CU22850A3 - Isobutilgaba y sus derivados para el tratamiento del dolor - Google Patents

Isobutilgaba y sus derivados para el tratamiento del dolor

Info

Publication number
CU22850A3
CU22850A3 CU1999008A CU1999008A CU22850A3 CU 22850 A3 CU22850 A3 CU 22850A3 CU 1999008 A CU1999008 A CU 1999008A CU 1999008 A CU1999008 A CU 1999008A CU 22850 A3 CU22850 A3 CU 22850A3
Authority
CU
Cuba
Prior art keywords
pain
hydrogen
formula
treatment
aminomethyl
Prior art date
Application number
CU1999008A
Other languages
English (en)
Inventor
Lakhbir Singh
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21809080&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU22850(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of CU22850A3 publication Critical patent/CU22850A3/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención es un método para usar un compuesto de la Fórmula I mostrada abajo en el tratamiento del dolor, especialmente para el tratamiento de trastornos de dolor crónicos. Tales trastornos incluyen, en forma no taxativa, dolor inflamatorio, dolor posoperatorio, dolor osteoartrítico asociado con cáncer metastático, neuralgia trigeminal, neuralgia herpética y posherpética aguda, neuropatía diabética, causalgia, avulsión del plexo braquial, neuralgia occipital, distrofia simpática refleja, fibromialgia, gota, dolor de miembro fantasma, dolor de quemadura, y otras formas de síndromes de dolor neurálgico, neuropático e idiopático. Un compuesto es aquel de la Fórmula I o una sal farmacéuticamente aceptable de él, donde R1 es un alquilo recto o ramificado de 1 a 6 átomos de carbono, fenilo, o cicloalquilo de 3 a 6 átomos de carbono; R2 es hidrógeno o metilo; y R3 es hidrógeno, metilo o carboxilo. Los diastereómeros y enantiómeros de compuestos de la Fórmula I están incluidos en la invención. Los compuestos preferidos de la invención son aquellos de 5 acuerdo con la reivindicación 1 donde R3 y R2 son hidrógeno, y R1 es - (CH2) 0-22-i C4H9 como un isómero (R) , (S) , o (R, S) . Los compuestos más preferidos de la invención son ácido (S)-3(aminometil)-5-metilhexanoico y ácido 3-aminometil-5-metil10 hexanoico.
CU1999008A 1996-07-24 1999-01-22 Isobutilgaba y sus derivados para el tratamiento del dolor CU22850A3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2233796P 1996-07-24 1996-07-24

Publications (1)

Publication Number Publication Date
CU22850A3 true CU22850A3 (es) 2003-04-28

Family

ID=21809080

Family Applications (1)

Application Number Title Priority Date Filing Date
CU1999008A CU22850A3 (es) 1996-07-24 1999-01-22 Isobutilgaba y sus derivados para el tratamiento del dolor

Country Status (22)

