CR8769A - Sistemas y procedimientos para unos bioreactores desechables - Google Patents

Sistemas y procedimientos para unos bioreactores desechables

Info

Publication number
CR8769A
CR8769A CR8769A CR8769A CR8769A CR 8769 A CR8769 A CR 8769A CR 8769 A CR8769 A CR 8769A CR 8769 A CR8769 A CR 8769A CR 8769 A CR8769 A CR 8769A
Authority
CR
Costa Rica
Prior art keywords
procedures
systems
disposable bioreactors
disposable
disposable reservoir
Prior art date
Application number
CR8769A
Other languages
English (en)
Inventor
Hodge Geoffrey
Galliher Parrish
Fisher Michael
Original Assignee
Xcellerex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35197799&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR8769(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Xcellerex Inc filed Critical Xcellerex Inc
Publication of CR8769A publication Critical patent/CR8769A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00Bioreactors or fermenters specially adapted for specific uses
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50Mixing receptacles
    • B01F35/513Flexible receptacles, e.g. bags supported by rigid containers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50Mixing receptacles
    • B01F35/53Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
    • B01F35/531Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom
    • B01F35/5312Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom with vertical baffles mounted on the walls
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/14Bags
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02Stirrer or mobile mixing elements
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/18Flow directing inserts
    • C12M27/20Baffles; Ribs; Ribbons; Auger vanes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48Automatic or computerized control
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/44Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Computer Hardware Design (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Packages (AREA)

Abstract

Por lo tanto, en una realizacion de la invencion, un sistema bioreactor esta presente e incluye un deposito desechable para alojar biomateriales para su procesamiento, incluyendo el deposito desechable, al menos un puerto de entrada , al menos, un puerto de escape, al menos un puerto de recoleccioon, y la integridad del medio esterilizado esta protegida con unos filtros esterilizados acoplados a todos los puertos externos abiertos.
CR8769A 2004-06-04 2006-11-23 Sistemas y procedimientos para unos bioreactores desechables CR8769A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57714304P 2004-06-04 2004-06-04
US66925205P 2005-04-07 2005-04-07

Publications (1)

Publication Number Publication Date
CR8769A true CR8769A (es) 2007-08-28

Family

ID=35197799

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8769A CR8769A (es) 2004-06-04 2006-11-23 Sistemas y procedimientos para unos bioreactores desechables

Country Status (15)

Country Link
US (1) US7629167B2 (es)
EP (1) EP1773976B2 (es)
JP (1) JP4680990B2 (es)
KR (1) KR101021203B1 (es)
CN (2) CN102492607B (es)
AU (1) AU2005250500B2 (es)
BR (1) BRPI0510648B1 (es)
CA (1) CA2569405C (es)
CR (1) CR8769A (es)
DK (1) DK1773976T4 (es)
ES (1) ES2612212T5 (es)
HK (1) HK1112479A1 (es)
MX (1) MXPA06014099A (es)
NO (1) NO20070069L (es)
WO (1) WO2005118771A2 (es)

