IL70830A - Process for the resolution of racemates of optically active bicyclic imino-alpha-carboxylic esters,and the use of the compounds thus obtained for the synthesis of carboxyalkyldipeptides - Google Patents

Process for the resolution of racemates of optically active bicyclic imino-alpha-carboxylic esters,and the use of the compounds thus obtained for the synthesis of carboxyalkyldipeptides

Info

Publication number
IL70830A
IL70830A IL70830A IL7083084A IL70830A IL 70830 A IL70830 A IL 70830A IL 70830 A IL70830 A IL 70830A IL 7083084 A IL7083084 A IL 7083084A IL 70830 A IL70830 A IL 70830A
Authority
IL
Israel
Prior art keywords
carboxyalkyldipeptides
racemates
alpha
resolution
synthesis
Prior art date
Application number
IL70830A
Other languages
English (en)
Other versions
IL70830A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19833303139 external-priority patent/DE3303139A1/de
Priority claimed from DE19833303112 external-priority patent/DE3303112A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL70830A0 publication Critical patent/IL70830A0/xx
Publication of IL70830A publication Critical patent/IL70830A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL70830A 1983-01-31 1984-01-30 Process for the resolution of racemates of optically active bicyclic imino-alpha-carboxylic esters,and the use of the compounds thus obtained for the synthesis of carboxyalkyldipeptides IL70830A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833303139 DE3303139A1 (de) 1983-01-31 1983-01-31 Verfahren zur herstellung von carboxyalkyldipeptiden
DE19833303112 DE3303112A1 (de) 1983-01-31 1983-01-31 Verfahren zur racemattrennung optisch aktiver bicyclischer imino-(alpha)-carbonsaeuren

Publications (2)

Publication Number Publication Date
IL70830A0 IL70830A0 (en) 1984-04-30
IL70830A true IL70830A (en) 1988-02-29

Family

ID=25807929

Family Applications (1)

Application Number Title Priority Date Filing Date
IL70830A IL70830A (en) 1983-01-31 1984-01-30 Process for the resolution of racemates of optically active bicyclic imino-alpha-carboxylic esters,and the use of the compounds thus obtained for the synthesis of carboxyalkyldipeptides

Country Status (17)

Country Link
EP (1) EP0115345B1 (xx)
JP (1) JPH0788358B2 (xx)
KR (1) KR910001438B1 (xx)
AU (1) AU566589B2 (xx)
CA (2) CA1283249C (xx)
DE (1) DE3468415D1 (xx)
DK (1) DK174386B1 (xx)
ES (2) ES8500228A1 (xx)
FI (1) FI88153C (xx)
GR (1) GR82650B (xx)
HU (1) HU191120B (xx)
IE (1) IE56654B1 (xx)
IL (1) IL70830A (xx)
MA (1) MA20020A1 (xx)
NO (1) NO166641C (xx)
NZ (1) NZ206980A (xx)
PT (1) PT78036B (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500713A (en) * 1982-09-23 1985-02-19 Usv Pharmaceutical Corporation Therapeutic dipeptides
DE3345355A1 (de) * 1983-12-15 1985-06-27 Hoechst Ag, 6230 Frankfurt Verfahren zur racematspaltung bicyclischer imino-(alpha)-carbonsaeureester
CA1244041A (en) * 1984-07-30 1988-11-01 Elijah H. Gold Process for the preparation of cis, endo- octahydrocyclopenta¬b|pyrrole-2-carboxylate
HU192914B (en) * 1985-02-11 1987-07-28 Richter Gedeon Vegyeszet Process for producing new 3-/substituted amino/-5-phenyl-2/3h/-furanone derivatives and pharmaceutically acceptable salts
FR2620703B1 (fr) * 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
HU904967D0 (en) * 1988-04-22 1991-01-28 Hoechst Ag Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
US6407262B1 (en) 2001-11-21 2002-06-18 Brantford Chemicals Inc. Process for the preparation of Ramipril
WO2006059347A2 (en) * 2004-12-01 2006-06-08 Morepen Laboratories Limited Improved process for preparation of ramipril
ES2686298T3 (es) 2010-04-20 2018-10-17 Chiral Quest, Inc. Procedimiento enantioselectivo para alaninas beta sustituidas con cicloalquenilo