Country Link
US (2) USRE41920E1 (es)
EP (1) EP0934061B3 (es)
JP (1) JP3693258B2 (es)
KR (1) KR100491282B1 (es)
CN (1) CN1094757C (es)
AT (1) ATE241351T1 (es)
AU (1) AU714980B2 (es)
BR (1) BR9710536A (es)
CU (1) CU22850A3 (es)
DE (1) DE69722426T3 (es)
DK (1) DK0934061T6 (es)
ES (1) ES2200184T7 (es)
HR (1) HRP970387A2 (es)
HU (2) HU228426B1 (es)
IL (1) IL126999A (es)
NO (2) NO325822B1 (es)
NZ (1) NZ332762A (es)
PL (1) PL189872B1 (es)
PT (1) PT934061E (es)
SI (1) SI0934061T1 (es)
WO (1) WO1998003167A1 (es)
ZA (1) ZA976562B (es)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP980342A2 (en) * 1997-06-25 1999-02-28 Warner Lambert Co Anti-inflammatory method
US6329429B1 (en) 1997-06-25 2001-12-11 Warner-Lambert Company Use of GABA analogs such as Gabapentin in the manufacture of a medicament for treating inflammatory diseases
AU750578B2 (en) * 1997-09-08 2002-07-25 Warner-Lambert Company Analgesic compositions comprising anti-epileptic compounds and methods of using same
EP0974351A3 (en) * 1998-04-24 2000-12-13 Jouveinal Medicament for preventing and treating gastrointestinal damage
HU228771B1 (en) * 1998-05-15 2013-05-28 Warner Lambert Co Stabilized pharmaceutical preparations of gamma-aminobutyric acid derivatives and process for preparing the same
US6680343B1 (en) 1998-07-09 2004-01-20 Warner-Lambert Comapny Treatment of renal colic with GABA analogs
CA2332927A1 (en) * 1998-07-09 2000-01-20 Catherine A. Segal Compositions comprising gaba analogs and a decongestant to relieve sinus headache pain
ATE279188T1 (de) * 1998-07-09 2004-10-15 Warner Lambert Co Pharmazeutische zusammensetzungen enthaltend gaba-analogen und ein antivirales mittel zur behandlung von herpes zoster
BR9911925A (pt) * 1998-07-09 2001-03-27 Warner Lambert Co O tratamento de cólica renal com análogos de gaba
US20030045500A1 (en) * 1998-07-09 2003-03-06 Leslie Magnus Pharmaceutical composition containing GABA analogs and an antiviral agent to treat shingles
US6992109B1 (en) * 1999-04-08 2006-01-31 Segal Catherine A Method for the treatment of incontinence
WO2000067742A2 (en) * 1999-05-05 2000-11-16 Warner-Lambert Company Use of gaba analogues for the modulation of substance p
US7164034B2 (en) * 1999-06-10 2007-01-16 Pfizer Inc. Alpha2delta ligands for fibromyalgia and other disorders
JP3904452B2 (ja) * 1999-06-10 2007-04-11 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー モノ−およびジ置換３−プロピルガンマ−アミノ酪酸
US20080207755A1 (en) * 2000-05-31 2008-08-28 Pfizer Inc Alpha 2 Delta Ligands For Fibromyalgia and Other Disorders
EP1840117A1 (en) * 1999-06-10 2007-10-03 Warner-Lambert Company LLC Mono- and disubstituted 3-propyl gamma-aminobutyric acids
IL139073A0 (en) * 1999-10-21 2001-11-25 Pfizer Treatment of neuropathy
SK287303B6 (sk) * 2000-01-27 2010-06-07 Warner-Lambert Company Spôsob prípravy derivátu (S)-3-kyano-5-metyl-hexánovej kyseliny, spôsob a medziprodukt na prípravu pregabalínu
US6687187B2 (en) * 2000-08-11 2004-02-03 Phonak Ag Method for directional location and locating system
CA2356829A1 (en) * 2000-09-22 2002-03-22 Warner-Lambert Company Method for treating asthma using pregabalin
US6620829B2 (en) * 2000-10-17 2003-09-16 Warner-Lambert Company Method of treating noninflammatory cartilage damage
GB2368579A (en) * 2000-10-31 2002-05-08 Parke Davis & Co Ltd Azole pharmaceutical agents
PT1243262E (pt) * 2001-03-20 2006-10-31 Sanol Arznei Schwarz Gmbh Nova utilizacao de uma classe de compostos peptideos para o tratamento da dor inflamatoria nao neuropatica
EP1243263B1 (en) * 2001-03-21 2002-11-27 Schwarz Pharma Ag Novel use of a peptide class of compound for treating allodynia or other different types of chronic or phantom pain
US7232924B2 (en) * 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
WO2002100347A2 (en) * 2001-06-11 2002-12-19 Xenoport, Inc. Prodrugs of gaba analogs, compositions and uses thereof
WO2002100344A2 (en) * 2001-06-11 2002-12-19 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) * 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
CA2459470C (en) * 2001-09-03 2010-10-12 Patricia Salvati Pharmaceutical composition comprising gabapentin or an analogue thereof and an .alpha.-aminoamide and its analgesic use
US6927036B2 (en) 2002-02-19 2005-08-09 Xero Port, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
WO2003099338A2 (en) * 2002-05-17 2003-12-04 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
GB0219024D0 (en) * 2002-08-15 2002-09-25 Pfizer Ltd Synergistic combinations
US7419981B2 (en) 2002-08-15 2008-09-02 Pfizer Inc. Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
US7273889B2 (en) * 2002-09-25 2007-09-25 Innovative Drug Delivery Systems, Inc. NMDA receptor antagonist formulation with reduced neurotoxicity
US20040162351A1 (en) * 2002-12-11 2004-08-19 Gallop Mark A. Orally administered dosage forms of fused GABA analog prodrugs having reduced toxicity
AU2003297927A1 (en) * 2002-12-11 2004-06-30 Xenoport, Inc. Prodrugs of fused gaba analogs, pharmaceutical compositions and uses thereof
ES2341240T3 (es) 2002-12-13 2010-06-17 Warner-Lambert Company Llc Ligando alfa-2-delta para tratar los sintomas del tracto urinario inferior.
NZ540336A (en) * 2002-12-13 2008-03-28 Warner Lambert Co Gabapentin analogues for fibromyalgia and other related disorders
EP1572187A1 (en) * 2002-12-13 2005-09-14 Warner-Lambert Company LLC Pregabalin and derivatives thereof for the treatment of fibromyalgia and other related disorders
CA2451267A1 (en) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
KR20050085636A (ko) * 2002-12-13 2005-08-29 워너-램버트 캄파니 엘엘씨 섬유근육통 및 기타 질환의 치료를 위한 프레가발린 유도체
US20080318908A1 (en) * 2002-12-17 2008-12-25 Trustees Of Tufts College Use of gaba and gabab agonists
MXPA06002789A (es) 2003-09-12 2006-06-14 Pfizer Combinaciones que comprenden ligandos alfa-2-delta.
MXPA06003043A (es) * 2003-09-17 2006-05-31 Xenoport Inc Tratamiento o prevencion del sindrome piernas inquietas utilizando prodrogas de analogos gaba.
WO2005037784A2 (en) * 2003-10-14 2005-04-28 Xenoport, Inc. Crystalline form of gamma-aminobutyric acid analog
ES2325995T3 (es) * 2003-12-02 2009-09-28 Schwarz Pharma Ag Nueva utilizacion de compuestos peptidicos para tratamiento del dolor neuropatico central.
