ATE435906T1 - Verfahren zur reinigung von viren - Google Patents
Verfahren zur reinigung von virenInfo
- Publication number
- ATE435906T1 ATE435906T1 AT06126383T AT06126383T ATE435906T1 AT E435906 T1 ATE435906 T1 AT E435906T1 AT 06126383 T AT06126383 T AT 06126383T AT 06126383 T AT06126383 T AT 06126383T AT E435906 T1 ATE435906 T1 AT E435906T1
- Authority
- AT
- Austria
- Prior art keywords
- cleaning viruses
- adenovirus
- viruses
- cleaning
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 238000004140 cleaning Methods 0.000 title 1
- 241000701161 unidentified adenovirus Species 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000005349 anion exchange Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10051—Methods of production or purification of viral material
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2004050190 | 2004-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE435906T1 true ATE435906T1 (de) | 2009-07-15 |
Family
ID=34878416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06126383T ATE435906T1 (de) | 2004-02-23 | 2005-02-21 | Verfahren zur reinigung von viren |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20070207461A1 (de) |
| EP (2) | EP1780269B1 (de) |
| JP (1) | JP2007522814A (de) |
| KR (1) | KR101211329B1 (de) |
| CN (2) | CN1922308A (de) |
| AT (1) | ATE435906T1 (de) |
| AU (1) | AU2005214090B2 (de) |
| CA (1) | CA2555412C (de) |
| DE (1) | DE602005015332D1 (de) |
| DK (1) | DK1780269T3 (de) |
| ES (1) | ES2329607T3 (de) |
| NZ (1) | NZ548495A (de) |
| WO (1) | WO2005080556A2 (de) |
Families Citing this family (91)
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| WO1997000326A1 (en) | 1995-06-15 | 1997-01-03 | Introgene B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| US6929946B1 (en) * | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
| EP1780269B1 (de) | 2004-02-23 | 2009-07-08 | Crucell Holland B.V. | Verfahren zur Reinigung von Viren |
| DK1869171T4 (en) * | 2005-04-11 | 2016-01-18 | Crucell Holland Bv | Virus cleaning using ultrafiltration |
| WO2007052163A2 (en) | 2005-11-01 | 2007-05-10 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Cell-derived viral vaccines with low levels of residual cell dna by beta-propiolactone treatment |
| US20090110695A1 (en) * | 2006-03-27 | 2009-04-30 | Menzo Jans Emko Havenga | Compositions Comprising a Recombinant Adenovirus and an Adjuvant |
| PL2007883T3 (pl) * | 2006-04-20 | 2012-07-31 | Wyeth Llc | Sposób oczyszczania do izolacji oczyszczonego wirusa pęcherzykowatego zapalenia jamy ustnej z hodowli komórkowej |
| DK2195418T3 (da) | 2007-10-02 | 2013-03-18 | Ptc Phage Technology Ct Gmbh | Fremgangsmåde og system til rensning af bakteriofager beregnet til bakteriofagterapi i industriel skala |
| JP2011511640A (ja) * | 2008-02-12 | 2011-04-14 | サノフィ パストゥール リミテッド | ポックス・ウイルスの精製方法 |
| ES2762864T3 (es) * | 2008-06-18 | 2020-05-26 | Oxford Biomedica Ltd | Purificación de virus |
| CN102215865B (zh) | 2008-09-24 | 2013-10-30 | 米迪缪尼有限公司 | 病毒纯化方法 |
| WO2010060719A1 (en) * | 2008-11-03 | 2010-06-03 | Crucell Holland B.V. | Method for the production of adenoviral vectors |
