PL399027A1 - Sposób otrzymywania N-[2-(dietylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamidu o wysokiej czystosci i jego zastosowanie do wytwarzania sunitynibu - Google Patents

Sposób otrzymywania N-[2-(dietylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamidu o wysokiej czystosci i jego zastosowanie do wytwarzania sunitynibu

Info

Publication number
PL399027A1
PL399027A1 PL399027A PL39902712A PL399027A1 PL 399027 A1 PL399027 A1 PL 399027A1 PL 399027 A PL399027 A PL 399027A PL 39902712 A PL39902712 A PL 39902712A PL 399027 A1 PL399027 A1 PL 399027A1
Authority
PL
Poland
Prior art keywords
formyl
pyrrole
dimethyl
ethyl
carboxamide
Prior art date
Application number
PL399027A
Other languages
English (en)
Inventor
Krzysztof Bankowski
Katarzyna Sidoryk
Urszula Chmielowiec
Magdalena Kossykowska
Joanna Zagrodzka
Marek Kubiszewski
Original Assignee
Instytut Farmaceutyczny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instytut Farmaceutyczny filed Critical Instytut Farmaceutyczny
Priority to PL399027A priority Critical patent/PL399027A1/pl
Priority to PCT/PL2013/000059 priority patent/WO2013162390A1/en
Publication of PL399027A1 publication Critical patent/PL399027A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Wynalazek dotyczy sposobu otrzymywania N-[2-(dietylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamidu o wysokiej czystosci obejmujacego jego oczyszczanie do zawartosci ponizej 0,07% desetylowej pochodnej, N-[2-(etylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamidu. N-[2-(dietylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamid zawierajacy ponizej 0,07% desetylowej pochodnej ma zastosowanie do wytwarzania inhibitora kinaz tyrozynowych sunitynibu o czystosci farmaceutycznej.
PL399027A 2012-04-27 2012-04-27 Sposób otrzymywania N-[2-(dietylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamidu o wysokiej czystosci i jego zastosowanie do wytwarzania sunitynibu PL399027A1 (pl)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL399027A PL399027A1 (pl) 2012-04-27 2012-04-27 Sposób otrzymywania N-[2-(dietylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamidu o wysokiej czystosci i jego zastosowanie do wytwarzania sunitynibu
PCT/PL2013/000059 WO2013162390A1 (en) 2012-04-27 2013-04-26 Process for preparation of high purity n- [2- (diethylamine) ethyl] - 5 - formyl - 2, 4 - dimethyl - 1h - pyrrole - 3 - carboxyamide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL399027A PL399027A1 (pl) 2012-04-27 2012-04-27 Sposób otrzymywania N-[2-(dietylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamidu o wysokiej czystosci i jego zastosowanie do wytwarzania sunitynibu

Publications (1)

Publication Number Publication Date
PL399027A1 true PL399027A1 (pl) 2013-10-28

Family

ID=48539365

Family Applications (1)

Application Number Title Priority Date Filing Date
PL399027A PL399027A1 (pl) 2012-04-27 2012-04-27 Sposób otrzymywania N-[2-(dietylamino)etylo]-5-formylo-2,4-dimetylo-1H-pirolo-3-karboksyamidu o wysokiej czystosci i jego zastosowanie do wytwarzania sunitynibu

Country Status (2)

Country Link
PL (1) PL399027A1 (pl)
WO (1) WO2013162390A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2017026119A1 (ja) * 2015-08-10 2018-05-24 大日本住友製薬株式会社 ５−（チアゾール−４−イル）インドリン−２−オン誘導体の精製方法
CN106588888B (zh) * 2015-10-16 2021-02-26 江苏创诺制药有限公司 一种制备高纯度l-苹果酸舒尼替尼的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122008000002I1 (de) 2000-02-15 2008-04-17 Sugen Inc Pyrrol substituierte indolin-2-on protein kinase inhibitoren
EP2332934B1 (en) 2001-08-15 2017-03-01 Pharmacia & Upjohn Company LLC Processes for the preparation of crystals including a malic acid salt of n-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3h-indole-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide.
US8501962B2 (en) * 2008-06-23 2013-08-06 Natco Pharma Limited Process for the preparation of high purity sunitinib and its pharmaceutically acceptable salt
CA2774634A1 (en) * 2009-09-16 2011-03-24 Ranbaxy Laboratories Limited Salts of sunitinib
WO2012059941A1 (en) * 2010-11-04 2012-05-10 Ind-Swift Laboratories Limited Process for preparation of sunitinib malate and salts thereof

Also Published As

Publication number Publication date
WO2013162390A1 (en) 2013-10-31

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