DE602005002253T2 (de) * 2004-03-12 2008-05-29 Warner-Lambert Company Llc C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin
US20070042969A1 (en) * 2004-03-26 2007-02-22 Srz Properties, Inc. Combination therapy for pain in painful diabetic neuropathy
US20100256179A1 (en) * 2004-03-26 2010-10-07 Ucb Pharma Gmbh Combination therapy for pain in painful diabetic neuropathy
JP2007530657A (ja) * 2004-04-01 2007-11-01 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー Ｐキラル性ホスホランの調製および不斉合成でのその使用
JP2007532607A (ja) 2004-04-16 2007-11-15 シュバルツ　ファルマ　アクチェンゲゼルシャフト 慢性頭痛の予防及び治療のためのペプチド化合物の使用
EP1604655A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating pain in trigeminal neuralgia
RS51210B (sr) * 2004-06-21 2010-12-31 Warner-Lambert Company Llc. Dobijanje pregaballina i srodnih jedinjenja
BRPI0514721A (pt) * 2004-08-27 2008-06-24 Sanol Arznei Schwarz Gmbh uso de compostos de peptìdeos para tratar dor de cáncer ósseo, dor induzida por quimioterapia e nucleosìdeo
EP1811986B1 (en) * 2004-11-04 2014-03-26 XenoPort, Inc. Gabapentin prodrug sustained release oral dosage forms
US7763749B2 (en) * 2005-05-10 2010-07-27 Teva Pharmaceutical Industries Ltd. Method for the preparation of Pregabalin and salts thereof
CA2604624A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
WO2006124609A2 (en) * 2005-05-16 2006-11-23 Joseph Johnson Methods and compositions for treating arg
KR20080003429A (ko) * 2005-05-20 2008-01-07 화이자 리미티드 비스테로이드 소염 약물 및 알파-델타-리간드의 상승작용적조합물
EP1754476A1 (en) * 2005-08-18 2007-02-21 Schwarz Pharma Ag Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia
US20070043120A1 (en) * 2005-08-18 2007-02-22 Bettina Beyreuther Therapeutic combination for painful medical conditions
US20070048372A1 (en) * 2005-08-18 2007-03-01 Srz Properties, Inc. Method for treating non-inflammatory osteoarthritic pain
ES2398579T3 (es) 2005-09-19 2013-03-20 Teva Pharmaceutical Industries Ltd Una síntesis asimétrica de ácido (S)-(+)-3-(aminometil)-5-metilhexanoico
TW200815323A (en) * 2006-05-24 2008-04-01 Teva Pharma Processes for the preparation of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof
ES2531118T5 (es) 2006-06-15 2022-06-14 Ucb Pharma Gmbh Composición farmacéutica que comprende lacosamida y levetiracetamo para uso en el tratamiento de la epilepsia
CA2681313C (en) * 2007-03-22 2012-09-11 Teva Pharmaceutical Industries Ltd. Synthesis of (s)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
KR20090101462A (ko) * 2007-10-03 2009-09-28 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법
US20100087525A1 (en) * 2008-06-23 2010-04-08 Lilach Hedvati Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
WO2010099200A1 (en) 2009-02-24 2010-09-02 Nektar Therapeutics Oligomer-amino acid conjugates
NZ610978A (en) * 2009-05-15 2014-11-28 Redx Pharma Ltd Redox drug derivatives
WO2010150221A1 (en) 2009-06-25 2010-12-29 Wockhardt Research Centre Taste masked pharmaceutical compositions of pregabalin
US20110130454A1 (en) * 2009-11-24 2011-06-02 Xenoport, Inc. Prodrugs of gamma-amino acid, alpha-2-delta ligands, pharmaceutical compositions and uses thereof
US20110124705A1 (en) * 2009-11-24 2011-05-26 Xenoport, Inc. Prodrugs of alpha-2-delta ligands, pharmaceutical compositions and uses thereof
EP2509596B1 (en) 2009-12-08 2019-08-28 Case Western Reserve University Gamma aminoacids for treating ocular disorders
HU230031B1 (hu) 2010-03-01 2015-05-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Pregabalint és izomaltot tartalmazó stabilizált gyógyszerkészítmény
WO2011141923A2 (en) 2010-05-14 2011-11-17 Lupin Limited Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin
IN2012MN02923A (es) 2010-06-01 2015-06-05 Rubicon Res Private Ltd
WO2012025861A1 (en) 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin
US8466297B2 (en) 2010-11-01 2013-06-18 Milan Soukup Manufacturing process for (S)-Pregabalin
WO2012059797A1 (en) 2010-11-04 2012-05-10 Lupin Limited Process for synthesis of (s) - pregabalin
WO2013114283A1 (en) 2012-01-30 2013-08-08 Ranbaxy Laboratories Limited Gastroretentive tablets
EP2809303A1 (en) 2012-01-30 2014-12-10 Ranbaxy Laboratories Limited Pregabalin gr tablets
CN102966602B (zh) * 2012-12-14 2015-08-05 江苏海鸥冷却塔股份有限公司 一种冷却塔节能导流风筒
US10004710B2 (en) 2013-01-18 2018-06-26 Kemphys Ltd. Medicament for therapeutic treatment of neuropathic disease
CN105051022B (zh) 2013-03-27 2017-10-27 辉瑞爱尔兰制药公司 用于制备普瑞巴林的方法和中间体
CA2953225A1 (en) 2015-05-26 2016-12-01 Isa Odidi Controlled extended release pregabalin
GB201617380D0 (en) * 2016-10-13 2016-11-30 St George's Hospital Medical School Treatment for Osteoarthritis
KR102039345B1 (ko) 2017-02-01 2019-11-01 지엘팜텍주식회사 프레가발린 함유 고팽윤성 서방성 삼중정제
KR102039344B1 (ko) 2017-02-01 2019-11-01 지엘팜텍주식회사 프레가발린 함유 경구용 서방성 삼중정제
GB201703123D0 (en) * 2017-02-27 2017-04-12 St George's Hospital Medical School Biomarkers
AU2019271799B2 (en) 2018-05-14 2023-10-12 Xgene Pharmaceutical Inc. Crystalline forms of 1-(acyloxy)-alkyl carbamate drug conjugates of naproxen and pregabalin
CN108926573A (zh) * 2018-07-03 2018-12-04 泓博元生命科技（深圳）有限公司 一种可降低尿酸指数的nadh组合物及其制备方法及应用
KR20200056719A (ko) 2018-11-15 2020-05-25 단국대학교 천안캠퍼스 산학협력단 가바펜티노이드를 포함하는, 척수손상 개체의 신경재생 또는 신경회복을 위한 조성물
PH12022551856A1 (en) 2020-01-22 2024-01-03 Seelos Therapeutics Inc Reducing side effects of nmda antagonists
WO2021191108A1 (en) 2020-03-23 2021-09-30 Plus Vitech, S.L. Treatment or prevention of acute organ damage induced by viral infection with a nk1 inhibitor and/or a gabapentinoid
WO2022038131A1 (en) 2020-08-19 2022-02-24 Plus Vitech, S.L. Method for the prediction of progression or prognosis of the response of a subject suffering from acute organ damage
WO2022157527A1 (en) 2021-01-22 2022-07-28 Egis Gyógyszergyár Zrt. Topical formulation containing dispersed pregabalin
HU231397B1 (hu) 2021-01-22 2023-06-28 Egis Gyógyszergyár Zrt. Pregabalint tartalmazó topikális gyógyszerkészítmény
WO2022234110A1 (en) 2021-05-07 2022-11-10 Plus Vitech, S.L. Gamma-aminobutyric acid derivatives for use in cancer therapy
WO2022243430A1 (en) 2021-05-20 2022-11-24 Plus Vitech, S.L. Treatment of acne
WO2022253748A1 (en) 2021-06-03 2022-12-08 Plus Vitech, S.L. Combinations for the treatment of hpv

