SG11202101860UA - Sterile chromatography resin and use thereof in manufacturing processes - Google Patents

Sterile chromatography resin and use thereof in manufacturing processes

Info

Publication number
SG11202101860UA
SG11202101860UA SG11202101860UA SG11202101860UA SG11202101860UA SG 11202101860U A SG11202101860U A SG 11202101860UA SG 11202101860U A SG11202101860U A SG 11202101860UA SG 11202101860U A SG11202101860U A SG 11202101860UA SG 11202101860U A SG11202101860U A SG 11202101860UA
Authority
SG
Singapore
Prior art keywords
manufacturing processes
chromatography resin
sterile chromatography
sterile
resin
Prior art date
Application number
SG11202101860UA
Inventor
Rohan Patil
Chad Varner
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of SG11202101860UA publication Critical patent/SG11202101860UA/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/081—Gamma radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1885—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in parallel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28052—Several layers of identical or different sorbents stacked in a housing, e.g. in a column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/3071—Washing or leaching
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/04—Processes using organic exchangers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/08—Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/12—Macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J47/00—Ion-exchange processes in general; Apparatus therefor
    • B01J47/014—Ion-exchange processes in general; Apparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J47/00—Ion-exchange processes in general; Apparatus therefor
    • B01J47/02—Column or bed processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J49/00—Regeneration or reactivation of ion-exchangers; Apparatus therefor
    • B01J49/60—Cleaning or rinsing ion-exchange beds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/21—Pharmaceuticals, e.g. medicaments, artificial body parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/52—Sorbents specially adapted for preparative chromatography
SG11202101860UA 2018-08-31 2019-08-16 Sterile chromatography resin and use thereof in manufacturing processes SG11202101860UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862726043P 2018-08-31 2018-08-31
PCT/US2019/046893 WO2020046602A1 (en) 2018-08-31 2019-08-16 Sterile chromatography resin and use thereof in manufacturing processes

Publications (1)

Publication Number Publication Date
SG11202101860UA true SG11202101860UA (en) 2021-03-30

Family

ID=67841180

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202101860UA SG11202101860UA (en) 2018-08-31 2019-08-16 Sterile chromatography resin and use thereof in manufacturing processes

Country Status (15)

