US6569868B2
(en)
|
1998-04-16 |
2003-05-27 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
US20040226056A1
(en)
*
|
1998-12-22 |
2004-11-11 |
Myriad Genetics, Incorporated |
Compositions and methods for treating neurological disorders and diseases
|
AU3208200A
(en)
|
1999-01-13 |
2000-08-01 |
Research Foundation Of The State University Of New York, The |
A novel method for designing protein kinase inhibitors
|
EP1255752B1
(en)
*
|
2000-02-15 |
2007-08-08 |
Sugen, Inc. |
Pyrrole substituted 2-indolinone protein kinase inhibitors
|
US7030219B2
(en)
|
2000-04-28 |
2006-04-18 |
Johns Hopkins University |
B7-DC, Dendritic cell co-stimulatory molecules
|
MY128449A
(en)
|
2000-05-24 |
2007-02-28 |
Sugen Inc |
Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
|
US6706709B2
(en)
|
2000-06-02 |
2004-03-16 |
Sugen, Inc. |
Indolinone derivatives as protein kinase/phosphatase inhibitors
|
JP2004502686A
(ja)
|
2000-06-30 |
2004-01-29 |
スージェン・インコーポレーテッド |
4−ヘテロアリール−3−ヘテロアリーリデニル−2−インドリノンおよび蛋白質キナーゼ阻害剤としてのその使用
|
TWI304061B
(en)
|
2000-10-20 |
2008-12-11 |
Eisai R&D Man Co Ltd |
Nitrogen-containing aromatic ring derivatives
|
PE20020776A1
(es)
*
|
2000-12-20 |
2002-08-22 |
Sugen Inc |
Indolinonas 4-aril sustituidas
|
AR042586A1
(es)
*
|
2001-02-15 |
2005-06-29 |
Sugen Inc |
3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
|
EP1247809A3
(en)
*
|
2001-03-30 |
2003-12-17 |
Pfizer Products Inc. |
Triazine compounds useful as sorbitol dehydrogenase inhibitors
|
US6599902B2
(en)
|
2001-05-30 |
2003-07-29 |
Sugen, Inc. |
5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
|
DE60227709D1
(de)
*
|
2001-06-29 |
2008-08-28 |
Ab Science |
Die verwendung von c-kithemmern zur behandlung von autoimmunerkrankungen
|
AR038957A1
(es)
*
|
2001-08-15 |
2005-02-02 |
Pharmacia Corp |
Terapia de combinacion para el tratamiento del cancer
|
AU2002324684B2
(en)
|
2001-08-15 |
2006-10-05 |
Pharmacia And Upjohn Company Llc |
Crystals including a malic acid salt of N-[2-(diethylamino) ethyl]-5-[(5-fluoro-2-oxo-3H-indole-3-ylidene) methyl]-2, 4-dimethyl-1H-pyrrole-3-carboxamide, processes for its preparation and compositions thereof
|
EP1436259A1
(en)
*
|
2001-09-10 |
2004-07-14 |
Congxin Liang |
3-(4,5,6,7-tetrahydroindol-2-ylmethylidiene)-2-indolinone derivatives as kinase inhibitors
|
EP1434774A1
(en)
*
|
2001-10-10 |
2004-07-07 |
Sugen, Inc. |
3-(4-substituted heterocyclyl)-pyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors
|
MXPA04003758A
(es)
*
|
2001-10-22 |
2005-06-20 |
Univ New York State Res Found |
Inhibidores de proteina - cinasas y proteina-fosfatasas, metodos para disenarlos y metodos para usarlos.
|
US7005445B2
(en)
|
2001-10-22 |
2006-02-28 |
The Research Foundation Of State University Of New York |
Protein kinase and phosphatase inhibitors and methods for designing them
|
US20030080191A1
(en)
*
|
2001-10-26 |
2003-05-01 |
Allen Lubow |
Method and apparatus for applying bar code information to products during production
|
TWI259081B
(en)
*
|
2001-10-26 |
2006-08-01 |
Sugen Inc |
Treatment of acute myeloid leukemia with indolinone compounds
|
US6797825B2
(en)
|
2001-12-13 |
2004-09-28 |
Abbott Laboratories |
Protein kinase inhibitors
|
US20030187026A1
(en)
|
2001-12-13 |
2003-10-02 |
Qun Li |
Kinase inhibitors
|
US7156308B2
(en)
*
|
2001-12-17 |
2007-01-02 |
International Barcode Corporation |
Double-sided bar code doubling as a single bar code
|
US20050131733A1
(en)
*
|
2001-12-17 |
2005-06-16 |
Allen Lubow |
Sealable individual bar coded packets
|
CA2470480C
(en)
|
2001-12-27 |
2010-12-14 |
Theravance, Inc. |
Indolinone derivatives useful as protein kinase inhibitors
|
WO2003070725A2
(en)
|
2002-02-15 |
2003-08-28 |
Pharmacia & Upjohn Company |
Process for preparing indolinone derivatives
|
US20040018528A1
(en)
*
|
2002-05-17 |
2004-01-29 |
Sugen, Inc. |
Novel biomarkers of tyrosine kinase inhibitor exposure and activity in mammals
|
ITMI20021620A1
(it)
*
|
2002-07-23 |
2004-01-23 |
Novuspharma Spa |
Composto ad ativita' antitumorale
|
US20060084697A1
(en)
*
|
2002-08-08 |
2006-04-20 |
Hallahan Dennis E |
Pi3k antagonists as radiosensitizers
|
EP1576129A4
(en)
*
|
2002-08-09 |
2008-01-23 |
Theravance Inc |
ONCOKINASE FUSION POLYPEPTIDES ASSOCIATED WITH HYPERPROLIFERATIVE DISORDERS, NUCLEIC ACIDS ENCODING THESE POLYPEPTIDES AND METHODS OF DETECTION AND IDENTIFICATION THEREOF
|
US20040121407A1
(en)
*
|
2002-09-06 |
2004-06-24 |
Elixir Pharmaceuticals, Inc. |
Regulation of the growth hormone/IGF-1 axis
|
TW200418836A
(en)
*
|
2002-09-10 |
2004-10-01 |
Pharmacia Italia Spa |
Formulations comprising an indolinone compound
|
WO2004050681A2
(en)
*
|
2002-11-15 |
2004-06-17 |
Exelixis, Inc. |
Kinase modulators
|
AR042042A1
(es)
*
|
2002-11-15 |
2005-06-08 |
Sugen Inc |
Administracion combinada de una indolinona con un agente quimioterapeutico para trastornos de proliferacion celular
|
US7452913B2
(en)
|
2003-02-24 |
2008-11-18 |
Pharmacia & Upjohn Company |
Polymorphs of pyrrole substituted 2-indolinone protein kinase inhibitors
|
US20040209937A1
(en)
*
|
2003-02-24 |
2004-10-21 |
Sugen, Inc. |
Treatment of excessive osteolysis with indolinone compounds
|
DK2476667T3
(da)
|
2003-02-26 |
2014-09-15 |
Sugen Inc |
Aminoheteroaryl-forbindelser som proteinkinase-inhibitorer
|
US20040266843A1
(en)
*
|
2003-03-07 |
2004-12-30 |
Sugen, Inc. |
Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK)
|
US7157577B2
(en)
*
|
2003-03-07 |
2007-01-02 |
Sugen Inc. |
5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors
|
US7994159B2
(en)
*
|
2003-03-10 |
2011-08-09 |
Eisai R&D Management Co., Ltd. |
c-Kit kinase inhibitor
|
US20050043233A1
(en)
|
2003-04-29 |
2005-02-24 |
Boehringer Ingelheim International Gmbh |
Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
|
DE10334582A1
(de)
*
|
2003-07-28 |
2005-02-24 |
Basf Ag |
Verfahren zur Herstellung von Maleinsäureanhydrid
|
WO2005023765A1
(en)
*
|
2003-09-11 |
2005-03-17 |
Pharmacia & Upjohn Company Llc |
Method for catalyzing amidation reactions by the presence of co2
|
KR20080007520A
(ko)
*
|
2003-10-02 |
2008-01-21 |
파마시아 앤드 업존 캄파니 엘엘씨 |
피롤-치환된 인돌리논 화합물의 염 및 다형체
|
SI1680140T1
(sl)
*
|
2003-10-16 |
2011-08-31 |
Imclone Llc |
Inhibitorji receptorja-1 za fibroblastni rastni faktor in metode za zdravljenje z le-temi
|
KR101224410B1
(ko)
|
2003-11-07 |
2013-01-23 |
노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 |
퀴놀리논 화합물을 합성하는 방법
|
JP4303726B2
(ja)
|
2003-11-11 |
2009-07-29 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
ウレア誘導体およびその製造方法
|
MXPA06006049A
(es)
*
|
2003-11-26 |
2007-05-24 |
Scripps Research Inst |
Inhibidores de proteina quinasa avanzados a base de indolinona.
