BRPI0921651A2 - Método para produzir adenovírus recombinante, e partículas virais, e, biorreator - Google Patents
Método para produzir adenovírus recombinante, e partículas virais, e, biorreatorInfo
- Publication number
- BRPI0921651A2 BRPI0921651A2 BRPI0921651-0A BRPI0921651A BRPI0921651A2 BR PI0921651 A2 BRPI0921651 A2 BR PI0921651A2 BR PI0921651 A BRPI0921651 A BR PI0921651A BR PI0921651 A2 BRPI0921651 A2 BR PI0921651A2
- Authority
- BR
- Brazil
- Prior art keywords
- bioreactor
- viral particles
- recombinant adenovirus
- producing recombinant
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10351—Methods of production or purification of viral material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Sustainable Development (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19812208P | 2008-11-03 | 2008-11-03 | |
| EP08168181 | 2008-11-03 | ||
| PCT/EP2009/064265 WO2010060719A1 (en) | 2008-11-03 | 2009-10-29 | Method for the production of adenoviral vectors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0921651A2 true BRPI0921651A2 (pt) | 2015-08-18 |
Family
ID=40344776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0921651-0A BRPI0921651A2 (pt) | 2008-11-03 | 2009-10-29 | Método para produzir adenovírus recombinante, e partículas virais, e, biorreator |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10041049B2 (pt) |
| EP (1) | EP2350268B1 (pt) |
| JP (1) | JP5770633B2 (pt) |
| KR (1) | KR101504392B1 (pt) |
| CN (1) | CN102203242B (pt) |
| AU (1) | AU2009319254B2 (pt) |
| BR (1) | BRPI0921651A2 (pt) |
| CA (1) | CA2742474C (pt) |
| DK (1) | DK2350268T3 (pt) |
| EA (1) | EA019928B1 (pt) |
| ES (1) | ES2532015T3 (pt) |
| HK (1) | HK1160664A1 (pt) |
| MX (1) | MX2011004292A (pt) |
| NZ (1) | NZ593235A (pt) |
| PL (1) | PL2350268T3 (pt) |
| WO (1) | WO2010060719A1 (pt) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5770633B2 (ja) | 2008-11-03 | 2015-08-26 | クルセル ホランド ベー ヴェー | アデノウイルスベクターの産生方法 |
| AU2010305768B2 (en) * | 2009-10-15 | 2015-05-14 | Crucell Holland B.V. | Process for adenovirus purification from high cell density cultures |
| BR112012008516B1 (pt) * | 2009-10-15 | 2021-10-19 | Janssen Vaccines & Prevention B.V. | Método para purificar partículas de adenovírus a partir de uma suspensão de célula |
| AU2011214262B2 (en) * | 2010-02-15 | 2015-05-21 | Crucell Holland B.V. | Method for the production of Ad26 adenoviral vectors |
| AP3390A (en) | 2010-09-20 | 2015-08-31 | Crucell Holland Bv | Therapeutic vaccination against active tuberculosis |
| CA2809463C (en) | 2010-09-27 | 2021-05-25 | Crucell Holland B.V. | Heterologous prime boost vaccination regimen against malaria |
| ES2529429T3 (es) | 2011-02-10 | 2015-02-20 | Crucell Holland B.V. | Sistema de separación de células de membrana de presión neumática alterna |
| EP2780034A1 (en) | 2011-11-14 | 2014-09-24 | Crucell Holland B.V. | Heterologous prime-boost immunization using measles virus-based vaccines |
| SI2825640T1 (sl) | 2012-03-12 | 2016-08-31 | Crucell Holland B.V. | Šarže rekombinantnega adenovirusa s spremenjenimi konci |
| US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
| US9125870B2 (en) | 2012-03-22 | 2015-09-08 | Crucell Holland B.V. | Vaccine against RSV |
| CN104334188B (zh) | 2012-03-22 | 2016-08-24 | 克鲁塞尔荷兰公司 | 抗rsv疫苗 |
| PL2988780T3 (pl) | 2013-04-25 | 2019-06-28 | Janssen Vaccines & Prevention B.V. | Stabilizowane rozpuszczalne prefuzyjne polipeptydy F RSV |
| AP2015008893A0 (en) | 2013-06-17 | 2015-12-31 | Crucell Holland Bv | Stabilized soluble pre-fusion rsv f polypeptides |
| JP6851827B2 (ja) * | 2013-08-30 | 2021-03-31 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 細胞培養中でのウイルスの大規模製造 |