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4374847A (en) * 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids

Also Published As

Publication number Publication date
FI88153C (fi) 1993-04-13
DK174386B1 (da) 2003-01-27
FI840350A0 (fi) 1984-01-27
FI88153B (fi) 1992-12-31
NO840350L (no) 1984-08-01
MA20020A1 (fr) 1984-10-01
JPH0517439A (ja) 1993-01-26
IE840210L (en) 1984-07-31
IL70830A0 (en) 1984-04-30
HUT34159A (en) 1985-02-28
ES529272A0 (es) 1984-10-01
DK41584A (da) 1984-08-01
CA1317067C (en) 1993-04-27
DK41584D0 (da) 1984-01-30
NO166641C (no) 1991-08-21
IE56654B1 (en) 1991-10-23
KR910001438B1 (ko) 1991-03-07
HU191120B (en) 1987-01-28
NZ206980A (en) 1988-05-30
EP0115345B1 (de) 1988-01-07
GR82650B (xx) 1985-02-07
PT78036A (de) 1984-02-01
PT78036B (de) 1986-05-30
DE3468415D1 (en) 1988-02-11
ES8500228A1 (es) 1984-10-01
ES8501759A1 (es) 1984-12-01
JPH0788358B2 (ja) 1995-09-27
AU2393384A (en) 1984-08-02
FI840350A (fi) 1984-08-01
AU566589B2 (en) 1987-10-22
ES531284A0 (es) 1984-12-01
CA1283249C (en) 1991-04-16
EP0115345A1 (de) 1984-08-08
NO166641B (no) 1991-05-13

Similar Documents

Publication Publication Date Title
ZA84669B (en) A process for the resolution of racemates of optically active bicyclic imino-alpha-carboxylic esters,and the use of the compounds thus obtainable for the synthesis of carboxyalkyldipeptides
PT79129B (en) Process for the preparation of new esters
CU21532A3 (en) Procedure for the production of bicyclic compounds
PT79065A (en) Process for the preparation of penems
EP0252406A3 (en) Process for the manufacture of polycyclic compounds
DE3460025D1 (en) Process for the preparation of delta-formyl-valeric-acid esters
ZA893392B (en) Process for the manufacture of optically active naphthothiazepinones
DE3261829D1 (en) Process for the synthesis of p-nitrophenetol
EP0130938A3 (en) Process for the preparation of 2-arylbenzotriazoles
IL70830A (en) Process for the resolution of racemates of optically active bicyclic imino-alpha-carboxylic esters,and the use of the compounds thus obtained for the synthesis of carboxyalkyldipeptides
NO844563L (no) Fremgangsmaate til fremstilling av titandioksyd
PT78787B (en) Process for the preparation of spyrosuccinimides
DE3460169D1 (en) Process for the manufacture of 3-hydroxytetrahydrofuran
DE3465185D1 (en) Process for producing optically active cyclopentenolones
DE3461176D1 (en) Catalytic process for the preparation of hexafluoracetone
DE3260239D1 (en) Process for the preparation of carbonic esters
DE3468111D1 (en) Process for the preparation of polyols
IT8448824A0 (it) Procedimento per la produzione difibre di carbonio
DE3369912D1 (en) Process for the calcination of phosphorus-molybdenum catalyst
EP0136429A3 (en) Process for the preparation of 2-phenylethylchlorsilanes
DE3160799D1 (en) Process for the preparation of 1-alkenyl isocyanates
PT79568A (en) Process for the preparation of new azabicyclo compounds
GB2207088B (en) Process for the manufacture of a liquid absorbing pad
DE3466679D1 (en) Process for the preparation of alpha-haloalkyl esters
DE3461078D1 (en) Process for the preparation of diacyloxybutenes

Legal Events

Date Code Title Description
KB Patent renewed
HP Change in proprietorship
EXP Patent expired