Families Citing this family (234)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
IL155588A0 (en) * 2003-04-27 2003-11-23 Metabogal Ltd Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
US7086778B2 (en) * 2000-10-09 2006-08-08 Levtech, Inc. System using a levitating, rotating pumping or mixing element and related methods
US8182137B2 (en) 2000-10-09 2012-05-22 Atmi Packaging, Inc. Mixing bag or vessel with a fluid-agitating element
US20030100945A1 (en) 2001-11-23 2003-05-29 Mindguard Ltd. Implantable intraluminal device and method of using same in treating aneurysms
EP1534412B1 (en) 2001-10-03 2010-08-18 Levtech Inc. Mixing vessel having a receiver for a fluid-agitating element
US7951557B2 (en) 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
CA2552717C (en) * 2004-01-07 2011-11-29 Levtech, Inc. Mixing bag with integral sparger and sensor receiver
EP1763575A4 (en) 2004-04-27 2009-09-23 Baxter Int REACTOR SYSTEM WITH AGITATION RESERVOIR
JP2008504118A (ja) * 2004-06-23 2008-02-14 リーブテック,インコーポレイテッド 混合用容器心合システム、デバイス及びそれらに関連する方法
US8603805B2 (en) 2005-04-22 2013-12-10 Hyclone Laboratories, Inc. Gas spargers and related container systems
WO2006119622A1 (en) 2005-05-09 2006-11-16 Saxonia Biotec Gmbh. Apparatus for providing media to cell culture modules
WO2008040567A1 (en) * 2006-10-03 2008-04-10 Artelis Flexible mixing bag, mixing device and mixing system
US8790913B2 (en) * 2005-10-26 2014-07-29 Pbs Biotech, Inc. Methods of using pneumatic bioreactors
US7628528B2 (en) * 2005-10-26 2009-12-08 PRS Biotech, Inc. Pneumatic bioreactor
DE102006001623B4 (de) * 2006-01-11 2009-05-07 Sartorius Stedim Biotech Gmbh Behälter und Verfahren zum Mischen von Medien
SE531572C2 (sv) * 2006-04-05 2009-05-26 Millipore Ab Engångsenhet för processa produkter
DE102006018824A1 (de) 2006-04-22 2007-10-25 Bayer Technology Services Gmbh Einweg-Bioreaktor
DE102006022307A1 (de) 2006-05-11 2007-11-15 Respironics Novametrix, LLC, Wallingford Einwegbioreaktor mit Sensoranordnung
EP2018416B1 (en) 2006-05-13 2018-10-24 Pall Life Sciences Belgium Disposable bioreactor
EP2044190B1 (en) 2006-06-16 2017-09-13 GE Healthcare Bio-Sciences Corp. Gas delivery configurations, foam control systems, and bag molding methods and articles for collapsible bag vessels and bioreactors
FR2902799B1 (fr) * 2006-06-27 2012-10-26 Millipore Corp Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide
EP2049646A2 (en) * 2006-07-14 2009-04-22 Xcellerex, Inc. Environmental containment systems
EP2049234B1 (en) 2006-08-01 2010-06-30 Celljet Biotech Limited Liquid circulation system comprising an inflatable guide
US20080032396A1 (en) * 2006-08-02 2008-02-07 Becton, Dickinson And Company Bioreactor and Method
US8008065B2 (en) * 2006-08-02 2011-08-30 Finesse Solutions, Llc. Disposable bioreactor vessel port
US10227555B2 (en) 2006-08-02 2019-03-12 Finesse Solutions, Inc. Composite sensor assemblies for single use bioreactors
US9267100B2 (en) 2006-08-02 2016-02-23 Finesse Solutions, Inc. Composite sensor assemblies for single use bioreactors
US11827875B2 (en) 2006-08-02 2023-11-28 Finesse Solutions, Inc. Method for manufacturing a composite sensor
WO2008040569A1 (en) 2006-10-03 2008-04-10 Artelis Flexible bag, mixing system and method for fixing a flexible bag inside a rigid container
US20080151683A1 (en) * 2006-11-14 2008-06-26 Charles Meadows Stir-bag system with stand and turbulence member
US10914698B2 (en) 2006-11-16 2021-02-09 General Electric Company Sensing method and system
US10018613B2 (en) 2006-11-16 2018-07-10 General Electric Company Sensing system and method for analyzing a fluid at an industrial site
US9536122B2 (en) 2014-11-04 2017-01-03 General Electric Company Disposable multivariable sensing devices having radio frequency based sensors
US9538657B2 (en) 2012-06-29 2017-01-03 General Electric Company Resonant sensor and an associated sensing method
US10260388B2 (en) 2006-11-16 2019-04-16 General Electric Company Sensing system and method
US9658178B2 (en) 2012-09-28 2017-05-23 General Electric Company Sensor systems for measuring an interface level in a multi-phase fluid composition
US9589686B2 (en) 2006-11-16 2017-03-07 General Electric Company Apparatus for detecting contaminants in a liquid and a system for use thereof
WO2008079302A2 (en) 2006-12-21 2008-07-03 Millipore Corporation Purification of proteins
US8362217B2 (en) 2006-12-21 2013-01-29 Emd Millipore Corporation Purification of proteins
US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
US20100075405A1 (en) * 2007-02-15 2010-03-25 Broadley-James Corporation Bioreactor jacket
US20100028990A1 (en) * 2007-02-15 2010-02-04 Broadley-James Corporation Sterile bioreactor bag with integrated drive unit
WO2008106193A1 (en) * 2007-02-28 2008-09-04 Xcellerex, Inc. Weight measurements of liquids in flexible containers
US7713730B2 (en) 2007-04-24 2010-05-11 Pbs Biotech, Inc. Pneumatic bioreactor
US9868095B2 (en) 2007-05-02 2018-01-16 Finesse Solutions, Inc. Disposable bioreactor system
US9090398B2 (en) 2007-05-04 2015-07-28 Emd Millipore Corporation Disposable processing bag with alignment feature
EP2150608B1 (en) 2007-05-07 2017-11-29 Protalix Ltd. Large scale disposable bioreactor
