ES2132072T3 - Anticuerpo monoclonal especifico para receptor iga. - Google Patents

Anticuerpo monoclonal especifico para receptor iga.

Info

Publication number
ES2132072T3
ES2132072T3 ES90916618T ES90916618T ES2132072T3 ES 2132072 T3 ES2132072 T3 ES 2132072T3 ES 90916618 T ES90916618 T ES 90916618T ES 90916618 T ES90916618 T ES 90916618T ES 2132072 T3 ES2132072 T3 ES 2132072T3
Authority
ES
Spain
Prior art keywords
iga
receiver
monoclonal antibody
specific monoclonal
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90916618T
Other languages
English (en)
Inventor
Li Shen
Michael W Fanger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dartmouth College
Original Assignee
Dartmouth College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dartmouth College filed Critical Dartmouth College
Application granted granted Critical
Publication of ES2132072T3 publication Critical patent/ES2132072T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE DESCRIBEN ANTICUERPOS MONOCLONALES QUE REACCIONAN ESPECIFICAMENTE AL RECEPTOR FC PARA IGA DE LAS CELULAS QUE EFECTUANTES HUMANAS. LOS ANTICUERPOS SON UTILES PARA BOMBARDEAR LAS CELULAS EFECTUANTES HUMANAS (POR EJ., MACROFAGOS) CONTRA UNA CELULA BLANCO (POR EJ., UNA CELULA DE CANCER, UN AGENTE INFECCIOSO ETC.). CON ESTE PROPOSITO, SE PUEDEN CONSTRUIR ANTICUERPOS BIFUNCIONALES O HETEROANTICUERPO CONTENIENDO LA REGION DE ENLACE DERIVADA DE UN ANTICUERPO ANTI-FC-ALFA RECEPTOR Y LA REGION DE ENLACE DE UN ANTICUERPO DE BLANCO ESPECIFICO. LAS CELULAS EFECTUANTES BOMBARDEADAS PUEDEN LISAR CELULAS BLANCO.
ES90916618T 1989-10-20 1990-10-19 Anticuerpo monoclonal especifico para receptor iga. Expired - Lifetime ES2132072T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42488389A 1989-10-20 1989-10-20

Publications (1)

Publication Number Publication Date
ES2132072T3 true ES2132072T3 (es) 1999-08-16

Family

ID=23684271

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90916618T Expired - Lifetime ES2132072T3 (es) 1989-10-20 1990-10-19 Anticuerpo monoclonal especifico para receptor iga.

Country Status (9)

Country Link
US (1) US5610057A (es)
EP (1) EP0496818B1 (es)
JP (1) JPH05504677A (es)
AT (1) ATE181558T1 (es)
CA (1) CA2067244C (es)
DE (1) DE69033181T2 (es)
DK (1) DK0496818T3 (es)
ES (1) ES2132072T3 (es)
WO (1) WO1991005805A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6018031A (en) * 1989-10-20 2000-01-25 Trustees Of Dartmouth College Binding agents specific for IgA receptor
US5582996A (en) * 1990-12-04 1996-12-10 The Wistar Institute Of Anatomy & Biology Bifunctional antibodies and method of preparing same
US6465253B1 (en) 1994-09-08 2002-10-15 Genvec, Inc. Vectors and methods for gene transfer to cells
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US5559099A (en) * 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
US6111166A (en) * 1994-09-19 2000-08-29 Medarex, Incorporated Transgenic mice expressing human Fcα and β receptors
US5770442A (en) 1995-02-21 1998-06-23 Cornell Research Foundation, Inc. Chimeric adenoviral fiber protein and methods of using same
US6127525A (en) * 1995-02-21 2000-10-03 Cornell Research Foundation, Inc. Chimeric adenoviral coat protein and methods of using same
EP0832134B1 (en) * 1995-06-07 2000-07-26 Medarex, Inc. Anti-allergy bispecific molecules
US6783980B2 (en) 1995-06-15 2004-08-31 Crucell Holland B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
US5922845A (en) * 1996-07-11 1999-07-13 Medarex, Inc. Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
US20030017138A1 (en) 1998-07-08 2003-01-23 Menzo Havenga Chimeric adenoviruses
US6929946B1 (en) 1998-11-20 2005-08-16 Crucell Holland B.V. Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells
US6913922B1 (en) 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
KR100816958B1 (ko) * 1999-07-30 2008-03-26 메다렉스, 인코포레이티드 항-Ｆｃ 수용체 결합제를 포함하는 치료 화합물
US20010051147A1 (en) * 2000-03-27 2001-12-13 Van De Winkel Jan G.J. Methods for immunostimulation using binding agents for the Fc receptor of immunoglobulin A
US7235233B2 (en) 2000-09-26 2007-06-26 Crucell Holland B.V. Serotype 5 adenoviral vectors with chimeric fibers for gene delivery in skeletal muscle cells or myoblasts
CA2437814C (en) 2001-02-12 2008-05-13 Medarex, Inc. Human monoclonal antibodies to fc alpha receptor (cd89)
ATE447037T1 (de) 2002-04-25 2009-11-15 Crucell Holland Bv Mittel und verfahren zur herstellung von adenovirusvektoren
US20060165675A1 (en) * 2002-08-02 2006-07-27 Richman-Eisenstat Janice Beth Modulation of mesenchymal cells via iga-receptors
JP2008518947A (ja) * 2004-10-29 2008-06-05 エルシス セラピューティクス， インク． 免疫応答のクリアランス及び誘導におけるｃｒ１結合分子の使用
EP2127666A1 (en) * 2008-05-28 2009-12-02 Drug Discovery Factory B.V. Method for the treatment or prophylaxis of chronic inflammatory diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4676980A (en) * 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4954617A (en) * 1986-07-07 1990-09-04 Trustees Of Dartmouth College Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes

Also Published As

Publication number Publication date
JPH05504677A (ja) 1993-07-22
EP0496818B1 (en) 1999-06-23
ATE181558T1 (de) 1999-07-15
EP0496818A1 (en) 1992-08-05
CA2067244A1 (en) 1991-04-21
DE69033181D1 (de) 1999-07-29
DE69033181T2 (de) 1999-10-21
CA2067244C (en) 2000-12-19
DK0496818T3 (da) 1999-11-22
US5610057A (en) 1997-03-11
WO1991005805A1 (en) 1991-05-02

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