ATE435906T1 - Verfahren zur reinigung von viren - Google Patents
Verfahren zur reinigung von virenInfo
- Publication number
- ATE435906T1 ATE435906T1 AT06126383T AT06126383T ATE435906T1 AT E435906 T1 ATE435906 T1 AT E435906T1 AT 06126383 T AT06126383 T AT 06126383T AT 06126383 T AT06126383 T AT 06126383T AT E435906 T1 ATE435906 T1 AT E435906T1
- Authority
- AT
- Austria
- Prior art keywords
- cleaning viruses
- adenovirus
- viruses
- cleaning
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 238000004140 cleaning Methods 0.000 title 1
- 241000701161 unidentified adenovirus Species 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000005349 anion exchange Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10051—Methods of production or purification of viral material
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2004050190 | 2004-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE435906T1 true ATE435906T1 (de) | 2009-07-15 |
Family
ID=34878416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06126383T ATE435906T1 (de) | 2004-02-23 | 2005-02-21 | Verfahren zur reinigung von viren |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20070207461A1 (de) |
| EP (2) | EP1780269B1 (de) |
| JP (1) | JP2007522814A (de) |
| KR (1) | KR101211329B1 (de) |
| CN (2) | CN1922308A (de) |
| AT (1) | ATE435906T1 (de) |
| AU (1) | AU2005214090B2 (de) |
| CA (1) | CA2555412C (de) |
| DE (1) | DE602005015332D1 (de) |
| DK (1) | DK1780269T3 (de) |
| ES (1) | ES2329607T3 (de) |
| NZ (1) | NZ548495A (de) |
| WO (1) | WO2005080556A2 (de) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL160406A0 (en) | 1995-06-15 | 2004-07-25 | Crucell Holland Bv | A cell harbouring nucleic acid encoding adenoritus e1a and e1b gene products |
| US6929946B1 (en) * | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
| AU2005214090B2 (en) | 2004-02-23 | 2008-09-11 | Crucell Holland B.V. | Virus purification methods |
| US8574595B2 (en) * | 2005-04-11 | 2013-11-05 | Crucell Holland B.V. | Virus purification using ultrafiltration |
| JP5602366B2 (ja) | 2005-11-01 | 2014-10-08 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | β−プロピオラクトン処理による低レベルの残存細胞DNAを含む細胞由来のウイルスワクチン |
| EP1998804B1 (de) * | 2006-03-27 | 2014-04-16 | Crucell Holland B.V. | Zusammensetzungen, die einen rekombinanten adenovirus und ein adjuvans umfassen |
| ATE539149T1 (de) * | 2006-04-20 | 2012-01-15 | Wyeth Llc | Reinigungsverfahren zur isolierung von gereinigtem vesikulärem stomatitisvirus aus zellkultur |
| PL2195418T3 (pl) | 2007-10-02 | 2013-05-31 | Ptc Phage Tech Center Gmbh | Sposób i układ do oczyszczania na skalę przemysłową bakteriofagów z przeznaczeniem do terapii bakteriofagowej |
| BRPI0908474A2 (pt) * | 2008-02-12 | 2016-07-26 | Sanofi Pasteur Ltd | métodos de uso de cromatografia de troca de íon e de filtração de gel para purificação de vírus causador da catapora |
| EP3192874B1 (de) * | 2008-06-18 | 2019-10-16 | Oxford BioMedica (UK) Limited | Virusreinigung |
| CN102215865B (zh) * | 2008-09-24 | 2013-10-30 | 米迪缪尼有限公司 | 病毒纯化方法 |
| US10041049B2 (en) | 2008-11-03 | 2018-08-07 | Janssen Vaccines & Prevention B.V. | Method for the production of adenoviral vectors |