Family Cites Families (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH449645A (de) 1963-07-09 1968-01-15 Ciba Geigy Verfahren zur Herstellung neuer Aminosäuren
JPS4940460Y2 (es) 1971-05-19 1974-11-06
US4087544A (en) 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
DE2460891C2 (de) 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4123438A (en) 1975-03-05 1978-10-31 Stamicarbon, B.V. Process for preparing 2-pyrrolidones
NZ194348A (en) 1979-07-26 1982-09-14 Merrell Toraude & Co Fluorinated methyl-beta-alanine derivatives and pharmaceutical compositions
US4322440A (en) 1980-06-25 1982-03-30 New York University Anticonvulsive compositions and method of treating convulsive disorders
US4513135A (en) 1982-03-05 1985-04-23 Eli Lilly And Company Diaryl-pyrazine derivatives affecting GABA binding
FI832935A7 (fi) 1982-08-20 1984-02-21 Midit Derivat av w-aminosyror, deras framstaellning samt dessa derivat innehaollande blandningar
US4479005A (en) 1982-12-16 1984-10-23 The Dow Chemical Company Selective preparation of isomers and enantiomers of cyclopropane carboxylic acids
WO1985000520A1 (en) 1983-08-01 1985-02-14 The Mclean Hospital Corporation Gaba esters and gaba analogue esters
US5051448A (en) 1984-07-24 1991-09-24 The Mclean Hospital Corporation GABA esters and GABA analog esters
GB8425872D0 (en) 1984-10-12 1984-11-21 Ciba Geigy Ag Chemical compounds
DK170473B1 (da) 1985-06-20 1995-09-11 Daiichi Seiyaku Co S(-)-pyridobenzoxazinforbindelser
US4956388A (en) 1986-12-22 1990-09-11 Eli Lilly And Company 3-aryloxy-3-substituted propanamines
JP2535001B2 (ja) 1987-01-13 1996-09-18 ダイセル化学工業株式会社 Ｎ−アルキル化アミノ酸エステルの製法
JPH07116064B2 (ja) 1987-07-21 1995-12-13 三菱化学株式会社 分離剤
US4908210A (en) 1988-10-28 1990-03-13 Eastman Kodak Company Lactylic salt tablet formulations and tablets
GB8911017D0 (en) 1989-05-13 1989-06-28 Ciba Geigy Ag Substituted aminoalkylphosphinic acids
DE3928183A1 (de) 1989-08-25 1991-02-28 Goedecke Ag Lactamfreie cyclische aminosaeuren
GB8921304D0 (en) 1989-09-20 1989-11-08 Wyeth John & Brother Ltd New method of treatment and heterocyclic compounds used therein
US5104869A (en) 1989-10-11 1992-04-14 American Cyanamid Company Renin inhibitors
US5084479A (en) 1990-01-02 1992-01-28 Warner-Lambert Company Novel methods for treating neurodegenerative diseases
US5025035A (en) 1990-10-12 1991-06-18 Warner-Lambert Company Method of treating depression
WO1992009560A1 (en) 1990-11-27 1992-06-11 Northwestern University Gaba and l-glutamic acid analogs for antiseizure treatment
US6197819B1 (en) 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
WO1992014443A1 (en) 1991-02-20 1992-09-03 Warner-Lambert Company Microsphere-in-oil emulsion
DK204791D0 (da) 1991-12-20 1991-12-20 Novo Nordisk As Hidtil ukendt farmaceutisk praeparat
JP3856816B2 (ja) 1992-05-20 2006-12-13 ノースウェスターン ユニヴァーシティ 抗発作治療用のｇａｂａ及びｌ−グルタミン酸類縁体
GB9308430D0 (en) 1993-04-23 1993-06-09 Glaxo Group Ltd Medicaments
US5492927A (en) 1993-12-21 1996-02-20 Eli Lilly And Company Non-peptide tachykinin receptor antagonists to treat allergy
US5652216A (en) 1994-05-26 1997-07-29 Novo Nordisk A/S Pharmaceutical preparation
MX9606674A (es) 1994-07-27 1997-03-29 Warner Lambert Co Tratamiento de enfermedades humanas que involucran la desregulacion o disfuncion del sistema nervioso.
US5792796A (en) 1994-07-27 1998-08-11 Warner-Lambert Company Methods for treating anxiety and panic
GB9420784D0 (en) 1994-10-14 1994-11-30 Glaxo Group Ltd Medicaments
US5767117A (en) 1994-11-18 1998-06-16 The General Hospital Corporation Method for treating vascular headaches
ES2229259T3 (es) 1995-01-12 2005-04-16 Glaxo Group Limited Derivados de piperidina con actividad antagonista de taquiquinina.
UA43396C2 (uk) 1995-02-28 2001-12-17 Х. Луннбек, А/С Похідні 4-амінотетрагідробензізоксазолу та ізотіазолу та фармацевтична композиція на їх основі
US5510381A (en) 1995-05-15 1996-04-23 Warner-Lambert Company Method of treatment of mania and bipolar disorder
US5616793A (en) 1995-06-02 1997-04-01 Warner-Lambert Company Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5637767A (en) 1995-06-07 1997-06-10 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
DK0888325T3 (da) 1996-02-07 2002-09-16 Warner Lambert Co Cykliske aminosyrer som farmaceutiske midler
WO1997033859A1 (en) 1996-03-14 1997-09-18 Warner-Lambert Company Novel bridged cyclic amino acids as pharmaceutical agents