|
JP2007513967A
(ja)
*
|
2003-12-11 |
2007-05-31 |
セラヴァンス, インコーポレーテッド |
変異レセプターチロシンキナーゼが駆動する細胞増殖性疾患の処置において使用するための組成物
|
US20050152943A1
(en)
*
|
2003-12-23 |
2005-07-14 |
Medtronic Vascular, Inc. |
Medical devices to treat or inhibit restenosis
|
WO2005118543A1
(ja)
*
|
2004-06-03 |
2005-12-15 |
Ono Pharmaceutical Co., Ltd. |
キナーゼ阻害薬およびその用途
|
EP1765313A2
(en)
|
2004-06-24 |
2007-03-28 |
Novartis Vaccines and Diagnostics, Inc. |
Compounds for immunopotentiation
|
SE0401790D0
(sv)
*
|
2004-07-07 |
2004-07-07 |
Forskarpatent I Syd Ab |
Tamoxifen response in pre- and postmenopausal breast cancer patients
|
US20060009510A1
(en)
*
|
2004-07-09 |
2006-01-12 |
Pharmacia & Upjohn Company Llc |
Method of synthesizing indolinone compounds
|
KR100859891B1
(ko)
*
|
2004-08-26 |
2008-09-23 |
화이자 인코포레이티드 |
단백질 키나제 억제제로서 거울상이성질체적으로 순수한아미노헤테로아릴 화합물
|
US8969379B2
(en)
|
2004-09-17 |
2015-03-03 |
Eisai R&D Management Co., Ltd. |
Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide
|
CN100432071C
(zh)
*
|
2004-11-05 |
2008-11-12 |
中国科学院上海药物研究所 |
取代1h-吲哚-2-酮类化合物及其制备方法和用途
|
GT200500321A
(es)
*
|
2004-11-09 |
2006-09-04 |
|
Compuestos y composiciones como inhibidores de proteina kinase.
|
EP1863532A1
(en)
*
|
2005-03-23 |
2007-12-12 |
Pfizer Products Incorporated |
Anti-ctla4 antibody and indolinone combination therapy for treatment of cancer
|
BRPI0608096A2
(pt)
|
2005-04-26 |
2009-11-10 |
Pfizer |
anticorpos p-caderina
|
US20080193448A1
(en)
*
|
2005-05-12 |
2008-08-14 |
Pfizer Inc. |
Combinations and Methods of Using an Indolinone Compound
|
KR20080019236A
(ko)
|
2005-05-18 |
2008-03-03 |
어레이 바이오파마 인크. |
Mek의 헤테로시클릭 억제제 및 그의 사용 방법
|
SG154451A1
(en)
|
2005-05-23 |
2009-08-28 |
Novartis Ag |
Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1- yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one lactic acid salts
|
WO2006127961A1
(en)
*
|
2005-05-26 |
2006-11-30 |
The Scripps Research Institute |
Enhanced indolinone based protein kinase inhibitors
|
JP5066446B2
(ja)
|
2005-08-01 |
2012-11-07 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
血管新生阻害物質の効果を予測する方法
|
EP1925676A4
(en)
|
2005-08-02 |
2010-11-10 |
Eisai R&D Man Co Ltd |
TEST METHOD FOR THE EFFECT OF A VASCULARIZATION INHIBITOR
|
PL2960253T3
(pl)
|
2005-09-07 |
2018-11-30 |
Amgen Fremont Inc. |
Ludzkie przeciwciała monoklonalne przeciwko kinazie podobnej do receptora aktywiny-1
|
KR101050906B1
(ko)
*
|
2005-09-19 |
2011-07-20 |
화이자 프로덕츠 인크. |
피롤 치환된 2-인돌리논의 고체 염 형태
|
AU2006309551B2
(en)
*
|
2005-11-07 |
2012-04-19 |
Eisai R & D Management Co., Ltd. |
Use of combination of anti-angiogenic substance and c-kit kinase inhibitor
|
UA96139C2
(uk)
|
2005-11-08 |
2011-10-10 |
Дженентек, Інк. |
Антитіло до нейропіліну-1 (nrp1)
|
US20080269212A1
(en)
*
|
2005-12-29 |
2008-10-30 |
The Scripps Research Institute |
Amino acid derivatives of indolinone based protein kinase inhibitors
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
CN101007801A
(zh)
*
|
2006-01-27 |
2007-08-01 |
上海恒瑞医药有限公司 |
吡咯取代的2-二氢吲哚酮衍生物、其制法与医药上的用途
|
AR060358A1
(es)
|
2006-04-06 |
2008-06-11 |
Novartis Vaccines & Diagnostic |
Quinazolinas para la inhibicion de pdk 1
|
TW200813091A
(en)
|
2006-04-10 |
2008-03-16 |
Amgen Fremont Inc |
Targeted binding agents directed to uPAR and uses thereof
|
MX2008013430A
(es)
|
2006-04-19 |
2009-01-26 |
Novartis Vaccines & Diagnostic |
Compuestos de indazol y metodos para la inhibición de cdc7.
|
BRPI0711358A2
(pt)
|
2006-05-09 |
2011-09-27 |
Pfizer Prod Inc |
derivados do ácido cicloalquilamino e suas composições farmacêuticas
|
CN101443009A
(zh)
*
|
2006-05-18 |
2009-05-27 |
卫材R&D管理有限公司 |
针对甲状腺癌的抗肿瘤剂
|
DE102006024834B4
(de)
*
|
2006-05-24 |
2010-07-01 |
Schebo Biotech Ag |
Neue Indol-Pyrrol-Derivate und deren Verwendungen
|
WO2008001956A1
(fr)
*
|
2006-06-29 |
2008-01-03 |
Eisai R & D Management Co., Ltd. |
Agent thérapeutique contre la fibrose hépatique
|
US7838542B2
(en)
|
2006-06-29 |
2010-11-23 |
Kinex Pharmaceuticals, Llc |
Bicyclic compositions and methods for modulating a kinase cascade
|
WO2008008981A1
(en)
|
2006-07-13 |
2008-01-17 |
Zymogenetics, Inc. |
Interleukin 21 and tyrosine kinase inhibitor combination therapy
|
CL2007002225A1
(es)
|
2006-08-03 |
2008-04-18 |
Astrazeneca Ab |
Agente de union especifico para un receptor del factor de crecimiento derivado de plaquetas (pdgfr-alfa); molecula de acido nucleico que lo codifica; vector y celula huesped que la comprenden; conjugado que comprende al agente; y uso del agente de un
|
CL2007002261A1
(es)
|
2006-08-04 |
2008-05-02 |
Takeda Pharmaceutical |
Compuestos derivados de imidazo[1,2-b]piridazina, inhibidores de quinasa; composicion farmaceutica; y uso en el tratamiento o prevencion del cancer.
