CY1105232T1 - Κυτταρικες σειρες συμπληρωματικοτητας - Google Patents
Κυτταρικες σειρες συμπληρωματικοτηταςInfo
- Publication number
- CY1105232T1 CY1105232T1 CY20061101321T CY061101321T CY1105232T1 CY 1105232 T1 CY1105232 T1 CY 1105232T1 CY 20061101321 T CY20061101321 T CY 20061101321T CY 061101321 T CY061101321 T CY 061101321T CY 1105232 T1 CY1105232 T1 CY 1105232T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cell lines
- human
- adenovirus
- primary
- cell line
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 abstract 7
- 241000701161 unidentified adenovirus Species 0.000 abstract 5
- 241000700605 Viruses Species 0.000 abstract 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 abstract 1
- 241000712079 Measles morbillivirus Species 0.000 abstract 1
- 241000702670 Rotavirus Species 0.000 abstract 1
- 210000001776 amniocyte Anatomy 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
- 210000003292 kidney cell Anatomy 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 229960000160 recombinant therapeutic protein Drugs 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/861—Adenoviral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
- C12N7/025—Packaging cell lines, e.g. transcomplementing cell lines, for production of virus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10041—Use of virus, viral particle or viral elements as a vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10051—Methods of production or purification of viral material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10351—Methods of production or purification of viral material
- C12N2710/10352—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Transducers For Ultrasonic Waves (AREA)
- Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
- Design And Manufacture Of Integrated Circuits (AREA)
Abstract
Μία κυτταρική σειρά πακεταρίσματος που είναι ικανή να δείχνει συμπληρωματικότητα με ανασυνδυασμένους αδενοϊούς που βασίζονται στους οροτύπους από την υποομάδα Β, κατά προτίμηση τον αδενοϊό τύπου 35. Η κυτταρική σειρά κατά προτίμηση προέρχεται από πρωτογενή, διπλοειδή ανθρώπινα κύτταρα (π.χ. πρωτογενείς ανθρώπινοι ρετινοβλάστες, πρωτογενή ανθρώπινα εμβρυϊκά κύτταρα νεφρού και πρωτογενή ανθρώπινα αμνιοκύτταρα) τα οποία επιμολύνονται από αλληλουχίες Ε1 του αδενοϊού. Επίσης παρουσιάζεται μία κυτταρική σειρά που προέρχεται από PER.C6 (ECACC αριθμός κατάθεσης 96022940), το οποίο κύτταρο εκφράζει λειτουργικές αλληλουχίες Ad35 Ε1B. Οι νέες κυτταρικές σειρές είναι χρήσιμες για την παραγωγή ανασυνδυασμένων αδενοϊών που σχεδιάσθηκαν για γονιδιακή θεραπεία και εμβολιασμό. Οι κυτταρικές σειρές μπορούν επίσης να χρησιμοποιηθούν για την παραγωγή ανθρώπινων ανασυνδυασμένων θεραπευτικών πρωτεϊνών. Επίσης, οι κυτταρικές σειρές είναι χρήσιμες για την παραγωγή ανθρώπινων ιών άλλων από τον αδενοϊό όπως ο ιός της γρίππης, ο ιός του συμπλέγματος του έρπητα, ο ροταϊός, ο ιός της ιλαράς.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/713,678 US6492169B1 (en) | 1999-05-18 | 2000-11-15 | Complementing cell lines |
PCT/NL2001/000824 WO2002040665A2 (en) | 2000-11-15 | 2001-11-14 | Complementing cell lines |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1105232T1 true CY1105232T1 (el) | 2010-03-03 |
Family
ID=24867049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061101321T CY1105232T1 (el) | 2000-11-15 | 2006-09-15 | Κυτταρικες σειρες συμπληρωματικοτητας |
Country Status (13)
Country | Link |
---|---|
US (8) | US6492169B1 (el) |
EP (1) | EP1349926B1 (el) |
JP (1) | JP4402881B2 (el) |
AT (1) | ATE332965T1 (el) |