DK2155852T3 (da) * 2007-06-15 2014-01-20 Cellution Biotech B V Forbedret fleksibel bioreaktor
US9109193B2 (en) 2007-07-30 2015-08-18 Ge Healthcare Bio-Sciences Corp. Continuous perfusion bioreactor system
US7832922B2 (en) 2007-11-30 2010-11-16 Levitronix Gmbh Mixing apparatus and container for such
JP2011509685A (ja) * 2008-01-25 2011-03-31 エクセレレックス インク. バイオリアクタシステムと製造施設における情報取得、管理システム及び方法
EP2247707A1 (en) * 2008-01-25 2010-11-10 Xcellerex, Inc. Bag wrinkel remover, leak detection systems, and electromagnetic agitation for liquid containment systems
WO2009116002A1 (fr) * 2008-03-19 2009-09-24 Sartorius Stedim Biotech Gmbh Recipient-melangeur
US9340763B2 (en) 2008-03-25 2016-05-17 Ge Healthcare Bio-Sciences Corp. Temperature controlling surfaces and support structures
US9534196B2 (en) 2009-03-25 2017-01-03 Ge Healthcare Bio-Sciences Corp. Temperature controlled support surfaces for single use flexible wall systems
US10767154B2 (en) 2008-03-25 2020-09-08 Global Life Sciences Solutions Usa Llc Temperature controlling surfaces and support structures
US20090242173A1 (en) * 2008-03-25 2009-10-01 Peter Mitchell Temperature control system
WO2009132192A2 (en) * 2008-04-25 2009-10-29 Pbs Biotech, Inc. Bioreactor apparatus
US8381780B2 (en) * 2008-05-22 2013-02-26 Xcellerex, Inc. Lift and support assemblies and methods for collapsible bag containers of vessels and bioreactors
DE102008025507A1 (de) 2008-05-28 2009-12-03 Sartorius Stedim Biotech Gmbh Mischsystem
DE102008025968B4 (de) * 2008-05-30 2014-08-21 Sartorius Stedim Biotech Gmbh Bioreaktor mit Kondensator
EP2130905A1 (en) 2008-06-04 2009-12-09 Pharmacell B.V. Method for culturing eukaryotic cells
WO2009151514A1 (en) * 2008-06-11 2009-12-17 Millipore Corporation Stirred tank bioreactor
US8192071B2 (en) 2008-07-16 2012-06-05 Sartorius Stedim Biotech Gmbh Agitator apparatus with collapsible impeller
FR2934371B1 (fr) * 2008-07-25 2012-06-08 Nanotec Solution Dispositif capteur de biomasse a usage unique, procede de realisation de ce dispositif et bioreacteur a usage unique integrant ce capteur
PL2330209T3 (pl) * 2008-09-30 2017-12-29 Toray Industries, Inc. Sposób i urządzenie do wytwarzania związku chemicznego oraz układ do hodowli ciągłej
CA2742474C (en) 2008-11-03 2016-05-31 Crucell Holland B.V. Method for the production of adenoviral vectors
GB0820779D0 (en) * 2008-11-13 2008-12-17 Artelis S A Cell culture device and method of culturing cells
SG171446A1 (en) 2008-12-16 2011-07-28 Millipore Corp Stirred tank reactor and method
WO2010069320A2 (en) 2008-12-19 2010-06-24 Stobbe Tech A/S Biopharmaceutical plant in a column
DE102009005962A1 (de) 2009-01-23 2010-07-29 Bayer Technology Services Gmbh Begasungssystem
ES2580804T3 (es) 2009-03-03 2016-08-26 The Trustees Of Columbia University In The City Of New York Métodos, dispositivos y sistemas para ingeniería de tejido óseo utilizando un biorreactor
FR2943355B1 (fr) * 2009-03-18 2011-04-08 Sartorius Stedim Biotech Sa Recipient-melangeur avec palier d'arbre en partie superieure
EP2409130B1 (en) * 2009-03-20 2013-12-04 Pbs Biotech, Inc. Automatable aseptic sample withdrawal system
FR2943560B1 (fr) * 2009-03-24 2011-05-27 Jean Pascal Zambaux Bioreacteur jetable et systeme d'agitation a usage unique
DE102009019697A1 (de) * 2009-05-05 2010-11-18 Bayer Technology Services Gmbh Container
SI2251407T1 (sl) * 2009-05-12 2016-09-30 Eppendorf Ag Bioreaktor za enkratno uporabo in postopek za njegovo proizvodnjo
DE102009050448A1 (de) * 2009-06-19 2011-12-08 Sartorius Stedim Biotech Gmbh Sensorvorrichtung, aufweisend einen optischen Sensor, einen Behälter und ein Kompartimentierungsmittel
MX2012000354A (es) 2009-07-06 2012-02-01 Genentech Inc Metodo para cultivar celulas eucarionticas.
JP5792177B2 (ja) 2009-09-30 2015-10-07 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 使い捨てバイオリアクター凝縮バッグおよびフィルターヒーター
US9719705B2 (en) * 2009-09-30 2017-08-01 Ge Healthcare Bio-Sciences Corp. Disposable bioreactor condenser bag and filter heater
FR2950802B1 (fr) * 2009-10-02 2012-02-03 Sartorius Stedim Biotech Sa Elaboration et/ou conservation d'un produit biopharmaceutique.
DE102009052670B4 (de) * 2009-11-12 2017-10-05 Sartorius Stedim Biotech Gmbh Begasungsvorrichtung für Bioreaktoren
CA2818514A1 (en) * 2009-11-17 2011-05-26 Harvard Bioscience, Inc. Bioreactors, systems, and methods for producing and/or analyzing organs
CA2784519A1 (en) * 2009-12-22 2011-06-30 Ge Healthcare Bio-Sciences Ab A method for controlling culture parameters in a bioreactor
US11773358B2 (en) 2009-12-22 2023-10-03 Cytiva Sweden Ab Method for controlling culture parameters in a bioreactor
US8455242B2 (en) * 2010-02-22 2013-06-04 Hyclone Laboratories, Inc. Mixing system with condenser
WO2011106659A2 (en) * 2010-02-25 2011-09-01 Jere Northrop Process and method for optimizing production of food and feed
CN102892487B (zh) 2010-03-09 2015-06-17 Emd密理博公司 具有传感器的处理袋容器
US20130115588A1 (en) * 2010-04-15 2013-05-09 G & G Technologies, Inc. Integrated bioreactor and separation system and methods of use therof
CN102892791B (zh) 2010-05-17 2017-05-17 Emd密理博公司 用于纯化生物分子的刺激响应性聚合物
US8480292B2 (en) * 2010-06-01 2013-07-09 Boris Dushine Systems, apparatus and methods to reconstitute dehydrated drinks