|
RU2445312C2
(ru)
|
2006-08-23 |
2012-03-20 |
Кудос Фармасьютиклз Лимитед |
ПРОИЗВОДНЫЕ 2-МЕТИЛМОРФОЛИН ПИРИДО-, ПИРАЗО- И ПИРИМИДО-ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ mTOR
|
WO2008026748A1
(fr)
|
2006-08-28 |
2008-03-06 |
Eisai R & D Management Co., Ltd. |
Agent antitumoral pour cancer gastrique non différencié
|
KR101507375B1
(ko)
|
2006-09-15 |
2015-04-07 |
엑스커버리 홀딩 컴퍼니 엘엘씨 |
키나아제 억제제 화합물
|
EP2130829A4
(en)
*
|
2006-11-06 |
2010-12-01 |
Theravalues Corp |
NEW HYDROXYINDOLE DERIVATIVE
|
EP2086979B1
(en)
|
2006-11-06 |
2015-06-03 |
Tolero Pharmaceuticals, Inc. |
Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
|
ES2383084T3
(es)
|
2006-12-04 |
2012-06-18 |
Jiangsu Simcere Pharmaceutical R&D Co., Ltd. |
Derivados de 3-pirrolo[b]ciclohexilen-2-dihidroindolinona y usos de los mismos
|
AU2008211952B2
(en)
|
2007-01-29 |
2012-07-19 |
Eisai R & D Management Co., Ltd. |
Composition for treatment of undifferentiated-type of gastric cancer
|
CA2677365A1
(en)
|
2007-02-06 |
2008-08-14 |
Pfizer Inc. |
2-amino-5, 7-dihydro-6h-pyrrolo [3, 4-d] pyrimidine derivatives as hsp- 90 inhibitors for treating cancer
|
US8044056B2
(en)
|
2007-03-20 |
2011-10-25 |
Dainippon Sumitomo Pharma Co., Ltd. |
Adenine compound
|
US20090004213A1
(en)
*
|
2007-03-26 |
2009-01-01 |
Immatics Biotechnologies Gmbh |
Combination therapy using active immunotherapy
|
US20090042906A1
(en)
*
|
2007-04-26 |
2009-02-12 |
Massachusetts Institute Of Technology |
Methods for treating cancers associated with constitutive egfr signaling
|
WO2008138184A1
(fr)
|
2007-05-14 |
2008-11-20 |
Shanghai Hengrui Pharmaceutical Co.Ltd. |
Dérivés de pyrrolo-azacycles, leur procédé de fabrication et leur utilisation en tant qu'inhibiteurs de protéine kinases
|
WO2008145398A1
(en)
*
|
2007-06-01 |
2008-12-04 |
Pfizer Italia S.R.L. |
4-arylpyrrole substituted 2-indoline derivatives active as protein kinase inhibitors
|
EP2162445B1
(en)
|
2007-06-05 |
2013-11-27 |
Takeda Pharmaceutical Company Limited |
Heterobicyclic compounds as kinase inhibitors
|
US8324395B2
(en)
|
2007-08-23 |
2012-12-04 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound and use thereof
|
US20090062368A1
(en)
*
|
2007-08-29 |
2009-03-05 |
Protia, Llc |
Deuterium-enriched sunitinib
|
CA2736177A1
(en)
|
2007-09-06 |
2009-03-12 |
Boston Biomedical, Inc. |
Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases
|
MY150059A
(en)
|
2007-10-11 |
2013-11-29 |
Astrazeneca Ab |
Pyrrolo [2,3-d] pyrimidin derivatives as protein kinase b inhibitors
|
EP2218712B1
(en)
|
2007-11-09 |
2015-07-01 |
Eisai R&D Management Co., Ltd. |
Combination of anti-angiogenic substance and anti-tumor platinum complex
|
CA2699305A1
(en)
*
|
2007-11-21 |
2009-05-28 |
Teva Pharmaceutical Industries Ltd. |
Polymorphs of sunitinib base and processes for preparation thereof
|
US20100256392A1
(en)
*
|
2007-11-21 |
2010-10-07 |
Teva Pharmaceutical Industries Ltd. |
Polymorphs of sunitinib base and processes for preparation thereof
|
WO2009074862A1
(en)
*
|
2007-12-12 |
2009-06-18 |
Medichem S.A. |
Polymorphic forms of a 3-pyrrole substituted 2-indolinone
|
AR069803A1
(es)
|
2007-12-19 |
2010-02-17 |
Genentech Inc |
5- anilinoimiazopiridinas y metodos de uso
|
CN101952282A
(zh)
|
2007-12-20 |
2011-01-19 |
诺瓦提斯公司 |
用作pi 3激酶抑制剂的噻唑衍生物
|
CN101945875B
(zh)
|
2007-12-21 |
2013-04-24 |
健泰科生物技术公司 |
氮杂吲嗪及其使用方法
|
JP5399926B2
(ja)
*
|
2008-01-29 |
2014-01-29 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
血管阻害物質とタキサンとの併用
|
EP2113248A1
(en)
|
2008-04-29 |
2009-11-04 |
Ratiopharm GmbH |
Pharmaceutical composition comprising N-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2-,4-dimethyl-1H-pyrrole-3-carboxamide
|
CA2713112A1
(en)
*
|
2008-02-13 |
2009-08-20 |
Ratiopharm Gmbh |
Pharmaceutical compositions comprising n-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide
|
EP2090306A1
(en)
|
2008-02-13 |
2009-08-19 |
Ratiopharm GmbH |
Pharmaceutical compositions comprising N-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
|
CN101255154B
(zh)
*
|
2008-02-18 |
2011-09-07 |
靳广毅 |
一种取代的2-吲哚啉酮衍生物和制备方法及其应用
|
CN101983195A
(zh)
*
|
2008-02-21 |
2011-03-02 |
基因里克斯(英国)有限公司 |
新型多晶型物及其制备方法
|
EP2098521A1
(en)
|
2008-03-06 |
2009-09-09 |
Ratiopharm GmbH |
Crystal forms of N-[2-(diethylamino) ethyl]-5-[fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrolle-3-carboxamide and methods for their prepparation
|
EP2274303B1
(en)
*
|
2008-03-31 |
2012-08-29 |
Teva Pharmaceutical Industries Ltd. |
Processes for preparing sunitinib and salts thereof
|
KR20100135910A
(ko)
|
2008-04-16 |
2010-12-27 |
낫코 파마 리미티드 |
수니티닙 염기의 신규한 다형 형태
|
US8158656B2
(en)
*
|
2008-05-16 |
2012-04-17 |
Shenzhen Chipscreen Biosciences Ltd. |
2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors
|
EP2292613B1
(en)
*
|
2008-05-23 |
2015-09-30 |
Shanghai Institute of Pharmaceutical Industry |
Dihydroindolinone derivatives
|
US8263547B2
(en)
|
2008-05-28 |
2012-09-11 |
Massachusetts Institute Of Technology |
DISC-1 pathway activators in the control of neurogenesis
|
ES2392762T3
(es)
*
|
2008-06-13 |
2012-12-13 |
Medichem, S.A. |
Procedimiento para preparar una sal de malato de 2-indolinona sustituida con 3-pirrol
|
US8501962B2
(en)
|
2008-06-23 |
2013-08-06 |
Natco Pharma Limited |
Process for the preparation of high purity sunitinib and its pharmaceutically acceptable salt
