ES8501759A1 - Procedimiento para preparar esteres de acidos imino-&-carboxilicos biciclicos opticamente puros - Google Patents
Procedimiento para preparar esteres de acidos imino-&-carboxilicos biciclicos opticamente purosInfo
- Publication number
- ES8501759A1 ES8501759A1 ES531284A ES531284A ES8501759A1 ES 8501759 A1 ES8501759 A1 ES 8501759A1 ES 531284 A ES531284 A ES 531284A ES 531284 A ES531284 A ES 531284A ES 8501759 A1 ES8501759 A1 ES 8501759A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- chain
- carbon atoms
- alpha
- together form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS IMINO-BAB-CARBOXILICOS BICICLICOS OPTICAMENTE PUROS, DE FORMULA (I) O (II), EN LAS QUE A, B, B, C, X, Y, Z, R Y R PUEDEN SER VARIOS RADICALES, Y R VALE 0 O 1.CONSISTE EN LA REACCION, EN PRESENCIA DE UN AGENTE CONDENSANTE, DE LOS COMPUESTOS OPTICAMENTE PUROS DE FORMULAS (III) Y (IV), CON COMPUESTOS OPTICAMENTE PUROS DE FORMULA (V), EN LAS QUE R PUEDE SER UNO DE VARIOS RADICALES Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LAS FORMULAS (I) Y (II).ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO HIPOTENSOR.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19833303139 DE3303139A1 (de) | 1983-01-31 | 1983-01-31 | Verfahren zur herstellung von carboxyalkyldipeptiden |
DE19833303112 DE3303112A1 (de) | 1983-01-31 | 1983-01-31 | Verfahren zur racemattrennung optisch aktiver bicyclischer imino-(alpha)-carbonsaeuren |
Publications (2)
Publication Number | Publication Date |
---|---|
ES531284A0 ES531284A0 (es) | 1984-12-01 |
ES8501759A1 true ES8501759A1 (es) | 1984-12-01 |
Family
ID=25807929
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES529272A Granted ES529272A0 (es) | 1983-01-31 | 1984-01-30 | Procedimiento para desdoblar mezclas racemicas de esteres de acidos imino- -carboxilicos biciclicos |
ES531284A Expired ES8501759A1 (es) | 1983-01-31 | 1984-04-04 | Procedimiento para preparar esteres de acidos imino-&-carboxilicos biciclicos opticamente puros |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES529272A Granted ES529272A0 (es) | 1983-01-31 | 1984-01-30 | Procedimiento para desdoblar mezclas racemicas de esteres de acidos imino- -carboxilicos biciclicos |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0115345B1 (es) |
JP (1) | JPH0788358B2 (es) |
KR (1) | KR910001438B1 (es) |
AU (1) | AU566589B2 (es) |
CA (2) | CA1283249C (es) |
DE (1) | DE3468415D1 (es) |
DK (1) | DK174386B1 (es) |
ES (2) | ES529272A0 (es) |
FI (1) | FI88153C (es) |
GR (1) | GR82650B (es) |
HU (1) | HU191120B (es) |
IE (1) | IE56654B1 (es) |
IL (1) | IL70830A (es) |
MA (1) | MA20020A1 (es) |
NO (1) | NO166641C (es) |
NZ (1) | NZ206980A (es) |
PT (1) | PT78036B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4500713A (en) * | 1982-09-23 | 1985-02-19 | Usv Pharmaceutical Corporation | Therapeutic dipeptides |
DE3345355A1 (de) * | 1983-12-15 | 1985-06-27 | Hoechst Ag, 6230 Frankfurt | Verfahren zur racematspaltung bicyclischer imino-(alpha)-carbonsaeureester |
EP0190224A1 (en) * | 1984-07-30 | 1986-08-13 | Schering Corporation | PROCESS FOR THE PREPARATION OF CIS, ENDOOCTAHYDROCYCLOPENTA [b] PYRROLE-2-CARBOXYLATE |
HU192914B (en) * | 1985-02-11 | 1987-07-28 | Richter Gedeon Vegyeszet | Process for producing new 3-/substituted amino/-5-phenyl-2/3h/-furanone derivatives and pharmaceutically acceptable salts |
