JP2000515149A - 痛みの処置のためのイソブチルgabaおよびその誘導体 - Google Patents
痛みの処置のためのイソブチルgabaおよびその誘導体Info
- Publication number
- JP2000515149A JP2000515149A JP10507062A JP50706298A JP2000515149A JP 2000515149 A JP2000515149 A JP 2000515149A JP 10507062 A JP10507062 A JP 10507062A JP 50706298 A JP50706298 A JP 50706298A JP 2000515149 A JP2000515149 A JP 2000515149A
- Authority
- JP
- Japan
- Prior art keywords
- pain
- treated
- footpad
- gabapentin
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.痛みの処置方法において、式I (式中、R1は炭素原子1〜6個の直鎖状または分枝状アルキル、フェニルまた は炭素原子3〜6個のシクロアルキルであり、R2は水素またはメチルであり、R3 は水素、メチルまたはカルボキシルである) の化合物またはその医薬的に許容される塩、鏡像異性体、もしくはエナンチオマ ーの治療有効量を上記処置を必要とする哺乳動物に投与することからなる方法。 2.投与される化合物は、式IにおいてR3およびR2はいずれも水素であり、R1は -(CH2)0-2-iC4H9である化合物の(R)、(S)、または(R,S)異性体である請求 項1記載の方法。 3.投与される化合物は、(S)−3−(アミノメチル)−5−メチルヘキサン酸お よび3−アミノメチル−5−メチルヘキサン酸である請求項1記載の方法。 4.処置される痛みは炎症性疼痛である請求項1記載の方法。 5.処置される痛みは神経障害による痛みである請求項1記載の方法。 6.処置される痛みは癌による痛みである請求項1記載の方法。 7.処置される痛みは術後疼痛である請求項1記載の方法。 8.処置される痛みは幻想肢痛である請求項1記載の方法。 9.処置される痛みは火傷痛である請求項1記載の方法。 10.処置される痛みは痛風の痛みである請求項1記載の方法。 11.処置される痛みは骨関節炎の痛みである請求項1記載の方法。 12.処置される痛みは三叉神経痛の痛みである請求項1記載の方法。 13.処置される痛みは急性ヘルペスおよびヘルペス後の痛みである請求項1記載 の方法。 14.処置される痛みはカウザルギーの痛みである請求項1記載の方法。 15.処置される痛みは特発性の痛みである請求項1記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US2233796P | 1996-07-24 | 1996-07-24 | |
US60/022,337 | 1996-07-24 | ||
PCT/US1997/012390 WO1998003167A1 (en) | 1996-07-24 | 1997-07-16 | Isobutylgaba and its derivatives for the treatment of pain |
Publications (3)
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JP2000515149A true JP2000515149A (ja) | 2000-11-14 |
JP2000515149A5 JP2000515149A5 (ja) | 2005-03-10 |
JP3693258B2 JP3693258B2 (ja) | 2005-09-07 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP50706298A Expired - Lifetime JP3693258B2 (ja) | 1996-07-24 | 1997-07-16 | イソブチルgabaまたはその誘導体を含有する鎮静剤 |
Country Status (24)
Country | Link |
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US (2) | USRE41920E1 (ja) |
EP (1) | EP0934061B3 (ja) |
JP (1) | JP3693258B2 (ja) |
KR (1) | KR100491282B1 (ja) |
CN (1) | CN1094757C (ja) |
AT (1) | ATE241351T1 (ja) |
AU (1) | AU714980B2 (ja) |
BR (1) | BR9710536A (ja) |
CA (1) | CA2255652C (ja) |
CU (1) | CU22850A3 (ja) |
DE (1) | DE69722426T3 (ja) |
DK (1) | DK0934061T6 (ja) |
ES (1) | ES2200184T7 (ja) |
HK (1) | HK1021134A1 (ja) |
HR (1) | HRP970387A2 (ja) |
HU (2) | HU228426B1 (ja) |
IL (1) | IL126999A (ja) |
NO (2) | NO325822B1 (ja) |
NZ (1) | NZ332762A (ja) |
PL (1) | PL189872B1 (ja) |
PT (1) | PT934061E (ja) |
SI (1) | SI0934061T1 (ja) |
WO (1) | WO1998003167A1 (ja) |
ZA (1) | ZA976562B (ja) |
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