|
EP2138167A1
(en)
*
|
2008-06-24 |
2009-12-30 |
ratiopharm GmbH |
Pharmaceutical composition comprising N-[2-(Diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene) methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
|
WO2009156837A2
(en)
*
|
2008-06-26 |
2009-12-30 |
Medichem, S.A. |
Amorphous form of a 3-pyrrole substituted 2-indolinone malate salt
|
AU2009269149B2
(en)
|
2008-06-30 |
2016-03-17 |
Mesoblast, Inc. |
Treatment of eye diseases and excessive neovascularization using a combined therapy
|
KR20110025996A
(ko)
*
|
2008-06-30 |
2011-03-14 |
사일린 파마슈티칼스, 인크 |
옥신돌 화합물
|
DE102008031038A1
(de)
|
2008-06-30 |
2009-12-31 |
Alexander Priv.-Doz. Dr. Dömling |
Sutent zur Anwendung in der Organtransplantation
|
EP2318364A2
(en)
*
|
2008-07-02 |
2011-05-11 |
Generics [UK] Limited |
Preparation of 3-pyrrole substituted 2-indolinone derivatives
|
CN102203085A
(zh)
*
|
2008-07-10 |
2011-09-28 |
基因里克斯(英国)有限公司 |
用于制备苹果酸舒尼替尼晶体形式的新方法
|
KR20110036588A
(ko)
|
2008-07-24 |
2011-04-07 |
테바 파마슈티컬 인더스트리즈 리미티드 |
수니티닙 아세테이트 및 이의 다형을 통한 수니티닙 말레이트의 제조 방법
|
EP2342195B1
(en)
|
2008-07-24 |
2014-09-10 |
Medichem, S.A. |
Crystalline forms of a 3-pyrrole substituted 2-indolinone malate salt
|
US8993615B2
(en)
*
|
2008-08-08 |
2015-03-31 |
The Johns Hopkins University |
Compositions and methods for treatment of neurodegenerative disease
|
WO2010023473A2
(en)
*
|
2008-08-25 |
2010-03-04 |
Generics [Uk] Limited |
Novel crystalline form and processes for its preparation
|
US20110223188A1
(en)
*
|
2008-08-25 |
2011-09-15 |
Solomon Langermann |
Targeted costimulatory polypeptides and methods of use to treat cancer
|
CA2735084A1
(en)
*
|
2008-08-25 |
2010-03-04 |
Generics [Uk] Limited |
Novel polymorphs of sunitinib and processes for their preparation
|
PE20110435A1
(es)
|
2008-08-25 |
2011-07-20 |
Amplimmune Inc |
Composiciones antagonistas del pd-1
|
RU2535975C2
(ru)
*
|
2008-09-05 |
2014-12-20 |
Империал Инновейшнз Лимитед |
Производные изатина для применения в качестве агентов визуализации in vivo
|
CA2735900A1
(en)
|
2008-09-19 |
2010-03-25 |
Medimmune, Llc |
Antibodies directed to dll4 and uses thereof
|
AR073807A1
(es)
*
|
2008-10-10 |
2010-12-01 |
Medichem Sa |
Proceso para preparar el malato de sunitinib, sal de un acido mas debil que el malato como compuesto intermediario, y proceso para preparar dicha sal intermediaria.
|
EP2181991A1
(en)
*
|
2008-10-28 |
2010-05-05 |
LEK Pharmaceuticals D.D. |
Novel salts of sunitinib
|
EP2186809A1
(en)
|
2008-11-13 |
2010-05-19 |
LEK Pharmaceuticals D.D. |
New crystal form of sunitinib malate
|
US20100222371A1
(en)
*
|
2008-11-20 |
2010-09-02 |
Children's Medical Center Corporation |
Prevention of surgical adhesions
|
WO2010064611A1
(ja)
|
2008-12-01 |
2010-06-10 |
武田薬品工業株式会社 |
複素環化合物およびその用途
|
JO3101B1
(ar)
|
2008-12-02 |
2017-09-20 |
Takeda Pharmaceuticals Co |
مشتقات بنزوثيازول كعوامل مضادة للسرطان
|
TW201028410A
(en)
|
2008-12-22 |
2010-08-01 |
Astrazeneca Ab |
Chemical compounds 610
|
US20120114667A1
(en)
|
2008-12-23 |
2012-05-10 |
Medimmune Limited |
TARGETED BINDING AGENTS DIRECTED TO a5BETA1 AND USES THEREOF
|
EP2896618A1
(en)
|
2009-01-02 |
2015-07-22 |
Hetero Research Foundation |
Polymorphs of sunitinib malate
|
TWI577664B
(zh)
|
2009-01-16 |
2017-04-11 |
艾克塞里克斯公司 |
N-(4-{〔6,7-雙(甲氧基)喹啉-4-基〕氧基}苯基)-n’-(4-氟苯基)環丙烷-1,1-二甲醯胺蘋果酸鹽、包含其之醫藥組合物及其用途
|
KR101835033B1
(ko)
|
2009-02-05 |
2018-03-08 |
이뮤노젠 아이엔씨 |
신규한 벤조디아제핀 유도체
|
CN102307875A
(zh)
|
2009-02-09 |
2012-01-04 |
苏伯俭股份有限公司 |
吡咯并嘧啶基axl激酶抑制剂
|
US9265764B2
(en)
*
|
2009-02-27 |
2016-02-23 |
Massachusetts Institute Of Technology |
Uses of chemicals to modulate GSK-3 signaling for treatment of bipolar disorder and other brain disorders
|
TW201035088A
(en)
|
2009-02-27 |
2010-10-01 |
Supergen Inc |
Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors
|
WO2010103094A1
(en)
|
2009-03-13 |
2010-09-16 |
Cellzome Limited |
PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
|
WO2010108503A1
(en)
|
2009-03-24 |
2010-09-30 |
Life & Brain Gmbh |
Promotion of neuronal integration in neural stem cell grafts
|
US20120040955A1
(en)
|
2009-04-14 |
2012-02-16 |
Richard John Harrison |
Fluoro substituted pyrimidine compounds as jak3 inhibitors
|
US8530492B2
(en)
|
2009-04-17 |
2013-09-10 |
Nektar Therapeutics |
Oligomer-protein tyrosine kinase inhibitor conjugates
|
EP2255792A1
(en)
|
2009-05-20 |
2010-12-01 |
Ratiopharm GmbH |
Pharmaceutical compositions for N-[2-(Diethylamino)ethyl]5-[(fluoro-1,2-dihydro-2-oxo-3H-indole-3-ylidene) methyl]-2,4-dimenthyl-1H-pyrrole-3-carboxamide
|
US8211901B2
(en)
|
2009-05-22 |
2012-07-03 |
Shenzhen Chipscreen Biosciences Ltd. |
Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors
|
EP2264027A1
(en)
*
|
2009-05-27 |
2010-12-22 |
Ratiopharm GmbH |
Process for the preparation of N-[2-(Diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene) methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
|
US8389580B2
(en)
|
2009-06-02 |
2013-03-05 |
Duke University |
Arylcyclopropylamines and methods of use
|
CN101906076B
(zh)
|
2009-06-04 |
2013-03-13 |
深圳微芯生物科技有限责任公司 |
作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用
|
US8293753B2
(en)
|
2009-07-02 |
2012-10-23 |
Novartis Ag |
Substituted 2-carboxamide cycloamino ureas
|
WO2011004200A1
(en)
|
2009-07-10 |