| EP3613841B1 (en) | 2014-03-25 | 2022-04-20 | Terumo BCT, Inc. | Passive replacement of media |
| LT3215187T (lt) | 2014-11-04 | 2018-12-27 | Janssen Vaccines & Prevention B.V. | Terapinės hpv16 vakcinos |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| JP6840718B2 (ja) | 2015-07-07 | 2021-03-10 | ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． | 安定化された可溶性融合前ｒｓｖ ｆポリペプチド |
| EA039065B1 (ru) | 2015-07-07 | 2021-11-29 | Янссен Вэксинс Энд Превеншн Б.В. | Вакцина против rsv |
| US9663766B2 (en) | 2015-07-24 | 2017-05-30 | Bio-Rad Laboratories, Inc. | Methods for purifying adenovirus vectors |
| SG10202001501QA (en) | 2015-08-20 | 2020-04-29 | Janssen Vaccines & Prevention Bv | Therapeutic hpv18 vaccines |
| PE20190433A1 (es) | 2016-04-05 | 2019-03-21 | Janssen Vaccines And Prevention B V | Vacuna contra vrs |
| ES2858315T3 (es) | 2016-04-05 | 2021-09-30 | Janssen Vaccines & Prevention Bv | Proteína F de prefusión de VRS soluble estabilizada para uso en la profilaxis de la infección por VRS |
| US10358626B2 (en) * | 2016-04-12 | 2019-07-23 | Artemis Biosystems, Inc. | Perfusion filtration systems |
| JP7053491B2 (ja) | 2016-05-02 | 2022-04-12 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | 治療用ｈｐｖワクチン組み合わせ |
| US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
| IL264119B2 (en) | 2016-05-30 | 2023-04-01 | Janssen Vaccines Prevention B V | f proteins of rsv are stabilized before fusion |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| JP7229151B2 (ja) | 2016-07-14 | 2023-02-27 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | Ｈｐｖワクチン |
| US11702634B2 (en) | 2017-03-31 | 2023-07-18 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| JP2020519663A (ja) | 2017-05-17 | 2020-07-02 | ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． | Ｒｓｖ感染に対する防御免疫を誘導するための方法及び組成物 |
| AU2018333566A1 (en) | 2017-09-15 | 2020-02-27 | Janssen Vaccines & Prevention B.V. | Method for the safe induction of immunity against RSV |
| CA3077630A1 (en) | 2017-10-31 | 2019-05-09 | Janssen Vaccines & Prevention B.V. | Adenovirus vectors and uses thereof |
| CN111295391B (zh) | 2017-10-31 | 2023-12-05 | 扬森疫苗与预防公司 | 腺病毒及其用途 |
| MA50502A (fr) | 2017-10-31 | 2020-09-09 | Janssen Vaccines & Prevention Bv | Adénovirus et utilisations associées |
| MX2020004492A (es) | 2017-10-31 | 2020-11-24 | Janssen Vaccines & Prevention Bv | Adenovirus y usos de los mismos. |
| BR112020011627A2 (pt) * | 2017-12-11 | 2020-11-17 | Amgen Inc. | processo de fabricação contínuo para produtos de anticorpos biespecíficos |
| CN110317832B (zh) * | 2018-03-28 | 2022-07-05 | 西比曼生物科技（香港）有限公司 | Gmp级规模化制备重组慢病毒载体的纯化制剂的方法 |
| CN110317791A (zh) | 2018-03-29 | 2019-10-11 | 西比曼生物科技（香港）有限公司 | Gmp级无血清悬浮细胞大规模生产慢病毒的方法 |
| US20210047626A1 (en) | 2018-04-24 | 2021-02-18 | Merck Sharp & Dohme Corp. | Scalable chromatography process for purification of human cytomegalovirus |
| BR112022000061A2 (pt) * | 2019-07-01 | 2022-05-24 | Ology Bioservices Inc | Método para o cultivo de células aderentes em um bioreator multiparalelo |
| WO2021155323A1 (en) | 2020-01-31 | 2021-08-05 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for preventing and treating coronavirus infection-sars-cov-2 vaccines |
| GB202013940D0 (en) | 2020-09-04 | 2020-10-21 | Synpromics Ltd | Regulatory nucleic acid sequences |
| US20230374542A1 (en) | 2020-10-07 | 2023-11-23 | Asklepios Biopharmaceutical, Inc. | Therapeutic adeno-associated virus delivery of fukutin related protein (fkrp) for treating dystroglycanopathy. disorders including limb girdle 21 (lgmd21) |