| US20110293660A1 (en) * | 2009-02-06 | 2011-12-01 | Bruno Rene Andre | Novel method |
| JP2010207800A (ja) * | 2009-02-16 | 2010-09-24 | Kuraray Co Ltd | ろ過ユニットおよびこれを備えたろ過装置 |
| JP2010193720A (ja) * | 2009-02-23 | 2010-09-09 | Asahi Kasei Chemicals Corp | アニオン交換基が固定された多孔膜を用いたウイルスの分離方法 |
| SG176554A1 (en) * | 2009-05-12 | 2012-01-30 | Transgene Sa | Method for orthopoxvirus production and purification |
| JP5827948B2 (ja) * | 2009-08-17 | 2015-12-02 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | ウイルスを単離する方法 |
| CA2777116C (en) | 2009-10-15 | 2020-09-01 | Crucell Holland B.V. | Process for adenovirus purification from high cell density cultures |
| EA028623B1 (ru) | 2009-10-15 | 2017-12-29 | Янссен Вэксинс Энд Превеншн Б.В. | Способ очистки аденовирусных частиц |
| EP2531592A1 (de) | 2010-02-04 | 2012-12-12 | Vivalis | Fed-batch-verfahren mit konzentriertem zellkulturmedium zur effizienten produktion von biologischen wirkstoffen bei eb66-zellen |
| KR101820980B1 (ko) | 2010-02-15 | 2018-01-22 | 얀센 백신스 앤드 프리벤션 비.브이. | Ad 26 아데노바이러스 벡터를 제조하는 방법 |
| US9644187B2 (en) | 2010-04-14 | 2017-05-09 | Emd Millipore Corporation | Methods of producing high titer, high purity virus stocks and methods of use thereof |
| US10087423B2 (en) | 2010-07-20 | 2018-10-02 | Bavarian Nordic A/S | Method for harvesting expression products |
| WO2012019354A1 (en) | 2010-08-12 | 2012-02-16 | Yisheng Biopharma Holdings Ltd. | Method for reducing dna impurities in viral compositions |
| AP3390A (en) | 2010-09-20 | 2015-08-31 | Crucell Holland Bv | Therapeutic vaccination against active tuberculosis |
| WO2012041669A1 (en) | 2010-09-27 | 2012-04-05 | Crucell Holland B.V. | Heterologous prime boost vaccination regimen against malaria |
| DE102010046817A1 (de) * | 2010-09-28 | 2012-03-29 | Sartorius Stedim Biotech Gmbh | Verfahren zur Abtrennung von Viren aus einem Kontaminanten enthaltenden flüssigen Medium |
| EP2643455B1 (de) * | 2010-11-26 | 2018-07-18 | ProBioGen AG | Entfernung von wirtszellkomponenten aus lebendvirus-impfstoffen |
| EP2718306A1 (de) * | 2011-06-13 | 2014-04-16 | Merck Sharp & Dohme Corp. | Verfahren zur reinigung nativer oder mutanter formen von diphtherietoxin |
| CN110684745A (zh) * | 2011-07-27 | 2020-01-14 | 韦克塔里斯公司 | 可用于转导真核细胞的基于病毒的载体组合物 |
| WO2013074501A1 (en) | 2011-11-14 | 2013-05-23 | Crucell Holland B.V. | Heterologous prime-boost immunization using measles virus-based vaccines |
| US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
| PL2825640T3 (pl) | 2012-03-12 | 2016-10-31 | Partie rekombinowanych adenowirusów o zmienionych końcach | |
| US9125870B2 (en) | 2012-03-22 | 2015-09-08 | Crucell Holland B.V. | Vaccine against RSV |
| AP2014007994A0 (en) | 2012-03-22 | 2014-10-31 | Crucell Holland Bv | Vaccine against rsv |
| CN103571800B (zh) * | 2012-07-27 | 2018-04-24 | 江苏康润生物科技有限公司 | 一种去除疫苗中宿主dna的方法 |
| RU2493872C1 (ru) * | 2012-08-08 | 2013-09-27 | Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации ( ФГУП "НПО "Микроген" Минздрава России) | Способ очистки вируса гриппа |
| CN103768589B (zh) * | 2012-10-18 | 2016-12-21 | 辽宁成大生物股份有限公司 | 利用中空纤维膜去除人用乙型脑炎疫苗制品中残留dna的方法 |
