DE602005015332D1 - Verfahren zur Reinigung von Viren - Google Patents
Verfahren zur Reinigung von VirenInfo
- Publication number
- DE602005015332D1 DE602005015332D1 DE602005015332T DE602005015332T DE602005015332D1 DE 602005015332 D1 DE602005015332 D1 DE 602005015332D1 DE 602005015332 T DE602005015332 T DE 602005015332T DE 602005015332 T DE602005015332 T DE 602005015332T DE 602005015332 D1 DE602005015332 D1 DE 602005015332D1
- Authority
- DE
- Germany
- Prior art keywords
- cleaning viruses
- adenovirus
- viruses
- cleaning
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10051—Methods of production or purification of viral material
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2004050190 | 2004-02-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005015332D1 true DE602005015332D1 (de) | 2009-08-20 |
Family
ID=34878416
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005015332T Active DE602005015332D1 (de) | 2004-02-23 | 2005-02-21 | Verfahren zur Reinigung von Viren |
Country Status (13)
Country | Link |
---|---|
US (2) | US20070207461A1 (de) |
EP (2) | EP1718738A2 (de) |
JP (1) | JP2007522814A (de) |
KR (1) | KR101211329B1 (de) |
CN (2) | CN101343625A (de) |
AT (1) | ATE435906T1 (de) |
AU (1) | AU2005214090B2 (de) |
CA (1) | CA2555412C (de) |
DE (1) | DE602005015332D1 (de) |
DK (1) | DK1780269T3 (de) |
ES (1) | ES2329607T3 (de) |
NZ (1) | NZ548495A (de) |
WO (1) | WO2005080556A2 (de) |
Families Citing this family (85)
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SI0833934T2 (sl) | 1995-06-15 | 2013-04-30 | Crucell Holland B.V. | Pakirni sistemi za humani rekombinantni adenovirus za uporabo v genski terapiji |
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EP1718738A2 (de) | 2004-02-23 | 2006-11-08 | Crucell Holland B.V. | Verfahren zur reinigung von viren |
CA2602944C (en) * | 2005-04-11 | 2015-08-11 | Crucell Holland B.V. | Virus purification using ultrafiltration |
CN101365480B (zh) | 2005-11-01 | 2014-11-05 | 诺华疫苗和诊断有限两合公司 | 经由β-丙内酯处理的残留细胞DNA水平降低的细胞衍生病毒疫苗 |
US20090110695A1 (en) * | 2006-03-27 | 2009-04-30 | Menzo Jans Emko Havenga | Compositions Comprising a Recombinant Adenovirus and an Adjuvant |
CN101426905B (zh) * | 2006-04-20 | 2013-03-27 | 惠氏公司 | 从细胞培养物分离纯化的水泡性口炎病毒的纯化方法 |
ES2401162T3 (es) | 2007-10-02 | 2013-04-17 | Ptc Phage Technology Center Gmbh | Procedimiento y sistema para la purificación a escala industrial de bacteriófagos destinados para terapia con bacteriófagos |
CA2713891A1 (en) * | 2008-02-12 | 2009-08-20 | Sanofi Pasteur Limited | Methods using ion exchange and gel filtration chromatography for poxvirus purification |
EP3192874B1 (de) * | 2008-06-18 | 2019-10-16 | Oxford BioMedica (UK) Limited | Virusreinigung |
KR20110074563A (ko) | 2008-09-24 | 2011-06-30 | 메디뮨 엘엘씨 | 바이러스의 정제 방법 |
CA2742474C (en) * | 2008-11-03 | 2016-05-31 | Crucell Holland B.V. | Method for the production of adenoviral vectors |
EP2393922A1 (de) * | 2009-02-06 | 2011-12-14 | GlaxoSmithKline Biologicals S.A. | Aufreinigung von virus oder viralen antigenen mittels dichtegradienten-ultrazentrifugation |
JP2010207800A (ja) * | 2009-02-16 | 2010-09-24 | Kuraray Co Ltd | ろ過ユニットおよびこれを備えたろ過装置 |
JP2010193720A (ja) * | 2009-02-23 | 2010-09-09 | Asahi Kasei Chemicals Corp | アニオン交換基が固定された多孔膜を用いたウイルスの分離方法 |
CN102740881A (zh) * | 2009-05-12 | 2012-10-17 | 特兰斯吉恩股份有限公司 | 正痘病毒产生和纯化方法 |
WO2011020530A2 (en) * | 2009-08-17 | 2011-02-24 | Merck Patent Gmbh | Method for isolating viruses |
CA2776461C (en) | 2009-10-15 | 2020-08-25 | Crucell Holland B.V. | Method for the purification of adenovirus particles. |