AU734173B2 (en) 1996-03-14 2001-06-07 Warner-Lambert Company Novel substituted cyclic amino acids as pharmaceutical agents
US20020077461A1 (en) 1996-04-24 2002-06-20 Soren Bjorn Pharmaceutical formulation
US6372792B1 (en) 1996-04-26 2002-04-16 Guy Chouinard Method for treating anxiety, anxiety disorders and insomnia
NZ333062A (en) 1996-06-26 2000-06-23 Warner Lambert Co Use of [R,S]-[2-(1H-indol-3-yl)-1-methyl-1-(1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2yl methyl ester in the treatment of emesis
SE9603408D0 (sv) 1996-09-18 1996-09-18 Astra Ab Medical use
HRP980342A2 (en) 1997-06-25 1999-02-28 Warner Lambert Co Anti-inflammatory method
US6329429B1 (en) 1997-06-25 2001-12-11 Warner-Lambert Company Use of GABA analogs such as Gabapentin in the manufacture of a medicament for treating inflammatory diseases
WO1999008667A2 (en) 1997-08-19 1999-02-25 Warner-Lambert Company Methods for treating physiological conditions associated with the use, or sequelae of use, of cocaine or other psychomotor stimulants
US6127418A (en) 1997-08-20 2000-10-03 Warner-Lambert Company GABA analogs to prevent and treat gastrointestinal damage
WO1999008670A1 (en) 1997-08-20 1999-02-25 Guglietta, Antonio Gaba analogs to prevent and treat gastrointestinal damage
AU750578B2 (en) 1997-09-08 2002-07-25 Warner-Lambert Company Analgesic compositions comprising anti-epileptic compounds and methods of using same
JP2002508361A (ja) 1997-12-16 2002-03-19 ワーナー−ランバート・カンパニー （（シクロ）アルキル置換）−γ−アミノ酪酸誘導体（＝ＧＡＢＡ類似体）、それらの製造および神経学的疾患の治療における使用
BR9910494B1 (pt) 1998-05-15 2011-11-01 composições sólidas contendo derivados de ácido gama-aminobutìrico e processo para o seu preparo.
HU228771B1 (en) 1998-05-15 2013-05-28 Warner Lambert Co Stabilized pharmaceutical preparations of gamma-aminobutyric acid derivatives and process for preparing the same
NZ508490A (en) 1998-07-09 2003-08-29 Warner Lambert Co Use of a combination of a GABA analog and caffeine as an analgesic
US20030045500A1 (en) 1998-07-09 2003-03-06 Leslie Magnus Pharmaceutical composition containing GABA analogs and an antiviral agent to treat shingles
US6680343B1 (en) 1998-07-09 2004-01-20 Warner-Lambert Comapny Treatment of renal colic with GABA analogs
JP2002520277A (ja) 1998-07-09 2002-07-09 ワーナー−ランバート・カンパニー 不眠症を治療する方法
DK1121114T3 (da) 1998-10-16 2007-04-10 Warner Lambert Co Anvendelse af GABA-analoger til fremstilling af et medikament til behandling af mani og bipolære lidelser
US6451857B1 (en) 1999-03-10 2002-09-17 Warner-Lambert Company Analgesic compositions comprising anti-epileptic compounds and methods of using same
US6992109B1 (en) 1999-04-08 2006-01-31 Segal Catherine A Method for the treatment of incontinence
IL145736A0 (en) 1999-04-09 2002-07-25 Warner Lambert Co Combinations of gaba analogs and tricyclic compounds to treat depression
PT1187832E (pt) 1999-06-02 2003-03-31 Warner Lambert Co Amino heterociclos uteis como agentes farmaceuticos
US6642398B2 (en) 1999-06-10 2003-11-04 Warner-Lambert Company Mono-and disubstituted 3-propyl gamma-aminobutyric acids
US7164034B2 (en) 1999-06-10 2007-01-16 Pfizer Inc. Alpha2delta ligands for fibromyalgia and other disorders
MXPA02000170A (es) 1999-07-02 2002-07-02 Warner Lambert Co Una combinacion sinergica: gabapentin y pregablin.
US7030119B1 (en) 1999-07-16 2006-04-18 Warner-Lambert Company Method for treating chronic pain using MEK inhibitors
CA2384911C (en) 1999-09-16 2008-07-22 Warner-Lambert Company Method for the screening of .alpha.2. delta.-1 subunit binding ligands
AP2002002501A0 (en) 1999-10-07 2002-06-30 Warner Lambert Co Synergistic combinations of an NK1 receptor antagonist and a gaba structural analog.
SK287303B6 (sk) 2000-01-27 2010-06-07 Warner-Lambert Company Spôsob prípravy derivátu (S)-3-kyano-5-metyl-hexánovej kyseliny, spôsob a medziprodukt na prípravu pregabalínu
US20010036943A1 (en) 2000-04-07 2001-11-01 Coe Jotham W. Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines
WO2001088101A2 (en) 2000-05-16 2001-11-22 Warner-Lambert Company CELL LINE FOR THE EXPRESSION OF AN α2δ2 CALCIUM CHANNEL SUBUNIT
GB2365425A (en) 2000-08-01 2002-02-20 Parke Davis & Co Ltd Alkyl amino acid derivatives useful as pharmaceutical agents
CA2356829A1 (en) 2000-09-22 2002-03-22 Warner-Lambert Company Method for treating asthma using pregabalin
US6620829B2 (en) 2000-10-17 2003-09-16 Warner-Lambert Company Method of treating noninflammatory cartilage damage