| CA2750055A1 (en) * | 2009-02-06 | 2010-08-12 | Glaxosmithkline Biologicals S.A. | Method for purifying viruses using a density gradient |
| JP2010207800A (ja) * | 2009-02-16 | 2010-09-24 | Kuraray Co Ltd | ろ過ユニットおよびこれを備えたろ過装置 |
| JP2010193720A (ja) * | 2009-02-23 | 2010-09-09 | Asahi Kasei Chemicals Corp | アニオン交換基が固定された多孔膜を用いたウイルスの分離方法 |
| NZ596595A (en) | 2009-05-12 | 2013-05-31 | Transgene Sa | Method for orthopoxvirus production and purification |
| US20120141980A1 (en) * | 2009-08-17 | 2012-06-07 | Merk Patent Gesellschaft Mit Beschrankter Haftung | Method for isolating viruses |
| EP2488636B1 (de) | 2009-10-15 | 2014-03-12 | Crucell Holland B.V. | Verfahren zur adenovirus-reinigung aus kulturen mit hoher zelldichte |
| CN102575233B (zh) | 2009-10-15 | 2014-07-16 | 克鲁塞尔荷兰公司 | 从高细胞密度培养物纯化腺病毒的方法 |
| EP2531592A1 (de) | 2010-02-04 | 2012-12-12 | Vivalis | Fed-batch-verfahren mit konzentriertem zellkulturmedium zur effizienten produktion von biologischen wirkstoffen bei eb66-zellen |
| DK2536829T3 (en) | 2010-02-15 | 2016-07-04 | Crucell Holland Bv | A process for the production of Ad26-adenovirus vectors |
| WO2011130119A2 (en) | 2010-04-14 | 2011-10-20 | Millipore Corporation | Methods of producing high titer, high purity virus stocks and methods of use thereof |
| US10087423B2 (en) | 2010-07-20 | 2018-10-02 | Bavarian Nordic A/S | Method for harvesting expression products |
| SG188947A1 (en) * | 2010-08-12 | 2013-06-28 | Yisheng Biopharma Holdings Ltd | Method for reducing dna impurities in viral compositions |
| CN103118702A (zh) | 2010-09-20 | 2013-05-22 | 克鲁塞尔荷兰公司 | 活动性结核病的治疗性接种 |
| AU2011310838B2 (en) | 2010-09-27 | 2015-11-05 | Crucell Holland B.V. | Heterologous prime boost vaccination regimen against malaria |
| DE102010046817A1 (de) * | 2010-09-28 | 2012-03-29 | Sartorius Stedim Biotech Gmbh | Verfahren zur Abtrennung von Viren aus einem Kontaminanten enthaltenden flüssigen Medium |
| WO2012069190A2 (en) * | 2010-11-26 | 2012-05-31 | Probiogen Ag | Depletion of host cell components from live vector vaccines |
| CN103732610A (zh) * | 2011-06-13 | 2014-04-16 | 默沙东公司 | 纯化天然或突变体形式的白喉毒素的方法 |
| US10273462B2 (en) * | 2011-07-27 | 2019-04-30 | Vectalys Sas | Virus-based vector compositions useful for transducing eukaryotic cells |
| WO2013074501A1 (en) | 2011-11-14 | 2013-05-23 | Crucell Holland B.V. | Heterologous prime-boost immunization using measles virus-based vaccines |
| CA2864956C (en) | 2012-03-12 | 2021-11-09 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
| US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
| US9119813B2 (en) | 2012-03-22 | 2015-09-01 | Crucell Holland B.V. | Vaccine against RSV |
| KR102023791B1 (ko) | 2012-03-22 | 2019-09-23 | 얀센 백신스 앤드 프리벤션 비.브이. | Rsv에 대한 백신 |
| CN103571800B (zh) * | 2012-07-27 | 2018-04-24 | 江苏康润生物科技有限公司 | 一种去除疫苗中宿主dna的方法 |
| RU2493872C1 (ru) * | 2012-08-08 | 2013-09-27 | Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации ( ФГУП "НПО "Микроген" Минздрава России) | Способ очистки вируса гриппа |
| CN103768589B (zh) * | 2012-10-18 | 2016-12-21 | 辽宁成大生物股份有限公司 | 利用中空纤维膜去除人用乙型脑炎疫苗制品中残留dna的方法 |
| AU2014222610A1 (en) * | 2013-02-28 | 2015-10-15 | Psioxus Therapuetics Limited | A process for the production of adenovirus |