Country Link
US (1) US11369703B2 (en)
EP (1) EP3843869A1 (en)
JP (2) JP2021536353A (en)
KR (1) KR20210049155A (en)
CN (1) CN112638488A (en)
AU (1) AU2019332764A1 (en)
BR (1) BR112021003420A2 (en)
CA (1) CA3110666A1 (en)
HK (1) HK40046210A (en)
IL (1) IL281077A (en)
MX (1) MX2021002314A (en)
SG (1) SG11202101860UA (en)
TW (1) TW202035435A (en)
WO (1) WO2020046602A1 (en)
ZA (1) ZA202100649B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI709569B (en) 2014-01-17 2020-11-11 美商健臻公司 Sterile chromatography resin and use thereof in manufacturing processes
TWI671312B (en) 2014-01-17 2019-09-11 美商健臻公司 Sterile chromatography and manufacturing processes
WO2020046602A1 (en) 2018-08-31 2020-03-05 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401108A (en) 1980-02-13 1983-08-30 Thomas Jefferson University Radioactive material loading, calibration and injection systems
JPS6075530A (en) 1983-09-30 1985-04-27 Asahi Chem Ind Co Ltd Novel method for separating and purifying metallic element
US4559175A (en) 1984-04-19 1985-12-17 The United States Of America As Represented By The Secretary Of The Air Force Halo-substituted diphospha-s-triazines and their derivatives
US4885250A (en) 1987-03-02 1989-12-05 E. I. Du Pont De Nemours And Company Enzyme immobilization and bioaffinity separations with perfluorocarbon polymer-based supports
US5612016A (en) 1988-04-01 1997-03-18 Immunomedics, Inc. Conjugates of antibodies and bifunctional ligands
US5169936A (en) 1989-04-14 1992-12-08 Biogen, Inc. Protein purification on immobilized metal affinity resins effected by elution using a weak ligand
EP0455757B1 (en) 1989-08-04 1999-03-31 GRANDICS, Peter An integrated cell culture-protein purification system for the automated production and purification of cell culture products
US5244816A (en) 1989-10-11 1993-09-14 Akzo N.V. Method for purifying chelator conjugated compounds
WO1992017403A1 (en) 1991-04-05 1992-10-15 Brigham Young University Support bonded polyalkylene-polyamine-poly(carboxylic acid) and extraction of metal ions therewith
RU2034853C1 (en) 1992-07-14 1995-05-10 Научно-исследовательский институт строительных материалов при Томской государственной инженерно-строительной академии Method of preparing of polymeric sorbent for chromatography
JP2871435B2 (en) 1993-04-22 1999-03-17 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー Method for producing a hydrophilic polymer coated perfluorocarbon polymer based matrix
US5478924A (en) 1994-02-16 1995-12-26 Cramer; Steven M. Displacement chromatography of proteins using low molecular weight displacers
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
US5856179A (en) 1994-03-10 1999-01-05 Genentech, Inc. Polypeptide production in animal cell culture
US5423982A (en) 1994-05-31 1995-06-13 Biosepra Inc. Liquid chromatography column adapted for in situ chemical sterilization
US5610285A (en) 1994-08-24 1997-03-11 Bayer Corporation Purification of α-1 proteinase inhibitor using novel chromatographic separation conditions
US6359114B1 (en) 1995-06-07 2002-03-19 Aphton Corp. System for method for the modification and purification of proteins
US5691152A (en) 1995-11-09 1997-11-25 E. R. Squibb & Sons, Inc. Stable avidin composition
AR005035A1 (en) 1995-12-11 1999-04-07 Merck Patent Ges Mit Beschränkter Haftung PROCEDURE TO PREPARE RECOMBINANT PROTEINS IN E. COLI, BY FERMENTATION WITH GREAT CONCENTRATION OF CELLS.
EP1864999B1 (en) 1996-11-27 2009-03-18 Genentech, Inc. Affinity purification of polypeptide on protein a matrix
US5886154A (en) 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
US6955917B2 (en) 1997-06-20 2005-10-18 Bayer Healthcare Llc Chromatographic method for high yield purification and viral inactivation of antibodies
US6265542B1 (en) 1997-10-24 2001-07-24 Genentech, Inc. Purification of molecules
US7611831B2 (en) * 1998-01-06 2009-11-03 Cerus Corporation Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
ATE321066T1 (en) 1998-05-06 2006-04-15 Genentech Inc ANTI-HER2 ANTIBODY COMPOSITION
DE19858892A1 (en) 1998-12-19 2000-06-21 Merck Patent Gmbh Continuous chromatographic separation of matter by molecular sizes useful e.g. for separation of isomers, uses a simulated moving bed for size exclusion chromatography