| SG11201506624SA (en) * | 2013-02-28 | 2015-09-29 | Psioxus Therapuetics Ltd | A process for the production of adenovirus |
| PE20151867A1 (es) | 2013-04-25 | 2016-01-07 | Crucell Holland Bv | Polipeptidos f de prefusion del virus sincicial respiratorio (rsv )solubles y estabilizados |
| SG11201510064WA (en) | 2013-06-14 | 2016-01-28 | Psioxus Theraupeutics Ltd | A dosing regime and formulations for type b adenoviruses |
| CA2914792C (en) | 2013-06-17 | 2024-02-27 | Crucell Holland B.V. | Stabilized soluble pre-fusion rsv f polypeptides |
| JP6385559B2 (ja) * | 2014-07-24 | 2018-09-05 | ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. | 細胞培養体からのポリオウイルスの精製プロセス |
| GB201417042D0 (en) * | 2014-09-29 | 2014-11-12 | Fkd Therapies Oy | Method |
| EP3421046A1 (de) | 2014-11-04 | 2019-01-02 | Janssen Vaccines & Prevention B.V. | Therapeutische hpv16-impfstoffe |
| US10570417B2 (en) | 2015-04-14 | 2020-02-25 | Janssen Vaccines & Prevention B.V. | Recombinant adenovirus expressing two transgenes with a bidirectional promoter |
| DK3307878T3 (da) * | 2015-06-10 | 2021-10-11 | Us Health | Fremgangsmåder til fremstilling og oprensning af nukleinsyreholdige sammensætninger |
| CA2991002C (en) | 2015-07-07 | 2023-11-28 | Janssen Vaccines & Prevention B.V. | Vaccine against rsv |
| CN107847581B (zh) | 2015-07-07 | 2022-03-22 | 扬森疫苗与预防公司 | 稳定化的可溶性融合前rsv f多肽 |
| EA037295B1 (ru) | 2015-08-20 | 2021-03-05 | Янссен Вэксинс Энд Превеншн Б.В. | Терапевтические вакцины против hpv18 |
| MY193584A (en) | 2016-04-05 | 2022-10-19 | Janssen Vaccines & Prevention Bv | Vaccine against rsv |
| PT3439672T (pt) | 2016-04-05 | 2021-02-24 | Janssen Vaccines & Prevention Bv | Proteína f do rsv pré-fusão solúvel e estabilizada para uso na profilaxia de infeção por rsv |
| BR112018072372A2 (pt) | 2016-05-02 | 2019-02-19 | Janssen Vaccines & Prevention B.V. | combinações de vacina terapêutica contra o hpv |
| KR102573534B1 (ko) | 2016-05-12 | 2023-08-31 | 얀센 백신스 앤드 프리벤션 비.브이. | 강력하고 균형 잡힌 양방향성 프로모터 |
| US10953087B2 (en) | 2016-05-30 | 2021-03-23 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion RSV F proteins |
| WO2017220499A1 (en) | 2016-06-20 | 2017-12-28 | Janssen Vaccines & Prevention B.V. | Potent and balanced bidirectional promoter |
| WO2018011196A1 (en) | 2016-07-14 | 2018-01-18 | Janssen Vaccines & Prevention B.V. | Hpv vaccines |
| CN106434571A (zh) * | 2016-10-19 | 2017-02-22 | 深圳源兴基因技术有限公司 | 一种wave无血清培养悬浮细胞制备重组腺病毒的方法 |
| CN108085301B (zh) * | 2016-11-22 | 2021-10-26 | 贺道耀 | 从宿主细胞提取和纯化腺相关病毒和腺病毒的方法及其组分和试剂盒 |
| US10294452B2 (en) | 2016-11-22 | 2019-05-21 | Dao-Yao He | Lysis, extraction and purification of adeno-associated virus and adenovirus from host cells |
| CA3053212C (en) | 2017-02-09 | 2021-04-13 | Janssen Vaccines & Prevention B.V. | Potent and short promoter for expression of heterologous genes |
| CN106868025B (zh) * | 2017-03-13 | 2020-01-21 | 中国人民解放军军事医学科学院生物工程研究所 | 用酵母制备三聚体埃博拉病毒糖蛋白突变体的方法 |
| US11229692B2 (en) | 2017-05-17 | 2022-01-25 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against RSV infection |
| CN107603959A (zh) * | 2017-08-30 | 2018-01-19 | 四川大学 | 提高缓冲液盐离子浓度纯化病毒的方法 |
| CN111163800A (zh) | 2017-09-15 | 2020-05-15 | 扬森疫苗与预防公司 | 用于安全诱导针对rsv的免疫的方法 |