AU (2) | AU1856902A (el) |
CA (1) | CA2428739C (el) |
CY (1) | CY1105232T1 (el) |
DE (1) | DE60121471T2 (el) |
DK (1) | DK1349926T3 (el) |
ES (1) | ES2267864T3 (el) |
NZ (1) | NZ525997A (el) |
PT (1) | PT1349926E (el) |
WO (1) | WO2002040665A2 (el) |
Families Citing this family (139)
Publication number | Priority date | Publication date | Assignee | Title |
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US6783980B2 (en) * | 1995-06-15 | 2004-08-31 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
ES2333425T5 (es) * | 1995-06-15 | 2012-08-28 | Crucell Holland B.V. | Sistemas de empaquetado para adenovirus recombinante humano destinados a terapia génica |
US20040043489A1 (en) * | 1998-07-08 | 2004-03-04 | Menzo Havenga | Gene delivery vectors provided with a tissue tropism for dendritic cells and methods of use |
US20030017138A1 (en) * | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
US6929946B1 (en) * | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
US6855544B1 (en) * | 1999-04-15 | 2005-02-15 | Crucell Holland B.V. | Recombinant protein production in a human cell |
WO2003048348A2 (en) * | 2001-12-07 | 2003-06-12 | Crucell Holland B.V. | Production of viruses, viral isolates and vaccines |
US20050170463A1 (en) * | 1999-04-15 | 2005-08-04 | Abraham Bout | Recombinant protein production in permanent amniocytic cells that comprise nucleic acid encoding adenovirus E1A and E1B proteins |
US20050164386A1 (en) * | 1999-04-15 | 2005-07-28 | Uytdehaag Alphonsus G. | Overexpression of enzymes involved in post-translational protein modifications in human cells |
US8236561B2 (en) * | 1999-04-15 | 2012-08-07 | Crucell Holland B.V. | Efficient production of IgA in recombinant mammalian cells |
US7604960B2 (en) * | 1999-04-15 | 2009-10-20 | Crucell Holland B.V. | Transient protein expression methods |
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US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
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US20060073123A1 (en) * | 2002-04-30 | 2006-04-06 | Jie Mi | Adenovirus vectors for immunotherapy |
JP4237449B2 (ja) * | 2002-06-05 | 2009-03-11 | 国立医薬品食品衛生研究所長 | アデノウィルスベクター |
US20080153083A1 (en) * | 2003-10-23 | 2008-06-26 | Crucell Holland B.V. | Settings for recombinant adenoviral-based vaccines |
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US9388427B2 (en) * | 2002-12-02 | 2016-07-12 | Biovec, Llc | In vivo and ex vivo gene transfer into renal tissue using gutless adenovirus vectors |
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AU2003298554A1 (en) * | 2003-03-28 | 2004-11-23 | Merck & Co., Inc. | Adenovirus serotype 34 vectors, nucleic acids and virus produced thereby |
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EP1626992B1 (en) * | 2003-05-23 | 2010-06-02 | Crucell Holland B.V. | Production of recombinant igm in per.c6 cells |
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WO2000052186A1 (en) | 1999-03-04 | 2000-09-08 | Introgene B.V. | Means and methods for fibroblast-like or macrophage-like cell transduction |
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DE19918023A1 (de) * | 1999-03-16 | 2000-09-21 | Guenter Cichon | Verfahren zur Herstellung von leberzellabgleiteten Verpackungszelllinien und ihre Verwendung |
US7604960B2 (en) | 1999-04-15 | 2009-10-20 | Crucell Holland B.V. | Transient protein expression methods |
EP1816205B1 (en) | 1999-05-17 | 2011-08-10 | Crucell Holland B.V. | Recombinant Adenovirus based on serotype 48 (Ad48). |
US6492169B1 (en) * | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