| WO2022207839A2 (en) | 2021-04-01 | 2022-10-06 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion piv3 f proteins |
| WO2023020939A1 (en) | 2021-08-17 | 2023-02-23 | Janssen Pharmaceuticals, Inc. | Sars-cov-2 vaccines |
| WO2023111725A1 (en) | 2021-12-14 | 2023-06-22 | Janssen Pharmaceuticals, Inc. | Sars-cov-2 vaccines |
| WO2023110618A1 (en) | 2021-12-16 | 2023-06-22 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion hmpv fusion proteins |
| WO2024061753A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Stabilized trimeric class i fusion proteins |
| WO2024061757A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Pre-fusion human piv1 f proteins |
| WO2024074584A1 (en) | 2022-10-06 | 2024-04-11 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion piv3 f proteins |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04241381A (ja) | 1991-01-16 | 1992-08-28 | Brother Ind Ltd | 電子学習機 |
| FR2705686B1 (fr) | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| JP3816518B2 (ja) | 1994-06-10 | 2006-08-30 | ジェンベク、インコーポレイティッド | 相補的なアデノウイルスベクター系と細胞系 |
| US5851806A (en) | 1994-06-10 | 1998-12-22 | Genvec, Inc. | Complementary adenoviral systems and cell lines |
| US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| US5559099A (en) | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
| US5965541A (en) | 1995-11-28 | 1999-10-12 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
| US5770442A (en) | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
| US5837520A (en) | 1995-03-07 | 1998-11-17 | Canji, Inc. | Method of purification of viral vectors |
| DE69638058D1 (de) | 1995-06-15 | 2009-11-26 | Crucell Holland Bv | Verpackungssysteme für humane rekombinante Adenoviren zur Gentherapie |
| CA2230655C (en) | 1995-08-30 | 2008-06-17 | Genzyme Corporation | Chromatographic purification of adenovirus and aav |
| US5837511A (en) | 1995-10-02 | 1998-11-17 | Cornell Research Foundation, Inc. | Non-group C adenoviral vectors |
| CA2177085C (en) | 1996-04-26 | 2007-08-14 | National Research Council Of Canada | Adenovirus e1-complementing cell lines |
| CA2258158A1 (fr) | 1996-07-01 | 1998-01-08 | Francis Blanche | Procede de production d'adenovirus recombinants |
| FR2751343B1 (fr) | 1996-07-16 | 1998-12-18 | Transgene Sa | Procede de conservation de virus recombinants infectieux, suspension aqueuse virale et utilisation comme medicament |
| ATE348155T1 (de) | 1996-11-20 | 2007-01-15 | Introgen Therapeutics Inc | Ein verbessertes verfahren zur produktion und reinigung von adenoviralen vektoren |
| US7732129B1 (en) * | 1998-12-01 | 2010-06-08 | Crucell Holland B.V. | Method for the production and purification of adenoviral vectors |
| US6261823B1 (en) | 1996-12-13 | 2001-07-17 | Schering Corporation | Methods for purifying viruses |
| JP2000509614A (ja) | 1997-03-04 | 2000-08-02 | バクスター インターナショナル インコーポレイテッド | アデノウイルスｅ１−相補性細胞系 |
| US6020191A (en) | 1997-04-14 | 2000-02-01 | Genzyme Corporation | Adenoviral vectors capable of facilitating increased persistence of transgene expression |
| US6210683B1 (en) | 1997-09-05 | 2001-04-03 | Merck & Co., Inc. | Stabilizers containing recombinant human serum albumin for live virus vaccines |
| ES2272053T3 (es) | 1998-02-17 | 2007-04-16 | Schering Corporation | Composiciones que comprenden virus y metodos para concentrar preparaciones de virus. |
| US5981225A (en) | 1998-04-16 | 1999-11-09 | Baylor College Of Medicine | Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same |
| HUP0102209A2 (hu) | 1998-04-22 | 2001-09-28 | Genvec, Inc. | Eljárás adenovírus hatékony tisztítására |
| US6113913A (en) | 1998-06-26 | 2000-09-05 | Genvec, Inc. | Recombinant adenovirus |
