PE20160045A1 - Polipeptidos f de prefusion del virus sincicial respiratorio (rsv) solubles y estabilizados - Google Patents
Polipeptidos f de prefusion del virus sincicial respiratorio (rsv) solubles y estabilizadosInfo
- Publication number
- PE20160045A1 PE20160045A1 PE2015002617A PE2015002617A PE20160045A1 PE 20160045 A1 PE20160045 A1 PE 20160045A1 PE 2015002617 A PE2015002617 A PE 2015002617A PE 2015002617 A PE2015002617 A PE 2015002617A PE 20160045 A1 PE20160045 A1 PE 20160045A1
- Authority
- PE
- Peru
- Prior art keywords
- prefusion
- rsv
- polypeptides
- soluble
- respiratory syncitial
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 241000700605 Viruses Species 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
- 241000725643 Respiratory syncytial virus Species 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/115—Paramyxoviridae, e.g. parainfluenza virus
- C07K14/135—Respiratory syncytial virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2999/00—Further aspects of viruses or vectors not covered by groups C12N2710/00 - C12N2796/00 or C12N2800/00
- C12N2999/002—Adverse teaching
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Polipetidos F de prefusion del virus sincicial respiratorio (RSV) estables, composiciones inmunogenicas que comprenden dichos polipeptidos y sus uso en la prevencion y/o el tratamiento de una infeccion por RSV. Estos polipeptidos comprenden al menos un epitope que presenta especificidad por la proteina de la conformacion de prefusion F. En ciertas formas de realizacion, los polipeptidos F de prefusion del RSV son solubles. La invencion tambien provee moleculas de acido nucleico que codifican los polipeptidos F de prefusion del RSV de acuerdo con la invencion y vectores que comprenden a dichas moleculas de acido nucleico
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13172256 | 2013-06-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20160045A1 true PE20160045A1 (es) | 2016-02-18 |
Family
ID=48625910
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2015002617A PE20160045A1 (es) | 2013-06-17 | 2014-06-17 | Polipeptidos f de prefusion del virus sincicial respiratorio (rsv) solubles y estabilizados |
Country Status (20)
Country | Link |
---|---|
US (1) | US10294279B2 (es) |
EP (1) | EP3010931B1 (es) |
JP (1) | JP6679475B2 (es) |
KR (1) | KR102313153B1 (es) |
CN (1) | CN105408348B (es) |
AP (1) | AP2015008893A0 (es) |
AU (1) | AU2014283334B2 (es) |
BR (1) | BR112015031509B1 (es) |
CA (1) | CA2914792C (es) |
CL (1) | CL2015003655A1 (es) |
EA (1) | EA034653B1 (es) |
HK (1) | HK1223949A1 (es) |
IL (1) | IL243053B (es) |
MX (1) | MX362792B (es) |
MY (1) | MY171210A (es) |
PE (1) | PE20160045A1 (es) |
PH (1) | PH12015502735B1 (es) |
SG (1) | SG11201510216RA (es) |
WO (1) | WO2014202570A1 (es) |
ZA (1) | ZA201509140B (es) |
Families Citing this family (31)
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PL2988780T3 (pl) * | 2013-04-25 | 2019-06-28 | Janssen Vaccines & Prevention B.V. | Stabilizowane rozpuszczalne prefuzyjne polipeptydy F RSV |
BR112015031509B1 (pt) | 2013-06-17 | 2023-05-09 | Janssen Vaccines & Prevention B.V. | Polipeptídeo de fusão (f) do vírus sincicial respiratório (rsv) pré- fusão recombinante e composição que o compreende |
CN107847580B (zh) * | 2015-07-07 | 2022-08-12 | 扬森疫苗与预防公司 | 针对rsv的疫苗 |
CA2991540A1 (en) | 2015-07-07 | 2017-01-12 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion respiratory syncytial sirus polypeptides |
KR102136678B1 (ko) | 2015-12-23 | 2020-07-22 | 화이자 인코포레이티드 | Rsv f 단백질 돌연변이체 |
WO2017174568A1 (en) | 2016-04-05 | 2017-10-12 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion rsv f proteins |
MX2018012095A (es) * | 2016-04-05 | 2019-01-10 | Janssen Vaccines & Prevention Bv | Vacuna contra vrs. |
WO2017207477A1 (en) | 2016-05-30 | 2017-12-07 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv f proteins |
CN109311946A (zh) * | 2016-05-30 | 2019-02-05 | 扬森疫苗与预防公司 | 稳定化的融合前rsv f蛋白 |
WO2018170260A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Respiratory syncytial virus vaccine |
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JP7168938B2 (ja) | 2017-04-04 | 2022-11-10 | ユニヴァーシティ オブ ワシントン | パラミクソウイルスおよび/またはニューモウイルスのfタンパク質を表示する自己アセンブリするタンパク質ナノ構造およびその使用 |
CA3062549A1 (en) | 2017-05-15 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
CN110603058A (zh) | 2017-05-15 | 2019-12-20 | 扬森疫苗与预防公司 | 含有病毒的稳定组合物 |