US6913922B1 (en) * | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
EP1067188A1 (en) | 1999-07-08 | 2001-01-10 | Introgene B.V. | Infection with chimaeric adenoviruses of cells negative for the adenovirus serotype 5 Coxsacki adenovirus receptor (CAR) |
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SI1497438T1 (sl) | 2002-04-25 | 2010-03-31 | Crucell Holland Bv | Sredstva in postopki za pripravo adenovirusnih vektorjev |
ES2310247T3 (es) | 2002-04-25 | 2009-01-01 | Crucell Holland B.V. | Vectores adenovirales estables y metodos de propagacion de los mismos. |
US20080153083A1 (en) | 2003-10-23 | 2008-06-26 | Crucell Holland B.V. | Settings for recombinant adenoviral-based vaccines |
EP1553983A2 (en) | 2002-10-23 | 2005-07-20 | Crucell Holland B.V. | New settings for recombinant adenoviral-based vaccines |
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-
2000
- 2000-11-15 US US09/713,678 patent/US6492169B1/en not_active Expired - Lifetime
-
2001
- 2001-11-14 CA CA2428739A patent/CA2428739C/en not_active Expired - Fee Related
- 2001-11-14 AU AU1856902A patent/AU1856902A/xx active Pending
- 2001-11-14 AT AT01996603T patent/ATE332965T1/de active
- 2001-11-14 ES ES01996603T patent/ES2267864T3/es not_active Expired - Lifetime
- 2001-11-14 DE DE60121471T patent/DE60121471T2/de not_active Expired - Lifetime
- 2001-11-14 WO PCT/NL2001/000824 patent/WO2002040665A2/en active IP Right Grant
- 2001-11-14 AU AU2002218569A patent/AU2002218569B2/en not_active Ceased
- 2001-11-14 JP JP2002543660A patent/JP4402881B2/ja not_active Expired - Lifetime
- 2001-11-14 NZ NZ525997A patent/NZ525997A/en not_active IP Right Cessation
- 2001-11-14 DK DK01996603T patent/DK1349926T3/da active
- 2001-11-14 PT PT01996603T patent/PT1349926E/pt unknown
- 2001-11-14 EP EP01996603A patent/EP1349926B1/en not_active Expired - Lifetime
- 2001-11-15 US US10/002,750 patent/US6974695B2/en not_active Expired - Lifetime
-
2002
- 2002-06-04 US US10/164,085 patent/US6869794B2/en not_active Expired - Lifetime
- 2002-10-15 US US10/272,041 patent/US7250293B2/en not_active Expired - Lifetime
-
2005
- 2005-06-24 US US11/165,697 patent/US7344883B2/en not_active Expired - Lifetime
-
2006
- 2006-09-15 CY CY20061101321T patent/CY1105232T1/el unknown
-
2007
- 2007-04-11 US US11/786,409 patent/US20080199433A1/en not_active Abandoned
-
2012
- 2012-03-27 US US13/431,806 patent/US20130156736A1/en not_active Abandoned
-
2014
- 2014-07-18 US US14/335,679 patent/US9228205B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20030119192A1 (en) | 2003-06-26 |
ES2267864T3 (es) | 2007-03-16 |
US20080199433A1 (en) | 2008-08-21 |
EP1349926A2 (en) | 2003-10-08 |
US7250293B2 (en) | 2007-07-31 |
US20030171336A1 (en) | 2003-09-11 |
NZ525997A (en) | 2005-10-28 |
PT1349926E (pt) | 2006-12-29 |
DE60121471T2 (de) | 2007-02-08 |
US20050277194A1 (en) | 2005-12-15 |
AU2002218569B2 (en) | 2007-04-05 |
JP2004513657A (ja) | 2004-05-13 |
US6492169B1 (en) | 2002-12-10 |
US9228205B2 (en) | 2016-01-05 |
US7344883B2 (en) | 2008-03-18 |
US20150010952A1 (en) | 2015-01-08 |
ATE332965T1 (de) | 2006-08-15 |
DK1349926T3 (da) | 2006-10-30 |
WO2002040665A2 (en) | 2002-05-23 |
AU1856902A (en) | 2002-05-27 |
CA2428739A1 (en) | 2002-05-23 |
WO2002040665A3 (en) | 2002-10-17 |
JP4402881B2 (ja) | 2010-01-20 |
CA2428739C (en) | 2010-11-16 |
EP1349926B1 (en) | 2006-07-12 |
US6869794B2 (en) | 2005-03-22 |
DE60121471D1 (de) | 2006-08-24 |
US20130156736A1 (en) | 2013-06-20 |
US6974695B2 (en) | 2005-12-13 |
US20030185801A1 (en) | 2003-10-02 |
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