2011-01-13 |
Generics [Uk] Limited |
Novel pyrrole derivatives
|
FR2948940B1
(fr)
*
|
2009-08-04 |
2011-07-22 |
Servier Lab |
Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
EP2475648A1
(en)
|
2009-09-11 |
2012-07-18 |
Cellzome Limited |
Ortho substituted pyrimidine compounds as jak inhibitors
|
EP2477978A1
(en)
|
2009-09-16 |
2012-07-25 |
Ranbaxy Laboratories Limited |
Salts of sunitinib
|
TW201125867A
(en)
|
2009-10-20 |
2011-08-01 |
Cellzome Ltd |
Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors
|
US20120271056A1
(en)
|
2009-11-12 |
2012-10-25 |
Ranbaxy Laboratories Limited |
Process for the preparation of crystalline form i of l-malic acid salt of sunitinib
|
US8916716B2
(en)
|
2009-11-19 |
2014-12-23 |
Ranbaxy Laboratories Limited |
Process for the preparation of crystalline form II of L-malic acid salt of sunitinib
|
RS56469B1
(sr)
|
2009-11-24 |
2018-01-31 |
Medimmune Ltd |
Ciljano vezujući agensi usmereni na b7-h1
|
JP2013512859A
(ja)
|
2009-12-03 |
2013-04-18 |
大日本住友製薬株式会社 |
トール様受容体(tlr)を介して作用するイミダゾキノリン
|
US10166142B2
(en)
|
2010-01-29 |
2019-01-01 |
Forsight Vision4, Inc. |
Small molecule delivery with implantable therapeutic device
|
WO2011095802A1
(en)
|
2010-02-02 |
2011-08-11 |
Generics [Uk] Limited |
Hplc method for analyzing sunitinib
|
WO2011100325A2
(en)
|
2010-02-09 |
2011-08-18 |
Sicor Inc. |
Polymorphs of sunitinib salts
|
RU2573994C2
(ru)
|
2010-02-10 |
2016-01-27 |
Иммьюноджен, Инк |
Антитела против cd20 и их применение
|
EP2539337A1
(en)
|
2010-02-22 |
2013-01-02 |
F. Hoffmann-La Roche AG |
Pyrido[3,2-d]pyrimidine pi3k delta inhibitor compounds and methods of use
|
WO2011104555A2
(en)
|
2010-02-25 |
2011-09-01 |
Generics [Uk] Limited |
Novel process
|
US20130123511A1
(en)
|
2010-03-04 |
2013-05-16 |
Ranbaxy Laboratories Limited |
Process for the direct preparation of malic acid salt of sunitinib
|
EP2542536B1
(en)
|
2010-03-04 |
2015-01-21 |
Cellzome Limited |
Morpholino substituted urea derivatives as mtor inhibitors
|
WO2011110199A1
(en)
|
2010-03-10 |
2011-09-15 |
Synthon B.V. |
A process for amidation of pyrrole carboxylate compounds
|
WO2011114246A1
(en)
|
2010-03-18 |
2011-09-22 |
Ranbaxy Laboratories Limited |
Process for the preparation of malic acid salt of sunitinib
|
US9162981B2
(en)
|
2010-03-23 |
2015-10-20 |
The Johns Hopkins University |
Compositions and methods for treatment of neurodegenerative disease
|
WO2011128699A2
(en)
|
2010-04-16 |
2011-10-20 |
Generics [Uk] Limited |
Novel process
|
JP2013525392A
(ja)
|
2010-04-30 |
2013-06-20 |
セルゾーム リミティッド |
Jak阻害剤としてのピラゾール化合物
|
WO2011138565A1
(fr)
|
2010-05-05 |
2011-11-10 |
Biorebus |
Association pharmaceutique contenant l'acide lipoïque, l'acide hydroxycitrique et une somatostatine a titre de principes actifs
|
EP2392324A1
(en)
|
2010-06-01 |
2011-12-07 |
Societe De Coordination De Recherches Therapeutiques |
Rhenium complexes and their pharmaceutical use
|
SA111320519B1
(ar)
|
2010-06-11 |
2014-07-02 |
Astrazeneca Ab |
مركبات بيريميدينيل للاستخدام كمثبطات atr
|
ES2573515T3
(es)
|
2010-06-25 |
2016-06-08 |
Eisai R&D Management Co., Ltd. |
Agente antitumoral que emplea compuestos con efecto inhibitorio de cinasas combinados
|
WO2012000970A1
(en)
|
2010-07-01 |
2012-01-05 |
Cellzome Limited |
Triazolopyridines as tyk2 inhibitors
|
EP2591004A1
(en)
|
2010-07-09 |
2013-05-15 |
F.Hoffmann-La Roche Ag |
Anti-neuropilin antibodies and methods of use
|
AR082418A1
(es)
|
2010-08-02 |
2012-12-05 |
Novartis Ag |
Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
|
JP2013534233A
(ja)
|
2010-08-20 |
2013-09-02 |
セルゾーム リミティッド |
選択的jak阻害剤としてのヘテロシクリルピラゾロピリミジン類似体
|
US8426418B2
(en)
|
2010-08-27 |
2013-04-23 |
CollabRx Inc. |
Method to treat melanoma in BRAF inhibitor-resistant subjects
|
WO2012042421A1
(en)
|
2010-09-29 |
2012-04-05 |
Pfizer Inc. |
Method of treating abnormal cell growth
|
CA2816559C
(en)
|
2010-11-01 |
2018-02-13 |
Scinopharm (Kunshan) Biochemical Technology Co., Ltd. |
Processes for the preparation of 3-((pyrrol-2-yl)methylene)-2-pyrrolones using 2-silyloxy-pyrroles
|
WO2012059941A1
(en)
*
|
2010-11-04 |
2012-05-10 |
Ind-Swift Laboratories Limited |
Process for preparation of sunitinib malate and salts thereof
|
JP2014500254A
(ja)
|
2010-11-09 |
2014-01-09 |
セルゾーム リミティッド |
Tyk2阻害剤としてのピリジン化合物およびそのアザ類似体
|
WO2012068487A1
(en)
|
2010-11-18 |
2012-05-24 |
Synta Pharmaceuticals Corp. |
Preselection of subjects for therapeutic treatment with oxygen sensitive agents based on hypoxic status
|
WO2012068549A2
(en)
|
2010-11-19 |
2012-05-24 |
Forsight Vision4, Inc. |
Therapeutic agent formulations for implanted devices
|
AR083868A1
(es)
|
2010-12-03 |
2013-03-27 |
Lilly Co Eli |
Compuestos de oxazol[5,4-b]piridin-5-ilo
|
US10220020B2
(en)
|
2010-12-23 |
2019-03-05 |
Nektar Therapeutics |
Polymer-des-ethyl sunitinib conjugates
|
WO2012088529A1
(en)
*
|
2010-12-23 |
2012-06-28 |
Nektar Therapeutics |
Polymer-sunitinib conjugates
|
UY33883A
(es)
|
2011-01-31 |
2012-08-31 |
Novartis Ag |
Novedosos derivados heterocíclicos
|
CA2824864C
(en)
|
2011-02-15 |
2019-04-09 |
Immunogen, Inc. |
Cytotoxic benzodiazepine derivatives
|
JP5937111B2
(ja)
|
2011-02-17 |
2016-06-22 |
カンサー・セラピューティクス・シーアールシー・プロプライエタリー・リミテッドCancer Therapeutics Crc Pty Limited |
Fak阻害剤
|
US9174946B2
(en)
|
2011-02-17 |
2015-11-03 |