| US20030017138A1 (en) | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
| US20040043489A1 (en) | 1998-07-08 | 2004-03-04 | Menzo Havenga | Gene delivery vectors provided with a tissue tropism for dendritic cells and methods of use |
| WO2000029024A1 (en) | 1998-11-16 | 2000-05-25 | Introgen Therapeutics, Inc. | Formulation of adenovirus for gene therapy |
| EP1141249A1 (fr) | 1998-12-31 | 2001-10-10 | Aventis Pharma S.A. | Methode de separation de particules virales |
| DE60029195T2 (de) | 1999-02-22 | 2007-06-28 | Transgene S.A. | Verfahren zur Gewinnung von purifizierter Virenzusammensetzung |
| AU777041B2 (en) | 1999-05-17 | 2004-09-30 | Crucell Holland B.V. | Adenovirus derived gene delivery vehicles comprising at least one element of adenovirus type 35 |
| US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
| US20050232900A1 (en) | 1999-05-18 | 2005-10-20 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
| US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| DE19955558C2 (de) | 1999-11-18 | 2003-03-20 | Stefan Kochanek | Permanente Amniozyten-Zelllinie, ihre Herstellung und Verwendung zur Herstellung von Gentransfervektoren |
| US6544424B1 (en) | 1999-12-03 | 2003-04-08 | Refined Technology Company | Fluid filtration system |
| WO2001066137A1 (en) | 2000-03-07 | 2001-09-13 | Merck & Co., Inc. | Adenovirus formulations |
| US7235233B2 (en) | 2000-09-26 | 2007-06-26 | Crucell Holland B.V. | Serotype 5 adenoviral vectors with chimeric fibers for gene delivery in skeletal muscle cells or myoblasts |
| US20020064860A1 (en) | 2000-11-29 | 2002-05-30 | Schering Corporation | Method for purifying adenoviruses |
| JP2005517394A (ja) | 2001-12-12 | 2005-06-16 | エフ エイチ フォールディング アンド カンパニー リミテッド | ウイルス保存のための組成物 |
| CA2474763A1 (en) | 2002-01-24 | 2003-07-31 | The Scripps Research Institute | Fiber shaft modifications for efficient targeting |
| US20030180936A1 (en) | 2002-03-15 | 2003-09-25 | Memarzadeh Bahram Eric | Method for the purification, production and formulation of oncolytic adenoviruses |
| PL208588B1 (pl) | 2002-04-25 | 2011-05-31 | Crucell Holland Bv | Rekombinowane adenowirusy, wyizolowane kwasy nukleinowe, komórki pakujące oraz sposoby zwiększania stabilności i/lub pojemności upakowania rekombinowanego adenowirusa |
| JP4495587B2 (ja) | 2002-04-25 | 2010-07-07 | クルセル ホランド ベー ヴェー | 組換えアデノウイルスベクターおよびその使用 |
| ES2357366T3 (es) | 2002-05-14 | 2011-04-25 | MERCK SHARP & DOHME CORP. | Procedimientos de purificación de adenovirus. |
| AU2003288273A1 (en) | 2002-10-23 | 2004-05-13 | Crucell Holland B.V. | New settings for recombinant adenoviral-based vaccines |
| US20080153083A1 (en) | 2003-10-23 | 2008-06-26 | Crucell Holland B.V. | Settings for recombinant adenoviral-based vaccines |
| SG156535A1 (en) | 2002-12-17 | 2009-11-26 | Crucell Holland Bv | Recombinant viral-based malaria vaccines |
| CA2519680A1 (en) | 2003-03-28 | 2004-11-18 | The Scripps Research Institute | Adenovirus particles with enhanced infectivity of dendritic cells and particles with decreased infectivity of hepatocytes |
| DK1670925T3 (da) | 2003-10-02 | 2013-07-08 | Crucell Holland Bv | Pakningsceller til rekombinat adenovirus |
| NZ548495A (en) * | 2004-02-23 | 2009-05-31 | Crucell Holland Bv | Virus purification methods |
| CN1930281A (zh) * | 2004-03-05 | 2007-03-14 | 帝斯曼知识产权资产管理有限公司 | 用于通过连续灌注和交互切向流来培养细胞的方法 |
| CN101001945B (zh) | 2004-06-04 | 2012-02-08 | 艾克塞勒雷克斯公司 | 一次性生物反应器系统及方法 |
| AP2351A (en) | 2004-10-13 | 2012-01-25 | Crucell Holland Bv | Improved adenoviral vectors and uses thereof. |