| CN111511800B (zh) | 2017-10-30 | 2023-11-28 | 武田药品工业株式会社 | 灭活脂包膜病毒的环境相容性去污剂 |
| US11603527B2 (en) * | 2017-12-27 | 2023-03-14 | Global Life Sciences Solutions Usa Llc | Method and kit for viral vector isolation |
| GB201814590D0 (en) * | 2018-09-07 | 2018-10-24 | Oxford Biomedica Ltd | Viral vector production system |
| CN110317832B (zh) * | 2018-03-28 | 2022-07-05 | 西比曼生物科技(香港)有限公司 | Gmp级规模化制备重组慢病毒载体的纯化制剂的方法 |
| EP3784276A4 (de) | 2018-04-24 | 2022-03-16 | Merck Sharp & Dohme Corp. | Skalierbares chromatographieverfahren zur reinigung von menschlichem cytomegalovirus |
| CN112566494B (zh) | 2018-06-12 | 2023-05-23 | Kbio控股有限公司 | 病毒和抗原纯化和偶联 |
| US11529413B2 (en) | 2018-06-12 | 2022-12-20 | Kbio Holdings Limited | Virus and antigen purification and conjugation |
| US11690907B2 (en) | 2018-06-12 | 2023-07-04 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| US11696948B2 (en) | 2018-06-12 | 2023-07-11 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| EP3880243A1 (de) | 2018-11-13 | 2021-09-22 | Janssen Vaccines & Prevention B.V. | Stabilisierte präfusionierte rsv-f-proteine |
| JP7625519B2 (ja) * | 2018-11-21 | 2025-02-03 | カリヴィル イムノセラピューティクス, インコーポレイテッド | ウイルスの製造 |
| PH12021552797A1 (en) * | 2019-05-14 | 2022-09-19 | Janssen Biotech Inc | Ultrafiltration/diafiltration (uf/df) process |
| GB201909081D0 (en) * | 2019-06-25 | 2019-08-07 | Psioxus Therapeutics Ltd | Method |
| JP7539420B2 (ja) * | 2019-06-28 | 2024-08-23 | 武田薬品工業株式会社 | アデノ随伴ウイルスの精製方法 |
| CN111249456A (zh) * | 2020-03-13 | 2020-06-09 | 武汉生物制品研究所有限责任公司 | 一种狂犬病病毒灭活疫苗的纯化方法 |
| CN111394390A (zh) * | 2020-03-26 | 2020-07-10 | 赛诺(深圳)生物医药研究有限公司 | 用于新型冠状病毒基因疫苗的批量生产重组腺病毒的方法 |
| EP4200048A1 (de) * | 2020-08-18 | 2023-06-28 | Sartorius BIA Separations d.o.o. | Metallaffinitätsextraktion von wirtszellen-dna |
| JP2023552531A (ja) | 2020-12-10 | 2023-12-18 | サレプタ セラピューティクス, インコーポレイテッド | 接着細胞のための懸濁モードシードトレイン開発 |
| IL308431A (en) | 2021-05-17 | 2024-01-01 | Sarepta Therapeutics Inc | Production of recombinant AAV vectors for the treatment of muscular dystrophy |
| MX2024001860A (es) * | 2021-08-10 | 2024-05-08 | Biocon Ltd | Purificacion de liraglutida. |
| CN113817689B (zh) * | 2021-11-22 | 2023-10-03 | 北京艺妙神州医药科技有限公司 | 慢病毒纯化工艺 |
| EP4499816A1 (de) * | 2022-03-30 | 2025-02-05 | CSL Behring LLC | Verfahren zur reinigung eines umhüllten virus |
| CN115807064A (zh) * | 2022-07-20 | 2023-03-17 | 上海泰昶生物技术有限公司 | 重组腺相关病毒载体制品中游离和错误包装dna的检测方法 |
| CN115141813A (zh) * | 2022-07-29 | 2022-10-04 | 深圳源兴基因技术有限公司 | 一种高效去除宿主细胞残留蛋白的腺病毒纯化方法 |
| EP4590838A1 (de) | 2022-09-23 | 2025-07-30 | Sarepta Therapeutics, Inc. | Rekombinante aav-vektoren zur behandlung von muskeldystrophie |
| EP4634371A1 (de) * | 2022-12-16 | 2025-10-22 | Avirmax Biopharma Inc. | Verfahren zur herstellung von viren und viruspartikeln |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE434914B (sv) | 1975-07-07 | 1984-08-27 | Jonsson U R S | Forfarande for att ur en suspension av bakterier och ett vetskeformigt medium genom filtrering avskilja mediet under samtidig anrikning av bakterierna |
| US4435289A (en) | 1981-12-23 | 1984-03-06 | Romicon, Inc. | Series ultrafiltration with pressurized permeate |