Cancer Therapeutics Crc Pty Ltd |
Selective FAK inhibitors
|
GB201103578D0
(en)
|
2011-03-02 |
2011-04-13 |
Sabrepharm Ltd |
Dipyridinium derivatives
|
US8630703B2
(en)
|
2011-03-09 |
2014-01-14 |
Technion Research & Development Foundation Limited |
Treatment utilizing hydrophobic weak bases chemotherapeutic agents and illumination
|
CN102115469A
(zh)
*
|
2011-03-21 |
2011-07-06 |
浙江大学 |
吲哚啉-2-酮类衍生物的制备和用途
|
JP2014510122A
(ja)
|
2011-04-04 |
2014-04-24 |
セルゾーム リミテッド |
mTOR阻害剤としてのジヒドロピロロピリミジン誘導体
|
EP2694058B1
(en)
*
|
2011-04-08 |
2015-11-04 |
Beta Pharma, Inc. |
New indolinone protein kinase inhibitors
|
WO2012143320A1
(en)
|
2011-04-18 |
2012-10-26 |
Cellzome Limited |
(7h-pyrrolo[2,3-d]pyrimidin-2-yl)amine compounds as jak3 inhibitors
|
US8962650B2
(en)
|
2011-04-18 |
2015-02-24 |
Eisai R&D Management Co., Ltd. |
Therapeutic agent for tumor
|
CN102898402B
(zh)
*
|
2011-04-26 |
2016-01-20 |
北京大学 |
一种苯并异硒唑酮修饰的吡咯甲酸酯取代的吲哚酮类化合物及其应用
|
JP6038128B2
(ja)
|
2011-06-03 |
2016-12-07 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
|
HUE052198T2
(hu)
|
2011-07-21 |
2021-04-28 |
Sumitomo Dainippon Pharma Oncology Inc |
Heterociklusos protein kináz inhibitorok
|
BR112014000360A2
(pt)
|
2011-07-28 |
2017-02-14 |
Cellzome Ltd |
análogos de heterociclil pirimidina como inibidores jak
|
WO2013017479A1
(en)
|
2011-07-29 |
2013-02-07 |
Cellzome Limited |
Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
|
WO2013017480A1
(en)
|
2011-07-29 |
2013-02-07 |
Cellzome Limited |
Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
|
RU2014115476A
(ru)
|
2011-09-20 |
2015-10-27 |
Целльзом Лимитед |
Производные пиразоло[4, 3-с]птридина в качестве ингибиторов киназ
|
EP2758379B1
(en)
|
2011-09-21 |
2016-10-19 |
Cellzome Limited |
Urea and carbamate derivatives of 2-morpholino-1,3,5-triazine as mTOR inhibitors for the treatment of immunological or proliferative diseases
|
AU2012320465B2
(en)
|
2011-10-07 |
2016-03-03 |
Cellzome Limited |
Morpholino substituted bicyclic pyrimidine urea or carbamate derivatives as mTOR inhibitors
|
CN102499917B
(zh)
|
2011-10-25 |
2014-12-17 |
澳门大学 |
吲哚酮类化合物在制备神经保护药物中的应用
|
MX340452B
(es)
|
2011-10-28 |
2016-07-08 |
Novartis Ag |
Novedosos derivados de purina y su uso en el tratamiento de enfermedades.
|
CN103130774B
(zh)
*
|
2011-11-22 |
2016-06-22 |
齐鲁制药有限公司 |
具有酪氨酸激酶抑制作用的化合物及其制备方法和应用
|
CN103127096B
(zh)
*
|
2011-12-02 |
2015-11-25 |
杨子娇 |
吡咯基取代的吲哚类化合物在治疗青光眼病的应用
|
BR112014015723A8
(pt)
|
2011-12-23 |
2017-07-04 |
Cellzome Ltd |
derivados de pirimidino-2,4-diamina como inibidores da quinase
|
US20130178520A1
(en)
|
2011-12-23 |
2013-07-11 |
Duke University |
Methods of treatment using arylcyclopropylamine compounds
|
CN102491932A
(zh)
*
|
2011-12-26 |
2012-06-13 |
天津科技大学 |
一种3-吲哚啉酮类衍生物及其制备方法及其应用
|
CN104114550A
(zh)
|
2012-03-23 |
2014-10-22 |
劳拉斯实验室私人有限公司 |
制备舒尼替尼及其酸加成盐的改进的方法
|
ES2621257T3
(es)
|
2012-04-20 |
2017-07-03 |
Annji Pharmaceutical Co., Ltd. |
Ésteres de ciclopropanocarboxilato de análogos de purinas
|
CN102653521B
(zh)
*
|
2012-04-27 |
2014-08-06 |
首都师范大学 |
吲哚-2-酮的哌嗪硫代甲酰肼衍生物及其制备方法和用途
|
PL399027A1
(pl)
|
2012-04-27 |
2013-10-28 |
Instytut Farmaceutyczny |
Sposób otrzymywania N-[2-(dietylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamidu o wysokiej czystosci i jego zastosowanie do wytwarzania sunitynibu
|
PL2844282T3
(pl)
|
2012-05-04 |
2019-11-29 |
Pfizer |
Antygeny związane z gruczołem krokowym i schematy immunoterapii oparte na szczepionce
|
AU2013263043B2
(en)
|
2012-05-16 |
2016-06-16 |
Novartis Ag |
Dosage regimen for a PI-3 kinase inhibitor
|
KR102172897B1
(ko)
|
2012-06-08 |
2020-11-02 |
서트로 바이오파마, 인크. |
부위-특이적 비-천연 아미노산 잔기를 포함하는 항체, 그의 제조 방법 및 그의 사용 방법
|
WO2014004639A1
(en)
|
2012-06-26 |
2014-01-03 |
Sutro Biopharma, Inc. |
Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
|
CN104736533B
(zh)
|
2012-08-17 |
2016-12-07 |
癌症治疗合作研究中心有限公司 |
Vegfr3抑制剂
|
EP2887965A1
(en)
|
2012-08-22 |
2015-07-01 |
ImmunoGen, Inc. |
Cytotoxic benzodiazepine derivatives
|
PL3584255T3
(pl)
|
2012-08-31 |
2022-05-16 |
Sutro Biopharma, Inc. |
Modyfikowane aminokwasy zawierające grupę azydkową
|
WO2014041349A1
(en)
|
2012-09-12 |
2014-03-20 |
Cancer Therapeutics Crc Pty Ltd |
Tetrahydropyran-4-ylethylamino- or tetrahydropyranyl-4-ethyloxy-pyrimidines or -pyridazines as isoprenylcysteincarboxymethyl transferase inhibitors
|
WO2014045101A1
(en)
|
2012-09-21 |
2014-03-27 |
Cellzome Gmbh |
Tetrazolo quinoxaline derivatives as tankyrase inhibitors
|
WO2014062838A2
(en)
|
2012-10-16 |
2014-04-24 |
Tolero Pharmaceuticals, Inc. |
Pkm2 modulators and methods for their use
|
US9260426B2
(en)
|
2012-12-14 |
2016-02-16 |
Arrien Pharmaceuticals Llc |
Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
|
KR20150098605A
(ko)
|
2012-12-21 |
2015-08-28 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
퀴놀린 유도체의 비정질 형태 및 그의 제조방법
|
EP2961434A2
(en)
|
2013-02-28 |
2016-01-06 |
ImmunoGen, Inc. |
Conjugates comprising cell-binding agents and cytotoxic agents
|
EP2961435B1
(en)
|
2013-02-28 |
2019-05-01 |
ImmunoGen, Inc. |
Conjugates comprising cell-binding agents and cytotoxic agents
|
MX2015011456A
(es)
*
|
2013-03-13 |
2016-05-31 |
Boston Biomedical Inc |
Derivados de 3-(arilo o heteroailo) metilenindolino-2-ona como inhibidores de cinasas de la via de las celulas madres cancerosas para el tratamiento del cancer.
