CN101001945B - 一次性生物反应器系统及方法 - Google Patents
一次性生物反应器系统及方法 Download PDFInfo
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- CN101001945B CN101001945B CN2005800265340A CN200580026534A CN101001945B CN 101001945 B CN101001945 B CN 101001945B CN 2005800265340 A CN2005800265340 A CN 2005800265340A CN 200580026534 A CN200580026534 A CN 200580026534A CN 101001945 B CN101001945 B CN 101001945B
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- impeller
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/14—Bags
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
- B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/50—Mixing receptacles
- B01F35/513—Flexible receptacles, e.g. bags supported by rigid containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/50—Mixing receptacles
- B01F35/53—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
- B01F35/531—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom
- B01F35/5312—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom with vertical baffles mounted on the walls
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/18—Flow directing inserts
- C12M27/20—Baffles; Ribs; Ribbons; Auger vanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/44—Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation
Abstract
Description
部件 | 数量 | 说明 |
槽槽壳 | 1 | 带配件的316SS槽壳 |
槽线圈和绝缘体 | 1 | 围绕槽壳包裹的热转移途 |
径 | ||
温度控制器单元 | 1 | 与主要的滑动控制器为一整体的单独树立的TCU |
槽套管 | 1 | 在TCU和槽线圈之间连接 |
槽观察镜 | 1 | 在槽壳侧的视窗 |
管道管理器 | 1 | 槽顶部具有管道索环的面板 |
I和C pH探头与分析仪 | 2 | |
溶解氧与分析仪 | 2 | |
上样细胞 | 3 | |
上样细胞分析仪 | 1 | |
热电偶 | 5 | |
流量计-鼓泡 | 1 | 提供至鼓泡元件的流量的局部可观察读数的转子流量计 |
流量计-头扫 | 1 | 提供至顶空的气流量的局部可观察读数的转子流量计 |
流量转换-排出线 | 1 | 指示过滤流量或阻滞的流量检测器 |
质量流动控制器-头扫 | 1 | |
质量流动控制器-鼓泡 | 4 | |
酸类进样泵 | 1 | 蠕动泵-小 |
碱类进样泵 | 1 | 蠕动泵-小 |
反式进样泵 | 1 | 蠕动泵-小 |
培养基进样泵 | 1 | 蠕动泵 |
排出泵 | 1 | 蠕动泵 |
搅拌器发动机,减速器,驱动头 | 1 | Baldor1/2HP(马力)冲洗功率或等值 |
搅拌器控制器 | 1 | Baldor冲洗功率或等值 |
功率分布 | 1 | |
I/O盒和开关 | 1 | |
PLC控制器 | 1 | |
操作者界面 | 1 |
Claims (1)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57714304P | 2004-06-04 | 2004-06-04 | |
US60/577,143 | 2004-06-04 | ||
US66925205P | 2005-04-07 | 2005-04-07 | |
US60/669,252 | 2005-04-07 | ||
PCT/US2005/020083 WO2005118771A2 (en) | 2004-06-04 | 2005-06-06 | Disposable bioreactor systems and methods |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201110402080.XA Division CN102492607B (zh) | 2004-06-04 | 2005-06-06 | 一次性生物反应器系统及方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101001945A CN101001945A (zh) | 2007-07-18 |
CN101001945B true CN101001945B (zh) | 2012-02-08 |
Family
ID=35197799
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005800265340A Active CN101001945B (zh) | 2004-06-04 | 2005-06-06 | 一次性生物反应器系统及方法 |
CN201110402080.XA Active CN102492607B (zh) | 2004-06-04 | 2005-06-06 | 一次性生物反应器系统及方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201110402080.XA Active CN102492607B (zh) | 2004-06-04 | 2005-06-06 | 一次性生物反应器系统及方法 |
Country Status (15)
Country | Link |
---|---|
US (1) | US7629167B2 (zh) |
EP (1) | EP1773976B2 (zh) |
JP (1) | JP4680990B2 (zh) |
KR (1) | KR101021203B1 (zh) |
CN (2) | CN101001945B (zh) |
AU (1) | AU2005250500B2 (zh) |
BR (1) | BRPI0510648B1 (zh) |
CA (1) | CA2569405C (zh) |
CR (1) | CR8769A (zh) |
DK (1) | DK1773976T4 (zh) |
ES (1) | ES2612212T5 (zh) |
HK (1) | HK1112479A1 (zh) |
MX (1) | MXPA06014099A (zh) |
NO (1) | NO20070069L (zh) |
WO (1) | WO2005118771A2 (zh) |
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- 2005-06-06 CN CN2005800265340A patent/CN101001945B/zh active Active
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- 2005-06-06 EP EP05763165.7A patent/EP1773976B2/en active Active
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- 2005-06-06 KR KR1020077000150A patent/KR101021203B1/ko active IP Right Grant
- 2005-06-06 AU AU2005250500A patent/AU2005250500B2/en active Active
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Also Published As
Publication number | Publication date |
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ES2612212T3 (es) | 2017-05-12 |
MXPA06014099A (es) | 2007-05-09 |
JP4680990B2 (ja) | 2011-05-11 |
EP1773976A2 (en) | 2007-04-18 |
US20050272146A1 (en) | 2005-12-08 |
EP1773976B2 (en) | 2020-01-01 |
CA2569405A1 (en) | 2005-12-15 |
NO20070069L (no) | 2007-03-05 |
AU2005250500B2 (en) | 2011-06-23 |
CN101001945A (zh) | 2007-07-18 |
CN102492607B (zh) | 2014-12-10 |
AU2005250500A1 (en) | 2005-12-15 |
BRPI0510648A (pt) | 2007-11-20 |
US7629167B2 (en) | 2009-12-08 |
EP1773976B1 (en) | 2016-12-07 |
DK1773976T3 (en) | 2017-01-30 |
CA2569405C (en) | 2011-05-03 |
ES2612212T5 (es) | 2020-06-25 |
CN102492607A (zh) | 2012-06-13 |
CR8769A (es) | 2007-08-28 |
WO2005118771A2 (en) | 2005-12-15 |
BRPI0510648B1 (pt) | 2016-04-26 |
KR20070053200A (ko) | 2007-05-23 |
KR101021203B1 (ko) | 2011-03-11 |
HK1112479A1 (en) | 2008-09-05 |
JP2008501347A (ja) | 2008-01-24 |
WO2005118771A3 (en) | 2006-02-02 |
DK1773976T4 (da) | 2020-02-10 |
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