AP2001002360A0 (en) 2000-11-30 2001-12-31 Pfizer Prod Inc Combination of gaba agonists and sorbitol dehydrogenase inhibitors.
CA2430309A1 (en) 2000-11-30 2002-06-06 Pfizer Products Inc. Combination of gaba agonists and aldose reductase inhibitors
EP1341799B1 (en) 2000-12-13 2005-03-16 Warner-Lambert Company LLC P-chirale bisphospholane ligands, their transition metal complexes
US20040002543A1 (en) 2001-02-16 2004-01-01 Leslie Magnus Compositions comprising GABA analogs and a decongestant to relieve sinus headache pain
ES2240657T3 (es) 2001-02-28 2005-10-16 Pfizer Products Inc. Compuestos de sulfonilpiridazinona utiles como inhibidores de aldosa reductasa.
MXPA02001147A (es) 2001-03-19 2004-04-21 Warner Lambert Co Sintesis de ligandos bisfosina no-c2-simetricos como catalizadores para la hidrogenacion asimetrica.
CA2442476A1 (en) 2001-03-30 2002-10-10 Pfizer Products Inc. Pyridazinone aldose reductase inhibitors
EP1247809A3 (en) 2001-03-30 2003-12-17 Pfizer Products Inc. Triazine compounds useful as sorbitol dehydrogenase inhibitors
US7022678B2 (en) 2001-03-30 2006-04-04 Warner-Lambert Company Pregabalin lactose conjugates
EA006396B1 (ru) 2001-04-19 2005-12-29 УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл Эл Си Конденсированные бициклические аминокислоты
DE60213592T2 (de) 2001-05-25 2007-08-09 Warner-Lambert Co. Llc Flüssige pharmazeutische zusammensetzung
US20030045449A1 (en) 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
DE10203122A1 (de) 2002-01-25 2003-07-31 Gruenenthal Gmbh Verfahren zur Herstellung von substituierten Acrylsäureestern bzw. deren Einsatz zur Herstellung von substituierten gamma-Aminosäuren
KR20040081478A (ko) 2002-01-31 2004-09-21 워너-램버트 캄파니 엘엘씨 이명을 치료하기 위한 알파 2 델타 리간드
US6855724B2 (en) 2002-04-08 2005-02-15 Agouron Pharmaceuticals, Inc. Tropane derivatives useful in therapy
US6713490B2 (en) 2002-04-26 2004-03-30 Pfizer, Inc. 3,4-dihydroquinolin-2(1H)-one compounds as NR2B receptor antagonists
US20030225149A1 (en) 2002-04-30 2003-12-04 Blazecka Peter G. Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids
AU2003239752A1 (en) 2002-06-27 2004-01-19 Warner-Lambert Company Llc Use of an alpha2delta ligand such as gabapentin or pregabalin for treating ttention deficit hyperactivity disorder
AU2003281355A1 (en) 2002-07-08 2004-01-23 Pfizer Products Inc. Modulators of the glucocorticoid receptor
US7053122B2 (en) 2002-08-09 2006-05-30 Pfizer Inc Therapeutic use of aryl amino acid derivatives
US7419981B2 (en) 2002-08-15 2008-09-02 Pfizer Inc. Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
US20040092522A1 (en) 2002-08-15 2004-05-13 Field Mark John Synergistic combinations
US7071339B2 (en) 2002-08-29 2006-07-04 Warner Lambert Company Llc Process for preparing functionalized γ-butyrolactones from mucohalic acid
US7659305B2 (en) 2002-10-31 2010-02-09 Pfizer Inc. Therapeutic proline derivatives
BR0316386A (pt) 2002-12-06 2005-09-27 Warner Lambert Co Benzoxazin-3-onas e seus derivados como inibidores de p13k
EP1572187A1 (en) 2002-12-13 2005-09-14 Warner-Lambert Company LLC Pregabalin and derivatives thereof for the treatment of fibromyalgia and other related disorders
CA2451267A1 (en) 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
US7572910B2 (en) 2003-02-20 2009-08-11 Pfizer, Inc. Pyridazinone aldose reductase inhibitors
EP1633400A2 (en) 2003-05-16 2006-03-15 Pfizer Products Inc. Therapeutic combinations of atypical antipsychotics with gaba modulators, anticonvulsants or benzodiazapines
EP1644360A1 (en) 2003-06-05 2006-04-12 Warner-Lambert Company LLC 3-substituted indoles and derivatives thereof as therapeutic agents
EP1680125A1 (en) 2003-07-02 2006-07-19 Warner-Lambert Company LLC Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor
ATE539077T1 (de) 2003-09-03 2012-01-15 Pfizer Benzimidazolonverbindungen mit agonistischer wirkung am 5-ht4 rezeptor
MXPA06002789A (es) 2003-09-12 2006-06-14 Pfizer Combinaciones que comprenden ligandos alfa-2-delta.
AU2004271796A1 (en) 2003-09-12 2005-03-24 Warner-Lambert Company Llc Combination comprising an alpha-2-delta ligand and an SSRI and/or SNRI for treatment of depression and anxiety disorders
GB0322140D0 (en) 2003-09-22 2003-10-22 Pfizer Ltd Combinations
CA2540247C (en) 2003-09-25 2011-01-25 Warner-Lambert Company Llc Prodrugs of amino acids with affinity for the .alpha.2.delta.-protein
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