WO2012005667A1 (en) * 2010-07-05 2012-01-12 Bioprocess Control Sweden Ab System for biological fermentation
DE102010036193A1 (de) * 2010-09-02 2012-03-08 Sartorius Stedim Biotech Gmbh Vorrichtung zur kontaktlosen Übertragung elektrischer Energie für Bioreaktorbauteile
WO2012040574A1 (en) 2010-09-23 2012-03-29 Xcellerex, Inc. Single use slurrying and chromatography systems
CN102559491A (zh) * 2010-10-14 2012-07-11 杨凯 一种用于百合籽球培养的鼓泡式生物反应器
US8542023B2 (en) 2010-11-09 2013-09-24 General Electric Company Highly selective chemical and biological sensors
JP2014501537A (ja) 2011-01-11 2014-01-23 エクセラレックス,インコーポレーテッド 直線的拡張性を有する使い捨て型バイオリアクタシステム
MY148876A (en) * 2011-01-14 2013-06-14 Univ Sains Malaysia A cell culture tank.
EP2484750A1 (en) * 2011-02-07 2012-08-08 Ecole Polytechnique Fédérale de Lausanne (EPFL) Monitoring system for cell culture
JP5923529B2 (ja) * 2011-03-18 2016-05-24 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 細胞培養用可撓性バッグ
WO2012130334A1 (de) 2011-04-01 2012-10-04 Siemens Aktiengesellschaft Einweg-bioreaktor und sensorsystem für einen bioreaktor
DE102011007013B4 (de) 2011-04-07 2015-08-27 Siemens Aktiengesellschaft Einweg-Bioreaktor
US8668886B2 (en) * 2011-04-24 2014-03-11 Therapeutic Proteins International, LLC Separative bioreactor
US9284841B1 (en) * 2011-07-14 2016-03-15 Julie C. Vickers Disposable heat exchanger assembly for sterile and aseptic biotechnology and pharmaceutical manufacturing applications
CN202786257U (zh) * 2011-08-31 2013-03-13 通用电气健康护理生物科学股份公司 用于生物反应器的排气过滤装置
HUE052865T2 (hu) * 2011-09-01 2021-05-28 Gicon Grossmann Ingenieur Consult Gmbh Eljárás és berendezés gázoknak vagy gázkeverékeknek folyadékba, szuszpenzióba vagy emulzióba történõ betárolására egy fotobioreaktorban
US8183035B1 (en) * 2011-09-07 2012-05-22 Therapeutic Proteins International, LLC Single container manufacturing of biological product
US9376655B2 (en) 2011-09-29 2016-06-28 Life Technologies Corporation Filter systems for separating microcarriers from cell culture solutions
WO2013049692A1 (en) 2011-09-30 2013-04-04 Hyclone Laboratories, Inc. Container with film sparger
WO2013052836A1 (en) * 2011-10-07 2013-04-11 Atmi Packaging, Inc. Fluid processing control system and related methods
US10717960B2 (en) 2011-10-10 2020-07-21 Dasgip Information And Technology Gmbh Biotechnological apparatus comprising a bioreactor, exhaust gas temperature control device for a bioreactor and a method for treating an exhaust gas stream in a biotechnological apparatus
EP2773328A2 (en) 2011-11-04 2014-09-10 Nitto Denko Corporation Method of producing lipid nanoparticles for drug delivery
BR112014016762B1 (pt) * 2012-01-13 2020-04-28 Ge Healthcare Bio Sciences Corp sistema de reator biológico tendo um recipiente flexível de único uso e um módulo de troca de calor
CN104220155B (zh) * 2012-03-07 2019-09-24 通用电气医疗集团生物科学公司 用于加压生物反应器的可弃阀和柔性容器
US9339764B2 (en) * 2012-03-12 2016-05-17 Uchicago Argonne, Llc Internal gas and liquid distributor for electrodeionization device
US9284521B2 (en) * 2012-03-24 2016-03-15 Therapeutic Proteins International, LLC Pivoting pressurized single-use bioreactor
US9339026B2 (en) 2012-06-14 2016-05-17 Therapeutic Proteins International, LLC Pneumatically agitated and aerated single-use bioreactor
US10598650B2 (en) 2012-08-22 2020-03-24 General Electric Company System and method for measuring an operative condition of a machine
US9746452B2 (en) 2012-08-22 2017-08-29 General Electric Company Wireless system and method for measuring an operative condition of a machine
US10684268B2 (en) 2012-09-28 2020-06-16 Bl Technologies, Inc. Sensor systems for measuring an interface level in a multi-phase fluid composition
KR101247515B1 (ko) * 2012-10-15 2013-03-26 김창수 버섯종균 배양장치
JP6938007B2 (ja) * 2012-12-03 2021-09-22 グローバル・ライフ・サイエンシズ・ソリューションズ・ユーエスエー・エルエルシー 温度制御面及び支持構造
CN103028336A (zh) * 2012-12-29 2013-04-10 上海乐纯生物技术有限公司 配液袋子
RU2768003C2 (ru) 2013-03-08 2022-03-22 Джензим Корпорейшн Интегрированное непрерывное производство терапевтических белковых лекарственных веществ
SG11201508282UA (en) * 2013-04-19 2015-11-27 Emd Millipore Corp Flexible film baffle in single use bioreactor
US9975658B2 (en) 2013-06-05 2018-05-22 Ge Healthcare Bio-Sciences Ab Disposable container and mixing system comprising the container
US10076753B2 (en) * 2013-06-12 2018-09-18 Ge Healthcare Bio-Sciences Corp. Disposable container and mixing system comprising the container
WO2014204384A1 (en) * 2013-06-17 2014-12-24 Ge Healthcare Bio-Sciences Ab Bioreactor system with a temperature sensor
JP6216449B2 (ja) * 2013-06-28 2017-10-18 サン−ゴバン パフォーマンス プラスティックス コーポレイション 磁気インペラを含む混合アセンブリ
US11944946B2 (en) 2013-06-28 2024-04-02 Saint-Gobain Performance Plastics Corporation Mixing assemblies including magnetic impellers
WO2015034416A1 (en) 2013-09-06 2015-03-12 Ge Healthcare Bio-Sciences Ab Cell culture bag with internal dialysis membrane
EP3046644A4 (en) * 2013-09-16 2017-08-09 F. Hoffmann-La Roche AG Bioreactors with multiple or adjustable -position agitator designs
EP3031901B1 (en) * 2013-10-11 2017-09-27 Panasonic Healthcare Holdings Co., Ltd. Culture apparatus
