RU94038050A - Рекомбинантный вирус, вектор, вакцина, способ иммунизации, клетка-хозяин - Google Patents

Рекомбинантный вирус, вектор, вакцина, способ иммунизации, клетка-хозяин

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RU94038050A
RU94038050A RU94038050/13A RU94038050A RU94038050A RU 94038050 A RU94038050 A RU 94038050A RU 94038050/13 A RU94038050/13 A RU 94038050/13A RU 94038050 A RU94038050 A RU 94038050A RU 94038050 A RU94038050 A RU 94038050A
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virus
swine pox
vaccine
recombinant
vector
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RU94038050/13A
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English (en)
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Д.Кочрэн Марк
Us]
Е.Джанкер Дэвид
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Синтро Корпорейшн (US)
Синтро Корпорейшн
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Abstract

Изобретение относится к способному реплицироваться рекомбинантному вирусу свиной оспы, содержащему чужеродную ДНК, вставленную в участок вирусной ДНК свиной оспы, не имеющий существенного значения для репликации вируса свиной оспы. Кроме того, изобретение относится к гомологичным векторам, продуцирующим рекомбинантные вирусы свиной оспы путем вставки чужеродной ДНК в вирусную ДНК свиной оспы.

Claims (1)

  1. Изобретение относится к способному реплицироваться рекомбинантному вирусу свиной оспы, содержащему чужеродную ДНК, вставленную в участок вирусной ДНК свиной оспы, не имеющий существенного значения для репликации вируса свиной оспы. Кроме того, изобретение относится к гомологичным векторам, продуцирующим рекомбинантные вирусы свиной оспы путем вставки чужеродной ДНК в вирусную ДНК свиной оспы.
RU94038050/13A 1992-01-13 1993-01-13 Рекомбинантный вирус, вектор, вакцина, способ иммунизации, клетка-хозяин RU94038050A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/820,154 1992-01-13
US07/820,154 US5382425A (en) 1992-01-13 1992-01-13 Recombinant swinepox virus

Publications (1)

Publication Number Publication Date
RU94038050A true RU94038050A (ru) 1996-05-10

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RU94038050/13A RU94038050A (ru) 1992-01-13 1993-01-13 Рекомбинантный вирус, вектор, вакцина, способ иммунизации, клетка-хозяин

Country Status (13)

Country Link
US (1) US5382425A (ru)
EP (1) EP0677114B1 (ru)
JP (1) JP3527240B2 (ru)
AT (1) ATE236262T1 (ru)
AU (1) AU675216B2 (ru)
CA (1) CA2127541C (ru)
DE (1) DE69332831T2 (ru)
DK (1) DK0677114T3 (ru)
ES (1) ES2191663T3 (ru)
NZ (1) NZ249278A (ru)
PT (1) PT677114E (ru)
RU (1) RU94038050A (ru)
WO (1) WO1993014194A1 (ru)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2528750C2 (ru) * 2008-11-19 2014-09-20 Лабораторио Ави-Мекс, С.А. Де С.В. Рекомбинантная вакцина на основе инактивированного вирусного вектора
RU2560420C2 (ru) * 2009-06-25 2015-08-20 МЕДИММЬЮН, ЭлЭлСи Варианты гемагглютининов вируса свиного гриппа