| US5173418A (en) * | 1985-05-10 | 1992-12-22 | Benzon Pharma, A/S | Production in Escherichia coli of extracellular Serratia spp. hydrolases |
| US4808315A (en) | 1986-04-28 | 1989-02-28 | Asahi Kasei Kogyo Kabushiki Kaisha | Porous hollow fiber membrane and a method for the removal of a virus by using the same |
| FR2705686B1 (fr) * | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| FR2716682B1 (fr) * | 1994-01-28 | 1996-04-26 | Centre Nat Rech Scient | Procédé de préparation de virus adéno-associés (AAV) recombinants et utilisations. |
| DE69535178T2 (de) * | 1994-06-10 | 2006-12-14 | Genvec, Inc. | Adenoviren-vektor systeme und zelllinien |
| US5851806A (en) * | 1994-06-10 | 1998-12-22 | Genvec, Inc. | Complementary adenoviral systems and cell lines |
| SE9500724D0 (sv) | 1994-06-23 | 1995-02-24 | Pharmacia Ab | Filtrering |
| US5559099A (en) * | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
| US5846782A (en) * | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| US5965541A (en) * | 1995-11-28 | 1999-10-12 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
| US6146873A (en) * | 1994-11-10 | 2000-11-14 | Baxter Aktiengesellschaft | Production of orthomyxoviruses in monkey kidney cells using protein-free media |
| US5770442A (en) | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
| US5837520A (en) * | 1995-03-07 | 1998-11-17 | Canji, Inc. | Method of purification of viral vectors |
| IL160406A0 (en) * | 1995-06-15 | 2004-07-25 | Crucell Holland Bv | A cell harbouring nucleic acid encoding adenoritus e1a and e1b gene products |
| FR2737730B1 (fr) * | 1995-08-10 | 1997-09-05 | Pasteur Merieux Serums Vacc | Procede de purification de virus par chromatographie |
| US5840565A (en) * | 1995-08-22 | 1998-11-24 | The Regents Of The University Of California | Methods for enhancing the production of viral vaccines in PKR-deficient cell culture |
| EP0847442A1 (de) | 1995-08-30 | 1998-06-17 | Genzyme Corporation | Chromatographische reinigung von adenoviren und aav |
| US5837511A (en) * | 1995-10-02 | 1998-11-17 | Cornell Research Foundation, Inc. | Non-group C adenoviral vectors |
| US5891690A (en) * | 1996-04-26 | 1999-04-06 | Massie; Bernard | Adenovirus E1-complementing cell lines |
| EP0944717A1 (de) * | 1996-07-01 | 1999-09-29 | Aventis Pharma S.A. | Methode zur produktion von rekombinantem adenovirus. |
| FR2751343B1 (fr) | 1996-07-16 | 1998-12-18 | Transgene Sa | Procede de conservation de virus recombinants infectieux, suspension aqueuse virale et utilisation comme medicament |
| BR9713368A (pt) * | 1996-11-20 | 2001-09-18 | Introgen Therapeutics Inc | Processo melhorado para a produção e a purificação de vetores adenovirais |
| US7732129B1 (en) * | 1998-12-01 | 2010-06-08 | Crucell Holland B.V. | Method for the production and purification of adenoviral vectors |
| US6261823B1 (en) * | 1996-12-13 | 2001-07-17 | Schering Corporation | Methods for purifying viruses |
| ES2273404T3 (es) | 1997-01-31 | 2007-05-01 | Schering Corporation | Metodos para cultivar celulas y propagar virus. |
| US6168944B1 (en) * | 1997-01-31 | 2001-01-02 | Schering Corporation | Methods for cultivating cells and propagating viruses |