JP5465331B2 (ja) | 2009-10-15 | 2014-04-09 | クルセル ホランド ベー ヴェー | 高細胞密度の培養物からのアデノウイルスの精製方法 |
US20120309056A1 (en) | 2010-02-04 | 2012-12-06 | Leon Arnaud | Fed-batch process using concentrated cell culture medium for the efficient production of biologics in eb66 cells |
DK2536829T3 (en) | 2010-02-15 | 2016-07-04 | Crucell Holland Bv | A process for the production of Ad26-adenovirus vectors |
SG184833A1 (en) | 2010-04-14 | 2012-11-29 | Emd Millipore Corp | Methods of producing high titer, high purity virus stocks and methods of use thereof |
WO2012010280A1 (en) * | 2010-07-20 | 2012-01-26 | Bavarian Nordic A/S | Method for harvesting expression products |
SG188947A1 (en) * | 2010-08-12 | 2013-06-28 | Yisheng Biopharma Holdings Ltd | Method for reducing dna impurities in viral compositions |
CN103118702A (zh) | 2010-09-20 | 2013-05-22 | 克鲁塞尔荷兰公司 | 活动性结核病的治疗性接种 |
WO2012041669A1 (en) | 2010-09-27 | 2012-04-05 | Crucell Holland B.V. | Heterologous prime boost vaccination regimen against malaria |
DE102010046817A1 (de) * | 2010-09-28 | 2012-03-29 | Sartorius Stedim Biotech Gmbh | Verfahren zur Abtrennung von Viren aus einem Kontaminanten enthaltenden flüssigen Medium |
EP2643455B1 (de) * | 2010-11-26 | 2018-07-18 | ProBioGen AG | Entfernung von wirtszellkomponenten aus lebendvirus-impfstoffen |
CN103732610A (zh) * | 2011-06-13 | 2014-04-16 | 默沙东公司 | 纯化天然或突变体形式的白喉毒素的方法 |
DK2737060T3 (da) * | 2011-07-27 | 2019-05-27 | Flash Therapeutics | Fremgangsmåde til fremstilling af retrovirale partikler, der er nyttige for transduktion af eukaryotiske celler |
WO2013074501A1 (en) | 2011-11-14 | 2013-05-23 | Crucell Holland B.V. | Heterologous prime-boost immunization using measles virus-based vaccines |
SI2825640T1 (sl) | 2012-03-12 | 2016-08-31 | Crucell Holland B.V. | Šarže rekombinantnega adenovirusa s spremenjenimi konci |
US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
KR102050616B1 (ko) | 2012-03-22 | 2019-12-03 | 얀센 백신스 앤드 프리벤션 비.브이. | Rsv에 대한 백신 |
US9125870B2 (en) | 2012-03-22 | 2015-09-08 | Crucell Holland B.V. | Vaccine against RSV |
CN103571800B (zh) * | 2012-07-27 | 2018-04-24 | 江苏康润生物科技有限公司 | 一种去除疫苗中宿主dna的方法 |
RU2493872C1 (ru) * | 2012-08-08 | 2013-09-27 | Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации ( ФГУП "НПО "Микроген" Минздрава России) | Способ очистки вируса гриппа |
CN103768589B (zh) * | 2012-10-18 | 2016-12-21 | 辽宁成大生物股份有限公司 | 利用中空纤维膜去除人用乙型脑炎疫苗制品中残留dna的方法 |
AU2014222610A1 (en) * | 2013-02-28 | 2015-10-15 | Psioxus Therapuetics Limited | A process for the production of adenovirus |
KR102236497B1 (ko) | 2013-04-25 | 2021-04-06 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정화된 가용성 예비융합 rsv f 폴리펩타이드 |
AP2015008893A0 (en) | 2013-06-17 | 2015-12-31 | Crucell Holland Bv | Stabilized soluble pre-fusion rsv f polypeptides |
SG11201700361QA (en) * | 2014-07-24 | 2017-02-27 | Janssen Vaccines & Prevention Bv | Process for the purification of poliovirus from cell cultures |
GB201417042D0 (en) * | 2014-09-29 | 2014-11-12 | Fkd Therapies Oy | Method |
MX2017005788A (es) | 2014-11-04 | 2017-08-02 | Janssen Vaccines & Prevention Bv | Vacunas terapeuticas contra el vph16. |
EP3283634B1 (de) | 2015-04-14 | 2019-05-22 | Janssen Vaccines & Prevention B.V. | Rekombinantes adenovirus mit expression von zwei transgenen mit einem bidirektionalen promotor |
ES2895148T3 (es) * | 2015-06-10 | 2022-02-17 | Us Health | Procesos para la producción y purificación de composiciones que contienen ácidos nucleicos |