WO2018210871A1 (en) * | 2017-05-17 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against rsv infection |
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CA3073790A1 (en) * | 2017-09-15 | 2019-03-21 | Janssen Vaccines & Prevention B.V. | Method for the safe induction of immunity against rsv |
US11911453B2 (en) | 2018-01-29 | 2024-02-27 | Modernatx, Inc. | RSV RNA vaccines |
CN113164583A (zh) * | 2018-11-13 | 2021-07-23 | 扬森疫苗与预防公司 | 稳定的融合前rsv f蛋白 |
BR112021022087A2 (pt) | 2019-05-15 | 2021-12-28 | Janssen Vaccines & Prevention Bv | Coadministração de vacina sazonal contra influenza e vacina contra vírus respiratório sincicial à base de adenovírus |
CA3140234A1 (en) | 2019-05-15 | 2020-11-19 | Janssen Vaccines & Prevention B.V. | Prophylactic treatment of respiratory syncytial virus infection with an adenovirus based vaccine |
CN114502572A (zh) | 2019-09-04 | 2022-05-13 | 华盛顿大学 | 展示副粘病毒和/或肺炎病毒f蛋白的自组装蛋白纳米结构及其用途 |
KR20220164543A (ko) | 2020-04-02 | 2022-12-13 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정화된 백신 조성물 |
JP2022060169A (ja) | 2020-10-02 | 2022-04-14 | ファイザー・インク | Rsv fタンパク質生産のための細胞培養工程 |
CN115161344A (zh) * | 2022-04-26 | 2022-10-11 | 北京智飞绿竹生物制药有限公司 | 一种针对呼吸道合胞病毒感染的疫苗的制备方法 |
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ES2578514T3 (es) | 2010-02-15 | 2016-07-27 | Crucell Holland B.V. | Método para la producción de vectores adenovíricos |
MX343298B (es) | 2010-07-09 | 2016-11-01 | Crucell Holland Bv | Anticuerpos contra el virus sincitial respiratorio (rsv) humano y metodos de uso. |
WO2012158613A1 (en) * | 2011-05-13 | 2012-11-22 | Novartis Ag | Pre-fusion rsv f antigens |
DK2825640T3 (en) | 2012-03-12 | 2016-08-01 | Crucell Holland Bv | BATCHES OF RECOMBINANT ADENOVIRUS WITH CHANGED TERMINAL END |
US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
MY169352A (en) | 2012-03-22 | 2019-03-25 | Janssen Vaccines & Prevention Bv | Vaccine against rsv |
JP2013247240A (ja) | 2012-05-25 | 2013-12-09 | Gigaphoton Inc | レーザ装置 |
US9738689B2 (en) | 2013-03-13 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
KR20220139415A (ko) * | 2013-03-13 | 2022-10-14 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | 선융합(prefusion) RSV F 단백질 및 이의 용도 |
AU2014255864B2 (en) | 2013-04-15 | 2019-07-18 | Janssen Vaccines & Prevention B.V. | Human antibodies binding to RSV G protein |
KR102201555B1 (ko) | 2013-04-15 | 2021-01-12 | 얀센 백신스 앤드 프리벤션 비.브이. | Rsv g 단백질에 결합하는 인간 항체 |
PL2988780T3 (pl) | 2013-04-25 | 2019-06-28 | Janssen Vaccines & Prevention B.V. | Stabilizowane rozpuszczalne prefuzyjne polipeptydy F RSV |
BR112015031509B1 (pt) | 2013-06-17 | 2023-05-09 | Janssen Vaccines & Prevention B.V. | Polipeptídeo de fusão (f) do vírus sincicial respiratório (rsv) pré- fusão recombinante e composição que o compreende |
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2014
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- 2014-06-17 MY MYPI2015704549A patent/MY171210A/en unknown
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- 2014-06-17 AP AP2015008893A patent/AP2015008893A0/xx unknown
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- 2014-06-17 WO PCT/EP2014/062655 patent/WO2014202570A1/en active Application Filing
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2015
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MX362792B (es) | 2019-02-13 |
ZA201509140B (en) | 2022-03-30 |
JP2016522230A (ja) | 2016-07-28 |
BR112015031509B1 (pt) | 2023-05-09 |
EA201690031A1 (ru) | 2016-07-29 |
JP6679475B2 (ja) | 2020-04-15 |
MY171210A (en) | 2019-10-02 |
IL243053B (en) | 2020-06-30 |
BR112015031509A2 (pt) | 2017-08-29 |
CN105408348B (zh) | 2021-07-06 |
PH12015502735A1 (en) | 2016-03-07 |
CA2914792A1 (en) | 2014-12-24 |
WO2014202570A1 (en) | 2014-12-24 |
AP2015008893A0 (en) | 2015-12-31 |
CL2015003655A1 (es) | 2016-06-03 |
US20160176932A1 (en) | 2016-06-23 |
SG11201510216RA (en) | 2016-01-28 |
AU2014283334A1 (en) | 2015-12-17 |
KR20160021196A (ko) | 2016-02-24 |
KR102313153B1 (ko) | 2021-10-15 |
CN105408348A (zh) | 2016-03-16 |
AU2014283334B2 (en) | 2018-10-18 |
EA034653B1 (ru) | 2020-03-03 |
MX2015017771A (es) | 2016-10-04 |
CA2914792C (en) | 2024-02-27 |
PH12015502735B1 (en) | 2016-03-07 |
EP3010931A1 (en) | 2016-04-27 |
HK1223949A1 (zh) | 2017-08-11 |
EP3010931B1 (en) | 2018-06-13 |
US10294279B2 (en) | 2019-05-21 |
NZ714594A (en) | 2021-07-30 |
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