| CA2283253A1 (en) | 1997-03-04 | 1998-09-11 | Baxter International Inc. | Adenovirus e1-complementing cell lines |
| TW570803B (en) * | 1997-04-09 | 2004-01-11 | Duphar Int Res | Influenza vaccine |
| US6020191A (en) * | 1997-04-14 | 2000-02-01 | Genzyme Corporation | Adenoviral vectors capable of facilitating increased persistence of transgene expression |
| US5947689A (en) | 1997-05-07 | 1999-09-07 | Scilog, Inc. | Automated, quantitative, system for filtration of liquids having a pump controller |
| EP1604685B1 (de) * | 1997-08-28 | 2012-02-22 | CJ Cheiljedang Corporation | Abgeschwächtes japanische Encephalitis Virus |
| US6210683B1 (en) | 1997-09-05 | 2001-04-03 | Merck & Co., Inc. | Stabilizers containing recombinant human serum albumin for live virus vaccines |
| DE69936948T2 (de) | 1998-02-17 | 2008-05-15 | Schering Corporation | Virusenthaltende Zusammensetzungen und Methoden zur Konzentration von Viruspräparaten |
| US5981225A (en) * | 1998-04-16 | 1999-11-09 | Baylor College Of Medicine | Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same |
| EA200001096A1 (ru) * | 1998-04-22 | 2001-04-23 | Джинвек, Инк. | Способ обогащения раствора аденовируса, способ точного подсчета числа аденовирусных частиц в образце раствора (варианты) и способ очистки аденовируса из клеток, инфицированных аденовирусом |
| US5994134A (en) * | 1998-05-04 | 1999-11-30 | Canji, Inc. | Viral production process |
| US6113913A (en) * | 1998-06-26 | 2000-09-05 | Genvec, Inc. | Recombinant adenovirus |
| US20030017138A1 (en) | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
| US6342384B1 (en) * | 1998-08-21 | 2002-01-29 | The University Of Va Patent Foundation | Production of adenoviral vectors using serum-free suspension cell culture in a hollow fiber system |
| AU1729600A (en) | 1998-11-16 | 2000-06-05 | Introgen Therapeutics, Inc. | Formulation of adenovirus for gene therapy |
| KR100762033B1 (ko) * | 1998-12-31 | 2007-10-04 | 아방티 파르마 소시에테 아노님 | 바이러스 입자의 분리방법 |
| US6120820A (en) | 1999-02-22 | 2000-09-19 | Land O'lakes, Inc. | Method of modifying the color of a dairy material |
| WO2000050573A1 (fr) | 1999-02-22 | 2000-08-31 | Transgene S.A. | Procede d'obtention d'une preparation virale purifiee |
| ES2231103T5 (es) | 1999-05-17 | 2010-04-15 | Crucell Holland B.V. | Vehiculos de transferencia de genes derivados de adenovirus que comprenden al menos un elemento de adenovirus tipo 35. |
| US6492169B1 (en) * | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| DE19955558C2 (de) | 1999-11-18 | 2003-03-20 | Stefan Kochanek | Permanente Amniozyten-Zelllinie, ihre Herstellung und Verwendung zur Herstellung von Gentransfervektoren |
| EP1103610A1 (de) | 1999-11-26 | 2001-05-30 | Introgene B.V. | Impfstoffherstellung von immortalisierten Säugetierzellinien |
| JP5118798B2 (ja) | 2000-03-07 | 2013-01-16 | メルク・シャープ・エンド・ドーム・コーポレイション | アデノウイルス製剤 |
| US6168941B1 (en) | 2000-04-07 | 2001-01-02 | Genvec, Inc. | Method of producing adenoviral vector stocks |
| DE10022258A1 (de) | 2000-05-08 | 2001-11-15 | Bayer Ag | Reinigung von Proteineinschlusskörpern durch Querstrom-Mikrofiltration |