FR2620703B1 (fr) * | 1987-09-17 | 1991-10-04 | Adir | Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides |
HU904967D0 (en) * | 1988-04-22 | 1991-01-28 | Hoechst Ag | Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives |
US6407262B1 (en) | 2001-11-21 | 2002-06-18 | Brantford Chemicals Inc. | Process for the preparation of Ramipril |
WO2006059347A2 (en) * | 2004-12-01 | 2006-06-08 | Morepen Laboratories Limited | Improved process for preparation of ramipril |
US8558023B2 (en) | 2010-04-20 | 2013-10-15 | Chiral Quest, Inc. | Enantioselective process for cycloalkenyl β-substituted alanines |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2503155A2 (fr) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
IE52663B1 (en) * | 1980-04-02 | 1988-01-20 | Warner Lambert Co | Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids |
US4374847A (en) * | 1980-10-27 | 1983-02-22 | Ciba-Geigy Corporation | 1-Carboxyalkanoylindoline-2-carboxylic acids |
-
1984
- 1984-01-25 HU HU84312A patent/HU191120B/hu unknown
- 1984-01-27 EP EP84100858A patent/EP0115345B1/de not_active Expired
- 1984-01-27 FI FI840350A patent/FI88153C/fi not_active IP Right Cessation
- 1984-01-27 DE DE8484100858T patent/DE3468415D1/de not_active Expired
- 1984-01-28 KR KR1019840000396A patent/KR910001438B1/ko not_active IP Right Cessation
- 1984-01-30 GR GR73651A patent/GR82650B/el unknown
- 1984-01-30 IL IL70830A patent/IL70830A/xx not_active IP Right Cessation
- 1984-01-30 NZ NZ206980A patent/NZ206980A/en unknown
- 1984-01-30 NO NO840350A patent/NO166641C/no not_active IP Right Cessation
- 1984-01-30 IE IE210/84A patent/IE56654B1/en not_active IP Right Cessation
- 1984-01-30 DK DK198400415A patent/DK174386B1/da not_active IP Right Cessation
- 1984-01-30 ES ES529272A patent/ES529272A0/es active Granted
- 1984-01-30 PT PT78036A patent/PT78036B/pt unknown
- 1984-01-30 MA MA20241A patent/MA20020A1/fr unknown
- 1984-01-30 CA CA000446349A patent/CA1283249C/en not_active Expired - Lifetime
- 1984-01-31 AU AU23933/84A patent/AU566589B2/en not_active Expired
- 1984-04-04 ES ES531284A patent/ES8501759A1/es not_active Expired
-
1988
- 1988-09-06 CA CA000576609A patent/CA1317067C/en not_active Expired - Lifetime
-
1991
- 1991-01-30 JP JP3027801A patent/JPH0788358B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
IE840210L (en) | 1984-07-31 |
EP0115345A1 (de) | 1984-08-08 |
ES531284A0 (es) | 1984-12-01 |
EP0115345B1 (de) | 1988-01-07 |
HUT34159A (en) | 1985-02-28 |
FI88153C (fi) | 1993-04-13 |
GR82650B (es) | 1985-02-07 |
DE3468415D1 (en) | 1988-02-11 |
DK174386B1 (da) | 2003-01-27 |
IL70830A0 (en) | 1984-04-30 |
IE56654B1 (en) | 1991-10-23 |
ES8500228A1 (es) | 1984-10-01 |
FI840350A (fi) | 1984-08-01 |
FI88153B (fi) | 1992-12-31 |
DK41584D0 (da) | 1984-01-30 |
NO166641B (no) | 1991-05-13 |
CA1317067C (en) | 1993-04-27 |
PT78036A (de) | 1984-02-01 |
DK41584A (da) | 1984-08-01 |
CA1283249C (en) | 1991-04-16 |
PT78036B (de) | 1986-05-30 |
JPH0517439A (ja) | 1993-01-26 |
NO840350L (no) | 1984-08-01 |
ES529272A0 (es) | 1984-10-01 |
KR910001438B1 (ko) | 1991-03-07 |
JPH0788358B2 (ja) | 1995-09-27 |
IL70830A (en) | 1988-02-29 |
AU566589B2 (en) | 1987-10-22 |
HU191120B (en) | 1987-01-28 |
NO166641C (no) | 1991-08-21 |
NZ206980A (en) | 1988-05-30 |
MA20020A1 (fr) | 1984-10-01 |
FI840350A0 (fi) | 1984-01-27 |
AU2393384A (en) | 1984-08-02 |
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