RO91183B - Procedeu de preparare a monoesterilor optici puri de acid tartric cu alcanolamine optic active - Google Patents

Procedeu de preparare a monoesterilor optici puri de acid tartric cu alcanolamine optic active

Info

Publication number
RO91183B
RO91183B RO115505A RO11550584A RO91183B RO 91183 B RO91183 B RO 91183B RO 115505 A RO115505 A RO 115505A RO 11550584 A RO11550584 A RO 11550584A RO 91183 B RO91183 B RO 91183B
Authority
RO
Romania
Prior art keywords
radical
carbon atoms
general formula
optically pure
tartaric acid
Prior art date
Application number
RO115505A
Other languages
English (en)
Other versions
RO91183A (ro
Inventor
Lindner Volfgang
Original Assignee
Chemie Linz Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemie Linz Aktiengesellschaft filed Critical Chemie Linz Aktiengesellschaft
Publication of RO91183A publication Critical patent/RO91183A/ro
Publication of RO91183B publication Critical patent/RO91183B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/38—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Inventia se refera la un procedeu pentru preparareamonoesterilor acidului tartic cu alcanolamine chirale, optic puri cu formula generala I: în care A reprezinta un radical nitrofenil, naftaloximetil sau indoliloximetil sau un radical fenil substituit cu formula: în care R3 reprezinta un radical metoxietl sau radicalul -Nh-acil, radicalul acid fiind definit ca radical alcanoil inferior cu maximum 4 atomi de carbon sau ca radical de dialchilcabamoil, în care alchil poseda 1 sau 2 atomi de carbon, iar R4 reprezinta hidrogen sau radicalul CH3 . CO-R2 reprezinta hidrogen sau un radical de alchil ramificat cu 3 sau 4 atomi de carbon si R1 reprezinta radicalul unui acid (R,R) sau formula generala II: HOOC - CH(OR5)-CH(OR5)-CO, R5 fiind un radical alchil cu 1 pâna la 4 atomi de carbon, benzil, un radical beta-beta-diclorvinil, un radical de alcanoil cu 1-5 atomi de carbon eventual substituit cu clor, un radical defenilacetil, un radical de benzoil sau toluenil, precum si a sarurilor lor cu acizi sau baze, caracterizat prin aceea ca un amestec de antipozi optici cu formula generala: în care A, R2, R3, R4 si acil sunt definiti ca mai sus, se lasa sa reactioneze în topitura sau într-un solvent aprotic, ales dintre diclormetan, 1,2-dicloretan, acetona, acetonitril, toluen, dimetilsulfoxid, tetrahidrofuran, dimetilformamida, etilenglicoldimetileter, acetat de etil, dietileter, N-metilpirolidona-2. cu un acid (R,R) sau (S,S) tartic disubstituit cu formula generala: HOOc-CH(OR5)-CH(OR5)-COOH în care R5 este definit ca mai sus, cu anhidrida acestuia la o temperatura între remperatura camerei si 90 degree C, cu conditia ca la reactia cu acidul liber s
RO115505A 1983-08-19 1984-08-16 Procedeu de preparare a monoesterilor optici puri de acid tartric cu alcanolamine optic active RO91183B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3330005A DE3330005A1 (de) 1983-08-19 1983-08-19 Weinsaeuremonoester von optisch aktiven alkanolaminen, verfahren zu ihrer herstellung und ihre verwendung

Publications (2)

Publication Number Publication Date
RO91183A RO91183A (ro) 1987-07-30
RO91183B true RO91183B (ro) 1987-07-31

Family

ID=6206976

Family Applications (1)

Application Number Title Priority Date Filing Date
RO115505A RO91183B (ro) 1983-08-19 1984-08-16 Procedeu de preparare a monoesterilor optici puri de acid tartric cu alcanolamine optic active

Country Status (22)