| WO2002022080A2 (en) | 2000-09-15 | 2002-03-21 | Merck & Co., Inc. | Enhanced first generation adenovirus vaccines expressing codon optimized hiv1-gag, pol, nef and modifications |
| US6365395B1 (en) | 2000-11-03 | 2002-04-02 | Millipore Corporation | Process for removing protein aggregates and virus from a protein solution |
| US20020064860A1 (en) | 2000-11-29 | 2002-05-30 | Schering Corporation | Method for purifying adenoviruses |
| IL152420A0 (en) | 2001-02-23 | 2003-05-29 | Novartis Ag | Novel oncolytic adenoviral vectors |
| ATE496120T1 (de) | 2001-03-01 | 2011-02-15 | Bayer Schering Pharma Ag | Konzentration und lyse von adenovirus-infizierten zellen in derselben prozesseinheit |
| DE60226911D1 (de) | 2001-10-01 | 2008-07-10 | Us Health | Entwicklung einer Vakzine zur Prävention von Infektionen mit Filovirus bei Primaten |
| US6951752B2 (en) | 2001-12-10 | 2005-10-04 | Bexter Healthcare S.A. | Method for large scale production of virus antigen |
| CA2469623C (en) | 2001-12-12 | 2012-05-29 | F H Faulding & Co Limited | Composition for the preservation of viruses |
| US20030180936A1 (en) | 2002-03-15 | 2003-09-25 | Memarzadeh Bahram Eric | Method for the purification, production and formulation of oncolytic adenoviruses |
| JP2005521417A (ja) | 2002-03-29 | 2005-07-21 | メルク エンド カムパニー インコーポレーテッド | アデノウイルスの大規模産生方法及びアデノウイルス種子ストック |
| CA2478508C (en) | 2002-04-25 | 2013-07-02 | Crucell Holland B.V. | Stable adenoviral vectors and methods for propagation thereof |
| PT1497438E (pt) | 2002-04-25 | 2010-02-04 | Crucell Holland Bv | Meios e métodos para a produção de vectores de adenovírus |
| AU2003229060A1 (en) * | 2002-05-14 | 2003-12-02 | Merck And Co., Inc. | Methods of adenovirus purification |
| US20050095705A1 (en) | 2003-04-15 | 2005-05-05 | Michael Kadan | Method for production of oncolytic adenoviruses |
| AU2004249199B2 (en) * | 2003-06-18 | 2008-07-24 | Onyx Pharmaceuticals, Inc. | Method for purifying virus |
| AU2005214090B2 (en) | 2004-02-23 | 2008-09-11 | Crucell Holland B.V. | Virus purification methods |
| US20060078628A1 (en) * | 2004-10-09 | 2006-04-13 | Karl Koman | Wound treating agent |
-
2005
- 2005-02-21 AU AU2005214090A patent/AU2005214090B2/en not_active Ceased
- 2005-02-21 DE DE602005015332T patent/DE602005015332D1/de not_active Expired - Lifetime
- 2005-02-21 AT AT06126383T patent/ATE435906T1/de active
- 2005-02-21 US US10/590,427 patent/US20070207461A1/en not_active Abandoned
- 2005-02-21 NZ NZ548495A patent/NZ548495A/en not_active IP Right Cessation
- 2005-02-21 CN CNA2005800056824A patent/CN1922308A/zh active Pending
- 2005-02-21 ES ES06126383T patent/ES2329607T3/es not_active Expired - Lifetime
- 2005-02-21 WO PCT/EP2005/050739 patent/WO2005080556A2/en not_active Ceased
- 2005-02-21 DK DK06126383T patent/DK1780269T3/da active
- 2005-02-21 EP EP06126383A patent/EP1780269B1/de not_active Revoked
- 2005-02-21 EP EP05729676A patent/EP1718738A2/de not_active Withdrawn
- 2005-02-21 JP JP2006553596A patent/JP2007522814A/ja active Pending
- 2005-02-21 CA CA2555412A patent/CA2555412C/en not_active Expired - Fee Related
- 2005-02-21 CN CNA2008101300506A patent/CN101343625A/zh active Pending
-
2006
- 2006-08-30 KR KR1020067017560A patent/KR101211329B1/ko not_active Expired - Fee Related