WO2015056267A1 (en) * 2013-10-14 2015-04-23 Algalo Industries Ltd. Algae growth system and method
DK3825394T3 (da) 2013-12-10 2024-01-15 Abec Inc Engangsbeholder omfattende et forseglingsarrangement samt anvendelse deraf
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
DE102014101839B4 (de) * 2014-02-13 2018-03-15 Sartorius Stedim Biotech Gmbh Verpackung für einen flexiblen Behälter und Transporteinheit
EP3782721B1 (en) 2014-03-21 2023-08-23 Life Technologies Corporation Gas filter systems for fluid processing systems
EP4324906A1 (en) 2014-03-21 2024-02-21 Life Technologies Corporation Condenser systems for fluid processing systems
JP6020513B2 (ja) * 2014-05-29 2016-11-02 横河電機株式会社 細胞培養バッグおよび細胞培養バッグの製造方法
US9079690B1 (en) 2014-06-26 2015-07-14 Advanced Scientifics, Inc. Freezer bag, storage system, and method of freezing
US9587215B2 (en) 2014-08-07 2017-03-07 General Electric Company Devices, systems and methods for automated transfer of a sample
US9457306B2 (en) * 2014-10-07 2016-10-04 Life Technologies Corporation Regulated vacuum off-gassing of gas filter for fluid processing system and related methods
DE102014117658B4 (de) 2014-12-02 2023-02-16 Sartorius Stedim Biotech Gmbh Mischvorrichtung mit Strömungsbrecher
WO2016167959A1 (en) * 2015-04-13 2016-10-20 Rosemount Analytical Inc. Single-use bioreactor port with multiple sensors
EP3286295A1 (en) * 2015-04-20 2018-02-28 GE Healthcare Bio-Sciences Corp. Inactivation of viruses
US11052165B2 (en) 2015-04-20 2021-07-06 Global Life Sciences Solutions Usa Llc Method for virus clearance
DE102015007061B4 (de) 2015-06-02 2023-12-14 Sartorius Stedim Biotech Gmbh System, Vorrichtung und Verfahren zum Aufnehmen eines Einwegbeutels
DE102015110894B3 (de) * 2015-07-06 2016-09-01 Sartorius Stedim Biotech Gmbh Verfahren zum Messen einer Mehrzahl von Zustandsparametern eines in einem Behälter enthaltenen Fluids
JP6764221B2 (ja) * 2015-07-22 2020-09-30 株式会社日立製作所 攪拌装置
US10323494B2 (en) 2015-07-23 2019-06-18 General Electric Company Hydrocarbon production system and an associated method thereof
US10047596B2 (en) 2015-07-23 2018-08-14 General Electric Company System and method for disposal of water produced from a plurality of wells of a well-pad
US10077646B2 (en) 2015-07-23 2018-09-18 General Electric Company Closed loop hydrocarbon extraction system and a method for operating the same
US9920292B2 (en) 2015-08-31 2018-03-20 General Electric Company System and method for initiating a cell culture
CN108026496B (zh) * 2015-10-01 2022-07-26 思拓凡瑞典有限公司 过滤器保持装置
US10836989B2 (en) * 2015-10-16 2020-11-17 Global Life Sciences Solutions Usa Llc Disposable container, mixing system and packaging
US11008540B2 (en) 2015-10-26 2021-05-18 Lonza Ltd. Manufacturing facility for the production of biopharmaceuticals
WO2017081288A1 (en) 2015-11-11 2017-05-18 Lonza Ltd Crispr-associated (cas) proteins with reduced immunogenicity
US10576393B2 (en) * 2015-12-18 2020-03-03 General Electric Company System and method for condensing moisture in a bioreactor gas stream
CN105413554B (zh) * 2015-12-25 2018-09-18 奥星制药设备(石家庄)有限公司 基于一次性无菌袋的配液平台及其搅拌配制和转运方法
US11268056B2 (en) 2015-12-29 2022-03-08 Life Technologies Corporation Flexible bioprocessing container with partial dividing partition
WO2017123788A2 (en) * 2016-01-12 2017-07-20 Sarfaraz Niazi Multipurpose bioreactor
WO2017149065A1 (en) 2016-03-02 2017-09-08 Lonza Ltd Improved fermentation process
US10689873B2 (en) 2016-03-10 2020-06-23 Lonza Ltd Customizable facility
AU2017230823A1 (en) 2016-03-10 2018-09-27 Lonza Ltd Customizable facility
US20180010082A1 (en) * 2016-06-03 2018-01-11 Lonza Ltd Bioreactor With Higher Agitation Rates
WO2017207822A1 (en) 2016-06-03 2017-12-07 Lonza Limited Single use bioreactor
EA201892820A1 (ru) 2016-06-10 2019-10-31 Способ стабилизации белков
TWI808057B (zh) 2016-06-24 2023-07-11 瑞士商隆沙有限公司 可變直徑生物感測器容器及系統,在接種階段列及生產感測器中使用減少量之感測器生產醱酵產物之方法,及生物生產設施
WO2018010929A1 (en) * 2016-07-12 2018-01-18 General Electric Company Microfluidic device for cell culture monitoring
KR102480770B1 (ko) 2016-08-02 2022-12-22 론자 리미티드 맞춤형 시설
JP2019533135A (ja) 2016-08-12 2019-11-14 ロンザ リミテッドLonza Limited 宿主細胞タンパク質のプロテオーム解析
US10808216B2 (en) 2016-10-05 2020-10-20 Lonza Ltd Reactor surface finish remediation
CN110072602A (zh) 2016-11-17 2019-07-30 龙沙有限公司 具有过滤器锁定设计的过滤器组件
US10919715B2 (en) 2016-11-17 2021-02-16 Lonza Ltd Filter moving device
CN208684945U (zh) 2016-12-01 2019-04-02 生命科技股份有限公司 过滤袋总成和过滤系统
CN110192053B (zh) 2016-12-09 2021-10-15 龙沙有限公司 生物反应器的破裂盘及其使用方法
EP3535047A1 (en) 2016-12-09 2019-09-11 Lonza Ltd Method for the reduction of viral titer in pharmaceuticals
US11643627B2 (en) 2016-12-29 2023-05-09 Cytiva Sweden Ab Housing for holding a flexible bioprocess bag
WO2018136450A1 (en) 2017-01-18 2018-07-26 Lonza Ltd Methods for evaluating monoclonality
KR20190115043A (ko) 2017-02-03 2019-10-10 론자 리미티드 생물학적 생성물 제조에서 복수의 세포를 분석하고 단백질 서열 변이체를 검출하는 방법
EP3565883A1 (en) 2017-02-10 2019-11-13 Lonza Ltd Cell culture system and method
CN110914413A (zh) 2017-02-17 2020-03-24 隆萨有限公司 产生腺相关病毒的哺乳动物细胞
EP3583121A1 (en) 2017-02-17 2019-12-25 Lonza Ltd Multi-site specific integration cells for difficult to express proteins
WO2018151819A1 (en) 2017-02-17 2018-08-23 Lonza Ltd A method for producing biologic product variants