GB9902000D0 (en) 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
GB0028879D0 (en) 2000-11-27 2001-01-10 Prometic Biosciences Ltd Adsorbents and their use
CA2438094C (en) 2001-02-23 2011-10-11 Immunex Corporation Increased recovery of active proteins
ITBO20010426A1 (en) 2001-07-06 2003-01-06 Alfa Wassermann Spa PHARMACOLOGICALLY ACTIVE PROTEIN PURIFICATION PROCESS BY CATIONIC EXCHANGE CHROMATOGRAPHY
US7252799B2 (en) * 2001-08-31 2007-08-07 Clearant, Inc. Methods for sterilizing preparations containing albumin
US20030095890A1 (en) 2001-09-24 2003-05-22 Shirley Miekka Methods for sterilizing biological materials containing non-aqueous solvents
AU2002343100A1 (en) 2001-11-27 2003-06-10 Prometic Biosciences Ltd. The use of metal-chelating adsorbents
US6660172B2 (en) 2002-01-31 2003-12-09 Koslow Technologies Corporation Precoat filtration media and methods of making and using
AU2003210802B2 (en) 2002-02-05 2009-09-10 Genentech Inc. Protein purification
CA2478925C (en) 2002-04-26 2016-06-07 Robert Lee Fahrner Non-affinity purification of proteins
US6902909B2 (en) 2002-07-09 2005-06-07 Synthecon, Inc. Methods for efficient production of mammalian recombinant proteins
ES2629602T5 (en) 2002-09-11 2021-06-08 Genentech Inc Protein purification
US7220356B2 (en) 2002-09-13 2007-05-22 Biogen Idec Inc. Method of purifying polypeptides by simulated moving bed chromatography
US7157276B2 (en) 2003-06-20 2007-01-02 Biogen Idec Inc. Use of depth filtration in series with continuous centrifugation to clarify mammalian cell cultures
CA2552639C (en) * 2004-02-27 2012-05-01 Ge Healthcare Bio-Sciences Ab A process for the purification of antibodies
CA2557229C (en) 2004-02-27 2012-07-10 Octapharma Ag A method of providing a purified, virus safe antibody preparation
DK1773976T4 (en) 2004-06-04 2020-02-10 Global Life Sciences Solutions Usa Llc SINGLE-BORE ACTOR SYSTEMS AND PROCEDURES
US20060004621A1 (en) 2004-06-30 2006-01-05 Malek Kamal M Real-time selection of survey candidates
WO2006026248A1 (en) 2004-08-25 2006-03-09 Sigma-Aldrich Co. Compositions and methods employing zwitterionic detergent combinations
DK1807101T3 (en) 2004-09-30 2016-05-23 Bayer Healthcare Llc Devices and methods for integrated continuous production of biological molecules
JP4831436B2 (en) 2004-10-21 2011-12-07 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ Chromatographic ligand
KR101370253B1 (en) 2004-10-22 2014-03-05 암젠 인크 Methods for refolding of recombinant antibodies
EP1836316A4 (en) 2004-12-22 2009-07-22 Ambrx Inc Methods for expression and purification of recombinant human growth hormone
EP1855729B1 (en) 2005-03-07 2013-10-30 GE Healthcare Bio-Sciences AB Method of heat sterilization of a chromatography column
CN1923290A (en) * 2005-04-29 2007-03-07 成都夸常医学工业有限公司 Virus deactivation method, treatment system and apparatus thereof
WO2007055789A2 (en) 2005-10-31 2007-05-18 Neose Technologies, Inc. Expression of soluble therapeutic proteins
WO2007075283A2 (en) 2005-12-06 2007-07-05 Amgen Inc. Polishing steps used in multi-step protein purification processes
CN101484464A (en) 2006-02-17 2009-07-15 诺华有限公司 Purification of bacterial antigens
US7673757B2 (en) 2006-02-17 2010-03-09 Millipore Corporation Adsorbent filter media for removal of biological contaminants in process liquids
EP2027252A4 (en) 2006-04-21 2012-10-03 Bayer Corp Apparatus, system, and method for in situ measurements
US20080132688A1 (en) 2006-09-22 2008-06-05 Amgen Inc. Methods for Removing Viral Contaminants During Protein Purification
WO2008073620A2 (en) 2006-11-02 2008-06-19 Neose Technologies, Inc. Manufacturing process for the production of polypeptides expressed in insect cell-lines
KR101496477B1 (en) * 2007-02-01 2015-02-26 아반토르 퍼포먼스 머티리얼스, 인크. Chromatographic media and chromatographic equipment storage solutions and use thereof
GB0704603D0 (en) 2007-03-09 2007-04-18 Ge Healthcare Bio Sciences Ab Packing system and method for chromatography columns
US9597610B2 (en) 2007-03-09 2017-03-21 Ge Healthcare Bioprocess R&D Ab Packing system and method for chromatography columns