-
2008
- 2008-07-28 US US12/220,828 patent/US8124106B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1718738A2 (de) | 2006-11-08 |
| US20070207461A1 (en) | 2007-09-06 |
| US8124106B2 (en) | 2012-02-28 |
| JP2007522814A (ja) | 2007-08-16 |
| AU2005214090B2 (en) | 2008-09-11 |
| KR101211329B1 (ko) | 2012-12-12 |
| CN101343625A (zh) | 2009-01-14 |
| US20090017523A1 (en) | 2009-01-15 |
| EP1780269A3 (de) | 2007-07-18 |
| DK1780269T3 (da) | 2009-10-12 |
| AU2005214090A1 (en) | 2005-09-01 |
| NZ548495A (en) | 2009-05-31 |
| DE602005015332D1 (de) | 2009-08-20 |
| ES2329607T3 (es) | 2009-11-27 |
| CA2555412A1 (en) | 2005-09-01 |
| EP1780269B1 (de) | 2009-07-08 |
| EP1780269A2 (de) | 2007-05-02 |
| CA2555412C (en) | 2013-06-25 |
| WO2005080556A3 (en) | 2006-02-23 |
| WO2005080556A9 (en) | 2006-10-26 |
| CN1922308A (zh) | 2007-02-28 |
| WO2005080556A2 (en) | 2005-09-01 |
| KR20070001163A (ko) | 2007-01-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE435906T1 (de) | Verfahren zur reinigung von viren | |
| ATE446792T1 (de) | Verfahren zur behandlung von sinuskopfschmerzen | |
| EP1726599A4 (de) | Verfahren zur herstellung von fluorpolymer | |
| ATE431139T1 (de) | Verfahren zur identifizierung von glp-1- sekretionsförderern | |
| DE602004021790D1 (de) | Verfahren zur behandlung von parkinson-krankheit | |
| DE50307672D1 (de) | Verfahren zur herstellung von polycarbonaten | |
| DE502004009768D1 (de) | Verfahren zur herstellung von dreiwertigen organophosphor-verbindungen | |
| ATE485517T1 (de) | Verfahren zur identifizierung von polypeptid- targets | |
| DE60234952D1 (de) | VERFAHREN ZUR HERSTELLUNG VON HEXAHYDROFUROc2,3-BÜFURAN-3-OL | |
| ATE435209T1 (de) | Verfahren zur herstellung von montelukast-natrium | |
| DE60217096D1 (de) | Verfahren zur herstellung von (s)-(+)- und (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepin-5-carboxamid | |
| DE60328522D1 (de) | Verfahren zur herstellung von bisphenol | |
| ATE474602T1 (de) | Verfahren zur behandlung von hiv-infektion | |
| DE502005010038D1 (de) | Verfahren zur herstellung von 3-pentennitril | |
| DE60302139D1 (de) | Verfahren zur herstellung von aripiprazole | |
| DE602004018249D1 (de) | Verfahren zur Dearomatisierung von Molkeprotein | |
| DE502004001216D1 (de) | Verfahren zur aufreinigung von blausäure | |
| DE502005000428D1 (de) | Verfahren zur Herstellung von 1,2-Diaminocyclohexan-Platin(II)-Komplexen | |
| DE502006002510D1 (de) | Verfahren zur herstellung von silikon-haltigen polymerisaten | |
| DE60226310D1 (de) | Verfahren zur herstellung von cycloolefinadditionspolymerisat | |
| DE502005007702D1 (de) | Verfahren zur herstellung von terrylen-3,4:11,12-t | |
| ATE394369T1 (de) | Verfahren zur aufreinigung von mesotrion | |
| DE60233130D1 (de) | Verfahren zur herstellung von imipenem | |
| DE502004002810D1 (de) | Verfahren zur herstellung von copolymerisaten | |
| DE602004029787D1 (de) | Verfahren zur herstellung von 5-iodo-2-methylbenzoesäure |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1780269 Country of ref document: EP |
|
| UEP | Publication of translation of european patent specification |
Ref document number: 1780269 Country of ref document: EP |