US10244406B2 (en) 2017-03-07 2019-03-26 Lonza Ltd. Wireless sensor information monitoring
ES2684630B2 (es) * 2017-03-30 2019-07-02 Inversiones Hiki6 S L Método, programa informático y planta multifuncional, modular y móvil de mezcla y envasado
CN110892060B (zh) 2017-04-07 2021-04-06 埃皮博恩股份有限公司 用于播种和培养的系统和方法
US11054362B2 (en) * 2017-04-10 2021-07-06 David Robert Howland System and method for bacterial detection using film formation promotion with enhanced corrosion imbalance
CN110785494B (zh) 2017-06-16 2024-07-02 隆萨有限公司 用于生产生物制品的通用自调节哺乳动物细胞系平台
WO2019060218A1 (en) * 2017-09-19 2019-03-28 Life Technologies Corporation SYSTEMS AND METHODS FOR A FLEXIBLE ROOM WITH FOLDABLE MIXING ELEMENT
KR102604994B1 (ko) 2017-09-29 2023-11-24 론자 리미티드 바이오반응기 시스템에서 사용하기 위한 관류 장치
EP3691781A4 (en) 2017-10-03 2021-01-20 Abec, Inc. REACTOR SYSTEMS
JP7323512B2 (ja) 2017-10-06 2023-08-08 ロンザ リミテッド ラマン分光法を使用する細胞培養の自動制御
WO2019077623A1 (en) * 2017-10-17 2019-04-25 Shree Biocare Solutions Pvt. Ltd. IMPROVED DISPOSABLE BIOREACTOR
WO2019100040A1 (en) 2017-11-20 2019-05-23 Lonza Ltd. Process and system for propagating cell cultures while preventing lactate accumulation
US20210178289A1 (en) 2017-12-05 2021-06-17 Lonza Ltd Methods of assaying tropolone
WO2019133555A1 (en) * 2017-12-28 2019-07-04 Locus Ip Company, Llc Reactors and submerged fermentation methods for producing microbe-based products
WO2019152876A2 (en) 2018-02-02 2019-08-08 Lonza Ltd Methods of cell selection and modifying cell metabolism
EP3781667A1 (en) 2018-04-20 2021-02-24 Global Life Sciences Solutions USA LLC Multiport plate for a bioprocess bag
EP3784372A1 (en) 2018-04-27 2021-03-03 Baxter International Inc. Method of mixing a pharmaceutical solution and mixing system
US11447730B2 (en) 2018-05-30 2022-09-20 Global Life Sciences Solutions Usa Llc Bioreactor system and method of bioprocessing
US20210230531A1 (en) * 2018-06-05 2021-07-29 Vbc Holdings Llc Automated and dynamically adjustable gas mixer for bioreactor system
SG11202013191TA (en) 2018-07-13 2021-01-28 Lonza Ag Methods for improving production of biological products by reducing the level of endogenous protein
WO2020028616A1 (en) 2018-08-02 2020-02-06 Lonza Ltd Methods for manufacturing recombinant protein comprising a disulfide bond
US10350561B1 (en) 2018-08-03 2019-07-16 Boris Dushine Magnetic stirring system for wine aeration and method of using same
US10220361B1 (en) 2018-08-03 2019-03-05 Boris Dushine Magnetic stirring system for the automated and optimized reconstitution of powdered infant formulations and methods of using same
EP3841193A1 (en) 2018-08-21 2021-06-30 Lonza Ltd. A process for creating reference data for predicting concentrations of quality attributes
JP2021536353A (ja) 2018-08-31 2021-12-27 ジェンザイム・コーポレーション 無菌クロマトグラフィー樹脂および製造方法におけるその使用
JP2022513319A (ja) 2018-10-01 2022-02-07 ロンザ リミテッド 予測可能かつ安定な導入遺伝子発現を有するssi細胞および形成の方法
GB201816897D0 (en) * 2018-10-17 2018-11-28 Ge Healthcare Bio Sciences Corp A Bioreactor System
KR102076363B1 (ko) * 2018-10-29 2020-02-11 바이오퍼스글로벌(주) 일회용 생물 발효기
US11065589B2 (en) 2018-12-10 2021-07-20 Pall Corporation Radially driven agitator
GB201900741D0 (en) 2019-01-18 2019-03-06 Synpromics Ltd Liver-specifc inducible prometers and methods of use thereof
AU2020214343A1 (en) * 2019-02-01 2021-08-26 Abec, Inc. Reactor systems
US20200255791A1 (en) * 2019-02-08 2020-08-13 Georgia Tech Research Corporation Sensing Systems
US11965152B2 (en) 2019-02-11 2024-04-23 Lonza Ltd. Buffer formulation method and system
DE102019110061B4 (de) * 2019-04-16 2023-11-30 Sartorius Stedim Biotech Gmbh Bioprozessbeutel für eine bioprozesstechnische Anlage
US20210016287A1 (en) 2019-07-16 2021-01-21 Ge Healthcare Bio-Sciences Corp. Reinforced bioreactor component structure system for cell cultivation
JP2023502916A (ja) 2019-11-14 2023-01-26 ロンザ リミテッド 細胞の選択方法
US11535421B2 (en) * 2019-12-30 2022-12-27 Global Life Sciences Solutions Usa Llc System and method for packaging a bioprocessing bag and associated components, and packaging for a bioprocessing bag
IL293823A (en) 2020-01-10 2022-08-01 Lonza Walkersville Inc Filter device and method for purification of biological processes and cell populations
CN115698300A (zh) 2020-03-26 2023-02-03 阿斯克肋匹奥生物制药公司 佛司可林诱导型启动子和低氧诱导型启动子
EP4136237A1 (en) 2020-04-15 2023-02-22 Asklepios Biopharmaceutical, Inc. Forskolin-inducible promoters and hypoxia-inducible promoters
US20240026264A1 (en) 2020-12-18 2024-01-25 Lonza Biologics Inc. Sterile Disconnect For Bioprocess Systems and Method For Using Same
NL2027815B1 (en) 2021-03-23 2022-10-07 Academisch Ziekenhuis Leiden Genomic integration
US11752509B2 (en) 2021-06-17 2023-09-12 Upside Foods, Inc. Fluid dispenser for recovering material from a surface
EP4380720A1 (en) 2021-09-15 2024-06-12 SaniSure, Inc. Low volume magnetic mixing system
WO2024006236A1 (en) 2022-06-28 2024-01-04 Amgen Inc. Flexible facility configurations for therapeutic product manufacturing
DE102022117005A1 (de) * 2022-07-07 2024-01-18 Bausch + Ströbel SE + Co. KG Pumpvorrichtung und Pumpanordnung mit mindestens einer Pumpvorrichtung
CN116948817A (zh) * 2023-05-06 2023-10-27 四川大学 一次性生物安全型生物反应器以及监测方法