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5651972A (en) 1989-04-21 1997-07-29 University Of Florida Research Foundation, Inc. Use of recombinant swine poxvirus as a live vaccine vector
US5869312A (en) * 1992-01-13 1999-02-09 Syntro Corporation Recombinant swinepox virus
US6497882B1 (en) * 1992-01-13 2002-12-24 Syntro Corporation Recombinant swinepox virus
US6127163A (en) * 1992-01-13 2000-10-03 Syntro Corporation Recombinant swinepox virus
EP0617478B1 (en) * 1993-03-25 1998-07-29 Matsushita Electric Industrial Co., Ltd. Laminated dielectric resonator and dielectric filter
US6875856B2 (en) 1993-09-24 2005-04-05 Syntro Corporation Recombinant infectious laryngotracheitis virus and uses thereof
US5698394A (en) * 1994-06-01 1997-12-16 Board Of Regents Of The University Of Nebraska Nucleotide sequences and methods for detection of Serpulina hyodysenteriae
US6221361B1 (en) * 1995-01-19 2001-04-24 Syntro Corporation Recombinant swinepox virus
WO1996022363A1 (en) * 1995-01-19 1996-07-25 Syntro Corporation Recombinant swinepox virus
AU755763B2 (en) * 1995-01-19 2002-12-19 Syntro Corporation Recombinant swinepox virus
EP0954593A1 (en) * 1996-07-25 1999-11-10 Therion Biologics Corporation Recombinant pox virus for immunization against tumor-associated antigens
WO1998020899A1 (en) * 1996-11-12 1998-05-22 Board Of Regents University Of Nebraska Lincoln Attenuated serpulina hyodysenteriae mutant for prevention of swine dysentery
US6517843B1 (en) 1999-08-31 2003-02-11 Merial Reduction of porcine circovirus-2 viral load with inactivated PCV-2
FR2772047B1 (fr) * 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
US6497883B1 (en) 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
ES2170622B1 (es) * 1999-12-03 2004-05-16 Consejo Superior De Investigaciones Cientificas Clones y vectores infectivos derivados de coronavirus y sus aplicaciones.
FR2823222B1 (fr) 2001-04-06 2004-02-06 Merial Sas Vaccin contre le virus de la fievre du nil
AU2003239589A1 (en) * 2002-05-24 2003-12-12 Schering-Plough Ltd. Eta-1 gene and methods for use
US7468273B2 (en) 2003-05-01 2008-12-23 Meial Limited Canine GHRH gene, polypeptides and methods of use
CA2548569C (en) * 2003-12-08 2012-07-10 Loma Linda University Methods for detecting dna viruses
ATE461710T1 (de) 2005-04-25 2010-04-15 Merial Ltd Nipah-virus-impfstoffe
US20080241184A1 (en) 2005-08-25 2008-10-02 Jules Maarten Minke Canine influenza vaccines
US7771995B2 (en) 2005-11-14 2010-08-10 Merial Limited Plasmid encoding human BMP-7
EP3147296A1 (en) 2005-11-14 2017-03-29 Merial, Inc. Gene therapy for renal failure
US7862821B2 (en) 2006-06-01 2011-01-04 Merial Limited Recombinant vaccine against bluetongue virus
US7794714B2 (en) * 2008-03-14 2010-09-14 The United States Of America As Represented By The Secretary Of Agriculture Newcastle disease virus monoclonal antibodies
AR078253A1 (es) 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
AR083533A1 (es) 2010-10-22 2013-03-06 Boehringer Ingelheim Vetmed Proteinas de hemaglutinina 5 (h5) para el tratamiento y prevencion de las infecciones de gripe
WO2012145577A1 (en) 2011-04-20 2012-10-26 Merial Limited Adjuvanted rabies vaccine with improved viscosity profile
CA2837375C (en) 2011-06-01 2019-07-16 Merial Limited Needle-free administration of prrsv vaccines
ES2626297T3 (es) 2011-08-12 2017-07-24 Merial, Inc. Preservación asistida por vacío de productos biológicos, en particular de vacunas
MX2016003855A (es) 2013-09-25 2016-08-04 Zoetis Services Llc Composicion de vacuna de circovirus porcino tipo 2b divergente y procedimientos de uso.
AU2015241107B2 (en) 2014-04-03 2019-10-03 Boehringer Ingelheim Animal Health USA Inc. Porcine epidemic diarrhea virus vaccine
MX2017005687A (es) 2014-11-03 2017-08-21 Merial Inc Metodos para usar formulaciones para vacuna con microagujas para elicitar en animales inmunidad protectora contra virus de la rabia.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0322417A1 (en) * 1986-09-08 1989-07-05 Applied Biotechnology, Inc. Empty viral capsid vaccines
EP0261940A3 (en) * 1986-09-23 1989-07-05 Applied Biotechnology, Inc. Pseudorabies vaccines and dna vectors for recombination with pox viruses
WO1989010965A2 (en) * 1988-05-03 1989-11-16 The Upjohn Company Glycoprotein h of herpes viruses
US5225336A (en) * 1989-03-08 1993-07-06 Health Research Incorporated Recombinant poxvirus host range selection system

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2528750C2 (ru) * 2008-11-19 2014-09-20 Лабораторио Ави-Мекс, С.А. Де С.В. Рекомбинантная вакцина на основе инактивированного вирусного вектора
RU2560420C2 (ru) * 2009-06-25 2015-08-20 МЕДИММЬЮН, ЭлЭлСи Варианты гемагглютининов вируса свиного гриппа

Also Published As

Publication number Publication date
ATE236262T1 (de) 2003-04-15
DE69332831T2 (de) 2004-01-29
CA2127541C (en) 2005-03-22
EP0677114A4 (en) 1995-07-13
WO1993014194A1 (en) 1993-07-22
ES2191663T3 (es) 2003-09-16
JPH07506481A (ja) 1995-07-20
PT677114E (pt) 2003-07-31
US5382425A (en) 1995-01-17
DK0677114T3 (da) 2003-04-22
AU3583093A (en) 1993-08-03
NZ249278A (en) 1996-05-28
EP0677114B1 (en) 2003-04-02
DE69332831D1 (de) 2003-05-08
CA2127541A1 (en) 1993-07-22
JP3527240B2 (ja) 2004-05-17
AU675216B2 (en) 1997-01-30
EP0677114A1 (en) 1995-10-18

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