| BRPI0518146A (pt) | 2004-10-14 | 2008-10-28 | Crucell Holland Bv | kit de partes, uso de um adenovìrus recombinante defectivo na replicação, e, método de vacinação de um mamìfero para a infecção por malária |
| BRPI0518933A2 (pt) | 2004-11-16 | 2008-12-16 | Crucell Holland B V E Aeras Gl | adenovÍrus recombinante defeituoso de replicaÇço, vetor de polinucleotÍdeo recombinante, vacina multivalente da tuberculose, e, uso do antÍgeno tb10.4 de mycobacterium |
| JP2008538894A (ja) | 2005-02-11 | 2008-11-13 | メルク エンド カムパニー インコーポレーテッド | アデノウイルス血清型２６ベクター、核酸およびそれにより製造されたウイルス |
| DK1869171T4 (en) | 2005-04-11 | 2016-01-18 | Crucell Holland Bv | Virus cleaning using ultrafiltration |
| CA2609276A1 (en) | 2005-05-23 | 2006-11-30 | De-Chu C. Tang | Rapid production of adenovirus-free recombinant adenovirus vectors |
| WO2007010409A2 (en) | 2005-07-22 | 2007-01-25 | Pergo (Europe) Ab | Flooring system including a preglue |
| US20070178115A1 (en) | 2005-08-15 | 2007-08-02 | Tang De-Chu C | Immunization of avians by administration of non-replicating vectored vaccines |
| US20100143302A1 (en) | 2006-03-16 | 2010-06-10 | Crucell Holland B.V. | Recombinant Adenoviruses Based on Serotype 26 and 48, and Use Thereof |
| EP1998804B1 (en) | 2006-03-27 | 2014-04-16 | Crucell Holland B.V. | Compositions comprising a recombinant adenovirus and an adjuvant |
| KR20090094213A (ko) | 2006-07-18 | 2009-09-04 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 말라리아 백신 |
| BRPI0808553A2 (pt) | 2007-03-02 | 2014-08-19 | Glaxosmithkline Biolog Sa | Métodos para elevar uma resposta imune contra um patógeno, para estimar a produção de células t cd4+ e/ou cd8+ e/ou anticorpos específicos de patógeno em mamíferos e para estimular uma resposta imune em um mamífero, composição de vacina, uso da mesma, e, kit |
| US9109193B2 (en) | 2007-07-30 | 2015-08-18 | Ge Healthcare Bio-Sciences Corp. | Continuous perfusion bioreactor system |
| JP5795164B2 (ja) | 2007-11-14 | 2015-10-14 | チャン、チュン−チエ | リチウムイオン電池での適用のための空気感受性電極材料を製造するための方法および装置 |
| WO2009117134A2 (en) | 2008-03-21 | 2009-09-24 | National Institutes Of Health | Aerosolized genetic vaccines and methods of use |
| JP5770633B2 (ja) | 2008-11-03 | 2015-08-26 | クルセル ホランド ベー ヴェー | アデノウイルスベクターの産生方法 |
| WO2011006823A1 (en) | 2009-07-16 | 2011-01-20 | Crucell Holland B.V. | Production of polio virus at high titers for vaccine production |
| AU2010305768B2 (en) | 2009-10-15 | 2015-05-14 | Crucell Holland B.V. | Process for adenovirus purification from high cell density cultures |
| US20120315696A1 (en) | 2010-02-15 | 2012-12-13 | Alfred Luitjens | METHOD FOR THE PRODUCTION OF Ad26 ADENOVIRAL VECTORS |
| AU2011214262B2 (en) | 2010-02-15 | 2015-05-21 | Crucell Holland B.V. | Method for the production of Ad26 adenoviral vectors |
-
2009
- 2009-10-29 JP JP2011533718A patent/JP5770633B2/ja active Active
- 2009-10-29 CN CN2009801438951A patent/CN102203242B/zh active Active
- 2009-10-29 KR KR1020117010793A patent/KR101504392B1/ko active IP Right Grant
- 2009-10-29 CA CA2742474A patent/CA2742474C/en active Active
- 2009-10-29 US US13/126,978 patent/US10041049B2/en active Active
- 2009-10-29 EP EP09744140.6A patent/EP2350268B1/en active Active
- 2009-10-29 AU AU2009319254A patent/AU2009319254B2/en not_active Ceased
- 2009-10-29 PL PL09744140T patent/PL2350268T3/pl unknown
- 2009-10-29 ES ES09744140.6T patent/ES2532015T3/es active Active
- 2009-10-29 MX MX2011004292A patent/MX2011004292A/es active IP Right Grant
- 2009-10-29 NZ NZ593235A patent/NZ593235A/xx not_active IP Right Cessation
- 2009-10-29 BR BRPI0921651-0A patent/BRPI0921651A2/pt not_active Application Discontinuation
- 2009-10-29 DK DK09744140.6T patent/DK2350268T3/en active