Country Link
US (1) US4652672A (ro)
EP (2) EP0145840B1 (ro)
JP (1) JPS6048954A (ro)
AT (2) ATE51614T1 (ro)
AU (1) AU573242B2 (ro)
CA (1) CA1239646A (ro)
CS (1) CS271307B2 (ro)
DD (1) DD231068A1 (ro)
DE (3) DE3330005A1 (ro)
DK (2) DK395884A (ro)
ES (1) ES8601098A1 (ro)
FI (1) FI84910C (ro)
GR (1) GR82176B (ro)
HU (1) HU193587B (ro)
IL (1) IL72634A (ro)
NO (1) NO159083C (ro)
PL (1) PL146074B1 (ro)
PT (1) PT79044B (ro)
RO (1) RO91183B (ro)
SU (1) SU1297723A3 (ro)
YU (1) YU45646B (ro)
ZA (1) ZA846225B (ro)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198448A (en) * 1988-08-10 1993-03-30 Otsuka Pharmaceutical Company, Limited Cardiotonics
US5053514A (en) * 1988-08-10 1991-10-01 Otsuka Pharmaceutical Company, Limited Cardiotonics
AU5546490A (en) * 1989-04-24 1990-11-16 Wilhelm Fleischhacker Enantiomer-free 1,2-aminoalcohols acetalically protected on the oxygen, their production and use
JPH0674243B2 (ja) * 1989-12-27 1994-09-21 ダイソー株式会社 光学純度の高い光学活性アテノロール塩及びアテノロールの製法
JP2801768B2 (ja) 1990-11-17 1998-09-21 日東電工株式会社 新規な光学活性メトプロロール・酒石酸誘導体塩及びその製法、並びにこの塩を用いる光学活性メトプロロールの製法
FI93833C (fi) * 1992-05-14 1995-06-12 Orion Yhtymae Oy Menetelmä propionihappojohdosten valmistamiseksi
WO2003029199A1 (en) * 2001-09-28 2003-04-10 Takeda Chemical Industries, Ltd. Benzene derivatives, process for preparing the same and use thereof
RU2245868C2 (ru) * 2003-04-09 2005-02-10 Институт органической и физической химии (ИОФХ) им. А.Е. Арбузова Казанского научного центра РАН Способ разделения на энантиомеры рацемического 1-(изопропиламино)-3-(1-нафтилокси)-2-пропанола
JP2005104895A (ja) * 2003-09-30 2005-04-21 Nippon Kayaku Co Ltd 光学活性なアミノアルコール化合物の製造法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL300886A (ro) * 1962-11-23
US3541130A (en) * 1967-02-06 1970-11-17 Boehringer Sohn Ingelheim 1-(cyanophenoxy)-2-hydroxy-3-tert.-butylamine propanes
CH635573A5 (en) * 1977-03-24 1983-04-15 Sandoz Ag Process for preparing novel 1,2-dihydroxypropane derivatives
GB8315495D0 (en) * 1983-06-06 1983-07-13 Sumitomo Chemical Co Fungicidal aniline derivatives

Also Published As

Publication number Publication date
DD231068A1 (de) 1985-12-18
GR82176B (ro) 1984-12-13
DE3481839D1 (de) 1990-05-10
YU45646B (sh) 1992-07-20
US4652672A (en) 1987-03-24
FI84910B (fi) 1991-10-31
IL72634A0 (en) 1984-11-30
CS625184A2 (en) 1989-04-14
YU142784A (en) 1988-04-30
IL72634A (en) 1987-12-20
ATE51614T1 (de) 1990-04-15
EP0135162A3 (en) 1986-04-16
DE3330005A1 (de) 1985-02-28
DK151892A (da) 1992-12-18
CA1239646A (en) 1988-07-26
EP0135162B1 (de) 1990-04-04
EP0145840A1 (de) 1985-06-26
CS271307B2 (en) 1990-09-12
ES535243A0 (es) 1985-10-16
ZA846225B (en) 1985-03-27
NO159083C (no) 1988-11-30
DE3463500D1 (en) 1987-06-11
EP0145840B1 (de) 1987-05-06
AU3176284A (en) 1985-02-21
SU1297723A3 (ru) 1987-03-15
DK395884D0 (da) 1984-08-17
ATE26974T1 (de) 1987-05-15
NO159083B (no) 1988-08-22
PT79044A (en) 1984-09-01
PL249228A1 (en) 1985-05-21
HU193587B (en) 1987-10-28
AU573242B2 (en) 1988-06-02
RO91183A (ro) 1987-07-30
ES8601098A1 (es) 1985-10-16
HUT34949A (en) 1985-05-28
JPS6048954A (ja) 1985-03-16
DK395884A (da) 1985-02-20
FI843148A7 (fi) 1985-02-20
FI84910C (fi) 1992-02-10
PT79044B (en) 1986-08-12
PL146074B1 (en) 1988-12-31
EP0135162A2 (de) 1985-03-27
FI843148A0 (fi) 1984-08-10
NO843285L (no) 1985-02-20

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