MA20020A1 - Procede de separation des racemates d'esters d'acides imino alpha carboxyliques bicycliques optiquement actifs et utilisation des composes ainsi obtenus pour la synthese de carboxyalcoyldipeptides. - Google Patents

Procede de separation des racemates d'esters d'acides imino alpha carboxyliques bicycliques optiquement actifs et utilisation des composes ainsi obtenus pour la synthese de carboxyalcoyldipeptides.

Info

Publication number
MA20020A1
MA20020A1 MA20241A MA20241A MA20020A1 MA 20020 A1 MA20020 A1 MA 20020A1 MA 20241 A MA20241 A MA 20241A MA 20241 A MA20241 A MA 20241A MA 20020 A1 MA20020 A1 MA 20020A1
Authority
MA
Morocco
Prior art keywords
bicyclic
carboxyalcoyldipeptides
racemates
synthesis
compounds
Prior art date
Application number
MA20241A
Other languages
English (en)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19833303139 external-priority patent/DE3303139A1/de
Priority claimed from DE19833303112 external-priority patent/DE3303112A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of MA20020A1 publication Critical patent/MA20020A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
MA20241A 1983-01-31 1984-01-30 Procede de separation des racemates d'esters d'acides imino alpha carboxyliques bicycliques optiquement actifs et utilisation des composes ainsi obtenus pour la synthese de carboxyalcoyldipeptides. MA20020A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833303139 DE3303139A1 (de) 1983-01-31 1983-01-31 Verfahren zur herstellung von carboxyalkyldipeptiden
DE19833303112 DE3303112A1 (de) 1983-01-31 1983-01-31 Verfahren zur racemattrennung optisch aktiver bicyclischer imino-(alpha)-carbonsaeuren

Publications (1)

Publication Number Publication Date
MA20020A1 true MA20020A1 (fr) 1984-10-01

Family

ID=25807929

Family Applications (1)

Application Number Title Priority Date Filing Date
MA20241A MA20020A1 (fr) 1983-01-31 1984-01-30 Procede de separation des racemates d'esters d'acides imino alpha carboxyliques bicycliques optiquement actifs et utilisation des composes ainsi obtenus pour la synthese de carboxyalcoyldipeptides.

Country Status (17)

Country Link
EP (1) EP0115345B1 (fr)
JP (1) JPH0788358B2 (fr)
KR (1) KR910001438B1 (fr)
AU (1) AU566589B2 (fr)
CA (2) CA1283249C (fr)
DE (1) DE3468415D1 (fr)
DK (1) DK174386B1 (fr)
ES (2) ES529272A0 (fr)
FI (1) FI88153C (fr)
GR (1) GR82650B (fr)
HU (1) HU191120B (fr)
IE (1) IE56654B1 (fr)
IL (1) IL70830A (fr)
MA (1) MA20020A1 (fr)
NO (1) NO166641C (fr)
NZ (1) NZ206980A (fr)
PT (1) PT78036B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500713A (en) * 1982-09-23 1985-02-19 Usv Pharmaceutical Corporation Therapeutic dipeptides
DE3345355A1 (de) * 1983-12-15 1985-06-27 Hoechst Ag, 6230 Frankfurt Verfahren zur racematspaltung bicyclischer imino-(alpha)-carbonsaeureester
AU581919B2 (en) * 1984-07-30 1989-03-09 Schering Corporation Process for the preparation of cis, endooctahydrocyclopenta (b) pyrrole-2-carboxylate
HU192914B (en) * 1985-02-11 1987-07-28 Richter Gedeon Vegyeszet Process for producing new 3-/substituted amino/-5-phenyl-2/3h/-furanone derivatives and pharmaceutically acceptable salts
FR2620703B1 (fr) * 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
HU904967D0 (en) * 1988-04-22 1991-01-28 Hoechst Ag Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
US6407262B1 (en) 2001-11-21 2002-06-18 Brantford Chemicals Inc. Process for the preparation of Ramipril
WO2006059347A2 (fr) * 2004-12-01 2006-06-08 Morepen Laboratories Limited Procede de preparation ameliore de ramipril
CN102984945B (zh) 2010-04-20 2014-08-20 凯瑞斯德生化(苏州)有限公司 一种环烯基在β位取代的丙氨酸的不对称合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4374847A (en) * 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids

Also Published As

Publication number Publication date
IE56654B1 (en) 1991-10-23
NO840350L (no) 1984-08-01
GR82650B (fr) 1985-02-07
ES8500228A1 (es) 1984-10-01
JPH0788358B2 (ja) 1995-09-27
AU566589B2 (en) 1987-10-22
ES8501759A1 (es) 1984-12-01
IL70830A (en) 1988-02-29
CA1317067C (fr) 1993-04-27
FI88153C (fi) 1993-04-13
DK41584D0 (da) 1984-01-30
HUT34159A (en) 1985-02-28
DK174386B1 (da) 2003-01-27
EP0115345A1 (fr) 1984-08-08
ES531284A0 (es) 1984-12-01
NO166641C (no) 1991-08-21
IE840210L (en) 1984-07-31
CA1283249C (fr) 1991-04-16
FI840350A0 (fi) 1984-01-27
EP0115345B1 (fr) 1988-01-07
JPH0517439A (ja) 1993-01-26
DK41584A (da) 1984-08-01
NZ206980A (en) 1988-05-30
FI840350A (fi) 1984-08-01
FI88153B (fi) 1992-12-31
IL70830A0 (en) 1984-04-30
DE3468415D1 (en) 1988-02-11
ES529272A0 (es) 1984-10-01
NO166641B (no) 1991-05-13
AU2393384A (en) 1984-08-02
KR910001438B1 (ko) 1991-03-07
HU191120B (en) 1987-01-28
PT78036A (de) 1984-02-01
PT78036B (de) 1986-05-30

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