|
KR102334260B1
(ko)
|
2013-03-14 |
2021-12-02 |
스미토모 다이니폰 파마 온콜로지, 인크. |
Jak2 및 alk2 억제제 및 이들의 사용 방법
|
WO2014152959A1
(en)
|
2013-03-14 |
2014-09-25 |
Forsight Vision4, Inc. |
Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
|
AR095443A1
(es)
|
2013-03-15 |
2015-10-14 |
Fundación Centro Nac De Investig Oncológicas Carlos Iii |
Heterociclos condensados con acción sobre atr
|
US9206188B2
(en)
|
2013-04-18 |
2015-12-08 |
Arrien Pharmaceuticals Llc |
Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors
|
CN104119321B
(zh)
*
|
2013-04-28 |
2017-09-08 |
齐鲁制药有限公司 |
二氢吲哚酮衍生物的二马来酸盐及其多晶型物
|
CN105264380B
(zh)
|
2013-05-14 |
2017-09-05 |
卫材R&D管理有限公司 |
用于预测和评价子宫内膜癌受试者对乐伐替尼化合物响应性的生物标志
|
WO2014194030A2
(en)
|
2013-05-31 |
2014-12-04 |
Immunogen, Inc. |
Conjugates comprising cell-binding agents and cytotoxic agents
|
WO2015006555A2
(en)
|
2013-07-10 |
2015-01-15 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
FR3008411B1
(fr)
*
|
2013-07-12 |
2015-07-03 |
Servier Lab |
Nouveau sel de la 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione, sa preparation, et les formulations qui le contiennent
|
JP6612232B2
(ja)
|
2013-08-28 |
2019-11-27 |
クラウン バイオサイエンス インコーポレイテッド(タイカン) |
対象のマルチキナーゼ阻害剤に対する応答性を予測する遺伝子発現シグネチャ、及びその使用
|
EP3055298B1
(en)
|
2013-10-11 |
2020-04-29 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
US9278955B2
(en)
|
2013-10-18 |
2016-03-08 |
Sun Pharmaceutical Industries Limited |
Ascorbic acid salt of sunitinib
|
CA2838587A1
(en)
|
2013-10-18 |
2015-04-18 |
Hari Babu Matta |
Pure crystalline form ii of l-malic acid salt of sunitinib and processes for its preparation
|
KR102006527B1
(ko)
|
2013-11-01 |
2019-08-02 |
화이자 인코포레이티드 |
전립선-연관 항원의 발현을 위한 벡터
|
RU2680246C1
(ru)
|
2013-12-06 |
2019-02-19 |
Новартис Аг |
Схема приема для селективного по альфа-изоформе ингибитора фосфатидилинозитол-3-киназы
|
CN104829596B
(zh)
*
|
2014-02-10 |
2017-02-01 |
石家庄以岭药业股份有限公司 |
吡咯取代吲哚酮类衍生物、其制备方法、包含该衍生物的组合物、及其用途
|
CN103923014A
(zh)
*
|
2014-05-05 |
2014-07-16 |
宁夏宝马药业有限公司 |
环肌酸制备方法
|
CA2957548A1
(en)
|
2014-08-08 |
2016-02-11 |
Forsight Vision4, Inc. |
Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
|
HRP20221047T1
(hr)
|
2014-08-28 |
2022-11-11 |
Eisai R&D Management Co., Ltd. |
Derivat kinolina visoke čistoće i postupak za njegovu proizvodnju
|
TWI595006B
(zh)
|
2014-12-09 |
2017-08-11 |
禮納特神經系統科學公司 |
抗pd-1抗體類和使用彼等之方法
|
WO2016114322A1
(ja)
|
2015-01-13 |
2016-07-21 |
国立大学法人京都大学 |
筋萎縮性側索硬化症の予防及び/又は治療剤
|
JP6792546B2
(ja)
|
2015-02-25 |
2020-11-25 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
キノリン誘導体の苦味抑制方法
|
CA2978226A1
(en)
|
2015-03-04 |
2016-09-09 |
Merck Sharpe & Dohme Corp. |
Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
|
US9901574B2
(en)
|
2015-04-20 |
2018-02-27 |
Tolero Pharmaceuticals, Inc. |
Predicting response to alvocidib by mitochondrial profiling
|
WO2016184793A1
(en)
|
2015-05-15 |
2016-11-24 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for treating a patient with vegfr inhibitor-resistant metastatic renal cell carcinoma
|
EP3298021B1
(en)
|
2015-05-18 |
2019-05-01 |
Tolero Pharmaceuticals, Inc. |
Alvocidib prodrugs having increased bioavailability
|
GB201510019D0
(en)
|
2015-06-09 |
2015-07-22 |
Cancer Therapeutics Crc Pty Ltd |
Compounds
|
CN107801379B
(zh)
|
2015-06-16 |
2021-05-25 |
卫材R&D管理有限公司 |
抗癌剂
|
EP3331510A4
(en)
|
2015-08-03 |
2019-04-03 |
Tolero Pharmaceuticals, Inc. |
COMBINATORIAL THERAPIES FOR THE TREATMENT OF CANCER
|
US9808531B2
(en)
|
2015-09-22 |
2017-11-07 |
Graybug Vision, Inc. |
Compounds and compositions for the treatment of ocular disorders
|
GB2543550A
(en)
|
2015-10-21 |
2017-04-26 |
Hox Therapeutics Ltd |
Peptides
|
JP2018532750A
(ja)
|
2015-11-02 |
2018-11-08 |
ノバルティス アーゲー |
ホスファチジルイノシトール3−キナーゼ阻害剤の投薬レジメン
|
CN114469872A
(zh)
|
2015-11-12 |
2022-05-13 |
灰色视觉公司 |
用于治疗的聚集性微粒
|
CN114796520A
(zh)
|
2016-01-27 |
2022-07-29 |
苏特罗生物制药公司 |
抗cd74抗体偶联物,包含抗cd74抗体偶联物的组合物以及抗cd74抗体偶联物的使用方法
|
EP3414330A4
(en)
|
2016-02-08 |
2019-07-03 |
Vitrisa Therapeutics, Inc. |
COMPOSITIONS WITH IMPROVED INTRAVITREAL HALF TIME AND USES THEREOF
|
EP3228630A1
(en)
|
2016-04-07 |
2017-10-11 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Combination of an apelin antagonist and an angiogenesis inhibitor for the treatment of cancer
|
CN107459519A
(zh)
|
2016-06-06 |
2017-12-12 |
上海艾力斯医药科技有限公司 |
稠合嘧啶哌啶环衍生物及其制备方法和应用
|
US10870694B2
(en)
|
2016-09-02 |
2020-12-22 |
Dana Farber Cancer Institute, Inc. |
Composition and methods of treating B cell disorders
|
WO2018060833A1
(en)
|
2016-09-27 |
2018-04-05 |
Novartis Ag |
Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
|
SG10202104386UA
(en)
|
2016-10-28 |
2021-05-28 |
Icahn School Med Mount Sinai |
Compositions and methods for treating ezh2-mediated cancer
|
WO2018094275A1
(en)
|
2016-11-18 |
2018-05-24 |
Tolero Pharmaceuticals, Inc. |
Alvocidib prodrugs and their use as protein kinase inhibitors
|
US10786502B2
(en)
|
2016-12-05 |