EP1543831A1 (en) 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Pregabalin composition
EP1737466A1 (en) 2004-01-29 2007-01-03 Pfizer Products Inc. COMBINATION OF y-AMINOBUTYRIC ACID MODULATORS AND 5-HT-1b RECEPTOR ANTAGONISTS
GB0405200D0 (en) 2004-03-08 2004-04-21 Pfizer Ltd Combinations comprising alpha-2-delta ligands
DE602005002253T2 (de) 2004-03-12 2008-05-29 Warner-Lambert Company Llc C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin
WO2005092858A2 (en) 2004-03-29 2005-10-06 Pfizer Japan Inc. Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as orl1-receptor antagonist
JP2007530657A (ja) 2004-04-01 2007-11-01 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー Ｐキラル性ホスホランの調製および不斉合成でのその使用
CA2562251C (en) 2004-04-07 2009-04-28 Pfizer Inc. Pyrazolo'4,3-d pyrimidines
UA82292C2 (uk) 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
BRPI0510043A (pt) 2004-04-20 2007-10-16 Pfizer método de tratamento de dor neuropática usando antagonista de receptor crth2
CA2563356A1 (en) 2004-04-20 2005-11-03 Pfizer Products Inc. Combinations comprising alpha-2-delta ligands and ep4 receptor antagonists
WO2005102390A2 (en) 2004-04-22 2005-11-03 Pfizer Japan, Inc. Combinations comprising alpha-2-delta ligands and nmda receptor antagonists
AP2006003771A0 (en) 2004-04-30 2006-10-31 Warner Lambert Co Substituted morpholine compounds for the treatmentof central nervous system disorders
US7737163B2 (en) 2004-06-15 2010-06-15 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
BRPI0512046A (pt) 2004-06-15 2008-02-06 Pfizer derivados de ácido benzimidazolona carboxìlico
RS51210B (sr) 2004-06-21 2010-12-31 Warner-Lambert Company Llc. Dobijanje pregaballina i srodnih jedinjenja
JP2008504360A (ja) 2004-06-29 2008-02-14 ファイザー・プロダクツ・インク ヒドロキシル保護された前駆体を脱保護することによる５−［４−（２−ヒドロキシ−プロピル）−３，５−ジオキソ−４，５−ジヒドロ−３ｈ−１，２，４−トリアジン−２−イル］−ベンズアミド誘導体の製造方法
US20060003344A1 (en) 2004-06-30 2006-01-05 Pfizer Inc. Methods related to a single nucleotide polymorphism of the G protein coupled receptor, GPR40
WO2006008640A1 (en) 2004-07-15 2006-01-26 Pharmacia & Upjohn Company Llc Non-aqueous suspension containing a drug having an unpleasant taste
BRPI0513717A (pt) 2004-07-23 2008-05-13 Pfizer derivados de piridina
GB0419849D0 (en) 2004-09-07 2004-10-13 Pfizer Ltd Pharmaceutical combination
ATE417830T1 (de) 2004-11-02 2009-01-15 Pfizer Sulfonylbenzimidazolderivate
CN101087771A (zh) 2004-11-10 2007-12-12 辉瑞大药厂 经取代n－磺酰基氨基苄基－2－苯氧基乙酰胺化合物
US7122683B2 (en) 2004-11-23 2006-10-17 Pfizer Inc. Amides useful as monoamine re-uptake inhibitors
CN101111494A (zh) 2004-11-29 2008-01-23 沃纳-兰伯特有限公司 具有治疗作用的吡唑并[3,4-b]吡啶和吲唑
NZ556627A (en) 2005-02-22 2010-09-30 Pfizer Oxyindole derivatives as 5HT4 receptor agonists
WO2006092692A1 (en) 2005-03-01 2006-09-08 Pfizer Limited Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain
CA2600409C (en) 2005-03-10 2011-07-05 Pfizer Inc. Substituted n-sulfonylaminophenylethyl-2-phenoxy acetamide compounds
AP2007004157A0 (en) 2005-03-17 2007-10-31 Pfizer N- (N-sulfonylaminomethyl) cyclo-propanecarboxamide derivatives useful for the treatment of pain
CA2604218A1 (en) 2005-04-20 2006-10-26 Pfizer Limited Pyrazole derivatives as progesterone receptor antagonists
EA200701852A1 (ru) 2005-04-28 2008-04-28 Пфайзер Лимитед Производные аминокислот
KR20080003429A (ko) 2005-05-20 2008-01-07 화이자 리미티드 비스테로이드 소염 약물 및 알파-델타-리간드의 상승작용적조합물
JP2008542355A (ja) 2005-05-31 2008-11-27 ファイザー株式会社 Ｖｒ１アンタゴニストとしての置換アリールオキシ−ｎ−ビシクロメチルアセトアミド化合物
NL2000281C2 (nl) 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
NL2000284C2 (nl) 2005-11-04 2007-09-28 Pfizer Ltd Pyrazine-derivaten.
CA2628844C (en) 2005-11-08 2011-12-06 Pfizer Limited Pyrazole derivatives and their medical use
CA2631535C (en) 2005-12-02 2010-07-27 Pfizer Limited Spirocyclic quinazoline derivatives as pde7 inhibitors
CA2530904C (en) 2005-12-20 2013-10-08 John Marino Pharmaceutical agents for the treatment of pain associated with spinal cord injury
RU2008135907A (ru) 2006-03-06 2010-04-20 Пфайзер Продактс Инк. (Us) Альфа-2-дельта лиганды для невосстановительного сна
GB0700786D0 (en) 2007-01-15 2007-02-21 Pfizer Ltd Morpholine dopamine agonists for the treatment of pain
ATE518872T1 (de) 2007-02-02 2011-08-15 Pfizer Prod Inc Trizyklische verbindungen und deren verwendung als glucocorticoidrezeptormodulatoren
WO2008132589A1 (en) 2007-05-01 2008-11-06 Pfizer Limited Combinations comprising pregabalin