| US10899800B2 (en) | 2013-04-25 | 2021-01-26 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion RSV F polypeptides |
| KR20210054067A (ko) | 2013-06-14 | 2021-05-12 | 싸이오서스 테라퓨틱스 엘티디. | 유형 b 아데노바이러스에 대한 투여 요법 및 제형 |
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| AU2015294014B2 (en) * | 2014-07-24 | 2018-08-23 | Janssen Vaccines & Prevention B.V. | Process for the purification of poliovirus from cell cultures |
| GB201417042D0 (en) * | 2014-09-29 | 2014-11-12 | Fkd Therapies Oy | Method |
| DK3215187T3 (en) | 2014-11-04 | 2018-12-10 | Janssen Vaccines & Prevention Bv | THERAPEUTIC HPV16 VACCINES |
| AU2016249798B2 (en) | 2015-04-14 | 2022-05-26 | Janssen Vaccines And Prevention B.V. | Recombinant adenovirus expressing two transgenes with a bidirectional promoter |
| JP6886410B2 (ja) | 2015-06-10 | 2021-06-16 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 核酸含有組成物の作製および精製のためのプロセス |
| KR102638978B1 (ko) | 2015-07-07 | 2024-02-22 | 얀센 백신스 앤드 프리벤션 비.브이. | Rsv에 대한 백신 |
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-
2005
- 2005-02-21 EP EP06126383A patent/EP1780269B1/de not_active Revoked
- 2005-02-21 CN CNA2005800056824A patent/CN1922308A/zh active Pending
- 2005-02-21 CN CNA2008101300506A patent/CN101343625A/zh active Pending
- 2005-02-21 CA CA2555412A patent/CA2555412C/en not_active Expired - Fee Related
- 2005-02-21 NZ NZ548495A patent/NZ548495A/en not_active IP Right Cessation
- 2005-02-21 AU AU2005214090A patent/AU2005214090B2/en not_active Ceased
- 2005-02-21 EP EP05729676A patent/EP1718738A2/de not_active Withdrawn
- 2005-02-21 US US10/590,427 patent/US20070207461A1/en not_active Abandoned
- 2005-02-21 ES ES06126383T patent/ES2329607T3/es not_active Expired - Lifetime
- 2005-02-21 AT AT06126383T patent/ATE435906T1/de active
- 2005-02-21 JP JP2006553596A patent/JP2007522814A/ja active Pending
- 2005-02-21 DE DE602005015332T patent/DE602005015332D1/de not_active Expired - Lifetime
- 2005-02-21 DK DK06126383T patent/DK1780269T3/da active
- 2005-02-21 WO PCT/EP2005/050739 patent/WO2005080556A2/en not_active Ceased
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2006
- 2006-08-30 KR KR1020067017560A patent/KR101211329B1/ko not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2005080556A2 (en) | 2005-09-01 |
| US8124106B2 (en) | 2012-02-28 |
| KR101211329B1 (ko) | 2012-12-12 |
| US20090017523A1 (en) | 2009-01-15 |
| NZ548495A (en) | 2009-05-31 |
| WO2005080556A3 (en) | 2006-02-23 |
| AU2005214090B2 (en) | 2008-09-11 |
| CA2555412A1 (en) | 2005-09-01 |
| EP1780269A2 (de) | 2007-05-02 |
| CA2555412C (en) | 2013-06-25 |
| DE602005015332D1 (de) | 2009-08-20 |
| KR20070001163A (ko) | 2007-01-03 |
| EP1780269A3 (de) | 2007-07-18 |
| CN101343625A (zh) | 2009-01-14 |
| JP2007522814A (ja) | 2007-08-16 |
| EP1718738A2 (de) | 2006-11-08 |
| WO2005080556A9 (en) | 2006-10-26 |
| EP1780269B1 (de) | 2009-07-08 |
| ES2329607T3 (es) | 2009-11-27 |
| US20070207461A1 (en) | 2007-09-06 |
| CN1922308A (zh) | 2007-02-28 |
| DK1780269T3 (da) | 2009-10-12 |
| AU2005214090A1 (en) | 2005-09-01 |
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