2020-09-29 |
Apros Therapeutics, Inc. |
Substituted pyrimidines containing acidic groups as TLR7 modulators
|
ES2906439T3
(es)
|
2016-12-05 |
2022-04-18 |
Apros Therapeutics Inc |
Compuestos de pirimidina que contienen grupos ácidos
|
EP3551185A4
(en)
|
2016-12-08 |
2021-07-14 |
Icahn School of Medicine at Mount Sinai |
COMPOSITIONS AND METHODS OF TREATMENT OF CDK4 / 6 MEDIATED CANCER
|
EP3362471B1
(en)
|
2016-12-19 |
2021-11-17 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Profiling peptides and methods for sensitivity profiling
|
CN106916143B
(zh)
*
|
2017-03-14 |
2019-09-27 |
哈尔滨医科大学 |
一种预防和治疗冠心病的药物及其应用
|
BR112019019452A2
(pt)
|
2017-03-23 |
2020-04-14 |
Graybug Vision Inc |
composto, e, uso de um composto
|
US11160870B2
(en)
|
2017-05-10 |
2021-11-02 |
Graybug Vision, Inc. |
Extended release microparticles and suspensions thereof for medical therapy
|
EP3658588A1
(en)
|
2017-07-26 |
2020-06-03 |
Sutro Biopharma, Inc. |
Methods of using anti-cd74 antibodies and antibody conjugates in treatment of t-cell lymphoma
|
US11497756B2
(en)
|
2017-09-12 |
2022-11-15 |
Sumitomo Pharma Oncology, Inc. |
Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib
|
EP3684814A1
(en)
|
2017-09-18 |
2020-07-29 |
Sutro Biopharma, Inc. |
Anti-folate receptor alpha antibody conjugates and their uses
|
WO2019075367A1
(en)
|
2017-10-13 |
2019-04-18 |
Tolero Pharmaceuticals, Inc. |
PKM2 ACTIVATORS IN COMBINATION WITH OXYGEN REACTIVE SPECIES FOR THE TREATMENT OF CANCER
|
NL2019801B1
(en)
|
2017-10-25 |
2019-05-02 |
Univ Leiden |
Delivery vectors
|
AU2019231689A1
(en)
|
2018-03-06 |
2020-09-24 |
Icahn School Of Medicine At Mount Sinai |
Serine threonine kinase (AKT) degradation / disruption compounds and methods of use
|
EP3539536A1
(en)
|
2018-03-15 |
2019-09-18 |
MH10 Spolka z ograniczona odpowiedzialnoscia |
A pharmaceutical composition of sunitinib or its salt thereof in its polymorphic form i
|
WO2020216450A1
(en)
|
2019-04-25 |
2020-10-29 |
Synthon B.V. |
Pharmaceutical composition comprising amorphous sunitinib
|
US10857153B2
(en)
|
2018-06-04 |
2020-12-08 |
Apros Therapeutics, Inc. |
Pyrimidine compounds containing acidic groups
|
GB201810092D0
(en)
|
2018-06-20 |
2018-08-08 |
Ctxt Pty Ltd |
Compounds
|
GB201810581D0
(en)
|
2018-06-28 |
2018-08-15 |
Ctxt Pty Ltd |
Compounds
|
KR20210038906A
(ko)
|
2018-07-26 |
2021-04-08 |
스미토모 다이니폰 파마 온콜로지, 인크. |
비정상적 acvr1 발현과 연관된 질환을 치료하는 방법 및 그에 사용하기 위한 acvr1 억제제
|
JP2022500454A
(ja)
|
2018-09-17 |
2022-01-04 |
ストロ バイオファーマ インコーポレーテッド |
抗葉酸受容体抗体コンジュゲートによる併用療法
|
CN113490499A
(zh)
|
2018-12-04 |
2021-10-08 |
大日本住友制药肿瘤公司 |
用作治疗癌症的活性剂的cdk9抑制剂及其多晶型物
|
TW202038957A
(zh)
|
2018-12-21 |
2020-11-01 |
日商第一三共股份有限公司 |
抗體-藥物結合物與激酶抑制劑之組合
|
JP2022520361A
(ja)
|
2019-02-12 |
2022-03-30 |
スミトモ ダイニッポン ファーマ オンコロジー, インコーポレイテッド |
複素環式タンパク質キナーゼ阻害剤を含む製剤
|
WO2020191326A1
(en)
|
2019-03-20 |
2020-09-24 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Treatment of acute myeloid leukemia (aml) with venetoclax failure
|
CA3129665A1
(en)
|
2019-03-21 |
2020-09-24 |
Onxeo |
A dbait molecule in combination with kinase inhibitor for the treatment of cancer
|
AU2020245437A1
(en)
|
2019-03-22 |
2021-09-30 |
Sumitomo Pharma Oncology, Inc. |
Compositions comprising PKM2 modulators and methods of treatment using the same
|
EP3962951A1
(en)
|
2019-05-03 |
2022-03-09 |
Sutro Biopharma, Inc. |
Anti-bcma antibody conjugates
|
JP2022531446A
(ja)
|
2019-05-06 |
2022-07-06 |
アイカーン スクール オブ メディスン アット マウント シナイ |
Hpk1の分解剤としてのヘテロ二官能性化合物
|
AU2020335054A1
(en)
|
2019-08-31 |
2022-03-24 |
Etern Biopharma (Shanghai) Co., Ltd. |
Pyrazole derivative for FGFR inhibitor and preparation method therefor
|
EP4054579A1
(en)
|
2019-11-08 |
2022-09-14 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
|
WO2021148581A1
(en)
|
2020-01-22 |
2021-07-29 |
Onxeo |
Novel dbait molecule and its use
|
WO2021178597A1
(en)
|
2020-03-03 |
2021-09-10 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific glutamine tags, methods of their preparation and methods of their use
|
CN111233841A
(zh)
*
|
2020-03-17 |
2020-06-05 |
湖北扬信医药科技有限公司 |
一种舒尼替尼有关物质及其制备方法和用途
|
WO2023278424A1
(en)
*
|
2021-06-28 |
2023-01-05 |
The Regents Of The University Of California |
Methods for treating and ameliorating t cell related diseases
|
CN113717159A
(zh)
*
|
2021-09-16 |
2021-11-30 |
中国药科大学 |
吲哚酮类化合物及其药物组合物、制备方法及用途
|
WO2023081923A1
(en)
|
2021-11-08 |
2023-05-11 |
Frequency Therapeutics, Inc. |
Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof
|
WO2023228095A1
(en)
|
2022-05-24 |
2023-11-30 |
Daiichi Sankyo Company, Limited |
Dosage regimen of an anti-cdh6 antibody-drug conjugate
|
US20240058465A1
(en)
|
2022-06-30 |
2024-02-22 |
Sutro Biopharma, Inc. |
Anti-ror1 antibody conjugates, compositions comprising anti ror1 antibody conjugates, and methods of making and using anti-ror1 antibody conjugates
|
WO2024017372A1
(zh)
*
|
2022-07-22 |
2024-01-25 |
成都百裕制药股份有限公司 |
一种吲哚酮衍生物及其应用
|