Also Published As

Publication number Publication date
EP0934061B1 (en) 2003-05-28
HK1021134A1 (en) 2000-06-02
EP0934061A1 (en) 1999-08-11
IL126999A (en) 2002-03-10
ZA976562B (en) 1998-02-03
NO990279D0 (no) 1999-01-22
DK0934061T6 (en) 2015-01-26
KR100491282B1 (ko) 2005-05-24
NZ332762A (en) 2000-09-29
HUP9904361A3 (en) 2000-11-28
JP3693258B2 (ja) 2005-09-07
US6001876A (en) 1999-12-14
NO990279L (no) 1999-01-22
NO325822B1 (no) 2008-07-21
BR9710536A (pt) 1999-08-17
CA2255652A1 (en) 1998-01-29
DK0934061T3 (da) 2003-09-22
IL126999A0 (en) 1999-09-22
NO2008018I2 (no) 2010-06-28
PL189872B1 (pl) 2005-10-31
CN1094757C (zh) 2002-11-27
CN1223574A (zh) 1999-07-21
JP2000515149A (ja) 2000-11-14
PL331325A1 (en) 1999-07-05
DE69722426T2 (de) 2004-04-08
ES2200184T7 (es) 2015-02-10
ES2200184T3 (es) 2004-03-01
USRE41920E1 (en) 2010-11-09
NO2008018I1 (no) 2008-12-15
SI0934061T1 (en) 2003-10-31
ATE241351T1 (de) 2003-06-15
ES2200184T9 (es) 2015-03-20
DE69722426T3 (de) 2015-05-07
AU3602497A (en) 1998-02-10
EP0934061B3 (en) 2015-01-21
HUS1300046I1 (hu) 2016-08-29
DE69722426D1 (de) 2003-07-03
PT934061E (pt) 2003-10-31
HUP9904361A2 (hu) 2000-05-28
HRP970387A2 (en) 1998-10-31
CA2255652C (en) 2004-07-13
WO1998003167A1 (en) 1998-01-29
KR20000068015A (ko) 2000-11-25
HU228426B1 (hu) 2013-03-28
AU714980B2 (en) 2000-01-13

Similar Documents

Publication Publication Date Title
CU22850A3 (es) Isobutilgaba y sus derivados para el tratamiento del dolor
ES8505333A1 (es) Un procedimiento para la preparacion de nuevas fenetanolaminas
Rajendra et al. Intramolecular electrophilic additions to olefins in organic syntheses. Stereoselective synthesis of 3, 4-substituted. beta.-lactams by bromine-induced oxidative cyclization of O-acyl. beta.,. gamma.-unsaturated hydroxamic acid derivatives
ES400862A1 (es) Procedimiento para redisolver isomeros opticos.
ES8205789A1 (es) Un procedimiento para la preparacion de derivados del indol
FR2375213A1 (fr) Polyalkylpiperidines utilisables comme stabilisants de matieres plastiques
Smith et al. An enantioselective synthesis of D-(-)-and L-(+)-2-amino-3-phosphonopropanoic acid
CA2216664A1 (fr) Nouvelles amines cycliques n-substituees, leur procede de preparation et les compositions pharmaceutiques les renfermant
AR018596A1 (es) Compuestos azapoliciclicos fusionados con arilo utiles en el tratamiento de desordenes neurologicos y fisiologicos, composiciones farmaceuticas,metodos de tratamiento que los utilizan
US5856518A (en) Production process of cyclic compound
PE20030617A1 (es) Aminoacidos, procedimiento para su preparacion y medicamentos que los contienen
PL143884B1 (en) Method of obtaining novel 1,4-dihydropyridinylolactones
ES8501759A1 (es) Procedimiento para preparar esteres de acidos imino-&-carboxilicos biciclicos opticamente puros
Chulakov et al. 2-Arylpropionyl chlorides in kinetic resolution of racemic 3-methyl-2, 3-dihydro-4 H-[1, 4] benzoxazines
RU2008101776A (ru) Соединения для ингибирования обратного захвата 5-гидрокситриптамина и норэпинефрина или для лечения депрессивных состояний, способы их получения и применения
Hulshof et al. Reassignment of the chirality to a series of 2, 6-disubstituted spiro [3.3] heptanes by X-ray methods and implications thereof on empirical rules and theoretical models
ES8104272A1 (es) Procedimiento para preparar compuesto 2-imino-1, 3-ditio-he-terociclicos sustituidos.
JP4084855B2 (ja) 環式化合物の製法
GB1423644A (en) 6-phenyl-s-triazolobenzotriazepines
AR034159A1 (es) Derivados de 5-amino-1-penten-3-ol sustituidos, procedimiento para su preparacion, medicamentos que contienen estos derivados y su uso para la preparacion de medicamentos
ES2074430T3 (es) Compuesto opticamente activo, procedimiento para su fabricacion y composicion de cristal liquido que lo contiene.
ES8504197A1 (es) Un procedimiento para la preparacion de un derivado de (1,2,4) triazolo (4,3-a) quinoxalin-4-amina
RU2004100966A (ru) Карбаматные соединения для применения для предотвращения или лечения невроматической боли и боли, связанной с кластерной и мигреневой головной болью
ES2095992T3 (es) Procedimiento para la separacion de los enantiomeros de la 5-hetaril-1,3,4-tiadiazinona.
CY1106038T1 (el) Καρβαμικες ενωσεις για χρηση στην προληψη ή την αγωγη του νeυpοπαθους πονου και του πονου που συνδεεται με την ισταμινογενη κεφαλαλγια και την ημικρανια