US10456462B2 (en) | 2015-07-07 | 2019-10-29 | Janssen Vaccines & Preventions B.V. | Vaccine against RSV |
CN107847581B (zh) | 2015-07-07 | 2022-03-22 | 扬森疫苗与预防公司 | 稳定化的可溶性融合前rsv f多肽 |
CN107921110B (zh) | 2015-08-20 | 2021-10-15 | 扬森疫苗与预防公司 | 治疗性hpv18疫苗 |
WO2017174564A1 (en) | 2016-04-05 | 2017-10-12 | Janssen Vaccines & Prevention B.V. | Vaccine against rsv |
PT3439672T (pt) | 2016-04-05 | 2021-02-24 | Janssen Vaccines & Prevention Bv | Proteína f do rsv pré-fusão solúvel e estabilizada para uso na profilaxia de infeção por rsv |
CA3021341A1 (en) | 2016-05-02 | 2017-11-09 | Janssen Vaccine & Prevention B.V. | Therapeutic hpv vaccine combinations |
BR112018072865A2 (pt) | 2016-05-12 | 2019-04-30 | Janssen Vaccines & Prevention B.V. | promotor bidirecional potente e equilibrado |
PL3464331T3 (pl) | 2016-05-30 | 2021-04-19 | Janssen Vaccines & Prevention B.V. | Stabilizowane przedfuzyjne białka F RSV |
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CN108085301B (zh) * | 2016-11-22 | 2021-10-26 | 贺道耀 | 从宿主细胞提取和纯化腺相关病毒和腺病毒的方法及其组分和试剂盒 |
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EP3990031A4 (de) * | 2019-06-28 | 2023-08-09 | Takeda Pharmaceutical Company Limited | Verfahren zur reinigung adeno-assoziierter viren |
CN111249456A (zh) * | 2020-03-13 | 2020-06-09 | 武汉生物制品研究所有限责任公司 | 一种狂犬病病毒灭活疫苗的纯化方法 |
CN111394390A (zh) * | 2020-03-26 | 2020-07-10 | 赛诺(深圳)生物医药研究有限公司 | 用于新型冠状病毒基因疫苗的批量生产重组腺病毒的方法 |
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CN113817689B (zh) * | 2021-11-22 | 2023-10-03 | 北京艺妙神州医药科技有限公司 | 慢病毒纯化工艺 |
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-
2005
- 2005-02-21 EP EP05729676A patent/EP1718738A2/de not_active Withdrawn
- 2005-02-21 WO PCT/EP2005/050739 patent/WO2005080556A2/en active Application Filing
- 2005-02-21 EP EP06126383A patent/EP1780269B1/de not_active Revoked
- 2005-02-21 ES ES06126383T patent/ES2329607T3/es active Active
- 2005-02-21 CN CNA2008101300506A patent/CN101343625A/zh active Pending
- 2005-02-21 AT AT06126383T patent/ATE435906T1/de active
- 2005-02-21 JP JP2006553596A patent/JP2007522814A/ja active Pending
- 2005-02-21 AU AU2005214090A patent/AU2005214090B2/en not_active Ceased
- 2005-02-21 US US10/590,427 patent/US20070207461A1/en not_active Abandoned
- 2005-02-21 CA CA2555412A patent/CA2555412C/en not_active Expired - Fee Related
- 2005-02-21 DK DK06126383T patent/DK1780269T3/da active
- 2005-02-21 NZ NZ548495A patent/NZ548495A/en not_active IP Right Cessation
- 2005-02-21 CN CNA2005800056824A patent/CN1922308A/zh active Pending
- 2005-02-21 DE DE602005015332T patent/DE602005015332D1/de active Active
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2006
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Also Published As
Publication number | Publication date |
---|---|
ATE435906T1 (de) | 2009-07-15 |
AU2005214090B2 (en) | 2008-09-11 |
CA2555412C (en) | 2013-06-25 |
EP1780269A2 (de) | 2007-05-02 |
NZ548495A (en) | 2009-05-31 |
US20070207461A1 (en) | 2007-09-06 |
WO2005080556A2 (en) | 2005-09-01 |
EP1718738A2 (de) | 2006-11-08 |
JP2007522814A (ja) | 2007-08-16 |
KR20070001163A (ko) | 2007-01-03 |
ES2329607T3 (es) | 2009-11-27 |
EP1780269A3 (de) | 2007-07-18 |
WO2005080556A3 (en) | 2006-02-23 |
CN1922308A (zh) | 2007-02-28 |
EP1780269B1 (de) | 2009-07-08 |
US20090017523A1 (en) | 2009-01-15 |
CN101343625A (zh) | 2009-01-14 |
WO2005080556A9 (en) | 2006-10-26 |
US8124106B2 (en) | 2012-02-28 |
CA2555412A1 (en) | 2005-09-01 |
KR101211329B1 (ko) | 2012-12-12 |
AU2005214090A1 (en) | 2005-09-01 |
DK1780269T3 (da) | 2009-10-12 |
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