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE200792C (es) 1907-09-28
US2793166A (en) * 1952-10-18 1957-05-21 Bristol Lab Inc Stirring device for laboratory fermenters
US2956739A (en) * 1957-02-13 1960-10-18 Tothill Gordon Roy Variable pitch impellers and closure seals therefor
US2958517A (en) * 1958-04-28 1960-11-01 Bellco Glass Inc Vessel for tissue culture and the like comprising a magnetic stirrer
US4162855A (en) * 1974-11-18 1979-07-31 Spectroderm International, Inc. Magnetic stirrer apparatus
SE397637B (sv) 1976-03-09 1977-11-14 Wik G Magnetomrorare
IT1106734B (it) 1977-01-10 1985-11-18 Schick Josef Hubert Metodo e dispositivo per la produzione microbiologica di proteinada organisni unicellulari mediante l impiego di alcool etilico
JPH0634698B2 (ja) * 1984-02-04 1994-05-11 オリンパス光学工業株式会社 反応分析装置
FR2569994B1 (fr) 1984-09-13 1986-11-21 Technicatome Dispositif de melange mobile
JPS6350311Y2 (es) 1984-11-16 1988-12-23
US4620794A (en) 1984-11-20 1986-11-04 Jule Inc. Gradient formers
EP0200792B1 (de) * 1985-02-01 1990-05-09 Herbert Prof. Dr.-Ing. Märkl Folienfermenter
US4668632A (en) 1985-02-06 1987-05-26 Vxr, Inc. Sparger and apparatus for and method of growing cells
WO1986006935A1 (en) * 1985-05-29 1986-12-04 Moskovsky Tekhnologichesky Institut Myasnoi I Molo Method of conservation of half-finished balyk
US4882062A (en) 1986-08-29 1989-11-21 Rainin Instrument Co., Inc. Solvent mixing chamber for a liquid chromatography system
US4830511A (en) 1986-10-29 1989-05-16 The Coca-Cola Company Postmix juice dispensing system
ATE80325T1 (de) 1987-03-02 1992-09-15 Ionode Pty Ltd Mischungsgeraet und -verfahren.
GB2202549A (en) 1987-03-20 1988-09-28 Philip John Whitney Foldable fermenter
JPS63233773A (ja) * 1987-03-23 1988-09-29 Reika Kogyo Kk 培養装置
JPS63278539A (ja) 1987-05-11 1988-11-16 Tosoh Corp 液分注装置
US4808348A (en) 1987-05-14 1989-02-28 The Coca-Cola Company Microgravity carbonator
JPS63283570A (ja) * 1987-05-15 1988-11-21 Daido Sanso Kk 発酵槽
US5081035A (en) * 1988-04-18 1992-01-14 The University Of Michigan Bioreactor system
IL86442A (en) 1988-05-19 1992-02-16 Plant Biotec Ltd Air lift fermenter formed from flexible plastic sheets
US5075234A (en) * 1988-11-02 1991-12-24 Josefino Tunac Fermentor/bioreactor systems having high aeration capacity
US5028142A (en) 1989-04-06 1991-07-02 Biotrack, Inc. Reciprocal mixer
JPH03160983A (ja) * 1989-11-21 1991-07-10 Toshiba Corp 培養装置
EP0487741A4 (en) 1990-06-14 1993-04-28 Kiichi Hirata Device for making emulsion and combustion system thereof
US5156701A (en) 1990-08-20 1992-10-20 Denco Inc. Total containment welding of plastic tubes
US5401212A (en) 1990-08-29 1995-03-28 Intelligent Enclosures Corporation Environmental control system
US5205783A (en) 1991-08-22 1993-04-27 Accu*Aire Systems, Inc. Air flow control equipment in chemical laboratory buildings
US5183336A (en) * 1992-01-21 1993-02-02 Kontes Glass Company Stirring assembly
US5664938A (en) 1992-03-05 1997-09-09 Yang; Frank Jiann-Fu Mixing apparatus for microflow gradient pumping
IT1258959B (it) 1992-06-09 1996-03-11 Impianto a moduli mobili per lo sviluppo e la produzione di prodotti biotecnologici su scala pilota
US5227138A (en) 1992-09-09 1993-07-13 Virginia Mason Clinic Blood transport apparatus
US5352036A (en) 1992-09-23 1994-10-04 Habley Medical Technology Corporation Method for mixing and dispensing a liquid pharmaceutical with a miscible component
US5240322A (en) 1992-09-23 1993-08-31 Habley Medical Technology Corporation Pharmaceutical mixing container with rotatable vaned internal magnetic mixing element
US5261742A (en) 1993-02-23 1993-11-16 Eastman Kodak Company Air-powered apparatus and method for mixing a liquefied sample and weighing the sample
US5368390A (en) 1993-03-01 1994-11-29 General Signal Corporation Mixer systems
JP2663327B2 (ja) * 1993-05-20 1997-10-15 哲夫 西田 培養処理槽及びこれを併設した水処理施設
US5342781A (en) 1993-07-15 1994-08-30 Su Wei Wen W External-loop perfusion air-lift bioreactor
DE69405873T2 (de) 1993-07-30 1998-04-09 Du Pont Vorrichtung zur gegenstromtrennung einer mehrphasigen flüssigkeit
US5591344A (en) 1995-02-13 1997-01-07 Aksys, Ltd. Hot water disinfection of dialysis machines, including the extracorporeal circuit thereof
US6500343B2 (en) 1995-02-21 2002-12-31 Iqbal W. Siddiqi Method for mixing and separation employing magnetic particles
ATE172890T1 (de) 1995-02-21 1998-11-15 Iqbal W Dr Siddiqi Apparat und verfahren zum mischen und trennen durch verwendung von magnetischen teilchen
US5478149A (en) 1995-04-24 1995-12-26 Magnetic Mixers, Inc. Magnetic mixer
JPH09141079A (ja) 1995-11-15 1997-06-03 Shiseido Co Ltd 水溶性両親媒性高分子電解質からなる乳化剤、これを配合した乳化組成物及び乳化化粧料
IL119310A (en) * 1996-09-26 1999-07-14 Metabogal Ltd Cell/tissue culturing device and method
US5779359A (en) 1996-12-05 1998-07-14 General Signal Corporation Mixer having exposed clean-in-place bearing assemblies
US5758965A (en) 1996-12-05 1998-06-02 General Signal Corporation Mixer system
JP3705461B2 (ja) 1996-12-26 2005-10-12 富士写真フイルム株式会社 ハロゲン化銀乳剤の製造方法及びハロゲン化銀写真乳剤
DE69839047T2 (de) 1997-05-20 2009-01-15 Zymequest, Inc., Beverly Flüssigkeitsüberwachungssystem
KR100234283B1 (ko) 1997-08-27 1999-12-15 윤종용 습식현상기의 현상액 공급 시스템
US5939313A (en) * 1997-09-12 1999-08-17 Praxair Technology, Inc. Stationary vortex system for direct injection of supplemental reactor oxygen
CN1064403C (zh) * 1997-12-31 2001-04-11 华南理工大学 管道气升式磁处理光生物反应器微藻生产系统及监控方法
US6247840B1 (en) 1998-01-15 2001-06-19 Shaik A. Gaffar Dialysis container with sample saver
US6245555B1 (en) 1998-09-01 2001-06-12 The Penn State Research Foundation Method and apparatus for aseptic growth or processing of biomass
US6086243A (en) 1998-10-01 2000-07-11 Sandia Corporation Electrokinetic micro-fluid mixer
US8026096B1 (en) 1998-10-08 2011-09-27 Protein Sciences Corporation In vivo active erythropoietin produced in insect cells
US6379625B1 (en) 1999-12-23 2002-04-30 Peter Zuk, Jr. Apparatus comprising a disposable device and reusable instrument for synthesizing chemical compounds, and for testing chemical compounds for solubility
US6416215B1 (en) 1999-12-14 2002-07-09 University Of Kentucky Research Foundation Pumping or mixing system using a levitating magnetic element
US6432698B1 (en) * 1999-01-06 2002-08-13 Rutgers, The State University Disposable bioreactor for culturing microorganisms and cells
US6391698B1 (en) 1999-02-26 2002-05-21 United Microelectronics Corp. Forming complementary metal-oxide semiconductor with gradient doped source/drain
US6132309A (en) 1999-03-10 2000-10-17 Panelli; Paul Giulo Modular clean room plenum
DE19917398C2 (de) 1999-04-16 2002-06-20 Accoris Gmbh Modulares chemisches Mikrosystem
IL129564A (en) 1999-04-23 2004-06-20 Atlantium Lasers Ltd A method for disinfecting and purifying liquids and gases and a device for its use
US6357907B1 (en) 1999-06-15 2002-03-19 V & P Scientific, Inc. Magnetic levitation stirring devices and machines for mixing in vessels
WO2001005510A1 (en) 1999-07-19 2001-01-25 Akzo Nobel N.V. Device and method for mixing magnetic particles with a fluid
FR2799138B1 (fr) * 1999-10-05 2002-02-08 Opifex Reacteur pour la realisation de cultures cellulaires ou de micro-organismes ou pour la mise en solution ou en suspension de poudre dans un milieu liquide
US6758593B1 (en) 2000-10-09 2004-07-06 Levtech, Inc. Pumping or mixing system using a levitating magnetic element, related system components, and related methods
US6402367B1 (en) 2000-06-01 2002-06-11 Aemp Corporation Method and apparatus for magnetically stirring a thixotropic metal slurry
US6837613B2 (en) 2001-04-10 2005-01-04 Levtech, Inc. Sterile fluid pumping or mixing system and related method
AU783125B2 (en) 2000-10-31 2005-09-29 Dsm Ip Assets B.V. Optimisation of fermentation processes
US6544788B2 (en) * 2001-02-15 2003-04-08 Vijay Singh Disposable perfusion bioreactor for cell culture
US6467946B1 (en) 2001-04-24 2002-10-22 Dade Microscan Inc. Method and apparatus for mixing liquid samples in a container using rotating magnetic fields
JP2002350500A (ja) * 2001-05-24 2002-12-04 Mitsubishi Electric Corp 半導体集積回路装置
US6670171B2 (en) * 2001-07-09 2003-12-30 Wheaton Usa, Inc. Disposable vessel
CA2460819A1 (en) 2001-09-18 2003-03-27 Affinium Pharmaceuticals, Inc. Methods and apparatuses for purification
EP1534412B1 (en) 2001-10-03 2010-08-18 Levtech Inc. Mixing vessel having a receiver for a fluid-agitating element
US7595043B2 (en) 2001-12-07 2009-09-29 Cytori Therapeutics, Inc. Method for processing and using adipose-derived stem cells
US6736906B2 (en) 2002-04-10 2004-05-18 International Business Machines Corporation Turbine part mount for supercritical fluid processor
US20030198128A1 (en) 2002-04-19 2003-10-23 Carlson Roger W. Mixing system having non-contacting bearings
US6837610B2 (en) 2002-09-27 2005-01-04 Ilc Dover Lpp Bioprocess container, bioprocess container mixing device and method of use thereof
US6673598B1 (en) 2002-10-29 2004-01-06 Synthecon, Inc. Disposable culture bag
US7144727B2 (en) 2003-04-14 2006-12-05 Synthecon, Inc. Interlinked culture chamber for biologicals
US20040229335A1 (en) 2003-05-15 2004-11-18 Introgen Therapeutics, Inc. Methods and compositions for the production of adenoviral vectors
US7168848B2 (en) 2003-07-02 2007-01-30 Spx Corporation Axial-pumping impeller apparatus and method for magnetically-coupled mixer
US20050076076A1 (en) 2003-08-08 2005-04-07 Liberty Logistics Inc. Collaborative logistics information exchange method and apparatus
CA2552717C (en) * 2004-01-07 2011-11-29 Levtech, Inc. Mixing bag with integral sparger and sensor receiver
EP1763575A4 (en) * 2004-04-27 2009-09-23 Baxter Int REACTOR SYSTEM WITH AGITATION RESERVOIR

