento en peso de cobre/solución; preparar una segunda solución acuo-etanólica con un compuesto de diimina en una relación del 50 - 55 por ciento en peso de diimina/solución; hacer reaccionar las soluciones acuosas preparadas en un reactor a temperatura ambiente; estabilizar el complejo de cobre obtenido (nitrato de monodiimina) con un agente regulador manteniendo un pH ácido entre 5 y 7; adicionar al complejo obtenido una solución acuosa del 10 - 15 por ciento en peso de un aminoacidato (N-O), manteniendo la reacción ligeramente alcalina para obtener complejos aromáticos aminoacidatos de cobre con propiedades anticancerígenas.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX018802A MX172248B (es) | 1989-12-20 | 1989-12-20 | Procedimiento para la obtencion de nuevos complejos aminoacidatos de cobre mixtos a base de fenantrolinas feniladas como agentes anticancerigenos |
| US07/628,843 US5107005A (en) | 1989-12-20 | 1990-12-11 | Process to obtain new mixed copper aminoactidate complexes from phenylate phenathrolines to be used as anticancerigenic agents |
| JP2417939A JPH04208285A (ja) | 1989-12-20 | 1990-12-20 | 抗癌剤に用いられる新規フェニル化フェナントロリン含有混合銅アミノ酸錯体の製造方法 |
| EP90314073A EP0434444A1 (en) | 1989-12-20 | 1990-12-20 | Process to obtain new mixed copper aminoacidate complexes from phenylate Phenathrolines to be used as anticancerigenic agents |
| US08/230,816 USRE35458E (en) | 1989-12-20 | 1994-04-21 | Process to obtain new mixed copper aminoacidate complexes from phenylate phenathrolines to be used as anticancerigenic agents |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX018802A MX172248B (es) | 1989-12-20 | 1989-12-20 | Procedimiento para la obtencion de nuevos complejos aminoacidatos de cobre mixtos a base de fenantrolinas feniladas como agentes anticancerigenos |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX172248B true MX172248B (es) | 1993-12-09 |
Family
ID=19742452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX018802A MX172248B (es) | 1989-12-20 | 1989-12-20 | Procedimiento para la obtencion de nuevos complejos aminoacidatos de cobre mixtos a base de fenantrolinas feniladas como agentes anticancerigenos |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US5107005A (es) |
| EP (1) | EP0434444A1 (es) |
| JP (1) | JPH04208285A (es) |
| MX (1) | MX172248B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5576326A (en) * | 1989-12-20 | 1996-11-19 | Universidad Nacional Autonoma De Mexico (Unam) | Copper amino acidate diimine nitrate compounds and their methyl derivatives and a process for preparing them |
| US6703050B1 (en) | 1998-09-04 | 2004-03-09 | The Regents Of The University Of Michigan | Methods and compositions for the prevention or treatment of cancer |
| AUPR330201A0 (en) * | 2001-02-23 | 2001-03-22 | University Of Sydney, The | Metal complexes and therapeutic uses thereof |
| WO2003099223A2 (en) * | 2002-05-24 | 2003-12-04 | The Regents Of The University Of Michigan | Copper lowering treatment of inflammatory and fibrotic diseases |
| US20070248689A1 (en) * | 2002-05-24 | 2007-10-25 | Regents Of The University Of Michigan | Copper lowering treatment of inflammatory and fibrotic diseases |
| EA008683B1 (ru) | 2002-07-23 | 2007-06-29 | Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган | Тетрапропиламмония тетратиомолибдат и родственные соединения для антиангиогенной терапии |
| CZ303009B6 (cs) * | 2010-12-15 | 2012-02-22 | Univerzita Palackého | Komplexy medi s deriváty 2-fenyl-3-hydroxychinolin-4(1H)-onu, zpusob jejich prípravy a použití techto komplexu jako léciv v protinádorové terapii |
| CZ307046B6 (cs) * | 2015-09-02 | 2017-12-13 | Univerzita PalackĂ©ho v Olomouci | Komplexy mědi s deriváty (E)-1-(2´-hydroxyfenyl)-3-fenylprop-2-en-1-onu a jejich použití jako léčiv v protinádorové terapii |
| WO2017049529A1 (en) | 2015-09-24 | 2017-03-30 | Innolife Co., Ltd. | A pharmaceutical composition comprising a copper chelating tetramine and the use thereof |
| CN109734729B (zh) * | 2019-03-05 | 2021-03-12 | 潍坊科技学院 | 一种六核酰胺化合物的制备方法及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4657928A (en) * | 1982-05-27 | 1987-04-14 | International Copper Research Association, Inc. | Organic copper complexes as radioprotectants |
| US4966985A (en) * | 1985-12-27 | 1990-10-30 | Daicel Chemical Industries, Ltd. | Optically active carboalkylated amino alcohols and their utilization in optical resolution |
| US4965384A (en) * | 1987-09-18 | 1990-10-23 | Amoco Corporation | Production of copper amine salt complexes for catalysts for the oxidative coupling of alkylphenols |
| US5164367A (en) * | 1990-03-26 | 1992-11-17 | Procyte Corporation | Method of using copper(ii) containing compounds to accelerate wound healing |
-
1989
- 1989-12-20 MX MX018802A patent/MX172248B/es unknown
-
1990
- 1990-12-11 US US07/628,843 patent/US5107005A/en not_active Ceased
- 1990-12-20 JP JP2417939A patent/JPH04208285A/ja active Pending
- 1990-12-20 EP EP90314073A patent/EP0434444A1/en not_active Withdrawn
-
1994
- 1994-04-21 US US08/230,816 patent/USRE35458E/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5107005A (en) | 1992-04-21 |
| JPH04208285A (ja) | 1992-07-29 |
| EP0434444A1 (en) | 1991-06-26 |
| USRE35458E (en) | 1997-02-18 |
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