US9012212B2 (en) 2007-04-17 2015-04-21 Xendo Holding B.V. Method and device for continuous membrane adsorption
US9109193B2 (en) 2007-07-30 2015-08-18 Ge Healthcare Bio-Sciences Corp. Continuous perfusion bioreactor system
RS53850B2 (en) 2007-10-30 2018-07-31 Genentech Inc Antibody purification by cation exchange chromatography
ES2424960T3 (en) 2007-12-27 2013-10-10 Otsuka Pharmaceutical Co., Ltd. Enzyme associated with the synthesis of ecuol
MX2010013908A (en) 2008-06-24 2011-01-21 Octapharma Ag A process of purifying coagulation factor viii.
CA2932207A1 (en) * 2008-10-20 2010-12-09 Abbvie Inc. Isolation and purification of antibodies using protein a affinity chromatography
CN102271775A (en) 2008-12-08 2011-12-07 诺沃-诺迪斯克有限公司 Counter current purification of polypeptides
EP2236617A1 (en) 2009-03-31 2010-10-06 Leukocare Ag Methods of terminal sterilization of biofunctional compositions
US8728479B2 (en) 2009-03-31 2014-05-20 The Trustees Of The University Of Pennsylvania Antigen-binding proteins comprising recombinant protein scaffolds
US8580554B2 (en) 2009-07-31 2013-11-12 Baxter International Inc. Method of producing a polypeptide or virus of interest in a continuous cell culture
AU2010311421B2 (en) 2009-10-29 2014-11-20 Ascendis Pharma A/S Sterilization of biodegradable hydrogels
GB0922426D0 (en) 2009-12-22 2010-02-03 Ge Healthcare Bio Sciences Ab Containers for chromatography media
CN102656452B (en) * 2009-12-22 2015-07-22 通用电气健康护理生物科学股份公司 Method for dry packing chromatography columns
US9943781B2 (en) 2010-06-03 2018-04-17 Ge Healthcare Bioprocess R&D Ab Parallel assembly of chromatography column modules
CA2801332C (en) * 2010-10-15 2016-08-23 Straumann Holding Ag New emd formulation comprising pga
WO2012071135A2 (en) 2010-11-23 2012-05-31 Biovec Transfusion, Llc Methods for removing pathogens from a platelet preparation
US20130260419A1 (en) 2010-12-06 2013-10-03 Thomas C. Ransohoff Continuous processing methods for biological products
CN102321316B (en) 2011-08-25 2013-04-24 上海恒方大高分子材料科技有限公司 Medical polyvinyl chloride (PVC) material for gamma-ray irradiation disinfection and preparation method thereof
EP2656892A1 (en) 2012-04-23 2013-10-30 Merck Patent GmbH Chromatography method
US20140154270A1 (en) * 2012-05-21 2014-06-05 Chen Wang Purification of non-human antibodies using kosmotropic salt enhanced protein a affinity chromatography
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
ES2895173T3 (en) 2012-06-29 2022-02-17 Emd Millipore Corp Methods to inactivate viruses during a protein purification process
CA2888824C (en) 2012-10-24 2021-02-02 Genzyme Corporation Elution of biomolecules from multi-modal resins using mes as mobile phase modifier
WO2014137903A2 (en) 2013-03-08 2014-09-12 Genzyme Corporation Integrated continuous manufacturing of therapeutic protein drug substances
CN103223333B (en) 2013-04-15 2015-01-14 河海大学 Di-amidoxime group containing modified silica gel adsorbent and preparation method thereof
KR102393642B1 (en) * 2014-01-17 2022-05-03 리플리겐 코포레이션 Sterilizing chromatography columns
TWI671312B (en) 2014-01-17 2019-09-11 美商健臻公司 Sterile chromatography and manufacturing processes
TWI709569B (en) 2014-01-17 2020-11-11 美商健臻公司 Sterile chromatography resin and use thereof in manufacturing processes
US20240100450A9 (en) * 2014-01-17 2024-03-28 Repligen Corporation Sterilizing chromatography columns
US10925986B2 (en) * 2017-01-30 2021-02-23 Regeneron Pharmaceuticals, Inc. Compositions and methods for reducing bioburden in chromatography
WO2020046602A1 (en) 2018-08-31 2020-03-05 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes

Also Published As

Publication number Publication date
WO2020046602A1 (en) 2020-03-05
US11369703B2 (en) 2022-06-28
HK40046210A (en) 2021-10-29
US20200069822A1 (en) 2020-03-05
KR20210049155A (en) 2021-05-04
JP2021536353A (en) 2021-12-27
EP3843869A1 (en) 2021-07-07
CN112638488A (en) 2021-04-09
AU2019332764A1 (en) 2021-05-06
CA3110666A1 (en) 2020-03-05
JP2024020347A (en) 2024-02-14
ZA202100649B (en) 2022-08-31
TW202035435A (en) 2020-10-01
IL281077A (en) 2021-04-29
MX2021002314A (en) 2021-04-28
BR112021003420A2 (en) 2021-05-18

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