Also Published As

Publication number Publication date
AU2005250500A1 (en) 2005-12-15
HK1112479A1 (en) 2008-09-05
KR101021203B1 (ko) 2011-03-11
CA2569405C (en) 2011-05-03
BRPI0510648A (pt) 2007-11-20
JP2008501347A (ja) 2008-01-24
EP1773976A2 (en) 2007-04-18
BRPI0510648B1 (pt) 2016-04-26
MXPA06014099A (es) 2007-05-09
KR20070053200A (ko) 2007-05-23
DK1773976T3 (en) 2017-01-30
EP1773976B1 (en) 2016-12-07
NO20070069L (no) 2007-03-05
WO2005118771A2 (en) 2005-12-15
EP1773976B2 (en) 2020-01-01
US20050272146A1 (en) 2005-12-08
DK1773976T4 (da) 2020-02-10
CN101001945A (zh) 2007-07-18
JP4680990B2 (ja) 2011-05-11
AU2005250500B2 (en) 2011-06-23
WO2005118771A3 (en) 2006-02-02
CN101001945B (zh) 2012-02-08
US7629167B2 (en) 2009-12-08
CN102492607B (zh) 2014-12-10
ES2612212T5 (es) 2020-06-25
CN102492607A (zh) 2012-06-13
CA2569405A1 (en) 2005-12-15
ES2612212T3 (es) 2017-05-12

Similar Documents

Publication Publication Date Title
CR8769A (es) Sistemas y procedimientos para unos bioreactores desechables
ECSP099447A (es) Derivados indólicos con anillo unido en las posiciones 4,5 y sus métodos de uso
CY1111875T1 (el) Μεθοδοι κατεργασιας μεσων κυτταρικων καλλιεργειων για χρηση σε βιοαντιδραστηρα
BRPI0815700A2 (pt) Sistema de fonte de combustível compreendendo câmara de gás comprimido e câmara de combustível líquido e sistema de célula de combustível.
ECSP088254A (es) Compuestos activos en ppar
BRPI0719184A2 (pt) Análise e gerenciamento de sistema
MY151119A (en) Duck embryonic derived stem cell lines for the production of viral vaccines
GEP20115280B (en) Inhibitors of serine proteases
TW200730241A (en) Fluid purification system with ultra violet light emitters
CL2011001224A1 (es) Compuestos derivados de benzofurano-3-carboxamida; composicion farmaceutica que los comprende; y su uso en tratamiento del virus de la hepatitis c.
DK1976559T6 (da) Influenzavacciner indeholdende hæmagglutinin og matrixproteiner
TW200740458A (en) Vaccination against dengue virus infection
DK1845926T3 (da) Sæt af engangsposer til virusinaktivering af biologiske væsker
EP2134857A4 (en) DETECTION AND IDENTIFICATION OF MICROORGANISMS ON TRANSPARENT PERMEABLE MEMBRANES
BRPI0818876A2 (pt) Sistema de contenção de tecido por multicâmara para diagnóstico molecular e histológico
IT1391274B1 (it) Sistema di irrigazione ed aspirazione, in particolare per chirurgia laparoscopica
BRPI1009288A2 (pt) biorreator descartável e sistema de agitação de uso único
WO2007035604A3 (en) Scaffold carrier cartridge
GB0721714D0 (en) A system to treat and/or kill bacteria and viral infections using micrwave atmospheric plasma
CN204969592U (zh) 带有uvled消毒功能的口罩
BRPI0919285A2 (pt) Dispositivo para cultivo/exposição, especialmente para culturas de células e/ou de bactérias.
ITRM20050393A1 (it) Sistema di rilascio controllato di sostanze farmacologicamente attive, processo di preparazione e impieghi in campo medico.
CR10023A (es) Métodos para tratar infecciones del tracto gastrointestinal con tigeciclina
DE602007013306D1 (de) Mutilinderivate und ihre verwendung als arzneimittel
ITTO20020080A0 (it) Sistema sterile e procedimento per filtrare liquidi biologici o organici, in particolare sangue o componenti del sangue.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)