- 2009-10-29 EA EA201170638A patent/EA019928B1/ru not_active IP Right Cessation
- 2009-10-29 WO PCT/EP2009/064265 patent/WO2010060719A1/en active Application Filing
-
2012
- 2012-01-31 HK HK12100868.5A patent/HK1160664A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2532015T3 (es) | 2015-03-23 |
| CN102203242A (zh) | 2011-09-28 |
| EP2350268B1 (en) | 2014-12-24 |
| PL2350268T3 (pl) | 2015-05-29 |
| NZ593235A (en) | 2013-02-22 |
| US20110207202A1 (en) | 2011-08-25 |
| AU2009319254A1 (en) | 2010-06-03 |
| KR20110093793A (ko) | 2011-08-18 |
| DK2350268T3 (en) | 2015-03-23 |
| JP2012507270A (ja) | 2012-03-29 |
| CA2742474A1 (en) | 2010-06-03 |
| CA2742474C (en) | 2016-05-31 |
| MX2011004292A (es) | 2011-05-31 |
| EP2350268A1 (en) | 2011-08-03 |
| AU2009319254B2 (en) | 2015-04-30 |
| EA201170638A1 (ru) | 2011-12-30 |
| EA019928B1 (ru) | 2014-07-30 |
| CN102203242B (zh) | 2013-06-12 |
| JP5770633B2 (ja) | 2015-08-26 |
| US10041049B2 (en) | 2018-08-07 |
| WO2010060719A1 (en) | 2010-06-03 |
| HK1160664A1 (en) | 2012-08-10 |
| KR101504392B1 (ko) | 2015-03-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0921651A2 (pt) | Método para produzir adenovírus recombinante, e partículas virais, e, biorreator | |
| BRPI1006141A2 (pt) | composições de anticorpo modificado, métodos para preparar e usar as mesmas | |
| BRPI0919252A2 (pt) | Métodos para cultivar células, propagação e purificação de vírus | |
| BRPI0919575A2 (pt) | método, e, composição | |
| EP2424814A4 (en) | OPTICAL MATERIALS, OPTICAL COMPONENTS AND METHOD | |
| BRPI0914145A2 (pt) | métodos para produzir polimerização por radical controlada, e para obter distribuição por radical atva controlada. | |
| BRPI0919199A2 (pt) | suspensões farmacêuticas submicrométricas estabilizadas e métodos para preparas as mesmas | |
| BRPI0912384A2 (pt) | composição, e, método para preparar uma composição | |
| BR112012005424A2 (pt) | método para produzir n-propanol, e, microorganismo | |
| BR112012000296A2 (pt) | composição e método para produção de um propante cerâmico ultraleve. | |
| BR112012002657A2 (pt) | composição polimerizável para material ótico, material ótico e processo para produção de material ótico | |
| BRPI0823277A2 (pt) | Composição, e , método | |
| BRPI0921106A2 (pt) | biocombustível e processo para preparação de biocombustível | |
| GB0822068D0 (en) | Methods for virus design | |
| BRPI0921438A2 (pt) | Hospedeiros e processos de fermentação para produção de celulase | |
| EP2767527A4 (en) | METHOD FOR MANUFACTURING CERAMIC BEES NICKEL STRUCTURE AND CERAMIC BEES NUT STRUCTURE | |
| BRPI0917714A2 (pt) | método para preparar uma microesfera de liberação prolongada, e, microesfera de liberação prolongada | |
| BRPI1014516A2 (pt) | Biorreator de estado sólido, estático, e método para usar o mesmo | |
| BRPI0921380A2 (pt) | processo para preparar partículas oxidantes, e, partículas oxidantes de tamanho reduzido | |
| BRPI0823238A2 (pt) | Composição, e, método | |
| BRPI1006996A2 (pt) | composição, método e uso | |
| BRPI0918633A2 (pt) | método para calcinar matérias-primas. | |
| EP2767528A4 (en) | METHOD FOR PRODUCING A CERAMIC WAVE STRUCTURE AND CERAMIC WAVE STRUCTURE | |
| BR112013030382A2 (pt) | célula hospedeira recombinante, composição, e, métodos para produzir n-propanol e propileno | |
| FI20075192A0 (fi) | Menetelmät analyysien valmistelemiseksi ja suorittamiseksi |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B25D | Requested change of name of applicant approved |
Owner name: JANSSEN VACCINES AND PREVENTION B.V. (NL) |
|
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |